BR112018012934A2 - reguladores cftr e métodos de uso dos mesmos - Google Patents
reguladores cftr e métodos de uso dos mesmosInfo
- Publication number
- BR112018012934A2 BR112018012934A2 BR112018012934A BR112018012934A BR112018012934A2 BR 112018012934 A2 BR112018012934 A2 BR 112018012934A2 BR 112018012934 A BR112018012934 A BR 112018012934A BR 112018012934 A BR112018012934 A BR 112018012934A BR 112018012934 A2 BR112018012934 A2 BR 112018012934A2
- Authority
- BR
- Brazil
- Prior art keywords
- methods
- cftr
- regulators
- cftr regulators
- disorders
- Prior art date
Links
- 206010010774 Constipation Diseases 0.000 abstract 1
- 208000003556 Dry Eye Syndromes Diseases 0.000 abstract 1
- 206010013774 Dry eye Diseases 0.000 abstract 1
- 230000003213 activating effect Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 208000037765 diseases and disorders Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/36—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
- C07D241/38—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems with only hydrogen or carbon atoms directly attached to the ring nitrogen atoms
- C07D241/40—Benzopyrazines
- C07D241/44—Benzopyrazines with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/498—Pyrazines or piperazines ortho- and peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/10—Laxatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/06—Peri-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Ophthalmology & Optometry (AREA)
- Epidemiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Abstract
são fornecidos no presente documento compostos que ativam cftr e métodos para tratar constipação, transtornos de olho seco e outras doenças e transtornos.
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201562387579P | 2015-12-24 | 2015-12-24 | |
US62/387,579 | 2015-12-24 | ||
US201662376808P | 2016-08-18 | 2016-08-18 | |
US62/376,808 | 2016-08-18 | ||
PCT/US2016/068566 WO2017112950A1 (en) | 2015-12-24 | 2016-12-23 | Cftr regulators and methods of use thereof |
Publications (2)
Publication Number | Publication Date |
---|---|
BR112018012934A2 true BR112018012934A2 (pt) | 2018-12-11 |
BR112018012934B1 BR112018012934B1 (pt) | 2023-11-07 |
Family
ID=59091221
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112018012934-8A BR112018012934B1 (pt) | 2015-12-24 | 2016-12-23 | Reguladores cftr e métodos de uso dos mesmos |
Country Status (18)
Country | Link |
---|---|
US (2) | US11084795B2 (pt) |
EP (2) | EP3394046B1 (pt) |
JP (2) | JP6938509B2 (pt) |
KR (1) | KR20180101416A (pt) |
CN (1) | CN108699040B (pt) |
AU (1) | AU2016377785B2 (pt) |
BR (1) | BR112018012934B1 (pt) |
CA (1) | CA3009534A1 (pt) |
CL (1) | CL2018001716A1 (pt) |
CO (1) | CO2018007236A2 (pt) |
DK (1) | DK3394046T3 (pt) |
ES (1) | ES2913051T3 (pt) |
IL (1) | IL260212B (pt) |
PL (1) | PL3394046T3 (pt) |
PT (1) | PT3394046T (pt) |
RU (1) | RU2730855C2 (pt) |
WO (1) | WO2017112950A1 (pt) |
ZA (1) | ZA201804229B (pt) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20180102590A (ko) | 2015-12-24 | 2018-09-17 | 더 리젠츠 오브 더 유니버시티 오브 캘리포니아 | Cftr 조절제 및 이의 사용방법 |
