BR112019018834A2 - preparação em grande escala de aminoglicosídeos de pseudotrissacarídeos e de seus intermediários - Google Patents

preparação em grande escala de aminoglicosídeos de pseudotrissacarídeos e de seus intermediários Download PDF

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Publication number
BR112019018834A2
BR112019018834A2 BR112019018834A BR112019018834A BR112019018834A2 BR 112019018834 A2 BR112019018834 A2 BR 112019018834A2 BR 112019018834 A BR112019018834 A BR 112019018834A BR 112019018834 A BR112019018834 A BR 112019018834A BR 112019018834 A2 BR112019018834 A2 BR 112019018834A2
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BR
Brazil
Prior art keywords
formula
protected
group
compound
compound represented
Prior art date
Application number
BR112019018834A
Other languages
English (en)
Portuguese (pt)
Inventor
Bushan Kotala Mani
Mizhiritskii Michael
PALIDI Ravinder
Original Assignee
Eloxx Pharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eloxx Pharmaceuticals Ltd filed Critical Eloxx Pharmaceuticals Ltd
Publication of BR112019018834A2 publication Critical patent/BR112019018834A2/pt

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H5/00—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium
    • C07H5/04—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium to nitrogen
    • C07H5/06—Aminosugars
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C07H13/12—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by acids having the group -X-C(=X)-X-, or halides thereof, in which each X means nitrogen, oxygen, sulfur, selenium or tellurium, e.g. carbonic acid, carbamic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
    • C07H15/222—Cyclohexane rings substituted by at least two nitrogen atoms
    • C07H15/224—Cyclohexane rings substituted by at least two nitrogen atoms with only one saccharide radical directly attached to the cyclohexyl radical, e.g. destomycin, fortimicin, neamine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
    • C07H15/222—Cyclohexane rings substituted by at least two nitrogen atoms
    • C07H15/226—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings
    • C07H15/228—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to adjacent ring-carbon atoms of the cyclohexane rings
    • C07H15/23—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to adjacent ring-carbon atoms of the cyclohexane rings with only two saccharide radicals in the molecule, e.g. ambutyrosin, butyrosin, xylostatin, ribostamycin
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
BR112019018834A 2017-03-15 2018-03-15 preparação em grande escala de aminoglicosídeos de pseudotrissacarídeos e de seus intermediários BR112019018834A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN201721008996 2017-03-15
PCT/IL2018/050306 WO2018167794A1 (en) 2017-03-15 2018-03-15 Large scale preparation of pseudo-trisaccharide aminoglycosides and of intermediates thereof

Publications (1)

Publication Number Publication Date
BR112019018834A2 true BR112019018834A2 (pt) 2020-04-14

Family

ID=63521924

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112019018834A BR112019018834A2 (pt) 2017-03-15 2018-03-15 preparação em grande escala de aminoglicosídeos de pseudotrissacarídeos e de seus intermediários

Country Status (9)

Country Link
US (2) US11136345B2 (https=)
EP (1) EP3609902A4 (https=)
JP (1) JP7187471B2 (https=)
CN (2) CN117466958A (https=)
AU (2) AU2018235441C1 (https=)
BR (1) BR112019018834A2 (https=)
CA (1) CA3055883A1 (https=)
IL (1) IL269364B (https=)
WO (1) WO2018167794A1 (https=)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2021061873A1 (en) * 2019-09-23 2021-04-01 Eloxx Pharmaceuticals, Inc. Methods, compositions, and kits for treating polycystic kidney disease

