BR112019010115A2 - método de proporcionar benefícios de higiene bucal - Google Patents
método de proporcionar benefícios de higiene bucal Download PDFInfo
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- BR112019010115A2 BR112019010115A2 BR112019010115A BR112019010115A BR112019010115A2 BR 112019010115 A2 BR112019010115 A2 BR 112019010115A2 BR 112019010115 A BR112019010115 A BR 112019010115A BR 112019010115 A BR112019010115 A BR 112019010115A BR 112019010115 A2 BR112019010115 A2 BR 112019010115A2
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- 229960002139 pilocarpine hydrochloride Drugs 0.000 description 1
- 239000010665 pine oil Substances 0.000 description 1
- 239000001739 pinus spp. Substances 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 229920003023 plastic Polymers 0.000 description 1
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- 229920000573 polyethylene Polymers 0.000 description 1
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- 235000013809 polyvinylpolypyrrolidone Nutrition 0.000 description 1
- 229920000523 polyvinylpolypyrrolidone Polymers 0.000 description 1
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- 235000015497 potassium bicarbonate Nutrition 0.000 description 1
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- 239000001103 potassium chloride Substances 0.000 description 1
- 235000011164 potassium chloride Nutrition 0.000 description 1
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- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 229920002414 procyanidin Polymers 0.000 description 1
- KCXFHTAICRTXLI-UHFFFAOYSA-N propane-1-sulfonic acid Chemical compound CCCS(O)(=O)=O KCXFHTAICRTXLI-UHFFFAOYSA-N 0.000 description 1
- 108010032966 protegrin-1 Proteins 0.000 description 1
- 150000003248 quinolines Chemical class 0.000 description 1
- 239000011541 reaction mixture Substances 0.000 description 1
- 239000012744 reinforcing agent Substances 0.000 description 1
- 239000010668 rosemary oil Substances 0.000 description 1
- 229940058206 rosemary oil Drugs 0.000 description 1
- 235000013533 rum Nutrition 0.000 description 1
- 235000019204 saccharin Nutrition 0.000 description 1
- 229940081974 saccharin Drugs 0.000 description 1
- 239000000901 saccharin and its Na,K and Ca salt Substances 0.000 description 1
- 239000010672 sassafras oil Substances 0.000 description 1
- 230000035910 sensory benefits Effects 0.000 description 1
- 235000020046 sherry Nutrition 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- 229910000029 sodium carbonate Inorganic materials 0.000 description 1
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- HRZFUMHJMZEROT-UHFFFAOYSA-L sodium disulfite Chemical compound [Na+].[Na+].[O-]S(=O)S([O-])(=O)=O HRZFUMHJMZEROT-UHFFFAOYSA-L 0.000 description 1
- 239000011775 sodium fluoride Substances 0.000 description 1
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- 241000894007 species Species 0.000 description 1
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- 238000005507 spraying Methods 0.000 description 1
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- 229940032147 starch Drugs 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 239000008223 sterile water Substances 0.000 description 1
- 229940013618 stevioside Drugs 0.000 description 1
- OHHNJQXIOPOJSC-UHFFFAOYSA-N stevioside Natural products CC1(CCCC2(C)C3(C)CCC4(CC3(CCC12C)CC4=C)OC5OC(CO)C(O)C(O)C5OC6OC(CO)C(O)C(O)C6O)C(=O)OC7OC(CO)C(O)C(O)C7O OHHNJQXIOPOJSC-UHFFFAOYSA-N 0.000 description 1
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- 239000000021 stimulant Substances 0.000 description 1
- 229910001631 strontium chloride Inorganic materials 0.000 description 1
