BR112021020359A2 - Composição autoemulsificante de fármaco de polifenol de flavonoide, método de preparação da mesma, composição farmacêutica da mesma e aplicação da mesma - Google Patents

Composição autoemulsificante de fármaco de polifenol de flavonoide, método de preparação da mesma, composição farmacêutica da mesma e aplicação da mesma

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Publication number
BR112021020359A2
BR112021020359A2 BR112021020359A BR112021020359A BR112021020359A2 BR 112021020359 A2 BR112021020359 A2 BR 112021020359A2 BR 112021020359 A BR112021020359 A BR 112021020359A BR 112021020359 A BR112021020359 A BR 112021020359A BR 112021020359 A2 BR112021020359 A2 BR 112021020359A2
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BR
Brazil
Prior art keywords
composition
flavonoid polyphenol
emulsifying
preparation
application
Prior art date
Application number
BR112021020359A
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English (en)
Other versions
BR112021020359B1 (pt
Inventor
Bangyuan Wang
Hengfeng Liao
Jun Ye
Junzhuo Zhou
Lu Liu
Wujun Dong
Xuejun Xia
Yanfang Yang
Yu Feng
Yue Gao
Yuling Liu
Yun Zhang
Zhihua Liu
Original Assignee
Beijing Wehand Bio Pharmaceutical Co Ltd
Inst Of Materia Medica Chinese Academy Of Medical Science & Peking Union Medical College
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Beijing Wehand Bio Pharmaceutical Co Ltd, Inst Of Materia Medica Chinese Academy Of Medical Science & Peking Union Medical College filed Critical Beijing Wehand Bio Pharmaceutical Co Ltd
Publication of BR112021020359A2 publication Critical patent/BR112021020359A2/pt
Publication of BR112021020359B1 publication Critical patent/BR112021020359B1/pt

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/05—Phenols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/12—Ketones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
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    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
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    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
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    • A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
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    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
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    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
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Abstract

composição autoemulsificante de fármaco de polifenol de flavonoide, método de preparação da mesma, composição farmacêutica da mesma e aplicação da mesma. trata-se de uma composição autoemulsificante de fármaco de polifenol de flavonoide com base em um complexo fosfolipídico de fármaco de polifenol de flavonoide que é usado como intermediário, em que a composição compreende um complexo fosfolipídico de fármaco de polifenol de flavonoide uma fase oleosa, um emulsificante e um coemulsificante, em que o fármaco de polifenol de flavonoide compreende um ou mais selecionados a partir de baicaleína, proantocianidina, quercetina, curcumina e resveratrol. a composição autoemulsificante descrita tem os efeitos benéficos de boa estabilidade, uma alta quantidade de carregamento de fármaco, alta biodisponibilidade e outros.
BR112021020359-1A 2019-04-09 2020-04-08 Composição autoemulsificante de fármaco de polifenol, método para preparar a mesma e composição farmacêutica compreendendo a mesma BR112021020359B1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN201910278955.6A CN111803632B (zh) 2019-04-09 2019-04-09 黄酮多酚类药物自乳化组合物、其制备方法、药物组合物及用途
CN201910278955-6 2019-04-09
PCT/CN2020/083837 WO2020207417A1 (zh) 2019-04-09 2020-04-08 黄酮多酚类药物自乳化组合物、其制备方法、药物组合物及用途

Publications (2)

Publication Number Publication Date
BR112021020359A2 true BR112021020359A2 (pt) 2021-12-07
BR112021020359B1 BR112021020359B1 (pt) 2024-06-04

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Also Published As

Publication number Publication date
CN111803632B (zh) 2022-04-29
CN114617968A (zh) 2022-06-14
AU2020256609A1 (en) 2021-11-11
CN114617968B (zh) 2023-10-03
EP3954380A1 (en) 2022-02-16
CN111803632A (zh) 2020-10-23
SG11202111116VA (en) 2021-11-29
KR20210149829A (ko) 2021-12-09
AU2020256609B2 (en) 2023-09-28
KR102497718B1 (ko) 2023-02-17
ZA202108771B (en) 2022-09-28
MX2021012268A (es) 2022-01-04
JP2022530752A (ja) 2022-07-01
CA3132454C (en) 2023-11-07
WO2020207417A1 (zh) 2020-10-15
EP3954380A4 (en) 2023-01-11
US20220168237A1 (en) 2022-06-02
US11771660B2 (en) 2023-10-03
CA3132454A1 (en) 2020-10-15

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B06W Patent application suspended after preliminary examination (for patents with searches from other patent authorities) chapter 6.23 patent gazette]
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B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

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