BR112018016050A2 - estruturas de paredes celulares descelularizadas provenientes de plantas e fungos e uso das mesmas como materiais de scaffold - Google Patents
estruturas de paredes celulares descelularizadas provenientes de plantas e fungos e uso das mesmas como materiais de scaffoldInfo
- Publication number
- BR112018016050A2 BR112018016050A2 BR112018016050A BR112018016050A BR112018016050A2 BR 112018016050 A2 BR112018016050 A2 BR 112018016050A2 BR 112018016050 A BR112018016050 A BR 112018016050A BR 112018016050 A BR112018016050 A BR 112018016050A BR 112018016050 A2 BR112018016050 A2 BR 112018016050A2
- Authority
- BR
- Brazil
- Prior art keywords
- tissue
- fungi
- plants
- cell wall
- scaffold
- Prior art date
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/3637—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the origin of the biological material other than human or animal, e.g. plant extracts, algae
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/3683—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/3683—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment
- A61L27/3687—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment characterised by the use of chemical agents in the treatment, e.g. specific enzymes, detergents, capping agents, crosslinkers, anticalcification agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/507—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials for artificial blood vessels
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/52—Hydrogels or hydrocolloids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/54—Biologically active materials, e.g. therapeutic substances
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/60—Materials for use in artificial skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/0062—General methods for three-dimensional culture
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/0068—General culture methods using substrates
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/412—Tissue-regenerating or healing or proliferative agents
- A61L2300/414—Growth factors
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/16—Materials or treatment for tissue regeneration for reconstruction of eye parts, e.g. intraocular lens, cornea
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/32—Materials or treatment for tissue regeneration for nerve reconstruction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/40—Preparation and treatment of biological tissue for implantation, e.g. decellularisation, cross-linking
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Biomedical Technology (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Botany (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Biotechnology (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Cell Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Dispersion Chemistry (AREA)
- Vascular Medicine (AREA)
- Ophthalmology & Optometry (AREA)
- Birds (AREA)
- Mycology (AREA)
- Materials For Medical Uses (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
a invenção se refere a biomateriais de scaffold compreendendo um tecido vegetal ou fúngico do qual materiais celulares e ácidos nucléicos do tecido são removidos, o tecido vegetal ou fúngico compreendendo uma estrutura porosa tridimensional baseada em celulose ou quitina. a invenção também se refere a métodos para preparar esses biomateriais de scaffold, bem como os usos dos mesmos como um scaffold implantável para suportar o crescimento celular animal, para promover a regeneração do tecido celular, para promover a angiogênese, para um procedimento de substituição de tecido, e/ou como um implante estrutural para cirurgia estética. adicionalmente são descritos tratamento terapêutico e/ou métodos cosméticos empregando tais scaffolds.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201662294671P | 2016-02-12 | 2016-02-12 | |
