BR112018075997A2 - extrato de células não diferenciadas de mimosa pudica e seus usos em dermocosméticos - Google Patents

extrato de células não diferenciadas de mimosa pudica e seus usos em dermocosméticos

Info

Publication number
BR112018075997A2
BR112018075997A2 BR112018075997A BR112018075997A BR112018075997A2 BR 112018075997 A2 BR112018075997 A2 BR 112018075997A2 BR 112018075997 A BR112018075997 A BR 112018075997A BR 112018075997 A BR112018075997 A BR 112018075997A BR 112018075997 A2 BR112018075997 A2 BR 112018075997A2
Authority
BR
Brazil
Prior art keywords
undifferentiated
dermocosmetics
cell extract
mimosa pudica
preparation
Prior art date
Application number
BR112018075997A
Other languages
English (en)
Other versions
BR112018075997B1 (pt
Inventor
COUSY Adrien
Nguyen Thien
Original Assignee
Fabre Pierre Dermo Cosmetique
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fabre Pierre Dermo Cosmetique filed Critical Fabre Pierre Dermo Cosmetique
Publication of BR112018075997A2 publication Critical patent/BR112018075997A2/pt
Publication of BR112018075997B1 publication Critical patent/BR112018075997B1/pt

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/16Amides, e.g. hydroxamic acids
    • A61K31/165Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19Carboxylic acids, e.g. valproic acid
    • A61K31/195Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4412Non condensed pyridines; Hydrogenated derivatives thereof having oxo groups directly attached to the heterocyclic ring
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7024Esters of saccharides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/42Amides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/44Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/44Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
    • A61K8/445Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof aromatic, i.e. the carboxylic acid directly linked to the aromatic ring
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/60Sugars; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/60Sugars; Derivatives thereof
    • A61K8/602Glycosides, e.g. rutin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783Angiosperms [Magnoliophyta]
    • A61K8/9789Magnoliopsida [dicotyledons]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/18Antioxidants, e.g. antiradicals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • A61Q19/08Anti-ageing preparations
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D11/00Solvent extraction
    • B01D11/02Solvent extraction of solids
    • B01D11/0288Applications, solvents
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0018Culture media for cell or tissue culture
    • C12N5/0037Serum-free medium, which may still contain naturally-sourced components
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/04Plant cells or tissues
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/10Preparation or pretreatment of starting material
    • A61K2236/11Preparation or pretreatment of starting material involving culturing conditions, e.g. cultivation in the dark or under defined water stress
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/52Stabilizers
    • A61K2800/522Antioxidants; Radical scavengers
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D21/00Separation of suspended solid particles from liquids by sedimentation
    • B01D21/26Separation of sediment aided by centrifugal force or centripetal force
    • B01D21/262Separation of sediment aided by centrifugal force or centripetal force by using a centrifuge

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Dermatology (AREA)
  • Biomedical Technology (AREA)
  • Birds (AREA)
  • Botany (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Mycology (AREA)
  • Cell Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Medical Informatics (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Gerontology & Geriatric Medicine (AREA)
  • Molecular Biology (AREA)
  • Cosmetics (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

a presente invenção refere-se a uma preparação obtida partindo de uma cultura in vitro de células não diferenciadas de mimosa pudica bem como ao seu método de preparação; uma composição cosmética ou dermatológica que compreende a dita preparação; e a seus usos para o tratamento de distúrbios inflamatórios da pele, como um agente antioxidante no tratamento de estresse oxidativo causado pela poluição ambiental e como agente antienvelhecimento.
BR112018075997-0A 2016-06-16 2017-06-14 Processo de preparação in vitro de um extrato de células de mimosa pudica, extrato de cultura e seu uso, composição dermatológica e cosmética e seu uso e método cosmético não terapêutico BR112018075997B1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR1655630A FR3052668B1 (fr) 2016-06-16 2016-06-16 Extrait de cellules indifferenciees de mimosa pudica et ses utilisations en dermo cosmetique
FR1655630 2016-06-16
PCT/EP2017/064640 WO2017216274A2 (fr) 2016-06-16 2017-06-14 Extrait de cellules indifferenciees de mimosa pudica et ses utilisations en dermo-cosmetique

