BR112019001712A2 - uso de um biomarcador, e, método para avaliar se o indivíduo tem um carcinoma - Google Patents

uso de um biomarcador, e, método para avaliar se o indivíduo tem um carcinoma

Info

Publication number
BR112019001712A2
BR112019001712A2 BR112019001712-7A BR112019001712A BR112019001712A2 BR 112019001712 A2 BR112019001712 A2 BR 112019001712A2 BR 112019001712 A BR112019001712 A BR 112019001712A BR 112019001712 A2 BR112019001712 A2 BR 112019001712A2
Authority
BR
Brazil
Prior art keywords
biomarker
carcinoma
individual
assessing whether
malignancy
Prior art date
Application number
BR112019001712-7A
Other languages
English (en)
Inventor
Lai Hung-Cheng
Original Assignee
Taipei Medical University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Taipei Medical University filed Critical Taipei Medical University
Publication of BR112019001712A2 publication Critical patent/BR112019001712A2/pt

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57407—Specifically defined cancers
    • G01N33/57419—Specifically defined cancers of colon
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57407—Specifically defined cancers
    • G01N33/57442—Specifically defined cancers of the uterus and endometrial
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/112—Disease subtyping, staging or classification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/118—Prognosis of disease development
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/154—Methylation markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
    • G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
    • G01N2333/4701—Details
    • G01N2333/4703—Regulators; Modulating activity
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/902—Oxidoreductases (1.)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2440/00—Post-translational modifications [PTMs] in chemical analysis of biological material
    • G01N2440/12—Post-translational modifications [PTMs] in chemical analysis of biological material alkylation, e.g. methylation, (iso-)prenylation, farnesylation
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/60—Complex ways of combining multiple protein biomarkers for diagnosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Analytical Chemistry (AREA)
  • Pathology (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Hospice & Palliative Care (AREA)
  • Oncology (AREA)
  • Cell Biology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Reproductive Health (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

são aqui descritos vários métodos para avaliar a presença de neoplasia ginecológica ou a malignidade da neoplasia ginecológica, com base na hipermetilação de um ou mais genes marcadores.
BR112019001712-7A 2016-07-29 2017-07-28 uso de um biomarcador, e, método para avaliar se o indivíduo tem um carcinoma BR112019001712A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662368182P 2016-07-29 2016-07-29
US62/368,182 2016-07-29
PCT/CN2017/094917 WO2018019294A1 (en) 2016-07-29 2017-07-28 Methods for gynecologic neoplasm diagnosis

Publications (1)

Publication Number Publication Date
BR112019001712A2 true BR112019001712A2 (pt) 2019-05-07

Family

ID=61015645

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112019001712-7A BR112019001712A2 (pt) 2016-07-29 2017-07-28 uso de um biomarcador, e, método para avaliar se o indivíduo tem um carcinoma

Country Status (16)

Country Link
US (1) US20190153544A1 (pt)
EP (1) EP3490612B1 (pt)
JP (3) JP6767512B2 (pt)
KR (1) KR102258887B1 (pt)
CN (1) CN109069670B (pt)
AU (1) AU2017304949B2 (pt)
BR (1) BR112019001712A2 (pt)
CA (1) CA3032038A1 (pt)
IL (1) IL264542B2 (pt)
MX (1) MX2019001214A (pt)
NZ (1) NZ750327A (pt)
RU (1) RU2723531C1 (pt)
SG (2) SG10202101024UA (pt)
TW (1) TWI648403B (pt)
WO (1) WO2018019294A1 (pt)
ZA (1) ZA201900570B (pt)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4130297A1 (en) 2021-08-05 2023-02-08 Beijing OriginPoly Bio-Tec Co., Ltd. Markers, primers, probes and kit for early screening and diagnosis of endometrial cancer
CN113337614A (zh) * 2021-08-05 2021-09-03 北京起源聚禾生物科技有限公司 子宫内膜癌早期筛查诊断用标志物、引物探针及试剂盒
EP4265738A1 (en) 2022-03-03 2023-10-25 Beijing OriginPoly Bio-Tec Co., Ltd. Dna methylation marker combination, use, primer probe for early detection of ovarian cancer and kit
CN115725591A (zh) * 2022-09-22 2023-03-03 上海奕谱生物科技有限公司 新型的肿瘤检测标志物TAGMe及其应用