US62/294.671 | 2016-02-12 | ||
PCT/CA2017/050163 WO2017136950A1 (en) | 2016-02-12 | 2017-02-10 | Decellularised cell wall structures from plants and fungus and use thereof as scaffold materials |
Publications (2)
Publication Number | Publication Date |
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BR112018016050A2 true BR112018016050A2 (pt) | 2018-12-26 |
BR112018016050B1 BR112018016050B1 (pt) | 2022-04-12 |
Family
ID=59563678
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112018016050-4A BR112018016050B1 (pt) | 2016-02-12 | 2017-02-10 | Biomaterial de estrutura tridimensional, método para preparar um tecido vegetal descelularizado, uso do biomaterial de estrutura tridimensional, e, kit |
Country Status (11)
Country | Link |
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US (3) | US11045582B2 (pt) |
EP (1) | EP3413939B1 (pt) |
JP (2) | JP6957486B2 (pt) |
CN (1) | CN109152863A (pt) |
AU (2) | AU2017218476B2 (pt) |
BR (1) | BR112018016050B1 (pt) |
CA (1) | CA3014256C (pt) |
ES (1) | ES2953657T3 (pt) |
IL (2) | IL260993B (pt) |
MX (1) | MX2018009551A (pt) |
WO (1) | WO2017136950A1 (pt) |
Families Citing this family (42)
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US9485917B2 (en) | 2006-12-15 | 2016-11-08 | Ecovative Design, LLC | Method for producing grown materials and products made thereby |
US11277979B2 (en) | 2013-07-31 | 2022-03-22 | Ecovative Design Llc | Mycological biopolymers grown in void space tooling |
US20150101509A1 (en) | 2013-10-14 | 2015-04-16 | Gavin R. McIntyre | Method of Manufacturing a Stiff Engineered Composite |
US11883275B2 (en) | 2014-06-11 | 2024-01-30 | Bard Shannon Limited | In vivo tissue engineering devices, methods and regenerative and cellular medicine employing scaffolds made of absorbable material |
US11638640B2 (en) | 2014-06-11 | 2023-05-02 | Bard Shannon Limited | In vivo tissue engineering devices, methods and regenerative and cellular medicine employing scaffolds made of absorbable material |
AU2017227612C1 (en) | 2016-03-01 | 2023-02-16 | The Fynder Group, Inc. | Filamentous fungal biomats, methods of their production and methods of their use |
US11359074B2 (en) | 2017-03-31 | 2022-06-14 | Ecovative Design Llc | Solution based post-processing methods for mycological biopolymer material and mycological product made thereby |
WO2018200753A1 (en) * | 2017-04-25 | 2018-11-01 | Paul Gatenholm | Biocompatible conductive inks based on cellulse nanofibrils for 3d printing of conductive biomedical devices |
TWI612966B (zh) * | 2017-06-06 | 2018-02-01 | 景鑫生物科技股份有限公司 | 南洋山蘇水萃物的用途 |
US11266085B2 (en) | 2017-11-14 | 2022-03-08 | Ecovative Design Llc | Increased homogeneity of mycological biopolymer grown into void space |
US11844683B2 (en) | 2018-03-12 | 2023-12-19 | Bard Shannon Limited | In vivo tissue engineering devices, methods and regenerative and cellular medicine employing scaffolds made of absorbable material |
US11920126B2 (en) | 2018-03-28 | 2024-03-05 | Ecovative Design Llc | Bio-manufacturing process |
US11293005B2 (en) | 2018-05-07 | 2022-04-05 | Ecovative Design Llc | Process for making mineralized mycelium scaffolding and product made thereby |
US11343979B2 (en) | 2018-05-24 | 2022-05-31 | Ecovative Design Llc | Process and apparatus for producing mycelium biomaterial |
CN112714788A (zh) * | 2018-07-23 | 2021-04-27 | 生态创新设计有限责任公司 | 生产真菌产品的方法和由此制备的产品 |
US11110203B2 (en) * | 2018-08-22 | 2021-09-07 | Worcester Polytechnic Institute | Decellularization of plant cell culture materials for tissue engineering and drug delivery |
US11359174B2 (en) | 2018-10-02 | 2022-06-14 | Ecovative Design Llc | Bioreactor paradigm for the production of secondary extra-particle hyphal matrices |
