BR112019000185A2 - proteína, ácido nucleico, célula, e, métodos para produzir um linfócito citotóxico geneticamente modificado, para tratar um indivíduo que tem ou é suspeito de ter câncer e para reduzir a interação entre pd-l1 em uma primeira célula e pd-1 em uma segunda célula. - Google Patents
proteína, ácido nucleico, célula, e, métodos para produzir um linfócito citotóxico geneticamente modificado, para tratar um indivíduo que tem ou é suspeito de ter câncer e para reduzir a interação entre pd-l1 em uma primeira célula e pd-1 em uma segunda célula.Info
- Publication number
- BR112019000185A2 BR112019000185A2 BR112019000185-9A BR112019000185A BR112019000185A2 BR 112019000185 A2 BR112019000185 A2 BR 112019000185A2 BR 112019000185 A BR112019000185 A BR 112019000185A BR 112019000185 A2 BR112019000185 A2 BR 112019000185A2
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- Prior art keywords
- cell
- protein
- cancer
- interaction
- methods
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Links
- 210000004027 cell Anatomy 0.000 title abstract 6
- 206010028980 Neoplasm Diseases 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 3
- 102000039446 nucleic acids Human genes 0.000 title abstract 3
- 108020004707 nucleic acids Proteins 0.000 title abstract 3
- 150000007523 nucleic acids Chemical class 0.000 title abstract 3
- 102000004169 proteins and genes Human genes 0.000 title abstract 3
- 108090000623 proteins and genes Proteins 0.000 title abstract 3
- 201000011510 cancer Diseases 0.000 title abstract 2
- 231100000433 cytotoxic Toxicity 0.000 title abstract 2
- 230000001472 cytotoxic effect Effects 0.000 title abstract 2
- 230000003993 interaction Effects 0.000 title abstract 2
- 210000004698 lymphocyte Anatomy 0.000 title abstract 2
- 102000008096 B7-H1 Antigen Human genes 0.000 abstract 1
- 108010074708 B7-H1 Antigen Proteins 0.000 abstract 1
- 208000036142 Viral infection Diseases 0.000 abstract 1
- 239000000427 antigen Substances 0.000 abstract 1
- 102000036639 antigens Human genes 0.000 abstract 1
- 108091007433 antigens Proteins 0.000 abstract 1
- 238000001727 in vivo Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 230000009385 viral infection Effects 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2827—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
- A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0636—T lymphocytes
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0636—T lymphocytes
- C12N5/0638—Cytotoxic T lymphocytes [CTL] or lymphokine activated killer cells [LAK]
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0646—Natural killers cells [NK], NKT cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2510/00—Genetically modified cells
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cell Biology (AREA)
- Biochemistry (AREA)
- Hematology (AREA)
- Medicinal Chemistry (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Virology (AREA)
- Developmental Biology & Embryology (AREA)
- Oncology (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
a presente descrição provê proteínas, tais como anticorpos, que incluem uma porção de ligação a antígeno que se liga especificamente a ligante 1 de morte programada 1 (pd-l1). são também providos ácidos nucleicos que codificam a proteínas, e células (por exemplo, linfócitos citotóxicos geneticamente modificados) que incluem tais ácidos nucleicos. em algumas modalidades, um método em questão inclui reduzir a interação entre pd-l1 em uma primeira célula e pd-1 em uma segunda célula. em alguns casos, o contato é in vivo. por exemplo, os métodos e composições providos podem ser usados no tratamento de infecção viral e câncer, tal como o tratamento de tumores sólidos através de act ou através de administração de uma proteína em questão que se liga especificamente ao pd-l1.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201662359612P | 2016-07-07 | 2016-07-07 | |
US62/359612 | 2016-07-07 | ||
PCT/US2017/041241 WO2018009894A1 (en) | 2016-07-07 | 2017-07-07 | Programmed death 1 ligand 1 (pd-l1) binding proteins and methods of use thereof |
Publications (1)
Publication Number | Publication Date |
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BR112019000185A2 true BR112019000185A2 (pt) | 2019-04-16 |
Family
ID=59366537
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112019000185-9A BR112019000185A2 (pt) | 2016-07-07 | 2017-07-07 | proteína, ácido nucleico, célula, e, métodos para produzir um linfócito citotóxico geneticamente modificado, para tratar um indivíduo que tem ou é suspeito de ter câncer e para reduzir a interação entre pd-l1 em uma primeira célula e pd-1 em uma segunda célula. |
Country Status (15)
Country | Link |
---|---|
US (2) | US11141434B2 (pt) |
EP (1) | EP3481867A1 (pt) |
JP (1) | JP7093771B2 (pt) |
KR (1) | KR102630017B1 (pt) |
CN (1) | CN109843921B (pt) |
AU (1) | AU2017292889A1 (pt) |
BR (1) | BR112019000185A2 (pt) |
CA (1) | CA3030156A1 (pt) |
EA (1) | EA201990230A1 (pt) |
IL (1) | IL264104B1 (pt) |
MA (1) | MA45595A (pt) |
MX (1) | MX2019000149A (pt) |
NZ (1) | NZ750005A (pt) |
SG (1) | SG11201900138TA (pt) |
WO (1) | WO2018009894A1 (pt) |
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2017
- 2017-07-07 CA CA3030156A patent/CA3030156A1/en active Pending
- 2017-07-07 BR BR112019000185-9A patent/BR112019000185A2/pt unknown
- 2017-07-07 WO PCT/US2017/041241 patent/WO2018009894A1/en unknown
- 2017-07-07 KR KR1020197003606A patent/KR102630017B1/ko active IP Right Grant
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IL264104A (en) | 2019-01-31 |
MA45595A (fr) | 2019-05-15 |
JP7093771B2 (ja) | 2022-06-30 |
US11141434B2 (en) | 2021-10-12 |
EP3481867A1 (en) | 2019-05-15 |
CN109843921A (zh) | 2019-06-04 |
US20190298770A1 (en) | 2019-10-03 |
US20220025052A1 (en) | 2022-01-27 |
IL264104B1 (en) | 2024-04-01 |
JP2019525771A (ja) | 2019-09-12 |
AU2017292889A1 (en) | 2019-02-14 |
CN109843921B (zh) | 2023-05-26 |
SG11201900138TA (en) | 2019-02-27 |
EA201990230A1 (ru) | 2019-07-31 |
KR20190038825A (ko) | 2019-04-09 |
CA3030156A1 (en) | 2018-01-11 |
WO2018009894A1 (en) | 2018-01-11 |
MX2019000149A (es) | 2019-09-23 |
KR102630017B1 (ko) | 2024-01-25 |
NZ750005A (en) | 2023-06-30 |
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