BR112019005748A2 - afinidade-conjugados de oligonucleotídeo e usos destes - Google Patents
afinidade-conjugados de oligonucleotídeo e usos destesInfo
- Publication number
- BR112019005748A2 BR112019005748A2 BR112019005748A BR112019005748A BR112019005748A2 BR 112019005748 A2 BR112019005748 A2 BR 112019005748A2 BR 112019005748 A BR112019005748 A BR 112019005748A BR 112019005748 A BR112019005748 A BR 112019005748A BR 112019005748 A2 BR112019005748 A2 BR 112019005748A2
- Authority
- BR
- Brazil
- Prior art keywords
- conjugates
- affinity
- oligonucleotides
- compositions
- methods
- Prior art date
Links
- 108091034117 Oligonucleotide Proteins 0.000 title abstract 2
- JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 title 1
- 238000012512 characterization method Methods 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6804—Nucleic acid analysis using immunogens
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6869—Methods for sequencing
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Health & Medical Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Engineering & Computer Science (AREA)
- Analytical Chemistry (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Pathology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/US2016/053598 WO2017053905A1 (en) | 2015-09-24 | 2016-09-24 | Affinity-oligonucleotide conjugates and uses thereof |
| PCT/US2017/013274 WO2018057051A1 (en) | 2016-09-24 | 2017-01-12 | Affinity-oligonucleotide conjugates and uses thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112019005748A2 true BR112019005748A2 (pt) | 2019-06-18 |
Family
ID=57960826
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112019005748A BR112019005748A2 (pt) | 2016-09-24 | 2017-01-12 | afinidade-conjugados de oligonucleotídeo e usos destes |
Country Status (5)
| Country | Link |
|---|---|
| JP (1) | JP6929354B2 (https=) |
| AU (1) | AU2017332495A1 (https=) |
| BR (1) | BR112019005748A2 (https=) |
| IL (1) | IL265471A (https=) |
| WO (1) | WO2018057051A1 (https=) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10550429B2 (en) | 2016-12-22 | 2020-02-04 | 10X Genomics, Inc. | Methods and systems for processing polynucleotides |
| US10815525B2 (en) | 2016-12-22 | 2020-10-27 | 10X Genomics, Inc. | Methods and systems for processing polynucleotides |
| WO2018165475A1 (en) * | 2017-03-08 | 2018-09-13 | California Institute Of Technology | Pairing antigen specificity of a t cell with t cell receptor sequences |
| SG11201907762RA (en) | 2017-03-24 | 2019-10-30 | Nat Univ Singapore | Methods for multiplex detection of molecules |
| ES2926722T3 (es) | 2017-05-26 | 2022-10-27 | Abvitro Llc | Secuenciación de alto rendimiento de biblioteca de polinucleótidos y análisis de transcriptoma |
| WO2019157529A1 (en) | 2018-02-12 | 2019-08-15 | 10X Genomics, Inc. | Methods characterizing multiple analytes from individual cells or cell populations |
| WO2019217758A1 (en) | 2018-05-10 | 2019-11-14 | 10X Genomics, Inc. | Methods and systems for molecular library generation |
| WO2019238939A1 (en) | 2018-06-15 | 2019-12-19 | F. Hoffmann-La Roche Ag | A system for identification of antigens recognized by t cell receptors expressed on tumor infiltrating lymphocytes |
| KR20210063379A (ko) * | 2018-09-24 | 2021-06-01 | 브리스톨-마이어스 스큅 컴퍼니 | 바코딩된 펩티드-mhc 복합체 및 그의 용도 |
| GB201816522D0 (en) * | 2018-10-10 | 2018-11-28 | Autolus Ltd | Methods and reagents for analysing nucleic acids from single cells |
| CA3124432A1 (en) * | 2018-12-18 | 2020-06-25 | Mbl International Corp. | Compositions of streptavidin-oligo conjugates of pmhc occupancy |
| JP6821230B2 (ja) * | 2019-02-04 | 2021-01-27 | 国立大学法人愛媛大学 | ＣＡＲライブラリおよびｓｃＦｖの製造方法 |
| EP4093884A4 (en) * | 2020-01-24 | 2024-05-15 | Vanderbilt University | Methods for identification of ligand-blocking antibodies and for determining antibody potency |
| US12449419B1 (en) | 2020-02-12 | 2025-10-21 | 10X Genomics, Inc. | Methods for detecting binding of peptide-MHC monomers to T cells |
| KR20230021697A (ko) * | 2020-06-09 | 2023-02-14 | 심센 다이아그노스틱스 에이비 | 림프구 클론성 결정 |
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-
2017
- 2017-01-12 BR BR112019005748A patent/BR112019005748A2/pt not_active Application Discontinuation
- 2017-01-12 AU AU2017332495A patent/AU2017332495A1/en not_active Abandoned
- 2017-01-12 WO PCT/US2017/013274 patent/WO2018057051A1/en not_active Ceased
- 2017-01-12 JP JP2019515986A patent/JP6929354B2/ja not_active Expired - Fee Related
-
2019
- 2019-03-19 IL IL265471A patent/IL265471A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JP6929354B2 (ja) | 2021-09-01 |
| JP2019537430A (ja) | 2019-12-26 |
| IL265471A (en) | 2019-05-30 |
| AU2017332495A1 (en) | 2019-04-11 |
| WO2018057051A1 (en) | 2018-03-29 |
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