BR112020022395A2 - Alterações em receptores de endotelina em seguida a hemorragia e ressuscitação por centaquina - Google Patents

Alterações em receptores de endotelina em seguida a hemorragia e ressuscitação por centaquina Download PDF

Info

Publication number
BR112020022395A2
BR112020022395A2 BR112020022395-6A BR112020022395A BR112020022395A2 BR 112020022395 A2 BR112020022395 A2 BR 112020022395A2 BR 112020022395 A BR112020022395 A BR 112020022395A BR 112020022395 A2 BR112020022395 A2 BR 112020022395A2
Authority
BR
Brazil
Prior art keywords
centaquin
endothelin
blood
etb
resuscitation
Prior art date
Application number
BR112020022395-6A
Other languages
English (en)
Portuguese (pt)
Inventor
Anil Gulati
Manish Lavhale
Bhawna Katia
Abhishek Kumar Singh
Original Assignee
Midwestern University
Pharmazz, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Midwestern University, Pharmazz, Inc. filed Critical Midwestern University
Publication of BR112020022395A2 publication Critical patent/BR112020022395A2/pt

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22Hormones
    • A61K38/2285Endothelin, vasoactive intestinal contractor [VIC]
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Urology & Nephrology (AREA)
  • Zoology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Endocrinology (AREA)
  • Vascular Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
BR112020022395-6A 2018-05-03 2019-05-03 Alterações em receptores de endotelina em seguida a hemorragia e ressuscitação por centaquina BR112020022395A2 (pt)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201862666675P 2018-05-03 2018-05-03
US62/666,675 2018-05-03
IN201841019588 2018-05-25
IN201841019588 2018-05-25
PCT/US2019/030652 WO2019213558A1 (en) 2018-05-03 2019-05-03 Alterations in endothelin receptors following hemorrhage and resuscitation by centhaquin

Publications (1)

Publication Number Publication Date
BR112020022395A2 true BR112020022395A2 (pt) 2021-04-13

Family

ID=68386694

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112020022395-6A BR112020022395A2 (pt) 2018-05-03 2019-05-03 Alterações em receptores de endotelina em seguida a hemorragia e ressuscitação por centaquina

Country Status (9)

Country Link
US (1) US20210169978A1 (https=)
EP (2) EP3813942B1 (https=)
JP (1) JP7458032B2 (https=)
CN (1) CN112469474A (https=)
AU (1) AU2019262612B2 (https=)
BR (1) BR112020022395A2 (https=)
ES (1) ES2978951T3 (https=)
PL (1) PL3813942T3 (https=)
WO (1) WO2019213558A1 (https=)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2010241564B2 (en) 2009-04-30 2014-07-31 Midwestern University Novel therapeutic treatments using centhaquin
JP2024517334A (ja) * 2021-05-11 2024-04-19 ファーマズ,インコーポレイテッド コロナウイルス疾患(covid-19)における急性呼吸窮迫症候群(ards)の治療のための医薬組成物及び方法
US20240207356A1 (en) * 2022-12-26 2024-06-27 Pharmazz, Inc. Composition and method for wound healing and repair of damaged nerves
US20240382461A1 (en) * 2023-05-15 2024-11-21 Pharmazz, Inc. Pharmaceutical composition and method for prevention and treatment of hearing loss
IN202411028038A (https=) * 2024-04-04 2025-05-23

