BR112020018585A8 - Uso de mimeticos de restrição calórica para potencializar a quimioimunoterapia para o tratamento de câncer - Google Patents
Uso de mimeticos de restrição calórica para potencializar a quimioimunoterapia para o tratamento de câncerInfo
- Publication number
- BR112020018585A8 BR112020018585A8 BR112020018585A BR112020018585A BR112020018585A8 BR 112020018585 A8 BR112020018585 A8 BR 112020018585A8 BR 112020018585 A BR112020018585 A BR 112020018585A BR 112020018585 A BR112020018585 A BR 112020018585A BR 112020018585 A8 BR112020018585 A8 BR 112020018585A8
- Authority
- BR
- Brazil
- Prior art keywords
- crms
- cancer
- chemoimmunotherapy
- caloric restriction
- enhance
- Prior art date
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/194—Carboxylic acids, e.g. valproic acid having two or more carboxyl groups, e.g. succinic, maleic or phthalic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/132—Amines having two or more amino groups, e.g. spermidine, putrescine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/136—Amines having aromatic rings, e.g. ketamine, nortriptyline having the amino group directly attached to the aromatic ring, e.g. benzeneamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A61K31/385—Heterocyclic compounds having sulfur as a ring hetero atom having two or more sulfur atoms in the same ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/4155—1,2-Diazoles non condensed and containing further heterocyclic rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/60—Salicylic acid; Derivatives thereof
- A61K31/612—Salicylic acid; Derivatives thereof having the hydroxy group in position 2 esterified, e.g. salicylsulfuric acid
- A61K31/616—Salicylic acid; Derivatives thereof having the hydroxy group in position 2 esterified, e.g. salicylsulfuric acid by carboxylic acids, e.g. acetylsalicylic acid
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Emergency Medicine (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
USO DE MIMETICOS DE RESTRIÇÃO CALÓRICA PARA POTENCIALIZAR A QUIMIOIMUNOTERAPIA PARA O TRATAMENTO DE CÂNCER . Na maioria dos casos, a quimioterapia e a imunoterapia contra o câncer não produzem respostas duráveis e a regressão completa e permanente dos tumores estabelecidos é rara. Aqui, os inventores mostram que os chamados miméticos de restrição calórica (CRMs), que são compostos naturais ou sintéticos que mimetizam farmacologicamente os efeitos do jejum ou da restrição calórica, podem ser usados para aumentar a probabilidade de cura do câncer. A administração de vários CRMs quimicamente distintos (como hidroxicitrato, ácido lipoico e a espermidina poliamina natural) levou à regressão completa e à indução de respostas imunológicas de proteção anticancerígenas em modelos de camundongos. Este efeito foi alcançado quando CRMs foram combinados com quimioterapia e imunoterapia tendo como alvo as moléculas de ponto de verificação imunológico CTLA-4 e/ou PD-1. Portanto, a restrição calórica e os CRMs podem ser usados para sensibilizar os cânceres à quimioimunoterapia.
