BR112018077257A2 - derivados de 5,7-di-hidro-pirrolo-piridina para o tratamento de doenças neurológicas e neurodegenerativas - Google Patents

derivados de 5,7-di-hidro-pirrolo-piridina para o tratamento de doenças neurológicas e neurodegenerativas

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Publication number
BR112018077257A2
BR112018077257A2 BR112018077257-7A BR112018077257A BR112018077257A2 BR 112018077257 A2 BR112018077257 A2 BR 112018077257A2 BR 112018077257 A BR112018077257 A BR 112018077257A BR 112018077257 A2 BR112018077257 A2 BR 112018077257A2
Authority
BR
Brazil
Prior art keywords
treatment
neurological
pyrrole
dihydro
neurodegenerative diseases
Prior art date
Application number
BR112018077257-7A
Other languages
English (en)
Inventor
Zhang Lei
Ryan Butler Christopher
Mary Beck Elizabeth
Aaron Brodney Michael
Frank Brown Matthew
Ann Mcallister Laura
Alphie Lachapelle Erik
Matthew Gilbert Adam
Original Assignee
Pfizer Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Inc. filed Critical Pfizer Inc.
Publication of BR112018077257A2 publication Critical patent/BR112018077257A2/pt

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Pulmonology (AREA)
  • Urology & Nephrology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Cardiology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Vascular Medicine (AREA)
  • Addiction (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

a presente invenção refere-se, em parte, a compostos de fórmula (i), ou um n-óxido dos mesmos, ou um sal farmaceuticamente aceitável do composto ou do n-óxido, em que: r1, r2, l, a, e e são como aqui descrito, processos para a preparação de; intermediários usados na preparação de; e composições contendo tais compostos, n-óxidos, ou sais, e seus usos para o tratamento de distúrbios mediados por m4 (ou associados a m4) incluindo, por exemplo, doença de alzheimer, esquizofrenia (por exemplo, seus sintomas cognitivos e negativos), dor, vício, e um distúrbio do sono.
BR112018077257-7A 2016-07-01 2017-06-15 derivados de 5,7-di-hidro-pirrolo-piridina para o tratamento de doenças neurológicas e neurodegenerativas BR112018077257A2 (pt)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201662357624P 2016-07-01 2016-07-01
US62/357,624 2016-07-01
US201662372421P 2016-08-09 2016-08-09
US62/372,421 2016-08-09
PCT/IB2017/053565 WO2018002760A1 (en) 2016-07-01 2017-06-15 5,7-dihydro-pyrrolo-pyridine derivatives for treating neurological and neurodegenerative diseases

Publications (1)

Publication Number Publication Date
BR112018077257A2 true BR112018077257A2 (pt) 2019-04-02

Family

ID=59215839

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112018077257-7A BR112018077257A2 (pt) 2016-07-01 2017-06-15 derivados de 5,7-di-hidro-pirrolo-piridina para o tratamento de doenças neurológicas e neurodegenerativas

Country Status (21)

Country Link
US (4) US10604519B2 (pt)
EP (2) EP3872078A1 (pt)
JP (1) JP7046018B2 (pt)
KR (1) KR102470497B1 (pt)
CN (1) CN109641898B (pt)
AU (1) AU2017286868B2 (pt)
BR (1) BR112018077257A2 (pt)
CA (1) CA2972070A1 (pt)
DK (1) DK3478679T3 (pt)
ES (1) ES2878160T3 (pt)
HU (1) HUE054857T2 (pt)
IL (1) IL263912B (pt)
MX (1) MX2019000231A (pt)
PH (1) PH12019500004A1 (pt)
PL (1) PL3478679T3 (pt)
PT (1) PT3478679T (pt)
SG (1) SG11201811712QA (pt)
TW (1) TWI736642B (pt)
UY (1) UY37311A (pt)
WO (1) WO2018002760A1 (pt)
ZA (1) ZA201900519B (pt)

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CN112174869B (zh) * 2020-10-12 2023-04-25 蔡霈 N-苯乙酰基-2-羟甲基吡咯烷-2-甲酰胺的制备方法及其药用用途
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DK3478679T3 (da) 2021-06-21
KR20190035713A (ko) 2019-04-03
ES2878160T3 (es) 2021-11-18
CA2972070A1 (en) 2018-01-01
WO2018002760A1 (en) 2018-01-04
EP3478679A1 (en) 2019-05-08
TW201811780A (zh) 2018-04-01
ZA201900519B (en) 2022-07-27
MX2019000231A (es) 2019-08-29
TWI736642B (zh) 2021-08-21
PH12019500004A1 (en) 2019-10-21
US10604519B2 (en) 2020-03-31
US20200207762A1 (en) 2020-07-02
IL263912B (en) 2022-04-01
US20180002331A1 (en) 2018-01-04
EP3872078A1 (en) 2021-09-01
PT3478679T (pt) 2021-06-30
AU2017286868B2 (en) 2021-11-11
EP3478679B1 (en) 2021-04-21
UY37311A (es) 2018-01-31
HUE054857T2 (hu) 2021-10-28
JP7046018B2 (ja) 2022-04-01
CN109641898B (zh) 2022-04-08
US20210309659A1 (en) 2021-10-07
PL3478679T3 (pl) 2021-10-25
CN109641898A (zh) 2019-04-16
AU2017286868A1 (en) 2019-02-21
US11905284B2 (en) 2024-02-20
JP2019519583A (ja) 2019-07-11
SG11201811712QA (en) 2019-01-30
US20230192690A1 (en) 2023-06-22
IL263912A (en) 2019-01-31
KR102470497B1 (ko) 2022-11-23

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