- AHBGXTDRMVNFER-UHFFFAOYSA-L strontium dichloride Chemical compound [Cl-].[Cl-].[Sr+2] AHBGXTDRMVNFER-UHFFFAOYSA-L 0.000 description 1
- 159000000008 strontium salts Chemical class 0.000 description 1
- RXSHXLOMRZJCLB-UHFFFAOYSA-L strontium;diacetate Chemical compound [Sr+2].CC([O-])=O.CC([O-])=O RXSHXLOMRZJCLB-UHFFFAOYSA-L 0.000 description 1
- 239000001384 succinic acid Substances 0.000 description 1
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- TUNFSRHWOTWDNC-HKGQFRNVSA-N tetradecanoic acid Chemical compound CCCCCCCCCCCCC[14C](O)=O TUNFSRHWOTWDNC-HKGQFRNVSA-N 0.000 description 1
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- LVBXEMGDVWVTGY-UHFFFAOYSA-N trans-2-octenal Natural products CCCCCC=CC=O LVBXEMGDVWVTGY-UHFFFAOYSA-N 0.000 description 1
- CRDAMVZIKSXKFV-UHFFFAOYSA-N trans-Farnesol Natural products CC(C)=CCCC(C)=CCCC(C)=CCO CRDAMVZIKSXKFV-UHFFFAOYSA-N 0.000 description 1
- BJIOGJUNALELMI-UHFFFAOYSA-N trans-isoeugenol Natural products COC1=CC(C=CC)=CC=C1O BJIOGJUNALELMI-UHFFFAOYSA-N 0.000 description 1
- NSSALFVIQPAIQK-UHFFFAOYSA-N trans-non-2-en-1-ol Natural products CCCCCCC=CCO NSSALFVIQPAIQK-UHFFFAOYSA-N 0.000 description 1
- 230000007704 transition Effects 0.000 description 1
- KVSKGMLNBAPGKH-UHFFFAOYSA-N tribromosalicylanilide Chemical compound OC1=C(Br)C=C(Br)C=C1C(=O)NC1=CC=C(Br)C=C1 KVSKGMLNBAPGKH-UHFFFAOYSA-N 0.000 description 1
- 229940078499 tricalcium phosphate Drugs 0.000 description 1
- 229910000391 tricalcium phosphate Inorganic materials 0.000 description 1
- 235000019731 tricalcium phosphate Nutrition 0.000 description 1
- ICUTUKXCWQYESQ-UHFFFAOYSA-N triclocarban Chemical compound C1=CC(Cl)=CC=C1NC(=O)NC1=CC=C(Cl)C(Cl)=C1 ICUTUKXCWQYESQ-UHFFFAOYSA-N 0.000 description 1
- 229960003500 triclosan Drugs 0.000 description 1
- VSJRDSLPNMGNFG-UHFFFAOYSA-H trizinc;2-hydroxypropane-1,2,3-tricarboxylate;trihydrate Chemical compound O.O.O.[Zn+2].[Zn+2].[Zn+2].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O.[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O VSJRDSLPNMGNFG-UHFFFAOYSA-H 0.000 description 1
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- 229960001322 trypsin Drugs 0.000 description 1
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- MWOOGOJBHIARFG-UHFFFAOYSA-N vanillin Chemical compound COC1=CC(C=O)=CC=C1O MWOOGOJBHIARFG-UHFFFAOYSA-N 0.000 description 1
- FGQOOHJZONJGDT-UHFFFAOYSA-N vanillin Natural products COC1=CC(O)=CC(C=O)=C1 FGQOOHJZONJGDT-UHFFFAOYSA-N 0.000 description 1
- 235000012141 vanillin Nutrition 0.000 description 1
- 239000005418 vegetable material Substances 0.000 description 1
- DCSCXTJOXBUFGB-UHFFFAOYSA-N verbenone Natural products CC1=CC(=O)C2C(C)(C)C1C2 DCSCXTJOXBUFGB-UHFFFAOYSA-N 0.000 description 1
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- 239000011782 vitamin Substances 0.000 description 1
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- 235000013343 vitamin Nutrition 0.000 description 1
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- 239000011719 vitamin A Substances 0.000 description 1
- 235000019165 vitamin E Nutrition 0.000 description 1
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- 235000020234 walnut Nutrition 0.000 description 1
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- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 description 1
- QUEDXNHFTDJVIY-UHFFFAOYSA-N γ-tocopherol Chemical class OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1 QUEDXNHFTDJVIY-UHFFFAOYSA-N 0.000 description 1
Classifications
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- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
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- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
