BR112019022288A2 - métodos para produzir células duplo-positivas cd4/cd8 e células simples-positivas cd8, população celular, e, reagente para separar células progenitoras hematopoiéticas. - Google Patents

métodos para produzir células duplo-positivas cd4/cd8 e células simples-positivas cd8, população celular, e, reagente para separar células progenitoras hematopoiéticas. Download PDF

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Publication number
BR112019022288A2
BR112019022288A2 BR112019022288-0A BR112019022288A BR112019022288A2 BR 112019022288 A2 BR112019022288 A2 BR 112019022288A2 BR 112019022288 A BR112019022288 A BR 112019022288A BR 112019022288 A2 BR112019022288 A2 BR 112019022288A2
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BR
Brazil
Prior art keywords
positive
cells
fraction
cell
antibody
Prior art date
Application number
BR112019022288-0A
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English (en)
Portuguese (pt)
Inventor
Kaneko Shin
Iriguchi Shoichi
Mishima Yuta
Kassai Yoshiaki
Hayashi Akira
Arima Suguru
Original Assignee
Kyoto University
Takeda Pharmaceutical Company Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Kyoto University, Takeda Pharmaceutical Company Limited filed Critical Kyoto University
Publication of BR112019022288A2 publication Critical patent/BR112019022288A2/pt

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0636—T lymphocytes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0636—T lymphocytes
    • C12N5/0638—Cytotoxic T lymphocytes [CTL] or lymphokine activated killer cells [LAK]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0657—Cardiomyocytes; Heart cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0696—Artificially induced pluripotent stem cells, e.g. iPS
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56966—Animal cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/50—Cell markers; Cell surface determinants
    • C12N2501/505—CD4; CD8
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/11—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from blood or immune system cells

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Cell Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • General Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Virology (AREA)
  • Transplantation (AREA)
  • Developmental Biology & Embryology (AREA)
  • Cardiology (AREA)
  • Rheumatology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
BR112019022288-0A 2017-04-26 2018-04-25 métodos para produzir células duplo-positivas cd4/cd8 e células simples-positivas cd8, população celular, e, reagente para separar células progenitoras hematopoiéticas. BR112019022288A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2017-087723 2017-04-26
JP2017087723 2017-04-26
PCT/JP2018/016864 WO2018199186A1 (ja) 2017-04-26 2018-04-25 造血前駆細胞マーカー

Publications (1)

Publication Number Publication Date
BR112019022288A2 true BR112019022288A2 (pt) 2020-05-19

Family

ID=63918584

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112019022288-0A BR112019022288A2 (pt) 2017-04-26 2018-04-25 métodos para produzir células duplo-positivas cd4/cd8 e células simples-positivas cd8, população celular, e, reagente para separar células progenitoras hematopoiéticas.

Country Status (13)

Country Link
US (1) US20210102167A1 (https=)
EP (1) EP3617307A4 (https=)
JP (2) JP7430877B2 (https=)
KR (1) KR102803233B1 (https=)
CN (1) CN110691843B (https=)
AU (1) AU2018257307B2 (https=)
BR (1) BR112019022288A2 (https=)
CA (1) CA3061289A1 (https=)
EA (1) EA201992483A1 (https=)
IL (1) IL270126B2 (https=)
SG (1) SG11201909795RA (https=)
TW (1) TWI860972B (https=)
WO (1) WO2018199186A1 (https=)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20250230411A1 (en) 2022-03-23 2025-07-17 Kyoto University Method for producing regulatory t cells
WO2023247722A1 (en) * 2022-06-22 2023-12-28 Fondazione Telethon Ets Method for isolating hemogenic endothelial cells
JPWO2024071010A1 (https=) 2022-09-26 2024-04-04
WO2024152926A1 (zh) * 2023-01-18 2024-07-25 深圳市人民医院 造血祖细胞的谱系及其命运决定基因的鉴定及应用

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8034613B2 (en) 2005-06-01 2011-10-11 Wisconsin Alumni Research Foundation Multipotent lymphohematopoietic progenitor cells
WO2011041912A1 (en) 2009-10-09 2011-04-14 University Health Network Self-renewing single human hematopoietic stem cells, an early lymphoid progenitor and methods of enriching the same
CN104053769A (zh) * 2011-11-21 2014-09-17 大学健康网络 造血祖细胞群体和富集其干细胞的方法
WO2015163185A1 (ja) * 2014-04-24 2015-10-29 学校法人関西医科大学 ヒト造血幹細胞濃縮画分の製造方法
EP3219791A4 (en) 2014-11-13 2018-07-18 Kyoto University Method for induction of t cells from pluripotent stem cells
WO2016168586A1 (en) * 2015-04-16 2016-10-20 The Board Of Regents, The University Of Texas System Cd133+ cells and method for expanding
US10961308B2 (en) * 2015-06-29 2021-03-30 The General Hospital Corporation Embigin inhibition for promotion of hematopoietic stem and progenitor cell expansion
CA3003152A1 (en) * 2015-11-04 2017-05-11 Fate Therapeutics, Inc. Methods and compositions for inducing hematopoietic cell differentiation
US10350873B2 (en) 2015-11-11 2019-07-16 Xerox Corporation System and method for removing support structure from three-dimensional printed objects using microwave energy and nanoparticles
EP3476934A4 (en) 2016-06-23 2020-02-26 Kyoto University METHOD FOR PRODUCING CD4 / CD8 POSITIVE DUAL T CELLS

Also Published As

Publication number Publication date
CN110691843B (zh) 2023-10-20
SG11201909795RA (en) 2019-11-28
KR102803233B1 (ko) 2025-05-07
JP2023164892A (ja) 2023-11-14
JP7610817B2 (ja) 2025-01-09
WO2018199186A1 (ja) 2018-11-01
US20210102167A1 (en) 2021-04-08
IL270126A (en) 2019-12-31
NZ758956A (en) 2024-11-29
EP3617307A1 (en) 2020-03-04
TWI860972B (zh) 2024-11-11
TW201843301A (zh) 2018-12-16
IL270126B1 (en) 2024-12-01
EA201992483A1 (ru) 2020-03-06
AU2018257307A1 (en) 2019-11-21
CN110691843A (zh) 2020-01-14
JPWO2018199186A1 (ja) 2020-05-14
AU2018257307B2 (en) 2024-11-07
EP3617307A4 (en) 2021-01-27
IL270126B2 (en) 2025-04-01
CA3061289A1 (en) 2019-10-23
JP7430877B2 (ja) 2024-02-14
KR20200002909A (ko) 2020-01-08

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