BR112019002415A2 - método para refinar sugammadex sódico - Google Patents

método para refinar sugammadex sódico

Info

Publication number
BR112019002415A2
BR112019002415A2 BR112019002415A BR112019002415A BR112019002415A2 BR 112019002415 A2 BR112019002415 A2 BR 112019002415A2 BR 112019002415 A BR112019002415 A BR 112019002415A BR 112019002415 A BR112019002415 A BR 112019002415A BR 112019002415 A2 BR112019002415 A2 BR 112019002415A2
Authority
BR
Brazil
Prior art keywords
sugammadex sodium
trisubstituted
dithiothreitol
mercaptopropionate
thioglycolate
Prior art date
Application number
BR112019002415A
Other languages
English (en)
Other versions
BR112019002415B1 (pt
Inventor
Wang Bingyong
Original Assignee
Wang Bingyong
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wang Bingyong filed Critical Wang Bingyong
Publication of BR112019002415A2 publication Critical patent/BR112019002415A2/pt
Publication of BR112019002415B1 publication Critical patent/BR112019002415B1/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
    • C08B37/0009—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid alpha-D-Glucans, e.g. polydextrose, alternan, glycogen; (alpha-1,4)(alpha-1,6)-D-Glucans; (alpha-1,3)(alpha-1,4)-D-Glucans, e.g. isolichenan or nigeran; (alpha-1,4)-D-Glucans; (alpha-1,3)-D-Glucans, e.g. pseudonigeran; Derivatives thereof
    • C08B37/0012—Cyclodextrin [CD], e.g. cycle with 6 units (alpha), with 7 units (beta) and with 8 units (gamma), large-ring cyclodextrin or cycloamylose with 9 units or more; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/716—Glucans
    • A61K31/724—Cyclodextrins
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/0003—General processes for their isolation or fractionation, e.g. purification or extraction from biomass

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Materials Engineering (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Sustainable Development (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

é provido um método para refinar sugammadex sódico: adição de um agente protetor a um sugammadex sódico bruto e obtenção de um sugammadex sódico puro por recristalização sob a proteção de gás inerte. entre eles, o agente protetor é um ou uma mistura de dois ou mais compostos, em qualquer proporção, selecionados do grupo que consiste em mercaptoetanol, tioglicolato, éster de tioglicolato, mercaptopropionato, éster de mercaptopropionato, glutationa, cisteína, cistamina, ditioeritritol, ditiotreitol, composto organofosforado trisubstituído e sal do composto organofosforado trisubstituído. o método é simples em termos de operação, excelente em termos de pureza do produto, bom em termos de economia e mais adequado para produção industrial.
BR112019002415-8A 2016-08-24 2017-08-02 Método para refinar sugammadex sódico BR112019002415B1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN201610716744.2A CN107778383B (zh) 2016-08-24 2016-08-24 一种舒更葡糖钠的精制方法
CN201610716744.2 2016-08-24
PCT/CN2017/095642 WO2018036353A1 (zh) 2016-08-24 2017-08-02 一种舒更葡糖钠的精制方法

Publications (2)

Publication Number Publication Date
BR112019002415A2 true BR112019002415A2 (pt) 2019-06-04
BR112019002415B1 BR112019002415B1 (pt) 2022-09-27

Family

ID=61245461

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112019002415-8A BR112019002415B1 (pt) 2016-08-24 2017-08-02 Método para refinar sugammadex sódico

Country Status (9)