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- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
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- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
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- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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- Coloring Foods And Improving Nutritive Qualities (AREA)
Abstract
Description
Fórmula de comprimido | E1 | E2 | E3 | E4 | C1 | C2 | C3 |
Peso (gramas) | 1,5 g | 1,5 g | 1,6 g | 1,2 g | 1 g | 1 g | 1 g |
Ingredientes (% em peso) | |||||||
Xilitol | 20 | 20 | 38,94 | 38,94 | 20 | 20 | 20 |
Eritritol não DC | 27,5 | 27,5 | |||||
Isomalte | 20,11 | 20,11 | |||||
Maltitol | 72,73 | 77,8 | 72,73 | 77,8 | 73,8 | ||
Carbonato de cálcio | 7 | 7 | |||||
Sucralose | 0,15 | 0,15 | 0,16 | 0,16 | 0,15 | 0,15 | 0,15 |
Acessulfame de potássio | 0,05 | 0,05 | 0,055 | 0,055 | 0,05 | 0,05 | 0,05 |
Cor | 0,169 | 0,169 |
Fórmula de comprimido | E1 | E2 | E3 | E4 | C1 | C2 | C3 |
Estearato de magnésio | 2 | 2 | 1 | 1 | 2 | 2 | 2 |
Agente salivar1 | 0,07 | 0,07 | 0,07 | 0,07 | |||
Sabor e aroma2 | 5 | 5 | 5 | 5 | |||
Sabor | 4 |
C1 | E1 | C2 | E2 | E3 | C4 | E4 | |
Média (G40) | 3,88 | 4,72 | 3,94 | 4,37 | 5,09 | 3,24 | 4,33 |
MEV | 0,22 | 0,25 | 0,22 | 0,28 | 0,26 | 0,23 | 0,31 |
N | 12 | 13 | 13 | 10 | 12 | 9 | 9 |
E1 vs C1 | E2 vs C2 | C1 vs C2 | E1 vs E2 | E3 vs E1 | E3 vs C4 | E4 vs C1 | |
Média | 0,89 | 0,59 | 0,08 | 0,33 | 0,33 | 1,76 | 0,48 |
MEV | 0,19 | 0,23 | 0,13 | 0,21 | 0,11 | 0,19 | 0,23 |
N | 12 | 10 | 11 | 10 | 12 | 9 | 9 |
95% Cl | 0,37 | 0,46 | 0,26 | 0,42 | 0,21 | 0,38 | 0,45 |
P<0,05 | Sim | Sim | Não | Não | Sim | Sim | Sim |
P<0,1 | Sim | Sim | Não | Sim | Sim | Sim | Sim |
E1 vs C1 | E2 vs C2 | C1 vs C2 | E1 vs E2 | E3 vs E1 | E3 vs C4 | E4 vs C1 | |
Média | 24% | 19% | 3% | 9% | 8% | 57% | 14% |
MEV | 5% | 8% | 4% | 6% | 3% | 8% | 6% |
Contagem | 12 | 10 | 11 | 10 | 12 | 9 | 9 |
95% Cl | 9% | 16% | 7% | 11% | 5% | 15% | 12% |
E1 vs C1 | E2 vs C2 | C1 vs C2 | E1 vs E2 | E3 vs E1 | E3 vs C4 | E4 vs C1 | |
P<0,05 | Sim | Sim | Não | Não | Sim | Sim | Sim |
P<0,1 | Sim | Sim | Não | Sim | Sim | Sim | Sim |
Nome | Controle de água | C1 | E1 | C2 | E2 | E3 |
CFU/ml | 1,29E+07 | 1,66E+06 | 4,37E+05 | 1,34E+07 | 1,22E+07 | 2,17E+06 |
Porcentagem de redução em comparação com o controle de água | n/a | 87% | 97% | -4% | 5% | 83% |
Fórmula | C1 | C2 | E1 | E2 | E3 | C4 |
Espessura (mm) | 7,50 | 7,78 | 10,91 | 11,11 | 7,48 | 6,11 |
Diâmetro/largura (mm) | 12,79 | 12,70 | 12,74 | 12,68 | 13,65 | 12,71 |
Dureza média (em Newtons) | 34,09 | 34,93 | 30,89 | 28,54 | 145,87 | 220,93 |
MEV | 0,45 | 0,25 | 0,54 | 0,89 | 2,95 | 6,68 |
N | 10 | 10 | 10 | 7 | 10 | 4 |
Participante | Linha de base de resíduo de Biscoito cracker (gramas) | Resíduo de biscoito cracker após uso do comprimido E3 (gramas) | Redução percentual em resíduo (linha de base - Comprimido)/linha de base*100 |
1 | 0,8341 | 0,2915 | 65,05% |
2 | 0,3396 | 0,234 | 31,10% |
3 | 0,3295 | 0,1175 | 64,34% |
4 | 0,3875 | 0,2998 | 22,63% |
5 | 0,7535 | 0,4275 | 43,26% |
MÉDIA | 45,28% |
% dos participantes emitindo relatório (N=96) | C3 | E3 |
Muito pouco líquido* | 38% | 19% |
Gostou da experiência de mastigação e bochecho com o produto* | 46% | 61% |
Claims (20)
- REIVINDICAÇÕES1. Método para fornecer ao menos um benefício de tratamento bucal caracterizado pelo fato de que compreende introduzir um comprimido na cavidade bucal, mastigar o dito comprimido para gerar fluido na cavidade bucal, e forçar pelo menos uma porção de fluido gerada ao redor da cavidade bucal antes de deglutir ou cuspir a dita porção de fluido para fornecer um benefício de tratamento bucal.
