BR112012019369A2 - fabricação de enxerto de nervo biológico construído e aplicação do mesmo. - Google Patents
fabricação de enxerto de nervo biológico construído e aplicação do mesmo.Info
- Publication number
- BR112012019369A2 BR112012019369A2 BR112012019369A BR112012019369A BR112012019369A2 BR 112012019369 A2 BR112012019369 A2 BR 112012019369A2 BR 112012019369 A BR112012019369 A BR 112012019369A BR 112012019369 A BR112012019369 A BR 112012019369A BR 112012019369 A2 BR112012019369 A2 BR 112012019369A2
- Authority
- BR
- Brazil
- Prior art keywords
- graft
- cells
- suitably
- constructed
- living
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/04—Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/3641—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the site of application in the body
- A61L27/3675—Nerve tissue, e.g. brain, spinal cord, nerves, dura mater
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
- A61L27/3886—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells comprising two or more cell types
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/54—Biologically active materials, e.g. therapeutic substances
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/0062—General methods for three-dimensional culture
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0618—Cells of the nervous system
- C12N5/0622—Glial cells, e.g. astrocytes, oligodendrocytes; Schwann cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
- C12N5/0662—Stem cells
- C12N5/0663—Bone marrow mesenchymal stem cells (BM-MSC)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K2035/124—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells the cells being hematopoietic, bone marrow derived or blood cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/32—Materials or treatment for tissue regeneration for nerve reconstruction
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2533/00—Supports or coatings for cell culture, characterised by material
- C12N2533/70—Polysaccharides
- C12N2533/76—Agarose, agar-agar
Abstract
fabricação de enxerto de nervo biológico construído e aplicação do mesmo. uma estrutura tridimensional construída inclui células vivas coerentes entre si. as células vivas adequadamente incluem células de schwann e pelo menos outro tipo de célula. as células que acompanham as células de schwann podem adequaquadamente ser células tronco de medula óssea ou de outro tipo de célula tendo uma ou mais propriedades anti-inflamatórias. a estrutura é, adequadamente, um enxerto que facilita o cresimento de axônio resturador quando o enxerto é implantado entre os topos proximal e distal de um nervo cortado em um organismo vivo. o enxerto podce opcionalmente incluir uma pluralidade de condutos acelulares que se prolongam entre extremidades axiais opostas do enxerto. técnicas de bio-impressão podem ser utilizadas para montar um constructo tridimensional que se surge maturando um enxerto guia de axônio empilhando uma pluralidade de corpos multicelulares, cada um dos quais inclui uma pluralidade de células vivas coerentes entre si para suficientemente evitar o calapso quando os corpos multicelulares são empilhados para formar a estrutura.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US33730710P | 2010-02-02 | 2010-02-02 | |
US201161438097P | 2011-01-31 | 2011-01-31 | |
PCT/US2011/023520 WO2011097330A2 (en) | 2010-02-02 | 2011-02-02 | Engineered biological nerve graft fabrication and application thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112012019369A2 true BR112012019369A2 (pt) | 2018-05-22 |
Family
ID=44356064
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112012019369A BR112012019369A2 (pt) | 2010-02-02 | 2011-02-02 | fabricação de enxerto de nervo biológico construído e aplicação do mesmo. |
Country Status (11)
Country | Link |
---|---|
US (1) | US8747880B2 (pt) |
EP (1) | EP2531228A4 (pt) |
JP (1) | JP2013518591A (pt) |
KR (1) | KR20120125331A (pt) |
CN (1) | CN102869391A (pt) |
AU (1) | AU2011212998A1 (pt) |
BR (1) | BR112012019369A2 (pt) |
CA (1) | CA2788514A1 (pt) |
IL (1) | IL221122A0 (pt) |
RU (1) | RU2012137080A (pt) |
WO (1) | WO2011097330A2 (pt) |
Families Citing this family (31)
Publication number | Priority date | Publication date | Assignee | Title |