KR20180101416A (ko) * | 2015-12-24 | 2018-09-12 | 더 리젠츠 오브 더 유니버시티 오브 캘리포니아 | Cftr 조절제 및 이의 이용 방법 |
KR20200044873A (ko) * | 2017-08-24 | 2020-04-29 | 더 리젠츠 오브 더 유니버시티 오브 캘리포니아 | 안구 제약학적 조성물 |
Family Cites Families (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ZA794209B (en) * | 1978-08-15 | 1980-07-30 | Fisons Ltd | Pharmaceutically active heterocyclic compounds |
EP0008864A1 (en) | 1978-08-15 | 1980-03-19 | FISONS plc | Pyridopyrazine and quinoxaline derivatives, processes for their preparation, and pharmaceutical compositions containing them |
US4181724A (en) | 1978-09-11 | 1980-01-01 | The Upjohn Company | Quinoxalinone compounds useful for expanding the lumina or air passages in mammals |
US4911920A (en) | 1986-07-30 | 1990-03-27 | Alcon Laboratories, Inc. | Sustained release, comfort formulation for glaucoma therapy |
FR2588189B1 (fr) | 1985-10-03 | 1988-12-02 | Merck Sharp & Dohme | Composition pharmaceutique de type a transition de phase liquide-gel |
DK175069B1 (da) | 1986-03-11 | 2004-05-24 | Hoffmann La Roche | Pyrocatecholderivater |
US5236952A (en) * | 1986-03-11 | 1993-08-17 | Hoffmann-La Roche Inc. | Catechol derivatives |
FR2653430B1 (fr) | 1989-10-23 | 1991-12-20 | Pf Medicament | Nouveaux derives de dihydro-1,2 oxo-2 quinoxalines, leur preparation et leur application en therapeutique. |
DE69212850T2 (de) | 1991-01-15 | 1997-03-06 | Alcon Lab Inc | Verwendung von Karrageenan in topischen ophthalmologischen Zusammensetzungen |
US5212162A (en) | 1991-03-27 | 1993-05-18 | Alcon Laboratories, Inc. | Use of combinations gelling polysaccharides and finely divided drug carrier substrates in topical ophthalmic compositions |
AU5433594A (en) | 1992-11-19 | 1994-06-08 | Dainippon Pharmaceutical Co. Ltd. | 3,4-dihydro-1-(2-hydroxyphenyl)-2(1h)-quinoxalinone derivative and related compound |
US6309853B1 (en) | 1994-08-17 | 2001-10-30 | The Rockfeller University | Modulators of body weight, corresponding nucleic acids and proteins, and diagnostic and therapeutic uses thereof |
AU1917999A (en) | 1998-03-31 | 1999-10-18 | Warner-Lambert Company | Quinoxalinones as serine protease inhibitors such as factor xa and thrombin |
DE102004023332A1 (de) | 2004-05-12 | 2006-01-19 | Bayer Cropscience Gmbh | Chinoxalin-2-on-derivate, diese enthaltende nutzpflanzenschützende Mittel und Verfahren zu ihrer Herstellung und deren Verwendung |
BRPI0811145A2 (pt) | 2007-05-22 | 2014-12-23 | Astellas Pharma Inc | Composto tetraidroisoquinolina 1-substituído |
EA021904B1 (ru) | 2008-03-05 | 2015-09-30 | Мерк Патент Гмбх | Производные хиноксалинона в качестве стимуляторов секреции инсулина, способы их получения и их применение для лечения диабета |
NZ592687A (en) * | 2008-10-23 | 2013-04-26 | Vertex Pharma | Modulators of cystic fibrosis transmembrane conductance regulator |
BR112015014433A2 (pt) * | 2012-12-19 | 2017-07-11 | Novartis Ag | compostos tricíclicos |
WO2015168079A1 (en) * | 2014-04-29 | 2015-11-05 | Infinity Pharmaceuticals, Inc. | Pyrimidine or pyridine derivatives useful as pi3k inhibitors |
KR20180101416A (ko) * | 2015-12-24 | 2018-09-12 | 더 리젠츠 오브 더 유니버시티 오브 캘리포니아 | Cftr 조절제 및 이의 이용 방법 |
-
2016