- 2. Método, de acordo com a reivindicação 1, caracterizado pelo fato de que o dito comprimido é maior que 1 grama.
- 3. Método, de acordo com a reivindicação 2, caracterizado pelo fato de que o dito comprimido é de cerca de 1,2 gramas ou mais.
- 4. Método, de acordo com a reivindicação 1, caracterizado pelo fato de que o dito comprimido tem uma dureza menor que 200 N.
- 5. Método, de acordo com a reivindicação 1, caracterizado pelo fato de que o dito comprimido tem uma dureza de cerca de 25 a cerca de 160 N.
- 6. Método, de acordo com a reivindicação 1, caracterizado pelo fato de que o dito comprimido tem uma G40 de cerca de 4,3 gramas ou mais.
- 7. Método, de acordo com a reivindicação 1, caracterizado pelo fato de que 0 dito comprimido compreende de cerca de 40% a cerca de 99% em peso do comprimido de um ou mais álcoois de açúcar selecionados do grupo que consiste em sorbitol, lactitol, xilitol, eritritol, manitol, maltitol, isomalte e combinações de dois ou mais dos mesmos.
- 8. Método, de acordo com a reivindicação 7, caracterizado pelo fato de que 0 dito comprimido compreende pelo menos 20% em peso de xilitol.
- 9. Método, de acordo com a reivindicação 7, caracterizado pelo fato de que 0 dito comprimido compreende xilitol, eritritol e isomal-Petição 870190053269, de 11/06/2019, pág. 37/442/3 te.
- 10. Método, de acordo com a reivindicação 9, caracterizado pelo fato de que o dito eritritol compreende eritritol não diretamente compressível.
- 11. Método, de acordo com a reivindicação 7, caracterizado pelo fato de que o dito comprimido é essencialmente isento de eritritol não diretamente compressível.
- 12. Método, de acordo com a reivindicação 1, caracterizado pelo fato de que o dito comprimido compreende um agente salivar.
- 13. Método, de acordo com a reivindicação 1, caracterizado pelo fato de que o dito comprimido compreende ao menos um óleo essencial selecionado do grupo que consiste em mentol, timol, eucaliptol, salicilato de metila, e combinações de dois ou mais dos mesmos.
- 14. Método, de acordo com a reivindicação 1, caracterizado pelo fato de que a dita etapa de forçar compreende forçar o fluido ao redor da cavidade bucal durante pelo menos 30 segundos.
- 15. Método de limpeza da cavidade bucal, caracterizado pelo fato de que compreende:a. introduzir na dita cavidade bucal um comprimido compreendendo um agente salivar e de cerca de 60 a cerca de 99%, em peso, de álcoois de açúcar selecionados do grupo consistindo em sorbitol, lactitol, xilitol, eritritol, manitol, maltitol, isomalte e combinações de dois ou mais dos mesmos, o dito comprimido tendo um peso de cerca de 1,3 a cerca de 2 gramas;b. mastigar o dito comprimido para gerar fluido na cavidade oral;c. forçar o dito fluido gerado em torno da cavidade bucal; ed. deglutir pelo menos uma porção do dito fluido gerado.
- 16. Método, de acordo com a reivindicação 15, caracterizado pelo fato de que o dito comprimido tem uma dureza de cerca de 25Petição 870190053269, de 11/06/2019, pág. 38/443/3 a cerca de 160 N.
- 17. Método, de acordo com a reivindicação 16, caracterizado pelo fato de que o dito comprimido compreende adicionalmente um ou mais óleos essenciais antimicrobianos.
- 18. Método, de acordo com a reivindicação 17, caracterizado pelo fato de que que o dito método compreende exterminar germes associados a mau hálito, placa, gengivite ou combinações de dois ou mais dos mesmos.
