BR112019025242A2 - método para produzir um composto, e, n-carbometoxi-2-[4-(trifluorometil)fenil]etilamina - Google Patents

método para produzir um composto, e, n-carbometoxi-2-[4-(trifluorometil)fenil]etilamina Download PDF

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Publication number
BR112019025242A2
BR112019025242A2 BR112019025242A BR112019025242A BR112019025242A2 BR 112019025242 A2 BR112019025242 A2 BR 112019025242A2 BR 112019025242 A BR112019025242 A BR 112019025242A BR 112019025242 A BR112019025242 A BR 112019025242A BR 112019025242 A2 BR112019025242 A2 BR 112019025242A2
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BR
Brazil
Prior art keywords
compound
ethylamine
trifluoromethyl
phenyl
producing
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BR112019025242A
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English (en)
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BR112019025242B1 (pt
Inventor
Koji Hagiya
Masaya Tanimoto
Shun Tanimura
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Innovative Vector Control Consortium
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Publication date
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Publication of BR112019025242A2 publication Critical patent/BR112019025242A2/pt
Publication of BR112019025242B1 publication Critical patent/BR112019025242B1/pt

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B61/00—Other general methods
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
    • C07C209/54—Preparation of compounds containing amino groups bound to a carbon skeleton by rearrangement reactions
    • C07C209/58—Preparation of compounds containing amino groups bound to a carbon skeleton by rearrangement reactions from or via amides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
    • C07C211/26—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring
    • C07C211/29—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring the carbon skeleton being further substituted by halogen atoms or by nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/02—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
    • C07C233/11—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with carbon atoms of carboxamide groups bound to carbon atoms of an unsaturated carbon skeleton containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C269/00—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/14—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by halogen atoms or by nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/30—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
    • C07C67/333—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by isomerisation; by change of size of the carbon skeleton
    • C07C67/343—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C07C67/347—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by addition to unsaturated carbon-to-carbon bonds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/62—Halogen-containing esters
    • C07C69/65—Halogen-containing esters of unsaturated acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/02—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
    • C07C233/08—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with carbon atoms of carboxamide groups bound to acyclic carbon atoms of a saturated carbon skeleton containing rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/612—Esters of carboxylic acids having a carboxyl group bound to an acyclic carbon atom and having a six-membered aromatic ring in the acid moiety

Abstract

resumo método para produzir um composto, e, n-carbometoxi-2-[4-(trifluorometil)fenil]etilamina a presente invenção provê um método para produzir industrialmente: um composto pirimidina tendo eficácia no controle de pragas; 2-[4-(trifluorometil)fenil] etilamina que é um intermediário de produção do composto pirimidina; um composto feniletilamina utilizável como um intermediário químico farmacêutico e agrícola; e adicionalmente um composto 3-arilpropionamida e um composto éster de ácido 3-arilpropiônico utilizável como intermediários de produção do composto feniletilamina. o composto 3-arilpropionamida ou o composto éster de ácido 3-arilpropiônico podem ser produzidos industrialmente e de modo eficaz em uma etapa única por reação de um composto representado por fórmula (1), (em que x representa um átomo de cloro ou um átomo de bromo; e y representa um grupo alquila opcionalmente substituído com átomo(s) de flúor, um átomo de hidrogênio, um átomo de flúor, um grupo ciano, um grupo alquilcarbonila, um grupo dialquilamino, ou similares) com acrilamida ou um éster de ácido acrílico na presença de um catalisador de metal e um agente redutor.
BR112019025242-8A 2017-05-31 2018-05-30 Método para produzir um composto BR112019025242B1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2017107506 2017-05-31
JP2017-107506 2017-05-31
PCT/JP2018/020798 WO2018221604A1 (ja) 2017-05-31 2018-05-30 ３－アリールプロピオンアミド化合物及び３－アリールプロピオン酸エステル化合物の製造方法

Publications (2)

Publication Number Publication Date
BR112019025242A2 true BR112019025242A2 (pt) 2020-06-09
BR112019025242B1 BR112019025242B1 (pt) 2023-03-21

Family

ID=64456260

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Application Number Title Priority Date Filing Date
BR112019025242-8A BR112019025242B1 (pt) 2017-05-31 2018-05-30 Método para produzir um composto

Country Status (8)

Country Link
US (1) US11028056B2 (pt)
EP (1) EP3632892A4 (pt)
JP (1) JP7138628B2 (pt)
KR (1) KR20200014305A (pt)
CN (1) CN110799490B (pt)
BR (1) BR112019025242B1 (pt)
IL (1) IL270970B2 (pt)
WO (1) WO2018221604A1 (pt)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110407715A (zh) * 2019-07-01 2019-11-05 陕西师范大学 一种普瑞巴林中间体的合成方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4323180A1 (de) 1993-07-10 1995-01-19 Hoechst Schering Agrevo Gmbh Verfahren zur Herstellung von 5-Chlor-4-hydroxypyrimidinen, 2-Chlorenamine als Zwischenprodukte dieses Verfahrens und deren Verwendung
DE19931116A1 (de) 1999-07-06 2001-01-11 Bayer Ag Verfahren zur Herstellung von Phenethylaminen und neue chemische Verbindungen
CN106164053B (zh) * 2014-03-28 2021-07-16 创新媒介控制联盟 嘧啶化合物
JP2017107506A (ja) 2015-12-11 2017-06-15 キヤノン電子株式会社 光学式情報読取装置

Also Published As

Publication number Publication date
WO2018221604A1 (ja) 2018-12-06
US11028056B2 (en) 2021-06-08
BR112019025242B1 (pt) 2023-03-21
EP3632892A1 (en) 2020-04-08
JP7138628B2 (ja) 2022-09-16
IL270970B1 (en) 2023-05-01
IL270970A (en) 2020-01-30
EP3632892A4 (en) 2021-03-03
US20200165209A1 (en) 2020-05-28
CN110799490A (zh) 2020-02-14
JPWO2018221604A1 (ja) 2020-04-02
KR20200014305A (ko) 2020-02-10
IL270970B2 (en) 2023-09-01
CN110799490B (zh) 2023-05-02

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B350 Update of information on the portal [chapter 15.35 patent gazette]
B06W Patent application suspended after preliminary examination (for patents with searches from other patent authorities) chapter 6.23 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

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