BR112018015316B1 - Aparelho de separação de partículas e método para separar partículas - Google Patents

Aparelho de separação de partículas e método para separar partículas Download PDF

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Publication number
BR112018015316B1
BR112018015316B1 BR112018015316-8A BR112018015316A BR112018015316B1 BR 112018015316 B1 BR112018015316 B1 BR 112018015316B1 BR 112018015316 A BR112018015316 A BR 112018015316A BR 112018015316 B1 BR112018015316 B1 BR 112018015316B1
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BR
Brazil
Prior art keywords
flow path
fluid
particles
inlet
substrate
Prior art date
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BR112018015316-8A
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English (en)
Portuguese (pt)
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BR112018015316A2 (ko
Inventor
Jong Wook Hong
Soo Jeong Shin
Sung Hoon Kim
Min Chul Park
Dae Young Han
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Exozum Inc
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Publication date
Application filed by Exozum Inc filed Critical Exozum Inc
Publication of BR112018015316A2 publication Critical patent/BR112018015316A2/ko
Publication of BR112018015316B1 publication Critical patent/BR112018015316B1/pt

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    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502753Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by bulk separation arrangements on lab-on-a-chip devices, e.g. for filtration or centrifugation
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00Sampling; Preparing specimens for investigation
    • G01N1/28Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/40Concentrating samples
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/02Investigating particle size or size distribution
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06Fluid handling related problems
    • B01L2200/0647Handling flowable solids, e.g. microscopic beads, cells, particles
    • B01L2200/0652Sorting or classification of particles or molecules
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/10Integrating sample preparation and analysis in single entity, e.g. lab-on-a-chip concept
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/08Geometry, shape and general structure
    • B01L2300/0848Specific forms of parts of containers
    • B01L2300/0858Side walls
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/08Geometry, shape and general structure
    • B01L2300/0861Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0864Configuration of multiple channels and/or chambers in a single devices comprising only one inlet and multiple receiving wells, e.g. for separation, splitting
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/08Geometry, shape and general structure
    • B01L2300/0861Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0867Multiple inlets and one sample wells, e.g. mixing, dilution
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00Moving or stopping fluids
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00Moving or stopping fluids
    • B01L2400/04Moving fluids with specific forces or mechanical means
    • B01L2400/0403Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0457Moving fluids with specific forces or mechanical means specific forces passive flow or gravitation
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/02Investigating particle size or size distribution
    • G01N2015/0288Sorting the particles

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Dispersion Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Clinical Laboratory Science (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Hematology (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Separation Of Solids By Using Liquids Or Pneumatic Power (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
BR112018015316-8A 2016-01-26 2017-01-25 Aparelho de separação de partículas e método para separar partículas BR112018015316B1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
KR10-2016-0009559 2016-01-26
KR1020160009559A KR101807256B1 (ko) 2016-01-26 2016-01-26 입자 분리 장치 및 입자 분리 방법
PCT/KR2017/000918 WO2017131452A1 (ko) 2016-01-26 2017-01-25 입자 분리 장치 및 입자 분리 방법

Publications (2)

Publication Number Publication Date
BR112018015316A2 BR112018015316A2 (ko) 2018-12-18
BR112018015316B1 true BR112018015316B1 (pt) 2023-01-31

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Family Applications (1)

Application Number Title Priority Date Filing Date
BR112018015316-8A BR112018015316B1 (pt) 2016-01-26 2017-01-25 Aparelho de separação de partículas e método para separar partículas

Country Status (7)

Country Link
US (1) US10710072B2 (ko)
EP (1) EP3409363A4 (ko)
JP (1) JP7029175B2 (ko)
KR (1) KR101807256B1 (ko)
CN (1) CN109070080B (ko)
BR (1) BR112018015316B1 (ko)
WO (1) WO2017131452A1 (ko)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102327920B1 (ko) 2017-12-28 2021-11-17 인하대학교 산학협력단 결정성 나노셀룰로오스의 길이별 분리장치
KR102260437B1 (ko) 2017-12-28 2021-06-02 인하대학교 산학협력단 결정성 나노셀룰로오스의 길이별 분리장치
KR102487734B1 (ko) * 2018-09-21 2023-01-12 주식회사 엘지화학 입자 분배기
KR102491618B1 (ko) * 2018-09-21 2023-01-20 주식회사 엘지화학 입자 분배기
KR102491617B1 (ko) * 2018-09-21 2023-01-20 주식회사 엘지화학 입자 분배기
KR102491149B1 (ko) * 2018-09-21 2023-01-19 주식회사 엘지화학 입자 분배기
KR102323361B1 (ko) 2019-05-24 2021-11-09 솔바이오 주식회사 스위치 성 부착반응을 이용한 친화 분리 시스템 및 방법
EP3978925A4 (en) 2019-05-24 2023-06-28 Sol Bio Corporation Affinity separation system and method using switch-like adhesion reaction
KR102323360B1 (ko) 2019-12-02 2021-11-09 솔바이오 주식회사 엑소좀 차아집단 액체생검 샘플 제조장치 및 제조방법
KR102498862B1 (ko) 2020-06-29 2023-02-13 솔바이오 주식회사 엑소좀 액체생검 샘플 분석방법
KR102439514B1 (ko) * 2020-07-27 2022-09-02 울산과학기술원 미세 대상물 분리장치 및 그 분리장치를 이용한 미세 대상물 분리방법
KR20220095646A (ko) 2020-12-30 2022-07-07 솔바이오 주식회사 엑소좀 차아집단 액체생검 샘플 제조장치 및 제조방법