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0597891A (ja) * 1991-04-24 1993-04-20 Banyu Pharmaceut Co Ltd 血管弛緩ペプチド類
CA2578709C (en) * 2004-06-17 2010-06-15 Virun, Inc. Compositions comprising a mucoadhesive protein and an active principle for mucosal delivery of said agents
JP2009506119A (ja) * 2005-08-31 2009-02-12 ユニバーシティ オブ テネシー リサーチ ファウンデーション 選択的アンドロゲン受容体モジュレーターを用いる腎疾患、熱傷、創傷および脊髄損傷の処置
US9829494B2 (en) 2005-12-01 2017-11-28 Adrenomed Ag Methods of treatment using ADM antibodies
US20080242687A1 (en) * 2007-04-02 2008-10-02 Auspex Pharmaceuticals, Inc. Substituted pyrimidines
AU2008237062A1 (en) 2007-04-10 2008-10-16 Auspex Pharmaceuticals, Inc. Substituted deuterium enriched thiophenes for the treatment of hypertension
EP2545920A1 (en) 2007-08-22 2013-01-16 Abbott GmbH & Co. KG Therapy for complications of diabetes
AU2010241564B2 (en) * 2009-04-30 2014-07-31 Midwestern University Novel therapeutic treatments using centhaquin
US20130296331A1 (en) 2010-11-26 2013-11-07 Technion Research And Development Foundation Ltd. Compositions and methods for ameliorating renal dysfunction induced by renal hypoperfusion or acute kidney injury
BR112015004643A2 (pt) 2012-08-31 2017-07-04 Univ Midwestern métodos e composições para ressucitação hipotensiva
AU2014287427B2 (en) 2013-07-08 2019-11-21 Midwestern University Compositions and methods for treating neuropsychiatric disorders using an endothelin-B receptor agonist

Also Published As

Publication number Publication date
EP3813942A1 (en) 2021-05-05
JP2021523125A (ja) 2021-09-02
EP3813942A4 (en) 2022-01-19
AU2019262612B2 (en) 2025-04-03
AU2019262612A1 (en) 2020-11-26
WO2019213558A1 (en) 2019-11-07
CA3099128A1 (en) 2019-11-07
US20210169978A1 (en) 2021-06-10
CN112469474A (zh) 2021-03-09
PL3813942T3 (pl) 2024-07-22
JP7458032B2 (ja) 2024-03-29
ES2978951T3 (es) 2024-09-23
EP3813942B1 (en) 2024-04-17
EP4364811A2 (en) 2024-05-08
EP4364811A3 (en) 2024-07-10

Similar Documents

Publication Publication Date Title
JP7458032B2 (ja) 出血およびセンタキンによる蘇生後のエンドセリン受容体の変化
US20200375953A1 (en) Methods of Treating Hepatorenal Syndrome and Hepatic Encephalopathy with Thromboxane-A2 Receptor Antagonists
JP3838065B2 (ja) 肺高血圧の治療剤
Adams et al. Physiology, pathophysiology, and anesthetic management of patients with gastrointestinal and endocrine disease
CN110354267A (zh) 用于低血压复苏的方法和组合物
ES2955158T3 (es) Composiciones y métodos de tratamiento de la distrofia muscular con antagonistas del receptor de tromboxano-A2
CA3099128C (en) Alterations in endothelin receptors following hemorrhage and resuscitation by centhaquin
BRPI0620242A2 (pt) combinação compreendendo a combretastatina e agentes anti-cancerìgenos
TW202404627A (zh) 使用cd39、重組cd39用於急性器官損傷的治療
JP2022544718A (ja) 敗血症性心筋症を治療するための組成物および方法
WO2021224494A1 (en) New treatments of viral infections
Briyal et al. Alterations in endothelin receptors following hemorrhage and resuscitation by centhaquin.
AU2017219121A1 (en) Methods of Treating Hepatorenal Syndrome and Hepatic Encephalopathy with Thromboxane-A2 Receptor Antagonists
RU2785893C2 (ru) Лечение почечно-клеточной карциномы ленватинибом и эверолимусом
HK40101211A (zh) 用於预防或治疗系统性硬化症的药物组合物
Bland-van den Berg Investigations into the hemodynamic and metabolic effects of fructose 1, 6 diphosphate and prostacyclin in hypovolemic shock
HK1258734B (en) Compositions and methods of treating muscular dystrophy with thromboxane-a2 receptor antagonists

Legal Events

Date Code Title Description
B06W Patent application suspended after preliminary examination (for patents with searches from other patent authorities) chapter 6.23 patent gazette]
B11B Dismissal acc. art. 36, par 1 of ipl - no reply within 90 days to fullfil the necessary requirements