BR112018075999A2 - derivados de piridina, pirazina e pirimidina bicíclicos como inibidores de pi3k beta - Google Patents
derivados de piridina, pirazina e pirimidina bicíclicos como inibidores de pi3k betaInfo
- Publication number
- BR112018075999A2 BR112018075999A2 BR112018075999A BR112018075999A BR112018075999A2 BR 112018075999 A2 BR112018075999 A2 BR 112018075999A2 BR 112018075999 A BR112018075999 A BR 112018075999A BR 112018075999 A BR112018075999 A BR 112018075999A BR 112018075999 A2 BR112018075999 A2 BR 112018075999A2
- Authority
- BR
- Brazil
- Prior art keywords
- pyrazine
- pyrimidine derivatives
- beta inhibitors
- bicyclic pyridine
- pi3k beta
- Prior art date
Links
- KYQCOXFCLRTKLS-UHFFFAOYSA-N Pyrazine Chemical compound C1=CN=CC=N1 KYQCOXFCLRTKLS-UHFFFAOYSA-N 0.000 title abstract 4
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 title abstract 4
- PCNDJXKNXGMECE-UHFFFAOYSA-N Phenazine Natural products C1=CC=CC2=NC3=CC=CC=C3N=C21 PCNDJXKNXGMECE-UHFFFAOYSA-N 0.000 title abstract 2
- 125000002619 bicyclic group Chemical group 0.000 title abstract 2
- 239000003112 inhibitor Substances 0.000 title abstract 2
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 title abstract 2
- 229940083082 pyrimidine derivative acting on arteriolar smooth muscle Drugs 0.000 title abstract 2
- 150000003230 pyrimidines Chemical class 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 3
- 239000004480 active ingredient Substances 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
a presente invenção refere-se a derivados de piridina, pira-zina e pirimidina bicíclicos da fórmula (i) em que as variáveis têm o significado definido nas reivindicações. os compostos de acordo com a presente invenção são úteis como inibidores de pi3kß. a invenção refere-se ainda a composições farmacêuticas compreendendo os referidos compostos como ingrediente ativo bem como o uso dos referidos compostos como um medicamento.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP16174715 | 2016-06-16 | ||
| PCT/EP2017/064671 WO2017216292A1 (en) | 2016-06-16 | 2017-06-15 | Bicyclic pyridine, pyrazine, and pyrimidine derivatives as pi3k beta inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112018075999A2 true BR112018075999A2 (pt) | 2019-04-02 |
Family
ID=56132835
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112018075999A BR112018075999A2 (pt) | 2016-06-16 | 2017-06-15 | derivados de piridina, pirazina e pirimidina bicíclicos como inibidores de pi3k beta |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US10894793B2 (pt) |
| EP (1) | EP3472160B1 (pt) |
| JP (1) | JP7149854B2 (pt) |
| KR (1) | KR102472453B1 (pt) |
| CN (1) | CN109311875A (pt) |
| AU (1) | AU2017286379B2 (pt) |
| BR (1) | BR112018075999A2 (pt) |
| CA (1) | CA3025594C (pt) |
| DK (1) | DK3472160T3 (pt) |
| EA (1) | EA037361B1 (pt) |
| ES (1) | ES2871140T3 (pt) |
| HR (1) | HRP20210508T1 (pt) |
| HU (1) | HUE054118T2 (pt) |
| IL (1) | IL263652A (pt) |
| LT (1) | LT3472160T (pt) |