Publications (2)

Publication Number Publication Date
BR112018075997A2 true BR112018075997A2 (pt) 2019-04-02
BR112018075997B1 BR112018075997B1 (pt) 2022-07-19

Family

ID=57233562

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112018075997-0A BR112018075997B1 (pt) 2016-06-16 2017-06-14 Processo de preparação in vitro de um extrato de células de mimosa pudica, extrato de cultura e seu uso, composição dermatológica e cosmética e seu uso e método cosmético não terapêutico

Country Status (15)

Country Link
US (1) US10954488B2 (pt)
EP (1) EP3471837B1 (pt)
JP (1) JP6957529B2 (pt)
KR (1) KR102507491B1 (pt)
CN (1) CN109414600B (pt)
AU (1) AU2017286361A1 (pt)
BR (1) BR112018075997B1 (pt)
CA (1) CA3026035A1 (pt)
ES (1) ES2828963T3 (pt)
FR (1) FR3052668B1 (pt)
MX (1) MX2018015536A (pt)
PT (1) PT3471837T (pt)
RU (1) RU2747479C2 (pt)
SG (1) SG11201810774TA (pt)
WO (1) WO2017216274A2 (pt)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112221189B (zh) * 2020-09-11 2022-04-12 陈祈明 一种提取活体植物中花精、花气精华的方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6290993B1 (en) * 1999-07-23 2001-09-18 E-L Management Corp. Compositions containing mimosa phenolic compounds
FR2864446B1 (fr) * 2003-12-29 2006-03-03 Secma Biotechnologies Marines Utilisation dans une composition cosmetique ou pharmaceutique d'au moins un lyiphilisat de cellules vegetales dedifferenciees afin de depigmenter et/ou eclaircir, de proteger et de regenerer l'epiderme
KR101064848B1 (ko) 2008-11-21 2011-09-14 대전대학교 산학협력단 알러지 치료용 미모사의 추출물 및 이를 유효성분으로 포함하는 알러지 치료용 약학적 조성물
SG181969A1 (en) * 2010-01-06 2012-08-30 Orf Liftaekni Hf Method of use of stabilized plant-derived growth factor in skin care
RU2429290C1 (ru) * 2010-02-25 2011-09-20 Общество с ограниченной ответственностью Научно-Производственное Предприятие "АстГретта" (ООО НПП "АстГретта") Способ получения каллусной ткани лотоса орехоносного
FR2958163B1 (fr) * 2010-03-31 2014-06-13 Fabre Pierre Dermo Cosmetique Preparation issue d'une culture in vitro de cellules dedifferencieres non elicitees d'arganier, leur utilisation pour le traitement du vieillissement cutane, de l'inflammation et de la cicatrisation, et leur obtention.

Also Published As

Publication number Publication date
FR3052668B1 (fr) 2018-06-01
RU2018145867A3 (pt) 2020-10-12
FR3052668A1 (fr) 2017-12-22
SG11201810774TA (en) 2019-01-30
CA3026035A1 (fr) 2017-12-21
RU2747479C2 (ru) 2021-05-05
US10954488B2 (en) 2021-03-23
PT3471837T (pt) 2020-11-16
JP2019518051A (ja) 2019-06-27
EP3471837A2 (fr) 2019-04-24
BR112018075997B1 (pt) 2022-07-19
AU2017286361A1 (en) 2019-01-17
ES2828963T3 (es) 2021-05-28
EP3471837B1 (fr) 2020-08-12
CN109414600A (zh) 2019-03-01
RU2018145867A (ru) 2020-07-16
WO2017216274A3 (fr) 2018-02-08
US20190136181A1 (en) 2019-05-09
KR102507491B1 (ko) 2023-03-08
MX2018015536A (es) 2019-03-14
CN109414600B (zh) 2022-11-01
WO2017216274A2 (fr) 2017-12-21
KR20190018163A (ko) 2019-02-21
JP6957529B2 (ja) 2021-11-02

