BR112018067563A2 - sistemas e métodos para a produção de hipericina sintética. - Google Patents

sistemas e métodos para a produção de hipericina sintética.

Info

Publication number
BR112018067563A2
BR112018067563A2 BR112018067563A BR112018067563A BR112018067563A2 BR 112018067563 A2 BR112018067563 A2 BR 112018067563A2 BR 112018067563 A BR112018067563 A BR 112018067563A BR 112018067563 A BR112018067563 A BR 112018067563A BR 112018067563 A2 BR112018067563 A2 BR 112018067563A2
Authority
BR
Brazil
Prior art keywords
production
methods
systems
synthetic hypericin
hypericin
Prior art date
Application number
BR112018067563A
Other languages
English (en)
Other versions
BR112018067563A8 (pt
Inventor
Schaber Christopher
Rauter Holger
Arumugham Rasappa
Werner Silvia
Original Assignee
Schaber Christopher
Holger Holger
Arumugham Rasappa
Werner Silvia
Soligenix Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schaber Christopher, Holger Holger, Arumugham Rasappa, Werner Silvia, Soligenix Inc filed Critical Schaber Christopher
Publication of BR112018067563A2 publication Critical patent/BR112018067563A2/pt
Publication of BR112018067563A8 publication Critical patent/BR112018067563A8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C46/00—Preparation of quinones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C46/00—Preparation of quinones
    • C07C46/10—Separation; Purification; Stabilisation; Use of additives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C50/00—Quinones
    • C07C50/26—Quinones containing groups having oxygen atoms singly bound to carbon atoms
    • C07C50/36—Quinones containing groups having oxygen atoms singly bound to carbon atoms the quinoid structure being part of a condensed ring system having four or more rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/54—Ortho- or ortho- and peri-condensed systems containing more than five condensed rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

a presente invenção se refere-se a sistemas e métodos aprimorados para a produção de hipericina sintética em alto volume e alta pureza.
BR112018067563A 2016-03-01 2016-03-01 sistemas e métodos para a produção de hipericina sintética. BR112018067563A8 (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US2016/020189 WO2017151111A1 (en) 2016-03-01 2016-03-01 Systems and methods for producing synthetic hypericin

Publications (2)

Publication Number Publication Date
BR112018067563A2 true BR112018067563A2 (pt) 2019-01-08
BR112018067563A8 BR112018067563A8 (pt) 2021-03-30

Family

ID=59744267

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112018067563A BR112018067563A8 (pt) 2016-03-01 2016-03-01 sistemas e métodos para a produção de hipericina sintética.

Country Status (14)

Country Link
EP (1) EP3423428B1 (pt)
JP (1) JP6890616B2 (pt)
KR (2) KR102592878B1 (pt)
CN (1) CN109071397A (pt)
AU (2) AU2016396033B2 (pt)
BR (1) BR112018067563A8 (pt)
CA (1) CA3016618C (pt)
DK (1) DK3423428T3 (pt)
FI (1) FI3423428T3 (pt)
IL (2) IL281618B2 (pt)
NZ (1) NZ773357A (pt)
RU (1) RU2719582C1 (pt)
SG (1) SG11201807454YA (pt)
WO (1) WO2017151111A1 (pt)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR3111640B1 (fr) 2020-06-22 2022-07-22 Total Marketing Services Composition aqueuse pour la lubrification des systèmes mécaniques

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL93682A (en) * 1989-03-16 1996-06-18 Yeda Res & Dev Polycyclic compounds with antigypical activity are used in the manufacture of medicines and pharmaceutical preparations containing them
IL92315A (en) * 1989-11-15 1996-12-05 Yeda Res & Dev Preparation of Hypericin from Amodin Enron
US5491144A (en) * 1991-05-30 1996-02-13 Ciba-Geigy Corporation Substituted diaminophthalimides and analogues
US5543016A (en) * 1991-07-12 1996-08-06 Inrad Photoconversion of steroids in microreactors
IL104693A0 (en) * 1992-02-14 1993-06-10 Yeda Res & Dev Hypericin derivatives and pharmaceutical compositions comprising them
US6576784B1 (en) * 1993-05-27 2003-06-10 Yeda Research And Development Co. Ltd. Antiviral agents
IL121440A0 (en) 1997-07-31 1998-01-04 Yeda Res & Dev The use of 1,3,4,6-tetrahydroxy-helianthrone and its derivatives in photodynamic therapy and certain such novel derivatives
WO2000002455A1 (en) * 1998-07-09 2000-01-20 Cv Technologies Inc. Hypericin and hypericum extract: specific t-type calcium channel blocker, and their use as t-type calcium channel targeted therapeutics
ES2275647T3 (es) 2000-01-31 2007-06-16 Yeda Research And Development Co. Ltd. Diantraquinonas policiclicas como agentes anti-cancerosos y anti-angiogenicos.
JP5349930B2 (ja) * 2008-12-04 2013-11-20 三井造船株式会社 トルエン類の酸化処理方法
EP2477957A4 (en) * 2009-09-15 2013-07-03 Hy Biopharma Inc PROCESS FOR PREPARING HYPERICIN
CN102180782B (zh) * 2011-03-23 2013-04-10 中国农业科学院兰州畜牧与兽药研究所 一种金丝桃素的合成方法
CN103274920B (zh) * 2013-06-14 2014-12-17 西北农林科技大学 一种单色光引发高效合成金丝桃素的方法
JP2015164980A (ja) * 2014-03-03 2015-09-17 川崎化成工業株式会社 光反応性組成物
CN104193610B (zh) * 2014-08-05 2015-12-02 中南大学 金丝桃素的合成方法

Also Published As

Publication number Publication date
CN109071397A (zh) 2018-12-21
EP3423428A4 (en) 2019-12-11
SG11201807454YA (en) 2018-09-27
AU2016396033A1 (en) 2018-10-18
EP3423428A1 (en) 2019-01-09
IL261531B (en) 2021-04-29
NZ746762A (en) 2023-09-29
RU2719582C1 (ru) 2020-04-21
DK3423428T3 (da) 2024-09-23
BR112018067563A8 (pt) 2021-03-30
AU2016396033B2 (en) 2021-07-08
IL281618A (en) 2021-05-31
KR102592878B1 (ko) 2023-10-20
IL281618B1 (en) 2024-01-01
AU2021203704B2 (en) 2023-02-16
AU2021203704A1 (en) 2021-07-08
KR20190004260A (ko) 2019-01-11
IL261531A (en) 2018-10-31
EP4414354A2 (en) 2024-08-14
IL281618B2 (en) 2024-05-01
CA3016618C (en) 2023-12-19
WO2017151111A1 (en) 2017-09-08
KR20230148401A (ko) 2023-10-24
JP6890616B2 (ja) 2021-06-18
NZ773357A (en) 2024-07-26
FI3423428T3 (fi) 2024-09-23
JP2019507192A (ja) 2019-03-14
CA3016618A1 (en) 2017-09-08
EP3423428B1 (en) 2024-07-24

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Legal Events

Date Code Title Description
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B350 Update of information on the portal [chapter 15.35 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]
B12B Appeal against refusal [chapter 12.2 patent gazette]