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4462058B2 (ja) 2004-09-22 2010-05-12 富士ゼロックス株式会社 微粒子の分級方法、及び微粒子の分級装置
JP2006263693A (ja) * 2005-03-22 2006-10-05 Minoru Seki 微粒子の連続分離機構及び装置
ATE442904T1 (de) * 2005-07-07 2009-10-15 Fraunhofer Ges Forschung Verfahren und vorrichtung zur akustischen manipulation von partikeln, zellen und viren
EP1795894A1 (en) * 2005-12-06 2007-06-13 Roche Diagnostics GmbH Plasma separation on a disk like device
WO2008122051A1 (en) * 2007-04-02 2008-10-09 Acoustic Cytometry Systems, Inc. Methods and devices for enhanced analysis of field focused cells and particles
WO2008142850A1 (ja) * 2007-05-15 2008-11-27 Panasonic Corporation 成分分離デバイス及びこれを用いた成分分離方法
FR2931141B1 (fr) 2008-05-13 2011-07-01 Commissariat Energie Atomique Systeme microfluidique et procede pour le tri d'amas de cellules et de preference pour leur encapsulation en continu suite a leur tri
US8387803B2 (en) * 2008-08-26 2013-03-05 Ge Healthcare Bio-Sciences Ab Particle sorting
US20100140185A1 (en) * 2008-12-05 2010-06-10 John Hill Wastewater treatment
KR101138904B1 (ko) 2010-05-10 2012-05-14 한국과학기술원 입자 분리 유닛 및 이를 이용한 입자 분리 시스템
WO2012135663A2 (en) * 2011-03-31 2012-10-04 University Of South Florida Two-stage microfluidic device for acoustic particle manipulation and methods of separation
KR20120113533A (ko) 2011-04-05 2012-10-15 삼성전자주식회사 타겟 분자 분리 장치 및 이를 이용한 타겟 분자 분리 방법
JP5870323B2 (ja) * 2011-05-23 2016-02-24 国立大学法人名古屋大学 がん細胞自動分離装置およびがん細胞自動分離方法
EP2761291B1 (en) 2011-09-28 2016-06-29 Acousort AB System and method to separate cells and/or particles
CN104321126B (zh) * 2012-03-27 2017-02-22 加利福尼亚大学董事会 连续的整体芯片三维dep细胞分选器及相关制造方法
KR101360135B1 (ko) * 2012-08-16 2014-02-12 한양대학교 산학협력단 경사진 채널 벽면을 갖는 미세유체칩
US9757726B2 (en) * 2013-03-14 2017-09-12 Inguran, Llc System for high throughput sperm sorting
US10705008B2 (en) * 2013-03-15 2020-07-07 Iris International, Inc. Autofocus systems and methods for particle analysis in blood samples
JP6733909B2 (ja) * 2013-10-30 2020-08-05 エービーエス グローバル インコーポレイテッド 複数の物質を識別する装置、複数の物質を識別するコンピュータシステム、複数の物質を識別するための複数の命令をコンピュータに実行させるプログラムおよびサンプル流体混合物中を流れる複数の物質を識別する方法
KR20160123305A (ko) * 2014-01-20 2016-10-25 핼시언 바이오메디컬, 인코퍼레이티드 전혈의 수동 분리
US20190168221A1 (en) * 2016-04-15 2019-06-06 Vortex Biosciences, Inc. Microfluidic Chips and Cartridges and Systems Utilizing Microfluidic Chips and Cartridges
US11150255B2 (en) * 2016-07-12 2021-10-19 EMULATE, Inc. Additive channels

Also Published As

Publication number Publication date
EP3409363A1 (en) 2018-12-05
BR112018015316A2 (ko) 2018-12-18
KR20170089303A (ko) 2017-08-03
JP2019512378A (ja) 2019-05-16
WO2017131452A1 (ko) 2017-08-03
JP7029175B2 (ja) 2022-03-03
KR101807256B1 (ko) 2017-12-08
CN109070080B (zh) 2021-12-24
US20190030534A1 (en) 2019-01-31
EP3409363A4 (en) 2019-07-17
CN109070080A (zh) 2018-12-21
US10710072B2 (en) 2020-07-14

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