Similar Documents

Publication Publication Date Title
BR112017008726A2 (pt) usos de um extrato de fermento e de um exopolissacarídeo, e, composição cosmética.
BR112017008344A2 (pt) extrato, uso de um extrato, e, composição cosmética ou dermofarmacêutica.
BR112017018919A8 (pt) Proteínas de fusão imunomoduladoras e seus usos
CL2013002029A1 (es) Celula progenitora y no diferenciada neural humana expandible aislada; composicion que la comprende; metodo de cultivo in vitro; dicho cultivo in vitro; y su uso para tratar una condicion causada por perdida de mielina o de oligodendrocitos.
BR112015021033A8 (pt) composição cosmética, métodos para regular ou prevenir uma condição de pele, para reduzir ou tratar sinais de envelhecimento de pele e para prevenir, clarear ou reduzir o aparecimento de descontinuidades visíveis da pele e usos de uma composição
MX367670B (es) Combinaciones de cromóforo para usos biofotónicos.
GB2502029A (en) Cosmetic or pharmaceutical formulation
DOP2013000240A (es) Composiciones y métodos para transferencia de energía mitocondrial de línea germinal autóloga
BR112014006455A2 (pt) alquilamidotiazóis, preparações cosméticas ou dermatológicas com um teor de um ou vários alquilamidotiazóis e uso de um ou vários alquilamidotiazóis
BR112012028802A2 (pt) composições contendo enzima de reparo de dna e extrato de anogeissus
BR112016018489A2 (pt) Método de qualificação de células, população isolada de células-tronco mesenquimais, método de tratamento de uma doença imune ou inflamatória, e uso de células-tronco mesenquimais
BR112017023744A2 (pt) método para obtenção de uma biomassa de uma microalga das espécies tetraselmis chuii enriquecidas em superóxido dismutase (sod)
WO2013102882A3 (en) Cosmetic use of dedifferentiated plant cells
BR112012024630B8 (pt) Processos para o tratamento cosmético de envelhecimento da pele
WO2012153064A3 (fr) Composition cosmetique ou dermatologique a base d'extraits d'immortelle et son utilisation
BR112018070293A2 (pt) diferenciação de células-tronco pluripotentes em células do endoderma intestinal do intestino médio
BR112018005315A2 (pt) abordagens para aprimorar hidratação ou umidificação de pele
BR112014012941A2 (pt) Composição para cuidado pessoal, método cosmético para tratar pele, e, métodos para inibir a degradação de colágeno na pele e para reduzir os sinais visíveis de envelhecimento
AR108935A1 (es) Extracto de aquenio de silybum marianum y sus usos en dermatología y dermocosmética
BR112015015341A2 (pt) composições para permeabilização de células sanguíneas fixadas e usos das mesmas
BR112018075997A2 (pt) extrato de células não diferenciadas de mimosa pudica e seus usos em dermocosméticos
BR112017020013A2 (pt) método para preparação de um substituto da pele, substituto da pele, substituto dérmico, enxerto, enxerto para uso, e kit para implementação do método
CL2020002646A1 (es) Composición para modular genes responsables de las funciones generales de la piel, que comprende al menos un extracto vegetal seleccionado de casearia sylvestris y schinus terebinthfolius y ácido hialurónico (divisional de la solicitud 03354-2018)
WO2015079469A8 (en) Daphne laureola extracts in the treatment of dermopathies
BR112016002580A2 (pt) composição para tratamento antienvelhecimento de pele

Legal Events

Date Code Title Description
B06W Patent application suspended after preliminary examination (for patents with searches from other patent authorities) chapter 6.23 patent gazette]
B350 Update of information on the portal [chapter 15.35 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 14/06/2017, OBSERVADAS AS CONDICOES LEGAIS