BR112018075039A2 - métodos de tratamento da síndrome de prader-willi - Google Patents

métodos de tratamento da síndrome de prader-willi

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Publication number
BR112018075039A2
BR112018075039A2 BR112018075039-5A BR112018075039A BR112018075039A2 BR 112018075039 A2 BR112018075039 A2 BR 112018075039A2 BR 112018075039 A BR112018075039 A BR 112018075039A BR 112018075039 A2 BR112018075039 A2 BR 112018075039A2
Authority
BR
Brazil
Prior art keywords
prader
willi syndrome
treatment methods
syndrome treatment
methods
Prior art date
Application number
BR112018075039-5A
Other languages
English (en)
Inventor
Cole BURNETT Lisa
Egli Dieter
L. Leibel Rudolph
COTTER Sara
Original Assignee
The Trustees Of Columbia University In The City Of New York
Levo Therapeutics, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by The Trustees Of Columbia University In The City Of New York, Levo Therapeutics, Inc. filed Critical The Trustees Of Columbia University In The City Of New York
Publication of BR112018075039A2 publication Critical patent/BR112018075039A2/pt

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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
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    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
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    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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    • A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
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Abstract

a presente invenção refere-se a métodos para a regulação da pró-hormônio convertase (pc1) e compostos e tratamentos, que aumentam os níveis de pc1, para o tratamento da síndrome de prader-willi (pws).
BR112018075039-5A 2016-06-03 2017-06-02 métodos de tratamento da síndrome de prader-willi BR112018075039A2 (pt)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201662345133P 2016-06-03 2016-06-03
US62/345,133 2016-06-03
US201662375662P 2016-08-16 2016-08-16
US62/375,662 2016-08-16
PCT/US2017/035655 WO2017210540A1 (en) 2016-06-03 2017-06-02 Methods of treating prader-willi syndrome

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BR112018075039A2 true BR112018075039A2 (pt) 2019-05-14

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US (2) US10842775B2 (pt)
EP (2) EP3478281B1 (pt)
JP (2) JP7044768B2 (pt)
KR (1) KR102478186B1 (pt)
CN (1) CN109562092B (pt)
AU (1) AU2017275652B2 (pt)
BR (1) BR112018075039A2 (pt)
CA (1) CA3026083C (pt)
ES (1) ES2847126T3 (pt)
IL (2) IL263412B (pt)
MX (2) MX2018014942A (pt)
RU (2) RU2748294C2 (pt)
WO (1) WO2017210540A1 (pt)
ZA (1) ZA201808607B (pt)

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CA3026083C (en) * 2016-06-03 2024-04-02 The Trustees Of Columbia University In The City Of New York Methods of treating prader-willi syndrome
WO2018183923A1 (en) * 2017-03-31 2018-10-04 Epizyme, Inc. Methods of using ehmt2 inhibitors
WO2018195450A1 (en) 2017-04-21 2018-10-25 Epizyme, Inc. Combination therapies with ehmt2 inhibitors
US10736894B2 (en) 2018-02-15 2020-08-11 Ovid Therapeutics Inc. Methods of treating developmental syndromes with PDE10A inhibitors
TW202031283A (zh) 2018-09-20 2020-09-01 馬克 Ｃ 曼寧 穩定卡貝縮宮素鼻內製劑
CN111264851A (zh) * 2020-03-03 2020-06-12 河南省儿童医院郑州儿童医院 Pws综合征靶向替代保健食品及其制备方法
WO2022235818A2 (en) * 2021-05-04 2022-11-10 Virginia Tech Intellectual Properties, Inc. Conjugated linoleic acid supplementation for disease treatment

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