BR112019011303B1 - Derivados de ácido hidroxibenzoico, métodos e usos dos mesmos - Google Patents

Derivados de ácido hidroxibenzoico, métodos e usos dos mesmos Download PDF

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Publication number
BR112019011303B1
BR112019011303B1 BR112019011303-7A BR112019011303A BR112019011303B1 BR 112019011303 B1 BR112019011303 B1 BR 112019011303B1 BR 112019011303 A BR112019011303 A BR 112019011303A BR 112019011303 B1 BR112019011303 B1 BR 112019011303B1
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BR
Brazil
Prior art keywords
mitochondrial
aryl
chain
alkyl
cancer
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BR112019011303-7A
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English (en)
Portuguese (pt)
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BR112019011303A2 (pt
Inventor
Maria Fernanda Martins Borges
Paulo Jorge Gouveia Simões Da Silva Oliveira
José Carlos Santos Teixeira
Fernando Cagide Fagin
Ana Catarina Gomes Oliveira
Original Assignee
Centro De Neurociências E Biologia Celular
Universidade Do Porto
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Application filed by Centro De Neurociências E Biologia Celular, Universidade Do Porto filed Critical Centro De Neurociências E Biologia Celular
Publication of BR112019011303A2 publication Critical patent/BR112019011303A2/pt
Publication of BR112019011303B1 publication Critical patent/BR112019011303B1/pt

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/28Phosphorus compounds with one or more P—C bonds
    • C07F9/54Quaternary phosphonium compounds
    • C07F9/5442Aromatic phosphonium compounds (P-C aromatic linkage)
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/28Phosphorus compounds with one or more P—C bonds
    • C07F9/54Quaternary phosphonium compounds
    • C07F9/5456Arylalkanephosphonium compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/66Phosphorus compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/55Phosphorus compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/02Local antiseptics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • A61Q19/08Anti-ageing preparations

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Urology & Nephrology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Birds (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Gerontology & Geriatric Medicine (AREA)
  • Dermatology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cosmetics (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
BR112019011303-7A 2016-12-29 2017-12-29 Derivados de ácido hidroxibenzoico, métodos e usos dos mesmos BR112019011303B1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
PT109818 2016-12-29
PT10981816 2016-12-29
PCT/IB2017/058508 WO2018122789A1 (en) 2016-12-29 2017-12-29 Hydroxybenzoic acid derivatives, methods and uses thereof

Publications (2)

Publication Number Publication Date
BR112019011303A2 BR112019011303A2 (pt) 2019-10-08
BR112019011303B1 true BR112019011303B1 (pt) 2023-03-14

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
BR112019011303-7A BR112019011303B1 (pt) 2016-12-29 2017-12-29 Derivados de ácido hidroxibenzoico, métodos e usos dos mesmos

Country Status (8)

Country Link
US (1) US11078222B2 (enExample)
EP (1) EP3562830B1 (enExample)
JP (2) JP2020503280A (enExample)
KR (1) KR102750630B1 (enExample)
CN (1) CN110114365B (enExample)
BR (1) BR112019011303B1 (enExample)
CA (1) CA3048966A1 (enExample)
WO (1) WO2018122789A1 (enExample)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2021085906A1 (ko) * 2019-10-30 2021-05-06 주식회사 퓨전바이오텍 미토콘드리아 표적 화합물 및 이를 포함하는 노화 관련 질환의 치료 또는 예방을 위한 조성물
WO2023053059A1 (en) * 2021-09-30 2023-04-06 Universidade Do Porto Antifouling compound, method and uses thereof
US20250312360A1 (en) * 2022-05-13 2025-10-09 Virginia Tech Intellectual Properties, Inc. Mitochondrial antioxidant treatment for cask-linked neurodevelopmental disorders
KR20240040435A (ko) * 2022-09-21 2024-03-28 울산과학기술원 미토콘드리아 표적 화합물을 유효성분으로 포함하는 망막 변성 치료용 약학적 조성물
KR102894216B1 (ko) * 2022-12-15 2025-12-18 울산과학기술원 Trap-1 억제제
CN116210697B (zh) * 2023-03-02 2024-05-14 西北农林科技大学 反式肉桂酸在提高苹果树腐烂病抗性中的应用
KR20250126454A (ko) * 2024-02-16 2025-08-25 울산과학기술원 암 세포의 티오에스테라제 및 활성산소종에 의해 자가 조립 중합되는 단량체 및 이의 용도

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010126719A1 (en) * 2009-04-27 2010-11-04 Mcw Research Foundation, Inc. Neuroprotective compounds and their use
GB201320636D0 (en) * 2013-11-22 2014-01-08 Medical Res Council Compounds
CN109328062A (zh) * 2016-03-08 2019-02-12 密执安大学评议会 小分子活性氧簇诱导剂和线粒体活性抑制剂
CN109843896B (zh) * 2016-10-14 2022-12-20 波尔图大学 羟基肉桂酸衍生物、方法及其用途

Also Published As

Publication number Publication date
EP3562830B1 (en) 2023-06-07
US11078222B2 (en) 2021-08-03
CN110114365A (zh) 2019-08-09
KR102750630B1 (ko) 2025-01-06
US20190330249A1 (en) 2019-10-31
EP3562830C0 (en) 2023-06-07
WO2018122789A1 (en) 2018-07-05
KR20190132622A (ko) 2019-11-28
JP7689690B2 (ja) 2025-06-09
BR112019011303A2 (pt) 2019-10-08
EP3562830A1 (en) 2019-11-06
CA3048966A1 (en) 2018-07-05
JP2023051961A (ja) 2023-04-11
JP2020503280A (ja) 2020-01-30
CN110114365B (zh) 2022-12-13

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B350 Update of information on the portal [chapter 15.35 patent gazette]
B06W Patent application suspended after preliminary examination (for patents with searches from other patent authorities) chapter 6.23 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

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