BR112018012047A2 - 3-azabiciclo[3.1.0]hexanos substituídos como inibidores de ceto-hexocinase - Google Patents
3-azabiciclo[3.1.0]hexanos substituídos como inibidores de ceto-hexocinaseInfo
- Publication number
- BR112018012047A2 BR112018012047A2 BR112018012047-2A BR112018012047A BR112018012047A2 BR 112018012047 A2 BR112018012047 A2 BR 112018012047A2 BR 112018012047 A BR112018012047 A BR 112018012047A BR 112018012047 A2 BR112018012047 A2 BR 112018012047A2
- Authority
- BR
- Brazil
- Prior art keywords
- azabicyclo
- hexanes
- substituted
- inhibitors
- ketohexokase
- Prior art date
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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Abstract
a presente invenção refere-se a 3-azabiciclo[3.1.0] hexanos substituídos como inibidores de ceto-hexocinase, processos para preparar os referidos compostos, e métodos compreendendo a administração dos referidos compostos a um mamífero com necessidade dos mesmos.
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562272598P | 2015-12-29 | 2015-12-29 | |
| US62/272,598 | 2015-12-29 | ||
| US201662423549P | 2016-11-17 | 2016-11-17 | |
| US62/423,549 | 2016-11-17 | ||
| PCT/IB2016/057728 WO2017115205A1 (en) | 2015-12-29 | 2016-12-16 | Substituted 3-azabicyclo[3.1.0]hexanes as ketohexokinase inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| BR112018012047A2 true BR112018012047A2 (pt) | 2018-12-04 |
| BR112018012047B1 BR112018012047B1 (pt) | 2023-08-15 |
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