BR112021016964A2 - Métodos de biocatálise de mogrosídeo - Google Patents
Métodos de biocatálise de mogrosídeoInfo
- Publication number
- BR112021016964A2 BR112021016964A2 BR112021016964A BR112021016964A BR112021016964A2 BR 112021016964 A2 BR112021016964 A2 BR 112021016964A2 BR 112021016964 A BR112021016964 A BR 112021016964A BR 112021016964 A BR112021016964 A BR 112021016964A BR 112021016964 A2 BR112021016964 A2 BR 112021016964A2
- Authority
- BR
- Brazil
- Prior art keywords
- siamenoside
- mogroside
- methods
- distribution
- change
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 4
- 229930189775 mogroside Natural products 0.000 title abstract 3
- XJIPREFALCDWRQ-UYQGGQRHSA-N (2r,3r,4s,5s,6r)-2-[[(2r,3s,4s,5r,6s)-3,4-dihydroxy-6-[(3r,6r)-2-hydroxy-6-[(3s,8s,9r,10r,11r,13r,14s,17r)-11-hydroxy-4,4,9,13,14-pentamethyl-3-[(2s,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-2,3,7,8,10,11,12,15,16,17-decahydro-1h-cyclop Chemical compound C([C@H]1O[C@H]([C@@H]([C@@H](O)[C@@H]1O)O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)O[C@H](CC[C@@H](C)[C@@H]1[C@]2(C[C@@H](O)[C@@]3(C)[C@H]4C(C([C@@H](O[C@H]5[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O5)O)CC4)(C)C)=CC[C@H]3[C@]2(C)CC1)C)C(C)(C)O)O[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O XJIPREFALCDWRQ-UYQGGQRHSA-N 0.000 abstract 3
- XJIPREFALCDWRQ-UHFFFAOYSA-N siamenoside I Natural products C1CC2(C)C3CC=C(C(C(OC4C(C(O)C(O)C(CO)O4)O)CC4)(C)C)C4C3(C)C(O)CC2(C)C1C(C)CCC(C(C)(C)O)OC(C(C(O)C1O)OC2C(C(O)C(O)C(CO)O2)O)OC1COC1OC(CO)C(O)C(O)C1O XJIPREFALCDWRQ-UHFFFAOYSA-N 0.000 abstract 3
- 102000004190 Enzymes Human genes 0.000 abstract 2
- 108090000790 Enzymes Proteins 0.000 abstract 2
- 239000007795 chemical reaction product Substances 0.000 abstract 2
- 241001409321 Siraitia grosvenorii Species 0.000 abstract 1
- 235000013361 beverage Nutrition 0.000 abstract 1
- 239000000356 contaminant Substances 0.000 abstract 1
- 235000013305 food Nutrition 0.000 abstract 1
- 235000019264 food flavour enhancer Nutrition 0.000 abstract 1
- 235000003599 food sweetener Nutrition 0.000 abstract 1
- 229940068517 fruit extracts Drugs 0.000 abstract 1
- 229930182470 glycoside Natural products 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- JLYBBRAAICDTIS-UHFFFAOYSA-N mogrol Natural products CC12C(O)CC3(C)C(C(CCC(O)C(C)(C)O)C)CCC3(C)C1CC=C1C2CCC(O)C1(C)C JLYBBRAAICDTIS-UHFFFAOYSA-N 0.000 abstract 1
- -1 mogrol glycosides Chemical class 0.000 abstract 1
- 238000000746 purification Methods 0.000 abstract 1
- 229930190082 siamenoside Natural products 0.000 abstract 1
- 239000003765 sweetening agent Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P33/00—Preparation of steroids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J17/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, having an oxygen-containing hetero ring not condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J17/005—Glycosides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
- C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
- C12Y302/01023—Beta-galactosidase (3.2.1.23), i.e. exo-(1-->4)-beta-D-galactanase
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biotechnology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Seasonings (AREA)
- Saccharide Compounds (AREA)
Abstract
métodos de biocatálise de mogrosídeo. trata-se de extratos de fruta-dos-monges contendo glicosídeos de mogrol como mogrosídeo v que podem ser tratados com enzimas sob condições de reação específicas para mudar a distribuição do produto de reação de siamenosídeo i. as enzimas modificadas são também empregadas para mudar a distribuição de siamenosídeo i de modo a aumentar o rendimento de siamenosídeo i e reduzir os contaminantes de reação. são também descritos métodos de purificação de produto de reação de bioconversão. o siamenosídeo i obtido usando esses métodos é um adoçante útil e intensificador de sabor para composições para alimentos e bebidas e similares.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962810553P | 2019-02-26 | 2019-02-26 | |
| PCT/US2020/019972 WO2020176668A1 (en) | 2019-02-26 | 2020-02-26 | Mogroside biocatalysis methods |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| BR112021016964A2 true BR112021016964A2 (pt) | 2021-11-23 |
| BR112021016964A8 BR112021016964A8 (pt) | 2021-12-14 |
Family
ID=72240173
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112021016964A BR112021016964A8 (pt) | 2019-02-26 | 2020-02-26 | Métodos de biocatálise de mogrosídeo |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20220205010A1 (pt) |
| EP (1) | EP3931202A4 (pt) |
| CN (1) | CN113614098A (pt) |
| BR (1) | BR112021016964A8 (pt) |
| CA (1) | CA3131398A1 (pt) |
| WO (1) | WO2020176668A1 (pt) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114395547B (zh) * | 2022-02-16 | 2023-06-13 | 江南大学 | 一种β-半乳糖苷酶的突变体及其在牛奶中的应用 |
| CN114854722B (zh) * | 2022-05-11 | 2024-01-09 | 成都普睿法药物研发有限公司 | 一种季也蒙念珠菌外切β-1,3-葡聚糖酶及其突变体及应用 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9101162B2 (en) * | 2010-09-03 | 2015-08-11 | Purecircle Sdn Bhd | High-purity mogrosides and process for their purification |
| RU2599166C2 (ru) * | 2011-12-19 | 2016-10-10 | Дзе Кока-Кола Компани | Способы очистки стевиоловых гликозидов и их применение |
| GB201310060D0 (en) * | 2013-03-15 | 2013-07-17 | Tate & Lyle Americas Llc | Redistribution of mogrol glyoside contact |
| ES2925017T3 (es) * | 2015-10-29 | 2022-10-13 | Firmenich Incorporated | Edulcorantes de alta intensidad |
| WO2017202997A1 (en) * | 2016-05-24 | 2017-11-30 | Novozymes A/S | Compositions comprising polypeptides having galactanase activity and polypeptides having beta-galactosidase activity |
-
2020
- 2020-02-26 CA CA3131398A patent/CA3131398A1/en active Pending
- 2020-02-26 EP EP20762270.5A patent/EP3931202A4/en active Pending
- 2020-02-26 WO PCT/US2020/019972 patent/WO2020176668A1/en unknown
- 2020-02-26 US US17/434,234 patent/US20220205010A1/en active Pending
- 2020-02-26 BR BR112021016964A patent/BR112021016964A8/pt unknown
- 2020-02-26 CN CN202080022983.2A patent/CN113614098A/zh active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| BR112021016964A8 (pt) | 2021-12-14 |
| EP3931202A1 (en) | 2022-01-05 |
| WO2020176668A1 (en) | 2020-09-03 |
| CN113614098A (zh) | 2021-11-05 |
| US20220205010A1 (en) | 2022-06-30 |
| WO2020176668A8 (en) | 2021-10-28 |
| CA3131398A1 (en) | 2020-09-03 |
| EP3931202A4 (en) | 2023-02-15 |
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