CN115279751A - 一种特异性降解tau蛋白的小分子化合物及其用途 - Google Patents
一种特异性降解tau蛋白的小分子化合物及其用途 Download PDFInfo
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Abstract
本发明涉及双功能分子化合物技术领域，公开了一种具有特异性降解tau蛋白功能的小分子化合物及其应用。该特异性降解tau蛋白的小分子化合物的化学结构为TBM‑L‑ULM或其药学上可接受的盐、对映体、立体异构体、溶剂化物、多晶型物或N‑氧化物，其中，TBM为tau蛋白结合部分，L为连接体基团，ULM为泛素连接酶结合部分，所述tau蛋白结合部分与所述泛素连接酶结合部分通过连接体基团连接。本发明所述的特异性降解tau蛋白的小分子化合物能增强细胞中tau蛋白的降解，从而降低tau蛋白的含量。
Description
PCT国内申请，说明书已公开。
Claims (8)
- PCT国内申请，权利要求书已公开。
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| CN202010090680.6A CN113248484A (zh) | 2020-02-13 | 2020-02-13 | 一种特异性降解tau蛋白的小分子化合物及其应用 |
| CN2020100906806 | 2020-02-13 | ||
| PCT/CN2021/075201 WO2021160012A1 (zh) | 2020-02-13 | 2021-02-04 | 一种特异性降解tau蛋白的小分子化合物及其用途 |
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| CN115385908B (zh) * | 2022-07-26 | 2024-04-12 | 阿茨可利(杭州)医学科技有限公司 | 靶向促进tau蛋白去磷酸化的小分子嵌合体及其应用 |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106458993A (zh) * | 2014-04-14 | 2017-02-22 | 阿尔维纳斯股份有限公司 | 基于酰亚胺的蛋白水解调节剂和相关使用方法 |
| CN108137507A (zh) * | 2015-07-10 | 2018-06-08 | 阿尔维纳斯股份有限公司 | 基于mdm2的蛋白水解调节剂和相关的使用方法 |
| CN110234646A (zh) * | 2016-11-01 | 2019-09-13 | 阿尔维纳斯股份有限公司 | 靶向PROTAC的Tau蛋白及相关使用方法 |
| WO2020014489A2 (en) * | 2018-07-11 | 2020-01-16 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | Dimeric immuno-modulatory compounds against cereblon-based mechanisms |
| CN110713480A (zh) * | 2019-10-28 | 2020-01-21 | 浙江省医学科学院 | AChE蛋白降解物及其制备方法和应用 |
-
2020
- 2020-02-13 CN CN202010090680.6A patent/CN113248484A/zh active Pending
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- 2021-02-04 CN CN202180012446.4A patent/CN115279751B/zh active Active
- 2021-02-04 WO PCT/CN2021/075201 patent/WO2021160012A1/zh active Application Filing
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106458993A (zh) * | 2014-04-14 | 2017-02-22 | 阿尔维纳斯股份有限公司 | 基于酰亚胺的蛋白水解调节剂和相关使用方法 |
| CN108137507A (zh) * | 2015-07-10 | 2018-06-08 | 阿尔维纳斯股份有限公司 | 基于mdm2的蛋白水解调节剂和相关的使用方法 |
| CN110234646A (zh) * | 2016-11-01 | 2019-09-13 | 阿尔维纳斯股份有限公司 | 靶向PROTAC的Tau蛋白及相关使用方法 |
| WO2020014489A2 (en) * | 2018-07-11 | 2020-01-16 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | Dimeric immuno-modulatory compounds against cereblon-based mechanisms |
| CN110713480A (zh) * | 2019-10-28 | 2020-01-21 | 浙江省医学科学院 | AChE蛋白降解物及其制备方法和应用 |
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| CN115279751B (zh) | 2023-12-12 |
| CN113248484A (zh) | 2021-08-13 |
| WO2021160012A1 (zh) | 2021-08-19 |
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