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP18305257.0 | 2018-03-12 | ||
EP18305257 | 2018-03-12 | ||
EP18305359 | 2018-03-29 | ||
EP18305359.4 | 2018-03-29 | ||
PCT/EP2019/056041 WO2019175113A1 (en) | 2018-03-12 | 2019-03-11 | Use of caloric restriction mimetics for potentiating chemo-immunotherapy for the treatment of cancers |
Publications (2)
Publication Number | Publication Date |
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BR112020018585A2 BR112020018585A2 (pt) | 2020-12-29 |
BR112020018585A8 true BR112020018585A8 (pt) | 2022-12-06 |
Family
ID=66102028
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112020018585A BR112020018585A8 (pt) | 2018-03-12 | 2019-03-11 | Uso de mimeticos de restrição calórica para potencializar a quimioimunoterapia para o tratamento de câncer |
Country Status (11)
Country | Link |
---|---|
US (1) | US20210030703A1 (pt) |
EP (1) | EP3765085A1 (pt) |
JP (1) | JP2021517589A (pt) |
KR (1) | KR20210004966A (pt) |
CN (1) | CN112218658A (pt) |
AU (1) | AU2019236402A1 (pt) |
BR (1) | BR112020018585A8 (pt) |
CA (1) | CA3093742A1 (pt) |
RU (1) | RU2020133451A (pt) |
SG (1) | SG11202008696RA (pt) |
WO (1) | WO2019175113A1 (pt) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
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EP4059518A4 (en) * | 2019-11-13 | 2023-11-29 | Kyoto University | COMBINATION THERAPY WITH PD-1 SIGNAL INHIBITOR |
IT202000007153A1 (it) * | 2020-04-03 | 2021-10-03 | Ifom Fondazione St Firc Di Oncologia Molecolare | Apporto calorico ridotto e immunoterapia per il trattamento del cancro |
EP4349362A1 (en) * | 2021-05-28 | 2024-04-10 | Nippon Kayaku Kabushiki Kaisha | Combined use of ubenimex and immune checkpoint inhibitors |
WO2023288299A1 (en) * | 2021-07-15 | 2023-01-19 | Farber Partners, Llc | Use of methanol and prodrugs thereof in therapy |
CN115590187A (zh) * | 2021-10-08 | 2023-01-13 | 南京纽邦生物科技有限公司(Cn) | 通过施用二氢小檗碱模拟热量限制的生物学益处的方法和组合物 |
CN115721659A (zh) * | 2021-12-09 | 2023-03-03 | 苏州百迈生物医药有限公司 | 一种表柔比星复方制剂及其制备方法和应用 |
EP4197525A1 (en) * | 2021-12-20 | 2023-06-21 | Scandion Oncology A/S | Combination of drugs for the treatment of cancer |
CN115531555B (zh) * | 2022-08-19 | 2024-02-09 | 上海市第一人民医院 | 一种甘露糖修饰的纳米颗粒在制备治疗骨肉瘤药物中的应用 |
CN115282147A (zh) * | 2022-08-31 | 2022-11-04 | 深圳市宝安区人民医院 | 罗拉匹坦或/和罗拉匹坦衍生物在抗结核分枝杆菌药物中的应用 |
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2019
- 2019-03-11 EP EP19716299.3A patent/EP3765085A1/en active Pending
- 2019-03-11 SG SG11202008696RA patent/SG11202008696RA/en unknown
- 2019-03-11 US US16/980,003 patent/US20210030703A1/en active Pending
- 2019-03-11 AU AU2019236402A patent/AU2019236402A1/en active Pending
- 2019-03-11 KR KR1020207028067A patent/KR20210004966A/ko unknown
- 2019-03-11 WO PCT/EP2019/056041 patent/WO2019175113A1/en unknown
- 2019-03-11 JP JP2020572608A patent/JP2021517589A/ja active Pending
- 2019-03-11 RU RU2020133451A patent/RU2020133451A/ru unknown
- 2019-03-11 BR BR112020018585A patent/BR112020018585A8/pt unknown
- 2019-03-11 CA CA3093742A patent/CA3093742A1/en active Pending
- 2019-03-11 CN CN201980031861.7A patent/CN112218658A/zh active Pending
Also Published As
Publication number | Publication date |
---|---|
WO2019175113A1 (en) | 2019-09-19 |
EP3765085A1 (en) | 2021-01-20 |
CN112218658A (zh) | 2021-01-12 |
US20210030703A1 (en) | 2021-02-04 |
BR112020018585A2 (pt) | 2020-12-29 |
JP2021517589A (ja) | 2021-07-26 |
SG11202008696RA (en) | 2020-10-29 |
KR20210004966A (ko) | 2021-01-13 |
CA3093742A1 (en) | 2019-09-19 |
AU2019236402A1 (en) | 2020-10-01 |
RU2020133451A (ru) | 2022-04-12 |
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