- 2016-12-23 KR KR1020187021223A patent/KR20180101416A/ko not_active Application Discontinuation
- 2016-12-23 BR BR112018012934-8A patent/BR112018012934B1/pt active IP Right Grant
- 2016-12-23 JP JP2018533117A patent/JP6938509B2/ja active Active
- 2016-12-23 EP EP16880159.5A patent/EP3394046B1/en active Active
- 2016-12-23 EP EP22159301.5A patent/EP4071140A1/en active Pending
- 2016-12-23 PL PL16880159T patent/PL3394046T3/pl unknown
- 2016-12-23 RU RU2018126957A patent/RU2730855C2/ru active
- 2016-12-23 AU AU2016377785A patent/AU2016377785B2/en active Active
- 2016-12-23 DK DK16880159.5T patent/DK3394046T3/da active
- 2016-12-23 CN CN201680082473.8A patent/CN108699040B/zh active Active
- 2016-12-23 CA CA3009534A patent/CA3009534A1/en active Pending
- 2016-12-23 PT PT168801595T patent/PT3394046T/pt unknown
- 2016-12-23 ES ES16880159T patent/ES2913051T3/es active Active
- 2016-12-23 WO PCT/US2016/068566 patent/WO2017112950A1/en active Application Filing
- 2016-12-23 US US16/016,281 patent/US11084795B2/en active Active
-
2018
- 2018-06-21 IL IL260212A patent/IL260212B/en unknown
- 2018-06-21 CL CL2018001716A patent/CL2018001716A1/es unknown
- 2018-06-22 ZA ZA2018/04229A patent/ZA201804229B/en unknown
- 2018-07-11 CO CONC2018/0007236A patent/CO2018007236A2/es unknown
-
2021
- 2021-04-08 US US17/226,004 patent/US20210347742A1/en active Pending
- 2021-08-31 JP JP2021141178A patent/JP7297828B2/ja active Active
Also Published As
Publication number | Publication date |
---|---|
US20210347742A1 (en) | 2021-11-11 |
IL260212A (en) | 2018-07-31 |
BR112018012934B1 (pt) | 2023-11-07 |
US11084795B2 (en) | 2021-08-10 |
EP3394046B1 (en) | 2022-03-09 |
JP7297828B2 (ja) | 2023-06-26 |
ZA201804229B (en) | 2021-10-27 |
AU2016377785A1 (en) | 2018-07-12 |
JP2018538352A (ja) | 2018-12-27 |
RU2730855C2 (ru) | 2020-08-26 |
AU2016377785A2 (en) | 2018-08-23 |
KR20180101416A (ko) | 2018-09-12 |
IL260212B (en) | 2021-08-31 |
AU2016377785B2 (en) | 2021-07-01 |
JP6938509B2 (ja) | 2021-09-22 |
EP3394046A4 (en) | 2019-06-19 |
EP3394046A1 (en) | 2018-10-31 |
CL2018001716A1 (es) | 2018-10-26 |
JP2021185186A (ja) | 2021-12-09 |
CN108699040B (zh) | 2021-08-10 |
EP4071140A1 (en) | 2022-10-12 |
CN108699040A (zh) | 2018-10-23 |
DK3394046T3 (da) | 2022-04-04 |
CA3009534A1 (en) | 2017-06-29 |
PT3394046T (pt) | 2022-04-05 |
PL3394046T3 (pl) | 2022-06-13 |
WO2017112950A1 (en) | 2017-06-29 |
US20190031622A1 (en) | 2019-01-31 |
RU2018126957A3 (pt) | 2020-02-28 |
RU2018126957A (ru) | 2020-01-27 |
ES2913051T3 (es) | 2022-05-31 |
CO2018007236A2 (es) | 2018-07-19 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B06U | Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette] | ||
B350 | Update of information on the portal [chapter 15.35 patent gazette] | ||
B15K | Others concerning applications: alteration of classification |
Free format text: AS CLASSIFICACOES ANTERIORES ERAM: C07D 403/04 , C07D 405/04 , C07D 401/04 Ipc: C07D 403/04 (2006.01), C07D 405/04 (2006.01), C07D |
|
B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] |
Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 23/12/2016, OBSERVADAS AS CONDICOES LEGAIS |