| MX (1) | MX2018015707A (pt) |
| SI (1) | SI3472160T1 (pt) |
| WO (1) | WO2017216292A1 (pt) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL272988B (en) * | 2017-09-08 | 2022-08-01 | Beigene Ltd | Imidazo-[1,5-a]pyrazine derivatives as pi3k-delta inhibitors |
| CN111039946A (zh) * | 2018-10-15 | 2020-04-21 | 上海轶诺药业有限公司 | 一类咪唑并芳环类化合物的制备和应用 |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20090170848A1 (en) | 2006-03-02 | 2009-07-02 | Smithkline Beecham Corporation | Thiazolones for use as pi3 kinase inhibitors |
| US20090215818A1 (en) | 2006-07-24 | 2009-08-27 | Smithkline Beecham Corporation | Thiozolidinedione derivatives as pi3 kinase inhibitors |
| WO2008101979A1 (en) | 2007-02-22 | 2008-08-28 | Merck Serono S.A. | Quinoxaline compounds and use thereof |
| WO2009021083A1 (en) | 2007-08-09 | 2009-02-12 | Smithkline Beecham Corporation | Quinoxaline derivatives as pi3 kinase inhibitors |
| KR101897881B1 (ko) | 2008-01-04 | 2018-09-12 | 인텔리카인, 엘엘씨 | 특정 화학 물질, 조성물 및 방법 |
| KR20110113197A (ko) | 2009-02-06 | 2011-10-14 | 오르토-맥닐-얀센 파마슈티칼스 인코포레이티드 | 감마 세크레타제 조절제로서의 신규 치환된 비사이클릭 헤테로사이클릭 화합물 |
| CA2752105C (en) | 2009-02-13 | 2017-10-31 | Matthias Vennemann | Fused pyrimidines |
| CA2755285C (en) | 2009-03-20 | 2014-02-11 | Yunxin Y. Bo | Inhibitors of pi3 kinase |
| NZ598220A (en) | 2009-08-17 | 2014-02-28 | Intellikine Llc | Heterocyclic compounds and uses thereof |
| US8569296B2 (en) | 2009-09-29 | 2013-10-29 | Xcovery Holding Company, Llc | PI3K (delta) selective inhibitors |
| DE102009052575A1 (de) | 2009-11-10 | 2011-05-12 | Siemens Medical Instruments Pte. Ltd. | Verfahren, Hörgerät und Anordnung zur Kalibrierung eines akustischen Anpasssystems |
| AR080754A1 (es) * | 2010-03-09 | 2012-05-09 | Janssen Pharmaceutica Nv | Derivados de imidazo (1,2-a) pirazina y su uso como inhibidores de pde10 |
| UY33304A (es) | 2010-04-02 | 2011-10-31 | Amgen Inc | Compuestos heterocíclicos y sus usos |
| ME02663B (me) | 2010-10-06 | 2017-06-20 | Glaxosmithkline Llc | Derivati benzimidazola kao inhibitori pi3 kinaze |
| JP5808826B2 (ja) | 2011-02-23 | 2015-11-10 | インテリカイン， エルエルシー | 複素環化合物およびその使用 |
| US9096605B2 (en) | 2011-08-24 | 2015-08-04 | Glaxosmithkline Llc | Pyrazolopyrimidine derivatives as PI3 kinase inhibitors |
| US8778937B2 (en) | 2011-12-20 | 2014-07-15 | Glaxosmithkline Llc | Benzimidazole boronic acid derivatives as PI3 kinase inhibitors |
| US8906910B2 (en) | 2011-12-20 | 2014-12-09 | Glaxosmithkline Llc | Imidazopyridine derivatives as PI3 kinase |
| CN104619709B (zh) | 2012-07-13 | 2016-11-09 | Ucb生物制药私人有限公司 | 作为tnf活性调节剂的咪唑并吡啶衍生物 |
| GB201212513D0 (en) | 2012-07-13 | 2012-08-29 | Ucb Pharma Sa | Therapeutic agents |
| TWI574962B (zh) * | 2012-11-14 | 2017-03-21 | 加拓科學公司 | 作爲ｐｉ３激酶調節劑的芳雜環化合物及其使用方法和用途 |
| RU2663999C2 (ru) | 2013-10-16 | 2018-08-14 | Шанхай Инли Фармасьютикал Ко., Лтд | Конденсированное гетероциклическое соединение, способ его получения, его фармацевтическая композиция и применения |