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3897412A (en) 1972-05-04 1975-07-29 Bristol Myers Co Paromomycin antibiotic derivatives
US4024332A (en) 1973-06-05 1977-05-17 Pfizer Inc. Aminoglycoside antibiotics and intermediates therefor
US4029882A (en) 1974-03-19 1977-06-14 Schering Corporation Selective acylation of the C-1 amino group of aminoglycoside antibiotics
US3996205A (en) 1975-09-08 1976-12-07 The Upjohn Company Aminoglycoside antibiotics and intermediates
JPS543043A (en) 1977-06-10 1979-01-11 Meiji Seika Kaisha Ltd Amino-glycoside antibiotics; 1-n-(omega-aminoalkanesulfonyl)derivatives and their preparation
FR2427341A1 (fr) 1978-06-02 1979-12-28 Delalande Sa Nouveaux derives aminoglycosidiques hemisynthetiques, leur procede de preparation et leur application en therapeutique
JPH0446189A (ja) 1990-06-08 1992-02-17 Meiji Seika Kaisha Ltd 新規なリボスタマイシン誘導体
EP2390255B1 (en) 2006-04-03 2016-07-13 Technion Research & Development Foundation Ltd. Novel aminoglycosides and uses thereof in the treatment of genetic disorders
WO2011044538A1 (en) * 2009-10-09 2011-04-14 Achaogen, Inc. Antibacterial aminoglycoside analogs
HRP20180056T1 (hr) 2010-11-18 2018-02-09 Technion Research & Development Foundation Ltd. Aminoglikozidi i upotreba istih u svrhu liječenja genetskih poremećaja
CA2949754A1 (en) * 2014-06-05 2015-12-10 Eloxx Pharmaceuticals Ltd. Use of aminoglycoside analogs in the treatment of rett syndrome
EP3344640A4 (en) 2015-09-02 2019-05-01 Eloxx Pharmaceuticals Ltd. AMINO-LIKES DERIVATIVES AND USES THEREOF FOR THE TREATMENT OF GENETIC DISEASES
EP3350194A4 (en) 2015-09-02 2019-04-24 Eloxx Pharmaceuticals Ltd. AMINO-LIKES DERIVATIVES AND USES THEREOF FOR THE TREATMENT OF GENETIC DISEASES
EP3344641A4 (en) 2015-09-02 2019-09-18 Eloxx Pharmaceuticals Ltd. AMINO-LIKES DERIVATIVES AND USES THEREOF FOR THE TREATMENT OF GENETIC DISEASES

Also Published As

Publication number Publication date
CN110637024B (zh) 2023-10-24
US11136345B2 (en) 2021-10-05
WO2018167794A1 (en) 2018-09-20
US20220033428A1 (en) 2022-02-03
IL269364B (en) 2022-04-01
AU2018235441B2 (en) 2022-07-21
AU2022256098A1 (en) 2022-11-17
US20200079809A1 (en) 2020-03-12
EP3609902A1 (en) 2020-02-19
CN110637024A (zh) 2019-12-31
AU2018235441A2 (en) 2019-11-07
CN117466958A (zh) 2024-01-30
JP7187471B2 (ja) 2022-12-12
AU2018235441C1 (en) 2024-10-24
AU2018235441A1 (en) 2019-09-26
AU2022256098B2 (en) 2024-07-11
JP2020514373A (ja) 2020-05-21
AU2022256098C1 (en) 2024-10-31
IL269364A (en) 2019-11-28
EP3609902A4 (en) 2021-01-06
CA3055883A1 (en) 2018-09-20

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Legal Events

Date Code Title Description
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]

Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI N? 10196/2001, QUE MODIFICOU A LEI N? 9279/96, A CONCESS?O DA PATENTE EST? CONDICIONADA ? ANU?NCIA PR?VIA DA ANVISA. CONSIDERANDO A APROVA??O DOS TERMOS DO PARECER N? 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL N? 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVID?NCIAS CAB?VEIS.

B15K Others concerning applications: alteration of classification

Free format text: AS CLASSIFICACOES ANTERIORES ERAM: C07H 5/06 , C07H 15/224 , C07H 15/232 , A61K 31/7036

Ipc: A61K 31/7036 (2006.01), C07H 15/224 (2006.01), C07

B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B350 Update of information on the portal [chapter 15.35 patent gazette]
B06W Patent application suspended after preliminary examination (for patents with searches from other patent authorities) chapter 6.23 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B11B Dismissal acc. art. 36, par 1 of ipl - no reply within 90 days to fullfil the necessary requirements