- 19. Método, de acordo com a reivindicação 18, caracterizado pelo fato de que os ditos um ou mais óleos essenciais antimicrobianos compreendem mentol, timol, eucaliptol, salicilato de metila, ou uma combinação de dois ou mais dos mesmos.
- 20. Método, de acordo com a reivindicação 19, caracterizado pelo fato de que a dita etapa de forçar compreende forçar o dito fluido durante ao menos 30 segundos antes da deglutição.
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PCT/DK2016/050377 WO2018091048A1 (en) | 2016-11-18 | 2016-11-18 | Oral delivery vehicle |
US15/356,175 US10543205B2 (en) | 2016-11-18 | 2016-11-18 | Oral delivery vehicle containing nicotine |
PCT/US2017/056554 WO2018093501A1 (en) | 2016-11-18 | 2017-10-13 | Method of providing oral care benefits |
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BR112019010115A2 true BR112019010115A2 (pt) | 2019-08-20 |
BR112019010115A8 BR112019010115A8 (pt) | 2022-07-26 |
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Application Number | Title | Priority Date | Filing Date |
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BR112019010115A BR112019010115A8 (pt) | 2016-11-18 | 2017-10-13 | Método de proporcionar benefícios de higiene bucal |
BR112019008138A BR112019008138A2 (pt) | 2016-11-18 | 2017-10-13 | comprimido que compreende agente aglutinante e eritritol separados |
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BR112019008138A BR112019008138A2 (pt) | 2016-11-18 | 2017-10-13 | comprimido que compreende agente aglutinante e eritritol separados |
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JP (2) | JP6840849B2 (pt) |
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Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US10543205B2 (en) | 2016-11-18 | 2020-01-28 | Fertin Pharma A/S | Oral delivery vehicle containing nicotine |
US10632076B2 (en) | 2016-11-18 | 2020-04-28 | Fertin Pharma A/S | Tablet comprising separate binder and erythritol |
WO2019219147A1 (en) * | 2018-05-17 | 2019-11-21 | Fertin Pharma A/S | A tableted chewing gum suitable for active pharmaceutical ingredients |
US11058641B2 (en) * | 2018-05-17 | 2021-07-13 | Fertin Pharma A/S | Oral tablet for taste masking of active ingredients |
US11096894B2 (en) * | 2018-05-17 | 2021-08-24 | Fertin Pharma A/S | Oral tablet for induced saliva generation |
US20190350858A1 (en) * | 2018-05-17 | 2019-11-21 | Fertin Pharma A/S | Oral tablet for delivery of active ingredients to the gastrointestinal tract |
US11135157B2 (en) * | 2018-05-17 | 2021-10-05 | Fertin Pharma A/S | Oral tablet for delivery of active ingredients to the throat |
US11090263B2 (en) | 2018-05-22 | 2021-08-17 | Fertin Pharma A/S | Tableted chewing gum suitable for active pharmaceutical ingredients |
US11096895B2 (en) * | 2018-05-17 | 2021-08-24 | Fertin Pharma A/S | Oral tablet suitable for active pharmaceutical ingredients |
US11096896B2 (en) | 2018-05-17 | 2021-08-24 | Fertin Pharma A/S | Tablet dosage form for buccal absorption of active ingredients |
US11058633B2 (en) | 2018-05-17 | 2021-07-13 | Fertin Pharma A/S | Disintegrating oral tablet suitable for active pharmaceutical ingredients |
US11052047B2 (en) | 2018-05-17 | 2021-07-06 | Fertin Pharma A/S | Oral tablet suitable for fast release of active pharmaceutical ingredients |
US20210106516A1 (en) * | 2019-10-11 | 2021-04-15 | Fertin Pharma A/S | Ion-Exchange Composition With Water-Soluble Mucoadhesive Polymers |
