BR112018006563A2 - síntese de derivados de ciclo-hexano carboxamida úteis como elementos sensoriais nos produtos destinados ao consumidor - Google Patents

síntese de derivados de ciclo-hexano carboxamida úteis como elementos sensoriais nos produtos destinados ao consumidor

Info

Publication number
BR112018006563A2
BR112018006563A2 BR112018006563A BR112018006563A BR112018006563A2 BR 112018006563 A2 BR112018006563 A2 BR 112018006563A2 BR 112018006563 A BR112018006563 A BR 112018006563A BR 112018006563 A BR112018006563 A BR 112018006563A BR 112018006563 A2 BR112018006563 A2 BR 112018006563A2
Authority
BR
Brazil
Prior art keywords
carboxamide
synthesis
consumer products
derivatives useful
cyclohexane derivatives
Prior art date
Application number
BR112018006563A
Other languages
English (en)
Other versions
BR112018006563B1 (pt
Inventor
Mark Bunke Gregory
Frederick Heath
August Wos John
Christian Haught John
Edward Yelm Kenneth
Tatachar Sreekrishna Koti
Hamilton Hoke Steve
Lin Yakang
Original Assignee
Procter & Gamble
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Procter & Gamble filed Critical Procter & Gamble
Publication of BR112018006563A2 publication Critical patent/BR112018006563A2/pt
Publication of BR112018006563B1 publication Critical patent/BR112018006563B1/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C237/10—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atom of at least one of the carboxamide groups bound to an acyclic carbon atom of a hydrocarbon radical substituted by nitrogen atoms not being part of nitro or nitroso groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/41—Amines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/02—Preparation of carboxylic acid amides from carboxylic acids or from esters, anhydrides, or halides thereof by reaction with ammonia or amines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C269/00—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C269/06—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups by reactions not involving the formation of carbamate groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
    • C07C319/14—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides
    • C07C319/20—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides by reactions not involving the formation of sulfide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
    • A61K2800/24—Thermal properties
    • A61K2800/244—Endothermic; Cooling; Cooling sensation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Birds (AREA)
  • Epidemiology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Cosmetics (AREA)

Abstract

métodos de síntese para produzir uma série de carboxamidas construídas a partir de uma cadeia principal de (s)-2-aminoácido ou de uma cadeia principal de (r)-2-aminoácido, dependendo do diastereômero desejado do produto final.
BR112018006563-3A 2015-10-22 2016-10-21 Método para preparar um derivado de nmentanocarboxamida úteis como elementos sensoriais nos produtos destinados ao consumidor BR112018006563B1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562245192P 2015-10-22 2015-10-22
US62/245,192 2015-10-22
PCT/US2016/058024 WO2017070418A1 (en) 2015-10-22 2016-10-21 Synthesis of cyclohexane carboxamide derivatives useful as sensates in consumer products

Publications (2)

Publication Number Publication Date
BR112018006563A2 true BR112018006563A2 (pt) 2018-12-11
BR112018006563B1 BR112018006563B1 (pt) 2022-05-10

Family

ID=57249879

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112018006563-3A BR112018006563B1 (pt) 2015-10-22 2016-10-21 Método para preparar um derivado de nmentanocarboxamida úteis como elementos sensoriais nos produtos destinados ao consumidor

Country Status (9)

Country Link
US (2) US20170057911A1 (pt)
EP (1) EP3365324A1 (pt)
JP (1) JP2018531948A (pt)
CN (1) CN108349879A (pt)
AU (2) AU2016342264A1 (pt)
BR (1) BR112018006563B1 (pt)
CA (1) CA3000022A1 (pt)
MX (1) MX2018004814A (pt)
WO (1) WO2017070418A1 (pt)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11542239B2 (en) 2018-07-23 2023-01-03 Abbvie Inc. Elagolix sodium compositions and processes
US10982172B2 (en) * 2018-10-24 2021-04-20 International Flavors & Fragrances Inc. Organoleptic compounds

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GB1315626A (en) 1971-02-04 1973-05-02 Wilkinson Sword Ltd Substituted p-menthanes and compositions containing them
US4136163A (en) 1971-02-04 1979-01-23 Wilkinson Sword Limited P-menthane carboxamides having a physiological cooling effect
US4150052A (en) 1971-02-04 1979-04-17 Wilkinson Sword Limited N-substituted paramenthane carboxamides
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US4157384A (en) 1972-01-28 1979-06-05 Wilkinson Sword Limited Compositions having a physiological cooling effect
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Also Published As

Publication number Publication date
WO2017070418A1 (en) 2017-04-27
US20180312463A1 (en) 2018-11-01
MX2018004814A (es) 2019-04-01
AU2016342264A1 (en) 2018-04-05
JP2018531948A (ja) 2018-11-01
US20170057911A1 (en) 2017-03-02
CN108349879A (zh) 2018-07-31
CA3000022A1 (en) 2017-04-27
EP3365324A1 (en) 2018-08-29
AU2019229433A1 (en) 2019-10-03
BR112018006563B1 (pt) 2022-05-10

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B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B350 Update of information on the portal [chapter 15.35 patent gazette]
B09W Correction of the decision to grant [chapter 9.1.4 patent gazette]

Free format text: RETIFIQUE-SE PARA INCLUSAO DA LISTAGEM DE SEQUENCIA

B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

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B21F Lapse acc. art. 78, item iv - on non-payment of the annual fees in time

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B24J Lapse because of non-payment of annual fees (definitively: art 78 iv lpi, resolution 113/2013 art. 12)

Free format text: EM VIRTUDE DA EXTINCAO PUBLICADA NA RPI 2693 DE 16-08-2022 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDA A EXTINCAO DA PATENTE E SEUS CERTIFICADOS, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.