| ES2760507T3 (es) | 2014-12-19 | 2020-05-14 | Janssen Pharmaceutica Nv | Derivados de imidazopiridazina enlazados a heterociclilo como inhibidores de PI3Kß |
| DK3233862T3 (da) | 2014-12-19 | 2019-10-07 | Janssen Pharmaceutica Nv | Imidazopyridazinderivater som pi3k-beta-inhibitorer |
| BR112018007068B1 (pt) | 2015-10-09 | 2024-01-02 | Janssen Pharmaceutica N.V. | Derivados de quinoxalina e piridopirazina como inibidores de pi3kbeta, seu uso e composição farmacêutica que os compreende |
-
2017
- 2017-06-15 CN CN201780037269.9A patent/CN109311875A/zh active Pending
- 2017-06-15 LT LTEP17732059.5T patent/LT3472160T/lt unknown
- 2017-06-15 SI SI201730708T patent/SI3472160T1/sl unknown
- 2017-06-15 EP EP17732059.5A patent/EP3472160B1/en active Active
- 2017-06-15 US US16/309,999 patent/US10894793B2/en active Active
- 2017-06-15 MX MX2018015707A patent/MX2018015707A/es active IP Right Grant
- 2017-06-15 EA EA201990046A patent/EA037361B1/ru not_active IP Right Cessation
- 2017-06-15 BR BR112018075999A patent/BR112018075999A2/pt active Search and Examination
- 2017-06-15 KR KR1020187035198A patent/KR102472453B1/ko active IP Right Grant
- 2017-06-15 CA CA3025594A patent/CA3025594C/en active Active
- 2017-06-15 DK DK17732059.5T patent/DK3472160T3/da active
- 2017-06-15 HU HUE17732059A patent/HUE054118T2/hu unknown
- 2017-06-15 JP JP2018564783A patent/JP7149854B2/ja active Active
- 2017-06-15 WO PCT/EP2017/064671 patent/WO2017216292A1/en unknown
- 2017-06-15 AU AU2017286379A patent/AU2017286379B2/en active Active
- 2017-06-15 ES ES17732059T patent/ES2871140T3/es active Active
-
2018
- 2018-12-11 IL IL263652A patent/IL263652A/en active IP Right Grant
-
2021
- 2021-03-30 HR HRP20210508TT patent/HRP20210508T1/hr unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US20190169199A1 (en) | 2019-06-06 |
| JP7149854B2 (ja) | 2022-10-07 |
| US10894793B2 (en) | 2021-01-19 |
| LT3472160T (lt) | 2021-04-26 |
| WO2017216292A1 (en) | 2017-12-21 |
| CN109311875A (zh) | 2019-02-05 |
| EA037361B1 (ru) | 2021-03-18 |
| ES2871140T3 (es) | 2021-10-28 |
| EA201990046A1 (ru) | 2019-05-31 |
| CA3025594C (en) | 2024-06-18 |
| KR20190016954A (ko) | 2019-02-19 |
| AU2017286379B2 (en) | 2021-07-01 |
| EP3472160A1 (en) | 2019-04-24 |
| EP3472160B1 (en) | 2021-02-24 |
| SI3472160T1 (sl) | 2021-07-30 |
| IL263652A (en) | 2019-01-31 |
| HUE054118T2 (hu) | 2021-08-30 |
| AU2017286379A1 (en) | 2018-12-06 |
| DK3472160T3 (da) | 2021-05-10 |
| HRP20210508T1 (hr) | 2021-05-28 |
| JP2019518032A (ja) | 2019-06-27 |
| KR102472453B1 (ko) | 2022-11-29 |
| CA3025594A1 (en) | 2017-12-21 |
| MX2018015707A (es) | 2019-03-21 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B350 | Update of information on the portal [chapter 15.35 patent gazette] | ||
| B06W | Patent application suspended after preliminary examination (for patents with searches from other patent authorities) chapter 6.23 patent gazette] | ||
| B06A | Patent application procedure suspended [chapter 6.1 patent gazette] | ||
| B09A | Decision: intention to grant [chapter 9.1 patent gazette] |