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US8241905B2 (en) | 2004-02-24 | 2012-08-14 | The Curators Of The University Of Missouri | Self-assembling cell aggregates and methods of making engineered tissue using the same |
CA2949615A1 (en) | 2008-06-24 | 2010-01-21 | The Curators Of The University Of Missouri | Self-assembling multicellular bodies and methods of producing a three-dimensional biological structure using the same |
US20120089238A1 (en) * | 2010-10-06 | 2012-04-12 | Hyun-Wook Kang | Integrated organ and tissue printing methods, system and apparatus |
BR112013009744A2 (pt) | 2010-10-21 | 2016-07-19 | Organovo Inc | dispositivo, sistemas e métodos para a fabricação de tecido |
CA3157246A1 (en) * | 2011-09-12 | 2013-03-21 | Organovo, Inc. | Engineered tissues for in vitro research uses, arrays thereof, and methods of making the same |
US9499779B2 (en) | 2012-04-20 | 2016-11-22 | Organovo, Inc. | Devices, systems, and methods for the fabrication of tissue utilizing UV cross-linking |
US9442105B2 (en) | 2013-03-15 | 2016-09-13 | Organovo, Inc. | Engineered liver tissues, arrays thereof, and methods of making the same |
CN103272288B (zh) * | 2013-06-24 | 2014-07-09 | 谢杨 | 基于生物打印技术的细胞-生物支架复合物的制备方法 |
CN103350572B (zh) * | 2013-07-18 | 2016-05-25 | 符晓友 | 3d堆叠打印方法及3d堆叠打印机 |
CN103405289B (zh) * | 2013-07-26 | 2015-04-15 | 清华大学 | 一种基于液体金属的用于缺损外周神经功能修复的装置 |
WO2015017579A1 (en) | 2013-07-31 | 2015-02-05 | Organovo, Inc. | Automated devices, systems, and methods for the fabrication of tissue |
WO2015048355A1 (en) * | 2013-09-26 | 2015-04-02 | Northwestern University | Poly(ethylene glycol) cross-linking of soft materials to tailor viscoelastic properties for bioprinting |
CN104287875A (zh) * | 2014-03-05 | 2015-01-21 | 青岛尤尼科技有限公司 | 一种多功能生物打印系统及基于生物打印系统制备组织工程器官的方法 |
CA3177480A1 (en) | 2014-04-04 | 2015-10-08 | Organovo, Inc. | Engineered three-dimensional breast tissue, adipose tissue, and tumor disease model |
USD789538S1 (en) * | 2014-08-15 | 2017-06-13 | Richard J. McMurtrey | Artificial composite neural tissue construct device |
MA40495A (fr) | 2014-10-06 | 2016-04-14 | Organovo Inc | Tissus rénaux produits par génie génétique, réseaux correspondants, et procédés de production |
US11529436B2 (en) | 2014-11-05 | 2022-12-20 | Organovo, Inc. | Engineered three-dimensional skin tissues, arrays thereof, and methods of making the same |
ES2819229T3 (es) | 2014-11-10 | 2021-04-15 | Univ Berlin Tech | Procedimiento y dispositivo para producir un objeto multicelular tridimensional |
US10294450B2 (en) | 2015-10-09 | 2019-05-21 | Deka Products Limited Partnership | Fluid pumping and bioreactor system |
WO2018013727A1 (en) | 2016-07-12 | 2018-01-18 | Deka Products Limited Partnership | System and method for applying force to a device |
US11254901B2 (en) | 2016-07-12 | 2022-02-22 | Deka Products Limited Partnership | System and method for printing tissue |
US11299705B2 (en) | 2016-11-07 | 2022-04-12 | Deka Products Limited Partnership | System and method for creating tissue |
AU2017375956C1 (en) * | 2016-12-12 | 2023-12-14 | The Regents Of The University Of California | Biomimetic implants |
EP3638325A1 (en) * | 2017-06-13 | 2020-04-22 | Anatoli D. Dosta | Implant for injured nerve tissue prosthetics, method of surgical treatment for injured nerve tissue and use of porous polytetrafluorethylene |
US10570362B2 (en) | 2017-07-12 | 2020-02-25 | Deka Products Limited Partnership | System and method for transferring tissue |
EP3427949A1 (en) | 2017-07-12 | 2019-01-16 | Albert-Ludwigs-Universität Freiburg | Mechanically tunable bioinks for bioprinting |
CN108273138B (zh) * | 2018-02-05 | 2021-01-05 | 北京诺康达医药科技股份有限公司 | 一种智能调控的可吸收外周神经修复导管及其制备方法 |
CN108187148B (zh) * | 2018-02-13 | 2021-03-12 | 中山大学附属第一医院 | 一种能提高轴突再生有序性的神经导管及其制备方法 |
CN110227184B (zh) * | 2019-07-16 | 2020-04-24 | 南通大学 | 差异性组织工程化神经及应用 |
CN115154674B (zh) * | 2022-07-29 | 2023-11-17 | 中国人民解放军总医院第四医学中心 | 一种基于类骨器官的3d生物打印类骨组织工程支架 |
CN115337458B (zh) * | 2022-08-16 | 2023-08-22 | 尧舜泽生物医药(南京)有限公司 | 一种修复周围神经损伤的细胞基质神经移植物及其制备方法 |
Family Cites Families (23)
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US4759764A (en) * | 1985-05-24 | 1988-07-26 | Clayton Foundation For Research | Peripheral nerve regeneration |
WO1999001538A1 (en) | 1997-07-03 | 1999-01-14 | Massachusetts Institute Of Technology | Tissue-engineered constructs |
