BR112018072198A2 - composição compreendendo micrornas, método de preparação de uma composição de célula-tronco restaurada, formulação farmacêutica e kit - Google Patents
composição compreendendo micrornas, método de preparação de uma composição de célula-tronco restaurada, formulação farmacêutica e kitInfo
- Publication number
- BR112018072198A2 BR112018072198A2 BR112018072198-0A BR112018072198A BR112018072198A2 BR 112018072198 A2 BR112018072198 A2 BR 112018072198A2 BR 112018072198 A BR112018072198 A BR 112018072198A BR 112018072198 A2 BR112018072198 A2 BR 112018072198A2
- Authority
- BR
- Brazil
- Prior art keywords
- composition
- mir
- seq
- micrornas
- kit
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- A61K48/005—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
- A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
- A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
- A61K9/1273—Polymersomes; Liposomes with polymerisable or polymerised bilayer-forming substances
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/14—Type of nucleic acid interfering N.A.
- C12N2310/141—MicroRNAs, miRNAs
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2320/00—Applications; Uses
- C12N2320/30—Special therapeutic applications
- C12N2320/31—Combination therapy
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Biophysics (AREA)
- Epidemiology (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Dispersion Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Peptides Or Proteins (AREA)
- Developmental Biology & Embryology (AREA)
- Transplantation (AREA)
- Cell Biology (AREA)
Abstract
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201662329486P | 2016-04-29 | 2016-04-29 | |
US62/329,486 | 2016-04-29 | ||
US201762482465P | 2017-04-06 | 2017-04-06 | |
US62/482,465 | 2017-04-06 | ||
PCT/US2017/030117 WO2017190000A1 (en) | 2016-04-29 | 2017-04-28 | Microrna compositions and methods of making and using same |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112018072198A2 true BR112018072198A2 (pt) | 2019-02-12 |
Family
ID=60158119
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112018072198-0A BR112018072198A2 (pt) | 2016-04-29 | 2017-04-28 | composição compreendendo micrornas, método de preparação de uma composição de célula-tronco restaurada, formulação farmacêutica e kit |
Country Status (9)
Country | Link |
---|---|
US (1) | US11203754B2 (pt) |
EP (1) | EP3436081A4 (pt) |
JP (2) | JP6999575B2 (pt) |
KR (1) | KR20180130589A (pt) |
CN (1) | CN109475645A (pt) |
BR (1) | BR112018072198A2 (pt) |
CA (1) | CA3023468A1 (pt) |
TW (1) | TW201739458A (pt) |
WO (1) | WO2017190000A1 (pt) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US11286463B2 (en) | 2012-03-08 | 2022-03-29 | Advanced ReGen Medical Technologies, LLC | Reprogramming of aged adult stem cells |
US10772911B2 (en) | 2013-12-20 | 2020-09-15 | Advanced ReGen Medical Technologies, LLC | Cell free compositions for cellular restoration and methods of making and using same |
JP6353073B2 (ja) | 2013-12-20 | 2018-07-04 | アドヴァンスド リジェン メディカル テクノロジーズ,エルエルシー | 細胞回復のための組成物並びにその作製及び使用方法 |
JP6999575B2 (ja) | 2016-04-29 | 2022-01-18 | アドヴァンスド リジェン メディカル テクノロジーズ,エルエルシー | マイクロrna組成物並びにその作製及び使用方法 |
US10717981B2 (en) | 2018-01-18 | 2020-07-21 | Advanced ReGen Medical Technologies, LLC | Therapeutic compositions and methods of making and using the same |
WO2020190888A1 (en) * | 2019-03-18 | 2020-09-24 | Advanced ReGen Medical Technologies, LLC | Methods and clinical protocols and kits pertaining to making and using therapeutic compositions for cellular treatment |
KR20210099917A (ko) | 2020-02-05 | 2021-08-13 | 이윤하 | 범죄자 유무 알리미 |
CN114107209B (zh) * | 2021-11-25 | 2024-02-02 | 青岛市市立医院 | 一种非治疗目的的高表达miR-146a-5p的外泌体抑制THP-1分化和巨噬细胞M1极化的方法 |
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JP6999575B2 (ja) | 2016-04-29 | 2022-01-18 | アドヴァンスド リジェン メディカル テクノロジーズ,エルエルシー | マイクロrna組成物並びにその作製及び使用方法 |
JP2020529477A (ja) | 2017-08-04 | 2020-10-08 | シーダーズ—シナイ メディカル センター | がんの治療及び防止のためのカルディオスフィア由来細胞及びその細胞外小胞 |
US10717981B2 (en) | 2018-01-18 | 2020-07-21 | Advanced ReGen Medical Technologies, LLC | Therapeutic compositions and methods of making and using the same |
WO2020190888A1 (en) | 2019-03-18 | 2020-09-24 | Advanced ReGen Medical Technologies, LLC | Methods and clinical protocols and kits pertaining to making and using therapeutic compositions for cellular treatment |
-
2017
- 2017-04-28 JP JP2018556440A patent/JP6999575B2/ja active Active
- 2017-04-28 EP EP17790538.7A patent/EP3436081A4/en active Pending
- 2017-04-28 BR BR112018072198-0A patent/BR112018072198A2/pt not_active IP Right Cessation
- 2017-04-28 WO PCT/US2017/030117 patent/WO2017190000A1/en active Application Filing
- 2017-04-28 CA CA3023468A patent/CA3023468A1/en not_active Abandoned
- 2017-04-28 CN CN201780026347.5A patent/CN109475645A/zh active Pending
- 2017-04-28 KR KR1020187034249A patent/KR20180130589A/ko not_active Application Discontinuation
- 2017-04-28 US US15/581,705 patent/US11203754B2/en active Active
- 2017-04-28 TW TW106114364A patent/TW201739458A/zh unknown
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2021
- 2021-06-01 JP JP2021092044A patent/JP7343549B2/ja active Active
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CN109475645A (zh) | 2019-03-15 |
EP3436081A4 (en) | 2019-07-24 |
US11203754B2 (en) | 2021-12-21 |
JP2021169449A (ja) | 2021-10-28 |
WO2017190000A1 (en) | 2017-11-02 |
US20170314019A1 (en) | 2017-11-02 |
EP3436081A1 (en) | 2019-02-06 |
TW201739458A (zh) | 2017-11-16 |
CA3023468A1 (en) | 2017-11-02 |
JP6999575B2 (ja) | 2022-01-18 |
KR20180130589A (ko) | 2018-12-07 |
JP7343549B2 (ja) | 2023-09-12 |
JP2019514927A (ja) | 2019-06-06 |
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