SG11202105283PA (en) * | 2018-11-20 | 2021-06-29 | Ecovative Design Llc | Methods of generating mycelial scaffolds and applications thereof |
CN111494722B (zh) * | 2019-01-31 | 2023-06-23 | 华东理工大学 | 干细胞发生器制备骨缺损修复材料的新用途 |
US20220142907A1 (en) * | 2019-03-13 | 2022-05-12 | Ecovative Design Llc | Mycelium biopolymers for health and beauty applications |
CN110257335B (zh) * | 2019-04-10 | 2020-09-29 | 首都医科大学附属北京天坛医院 | 单层或多层的3d脑胶质瘤细胞培养模型及其构建方法和应用 |
JP2022533973A (ja) * | 2019-05-14 | 2022-07-27 | スパイダーワート インク. | 複合生体材料 |
MX2021013859A (es) * | 2019-05-14 | 2022-03-22 | Spiderwort Inc | Microcanales de alta densidad. |
US20220236255A1 (en) * | 2019-06-28 | 2022-07-28 | Arizona Board Of Regents On Behalf Of The University Of Arizona | Self-Contained Responsive Biological Systems and Methods |
KR102334114B1 (ko) * | 2019-11-25 | 2021-12-02 | 영남대학교 산학협력단 | 진균을 이용한 스캐폴드 제조 및 이를 이용한 조직 재생방법 |
WO2021119830A1 (en) * | 2019-12-19 | 2021-06-24 | Spiderwort Inc. | Biomaterials for bone tissue engineering |
KR102151203B1 (ko) * | 2019-12-19 | 2020-09-02 | 주식회사 씨위드 | 세포 배양용 지지체 및 그 제조 방법 |
BR122023021841A2 (pt) | 2020-03-23 | 2024-02-20 | Bard Shannon Limited | Prótese implantável que compreende estrutura de material biocompatível |
WO2021231372A1 (en) * | 2020-05-11 | 2021-11-18 | Worcester Polytechnic Institute | Non-decellularized plant leaf cultures for meat |
AU2021287463A1 (en) * | 2020-06-08 | 2023-01-05 | Spiderwort Inc. | Dermal fillers |
CN111982629B (zh) * | 2020-08-25 | 2023-11-17 | 北京市农林科学院 | 一种食用菌组织细胞的超薄冷冻切片方法 |
CA3197332A1 (en) * | 2020-11-12 | 2022-05-19 | Jessica T. HOLMES | Porous scaffold, method of making and uses thereof |
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CN113908336B (zh) * | 2021-09-29 | 2022-11-04 | 重庆医科大学附属口腔医院 | 一种溶菌酶相转变膜改性纤维素支架及其制备方法和用途 |
CN114134048B (zh) * | 2021-11-23 | 2023-09-05 | 广西壮族自治区药用植物园 | 一株内生真菌及其应用于桑寄生繁育中的方法和其用途 |
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GB2466073A (en) | 2008-12-12 | 2010-06-16 | Univ Manchester | Tissue repair scaffold |
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WO2013096741A2 (en) * | 2011-12-23 | 2013-06-27 | Anthrogenesis Corporation | Organoids comprising decellularized and repopulated placental vascular scaffold |
GB201212771D0 (en) * | 2012-07-18 | 2012-08-29 | Northwick Park Inst For Medcal Res Ltd | Implant and method for producing an implant |
KR102282769B1 (ko) * | 2013-03-15 | 2021-07-29 | 미로매트릭스 메디칼 인크. | 탈세포화된 기관 및 조직에 대한 마이크로입자 및 내피 세포의 용도 |
GB201310773D0 (en) * | 2013-06-17 | 2013-07-31 | Northwick Park Inst For Medcal Res Ltd | Implant and method of producing an implant |
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2017
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- 2017-02-10 EP EP17749878.9A patent/EP3413939B1/en active Active
- 2017-02-10 CN CN201780023019.XA patent/CN109152863A/zh active Pending
- 2017-02-10 JP JP2018541257A patent/JP6957486B2/ja active Active
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AU2017218476A1 (en) | 2018-09-27 |
AU2022200696B2 (en) | 2023-09-28 |
US11045582B2 (en) | 2021-06-29 |
EP3413939C0 (en) | 2023-06-07 |
JP6957486B2 (ja) | 2021-11-02 |
WO2017136950A1 (en) | 2017-08-17 |
ES2953657T3 (es) | 2023-11-15 |
US20210001007A1 (en) | 2021-01-07 |
CA3014256C (en) | 2024-04-23 |
MX2018009551A (es) | 2019-05-06 |
IL284915A (en) | 2021-08-31 |
JP2019509723A (ja) | 2019-04-11 |
US20190060520A1 (en) | 2019-02-28 |
EP3413939B1 (en) | 2023-06-07 |
EP3413939A1 (en) | 2018-12-19 |
CA3014256A1 (en) | 2017-08-17 |
US20220016317A1 (en) | 2022-01-20 |
US11167062B2 (en) | 2021-11-09 |
BR112018016050B1 (pt) | 2022-04-12 |
CN109152863A (zh) | 2019-01-04 |
IL260993B (en) | 2021-08-31 |
AU2017218476B2 (en) | 2022-02-17 |
IL284915B (en) | 2022-02-01 |
JP2022002536A (ja) | 2022-01-11 |
AU2022200696A1 (en) | 2022-02-24 |
EP3413939A4 (en) | 2019-10-30 |
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