US6979670B1 (en) | 1999-03-10 | 2005-12-27 | Biora Bioex Ab | Matrix protein compositions for grafting |
US6503273B1 (en) | 1999-11-22 | 2003-01-07 | Cyograft Tissue Engineering, Inc. | Tissue engineered blood vessels and methods and apparatus for their manufacture |
DE10013223C2 (de) | 2000-03-13 | 2002-07-18 | Co Don Ag | Verfahren zur in vitro-Herstellung von dreidimensionalem, vitalem Knorpel- oder Knochengewebe und dessen Verwendung als Transplantationsmaterial |
DE10018987A1 (de) | 2000-04-17 | 2001-10-31 | Envision Technologies Gmbh | Vorrichtung und Verfahren zum Herstellen von dreidimensionalen Objekten |
WO2002004113A2 (en) | 2000-07-11 | 2002-01-17 | The Johns Hopkins University School Of Medicine | Methods of patterning protein and cell adhesivity |
US20030049839A1 (en) * | 2001-08-01 | 2003-03-13 | The University Of Texas System | Transparent multi-channel cell scaffold that creates a cellular and/or molecular gradient |
US6986739B2 (en) | 2001-08-23 | 2006-01-17 | Sciperio, Inc. | Architecture tool and methods of use |
AU2003224710A1 (en) | 2002-03-18 | 2003-10-08 | Carnegie Mellon University | Method and apparatus for preparing biomimetic scaffold |
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US7051654B2 (en) | 2003-05-30 | 2006-05-30 | Clemson University | Ink-jet printing of viable cells |
US20050276791A1 (en) | 2004-02-20 | 2005-12-15 | The Ohio State University | Multi-layer polymer scaffolds |
US8241905B2 (en) | 2004-02-24 | 2012-08-14 | The Curators Of The University Of Missouri | Self-assembling cell aggregates and methods of making engineered tissue using the same |
US20090142307A1 (en) | 2004-07-09 | 2009-06-04 | Athanasiou Kyriacos A | Shape-Based Approach for Scaffoldless Tissue Engineering |
US7625198B2 (en) | 2004-08-11 | 2009-12-01 | Cornell Research Foundation, Inc. | Modular fabrication systems and methods |
US8690957B2 (en) * | 2005-12-21 | 2014-04-08 | Warsaw Orthopedic, Inc. | Bone graft composition, method and implant |
US20070231787A1 (en) * | 2006-04-04 | 2007-10-04 | Voelker Mark A | Methods and devices for imaging and manipulating biological samples |
US20090208466A1 (en) | 2006-04-21 | 2009-08-20 | James Yoo | Ink-jet printing of tissues |
EP2090584A1 (en) | 2008-02-13 | 2009-08-19 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Identification of a novel cysteine-rich cell penetrating peptide |
US20090248145A1 (en) | 2008-03-28 | 2009-10-01 | Nanyang Technological University | Method of forming a three-dimensional structure of unidirectionally aligned cells |
CA2949615A1 (en) * | 2008-06-24 | 2010-01-21 | The Curators Of The University Of Missouri | Self-assembling multicellular bodies and methods of producing a three-dimensional biological structure using the same |
WO2010030964A2 (en) | 2008-09-12 | 2010-03-18 | The Brigham And Women's Hospital, Inc. | 3-dimensional multi-layered hydrogels and methods of making the same |
-
2011
- 2011-02-02 CN CN2011800172271A patent/CN102869391A/zh active Pending
- 2011-02-02 WO PCT/US2011/023520 patent/WO2011097330A2/en active Application Filing
- 2011-02-02 EP EP11740319.6A patent/EP2531228A4/en not_active Withdrawn
- 2011-02-02 BR BR112012019369A patent/BR112012019369A2/pt not_active IP Right Cessation
- 2011-02-02 AU AU2011212998A patent/AU2011212998A1/en not_active Abandoned
- 2011-02-02 CA CA2788514A patent/CA2788514A1/en not_active Abandoned
- 2011-02-02 KR KR1020127022856A patent/KR20120125331A/ko not_active Application Discontinuation
- 2011-02-02 JP JP2012552066A patent/JP2013518591A/ja not_active Withdrawn
- 2011-02-02 RU RU2012137080/14A patent/RU2012137080A/ru not_active Application Discontinuation
- 2011-02-02 US US13/020,000 patent/US8747880B2/en not_active Expired - Fee Related
-
2012
- 2012-07-26 IL IL221122A patent/IL221122A0/en unknown
Also Published As
Publication number | Publication date |
---|---|
JP2013518591A (ja) | 2013-05-23 |
EP2531228A4 (en) | 2013-08-14 |
IL221122A0 (en) | 2012-09-24 |
EP2531228A2 (en) | 2012-12-12 |
CN102869391A (zh) | 2013-01-09 |
KR20120125331A (ko) | 2012-11-14 |
CA2788514A1 (en) | 2011-08-11 |
US8747880B2 (en) | 2014-06-10 |
WO2011097330A2 (en) | 2011-08-11 |
US20110313542A1 (en) | 2011-12-22 |
AU2011212998A1 (en) | 2012-08-16 |
RU2012137080A (ru) | 2014-03-10 |
WO2011097330A3 (en) | 2011-12-22 |
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