Family Cites Families (15)

* Cited by examiner, † Cited by third party
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JP2007537246A (ja) * 2004-05-12 2007-12-20 バイオランクス カンパニー リミテッド ニコチン酸誘導体を有効成分として含む癌予防及び治療剤
US7754428B2 (en) * 2006-05-03 2010-07-13 The Chinese University Of Hong Kong Fetal methylation markers
CN101230399B (zh) * 2008-01-07 2010-06-02 中国科学院化学研究所 一种检测dna甲基化的方法
CN105586408B (zh) * 2008-04-29 2021-03-23 赖鸿政 一种癌症筛检的方法
US9458495B2 (en) * 2008-07-01 2016-10-04 The Board Of Trustees Of The Leland Stanford Junior University Methods and systems for assessment of clinical infertility
CN101864480B (zh) * 2009-04-17 2013-12-18 国防医学院 一种癌症筛检的方法
US20110195848A1 (en) * 2010-01-08 2011-08-11 Roopra Avtar S Gene expression and breast cancer
JP2014508528A (ja) * 2011-03-10 2014-04-10 オスロ ウニヴェルスィテーツスィーケフース ハーエフ 消化管癌の検出方法および検出マーカー
JP2014525269A (ja) * 2011-08-30 2014-09-29 ディーシービー−ユーエスエー エルエルシー 卵巣新生物に対する易罹患性及び／又は卵巣がんの予後若しくは悪性度を予測する方法
WO2013174432A1 (en) * 2012-05-24 2013-11-28 Fundació Institut D'investigació Biomèdica De Bellvitge (Idibell) Method for the identification of the origin of a cancer of unknown primary origin by methylation analysis
EP3447495B2 (en) * 2012-10-29 2024-03-13 The Johns Hopkins University Papanicolaou test for ovarian and endometrial cancers
CN104513851B (zh) * 2013-10-08 2017-01-11 陈永恩 侦测膀胱癌的新颖表基因生物标记及其方法
US10301680B2 (en) * 2014-03-31 2019-05-28 Mayo Foundation For Medical Education And Research Detecting colorectal neoplasm
WO2016049024A2 (en) * 2014-09-24 2016-03-31 The Broad Institute Inc. Delivery, use and therapeutic applications of the crispr-cas systems and compositions for modeling competition of multiple cancer mutations in vivo
WO2016115354A1 (en) * 2015-01-14 2016-07-21 Taipei Medical University Methods for cancer diagnosis and prognosis

Also Published As

Publication number Publication date
WO2018019294A1 (en) 2018-02-01
EP3490612A4 (en) 2020-04-01
CN109069670A (zh) 2018-12-21
JP2021019587A (ja) 2021-02-18
EP3490612A1 (en) 2019-06-05
EP3490612C0 (en) 2024-08-21
SG11201900589PA (en) 2019-02-27
EP3490612B1 (en) 2024-08-21
IL264542B2 (en) 2024-02-01
RU2723531C1 (ru) 2020-06-16
MX2019001214A (es) 2019-09-19
AU2017304949A1 (en) 2019-02-21
NZ750327A (en) 2022-07-29
JP6767512B2 (ja) 2020-10-14
JP2022036935A (ja) 2022-03-08
AU2017304949B2 (en) 2024-06-20
KR20190025941A (ko) 2019-03-12
SG10202101024UA (en) 2021-03-30
JP2019524058A (ja) 2019-09-05
IL264542B1 (en) 2023-10-01
TWI648403B (zh) 2019-01-21
TW201805433A (zh) 2018-02-16
JP7182317B2 (ja) 2022-12-02
ZA201900570B (en) 2019-10-30
JP6971502B2 (ja) 2021-11-24
CA3032038A1 (en) 2018-02-01
IL264542A (en) 2019-05-30
CN109069670B (zh) 2022-05-10
US20190153544A1 (en) 2019-05-23
KR102258887B1 (ko) 2021-06-01

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