Country Link
US (1) US10941219B2 (pt)
EP (1) EP3505540B1 (pt)
JP (1) JP6771723B2 (pt)
KR (1) KR102197101B1 (pt)
CN (1) CN107778383B (pt)
BR (1) BR112019002415B1 (pt)
ES (1) ES2890323T3 (pt)
SG (1) SG11201900898PA (pt)
WO (1) WO2018036353A1 (pt)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112724280A (zh) * 2017-06-08 2021-04-30 天津科伦药物研究有限公司 一种舒更葡糖钠的纯化方法
CN110627925B (zh) * 2018-06-22 2022-09-06 四川科伦药物研究院有限公司 一种精制舒更葡糖钠的方法
CN110818816B (zh) * 2018-08-10 2021-06-01 乳源东阳光药业有限公司 一种舒更葡糖钠的精制结晶方法
CN111196862B (zh) * 2018-11-19 2023-02-03 睿辰康达生物医药(武汉)有限公司 一种舒更葡糖钠的精制方法
CN109517094A (zh) * 2019-01-18 2019-03-26 苏州纳微科技股份有限公司 一种舒更葡糖的分离纯化方法
CN111978435B (zh) * 2019-05-22 2021-05-25 合肥博思科创医药科技有限公司 一种高纯度舒更葡糖钠的制备方法
CN112538124B (zh) * 2019-09-20 2023-06-02 鲁南制药集团股份有限公司 一种舒更葡糖钠晶型
CN112538123B (zh) * 2019-09-20 2023-06-02 鲁南制药集团股份有限公司 一种舒更葡糖钠晶型m
CN112574330B (zh) * 2019-09-28 2023-06-06 鲁南制药集团股份有限公司 一种舒更葡糖钠晶型
US11097023B1 (en) 2020-07-02 2021-08-24 Par Pharmaceutical, Inc. Pre-filled syringe containing sugammadex

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI242015B (en) * 1999-11-29 2005-10-21 Akzo Nobel Nv 6-mercapto-cyclodextrin derivatives: reversal agents for drug-induced neuromuscular block
EP2609120B1 (en) * 2010-08-25 2015-07-29 Davuluri, Ramamohan Rao Improved process for preparation of sugammadex
EP2570182A1 (en) * 2011-09-15 2013-03-20 InstrAction GmbH Sorbent comprising on its surface a cationic or protonizable aliphatic residue for the purification of organic molecules
US9879096B2 (en) * 2013-02-14 2018-01-30 Neuland Laboratories Limited Process for preparation of sugammadex sodium
CN105273095A (zh) * 2014-05-28 2016-01-27 四川海思科制药有限公司 一种舒更葡糖钠及其中间体的制备方法
CN105348412B (zh) * 2014-08-22 2018-06-05 江苏恩华药业股份有限公司 一种舒更葡糖钠的纯化方法
CN104844732B (zh) * 2015-03-27 2017-05-03 山东滨州智源生物科技有限公司 一种舒更葡糖钠的制备方法
US10526422B2 (en) * 2016-06-29 2020-01-07 Beijing Creatron Institute Of Pharmaceutical Research Co., Ltd. Process for preparation and purification of Sugammades sodium
US20180016359A1 (en) 2016-06-29 2018-01-18 Beijing Creatron Institute Of Pharmaceutical Research Co., Ltd. Sugammadex preparation and purification method

Also Published As

Publication number Publication date
BR112019002415B1 (pt) 2022-09-27
KR20190032421A (ko) 2019-03-27
CN107778383A (zh) 2018-03-09
EP3505540B1 (en) 2021-08-18
JP2019526625A (ja) 2019-09-19
CN107778383B (zh) 2020-03-10
US10941219B2 (en) 2021-03-09
SG11201900898PA (en) 2019-03-28
WO2018036353A1 (zh) 2018-03-01
EP3505540A1 (en) 2019-07-03
KR102197101B1 (ko) 2020-12-31
US20200172635A1 (en) 2020-06-04
ES2890323T3 (es) 2022-01-18
JP6771723B2 (ja) 2020-10-21
EP3505540A4 (en) 2020-05-06

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Legal Events

Date Code Title Description
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]

Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS.

B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B06W Patent application suspended after preliminary examination (for patents with searches from other patent authorities) chapter 6.23 patent gazette]
B350 Update of information on the portal [chapter 15.35 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 02/08/2017, OBSERVADAS AS CONDICOES LEGAIS