KR102345862B1 (ko) * | 2021-03-18 | 2022-01-03 | 김현진 | 팝핑 성분을 포함하는 고체 구강청결용 조성물 |
Family Cites Families (31)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4627977A (en) | 1985-09-13 | 1986-12-09 | Colgate-Palmolive Company | Anticalculus oral composition |
US4820506A (en) | 1987-05-01 | 1989-04-11 | Research Foundation, State University Of New York | Salivary stimulant |
TW469135B (en) * | 1995-10-03 | 2001-12-21 | Chugai Pharmaceutical Co Ltd | Chewable tablet |
CN1222317C (zh) * | 1996-07-12 | 2005-10-12 | 第一制药株式会社 | 可迅速崩解的压模物质及其生产方法 |
GB9716432D0 (en) * | 1997-08-05 | 1997-10-08 | Cerestar Holding Bv | Tableting of erythritol |
US5874068A (en) | 1997-12-08 | 1999-02-23 | Warner-Lambert Company | Stabilized antiplaque and antigingivitis oral compositions containing N.sup.α -alkyl-L-arginine alkyl ester salts |
WO2000025598A1 (en) | 1998-11-03 | 2000-05-11 | Dandy A/S | Sucrose fatty acid esters for use as increased release of active ingredients |
US6746697B2 (en) * | 2000-12-15 | 2004-06-08 | Phytos, Inc. | Composition containing Heliopsis longipes root extract and oral carrier |
KR20030081472A (ko) * | 2001-03-06 | 2003-10-17 | 교와 핫꼬 고교 가부시끼가이샤 | 구강내 속붕괴성 제제 |
JP2003125706A (ja) | 2001-10-23 | 2003-05-07 | Lion Corp | 口中清涼製剤 |
US20040101494A1 (en) | 2002-11-26 | 2004-05-27 | Scott Douglas Craig | Chewable solid unit dosage forms and methods for delivery of active agents into occlusal surfaces of teeth |
US20040223921A1 (en) | 2003-05-07 | 2004-11-11 | Rau Allen H. | Oral care tablet |
US20060045851A1 (en) | 2004-09-02 | 2006-03-02 | The Procter & Gamble Company | Oral care composition comprising essential oils |
US8435542B2 (en) | 2005-03-03 | 2013-05-07 | Takasago International Corp. (Usa) | Synergistic salivation agents |
JP2006335686A (ja) * | 2005-06-02 | 2006-12-14 | Hamari Chemicals Ltd | 直打用エリスリトール・ソルビトール混合顆粒の製造方法 |
CN1709229A (zh) * | 2005-06-10 | 2005-12-21 | 北京阜康仁生物制药科技有限公司 | 盐酸美金刚口腔崩解片及其制备方法 |
US20070077300A1 (en) * | 2005-09-30 | 2007-04-05 | Wynn David W | Oral compositions containing a salivation inducing agent |
CN100446759C (zh) * | 2006-10-16 | 2008-12-31 | 北京科信必成医药科技发展有限公司 | 一种天麻素口腔崩解片及其制备方法 |
JP5766899B2 (ja) * | 2007-04-11 | 2015-08-19 | ニプロ株式会社 | 口腔内崩壊剤及びその製造方法 |
WO2009007768A1 (en) * | 2007-07-06 | 2009-01-15 | Gumlink A/S | Compressed tablet comprising polyol |
BRPI0814175A2 (pt) * | 2007-07-27 | 2015-01-20 | Cargill Inc | Micronização de polióis |
RU2498636C2 (ru) * | 2008-09-04 | 2013-11-20 | Карджилл Инкорпорейтед | Таблетирование эритрита |
US9591852B2 (en) | 2009-11-23 | 2017-03-14 | Mcneil-Ppc, Inc. | Biofilm disruptive compositions |
US8658139B1 (en) * | 2010-02-27 | 2014-02-25 | Squigle, Inc. | Prevention and treatment of oral diseases |
WO2013125350A1 (ja) * | 2012-02-23 | 2013-08-29 | フロイント産業株式会社 | 口腔内崩壊錠用直打賦形剤及びその製造方法、並びに口腔内崩壊錠 |
JP6266891B2 (ja) | 2013-03-29 | 2018-01-24 | 株式会社ロッテ | 口腔内洗浄用組成物 |
US10357054B2 (en) * | 2013-10-16 | 2019-07-23 | R.J. Reynolds Tobacco Company | Smokeless tobacco pastille |
WO2015158637A1 (en) | 2014-04-17 | 2015-10-22 | Unilever Plc | Solid oral care compositions |
JP6718866B2 (ja) * | 2014-10-16 | 2020-07-08 | カーギル インコーポレイテッド | 直接圧縮性のエリスリトールの調製方法及びその使用 |
CA2967332C (en) | 2014-11-11 | 2024-05-21 | Johnson & Johnson Consumer Inc. | Amino acid derivatives and their uses |
CN104546807B (zh) * | 2015-01-21 | 2020-09-01 | 齐鲁制药有限公司 | 奥氮平口腔速溶膜剂 |
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