BR112018002026A2 - método para se obter arroz resistente a glifosato através da substituição de nucleotídeo direcionada ao sítio - Google Patents

método para se obter arroz resistente a glifosato através da substituição de nucleotídeo direcionada ao sítio

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Publication number
BR112018002026A2
BR112018002026A2 BR112018002026-5A BR112018002026A BR112018002026A2 BR 112018002026 A2 BR112018002026 A2 BR 112018002026A2 BR 112018002026 A BR112018002026 A BR 112018002026A BR 112018002026 A2 BR112018002026 A2 BR 112018002026A2
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Brazil
Prior art keywords
site
glyphosate resistant
directed
nucleotide substitution
substitution
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BR112018002026-5A
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English (en)
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Gao Caixia
Li Jun
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Institute Of Genetics And Developmental Biology, Chinese Academy Of Sciences
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Application filed by Institute Of Genetics And Developmental Biology, Chinese Academy Of Sciences filed Critical Institute Of Genetics And Developmental Biology, Chinese Academy Of Sciences
Publication of BR112018002026A2 publication Critical patent/BR112018002026A2/pt

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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1085—Transferases (2.) transferring alkyl or aryl groups other than methyl groups (2.5)
    • C12N9/1092—3-Phosphoshikimate 1-carboxyvinyltransferase (2.5.1.19), i.e. 5-enolpyruvylshikimate-3-phosphate synthase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8261—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield
    • C12N15/8271—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance
    • C12N15/8274—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance for herbicide resistance
    • C12N15/8275—Glyphosate
    • C—CHEMISTRY; METALLURGY
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/66—General methods for inserting a gene into a vector to form a recombinant vector using cleavage and ligation; Use of non-functional linkers or adaptors, e.g. linkers containing the sequence for a restriction endonuclease
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8201—Methods for introducing genetic material into plant cells, e.g. DNA, RNA, stable or transient incorporation, tissue culture methods adapted for transformation
    • C12N15/8213—Targeted insertion of genes into the plant genome by homologous recombination
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/10—Cells modified by introduction of foreign genetic material
    • C12N5/12—Fused cells, e.g. hybridomas
    • C12N5/14—Plant cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/20—Type of nucleic acid involving clustered regularly interspaced short palindromic repeats [CRISPRs]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y205/00—Transferases transferring alkyl or aryl groups, other than methyl groups (2.5)
    • C12Y205/01—Transferases transferring alkyl or aryl groups, other than methyl groups (2.5) transferring alkyl or aryl groups, other than methyl groups (2.5.1)
    • C12Y205/01019—3-Phosphoshikimate 1-carboxyvinyltransferase (2.5.1.19), i.e. 5-enolpyruvylshikimate-3-phosphate synthase

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  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
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  • Organic Chemistry (AREA)
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  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Medicinal Chemistry (AREA)
  • Botany (AREA)
  • Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

a presente invenção refere-se a um método para a obtenção de arroz resistente a glifosato através de uma substituição de nucleotídeo dire-cionada ao sítio, que compreende as seguintes etapas: apenas a substituição de treonina (t) na posição 8 da sequência de aminoácido de uma região conservada da proteína epsps endógena de uma planta alvo por isoleucina (i), e a substituição de prolina (p) na posição 12 por serina (s) para obter uma planta, isto é, uma planta resistente ao glifosato. é fornecido um método capaz de gerar uma substituição de nucleotídeo direcionada ao sítio e uma substituição de fragmento utilizando uma via de nhej mediada por crispr para substituir uma região entre dois sítios de grna através da concepção dos dois sítios de grna.
BR112018002026-5A 2015-08-14 2016-08-15 método para se obter arroz resistente a glifosato através da substituição de nucleotídeo direcionada ao sítio BR112018002026A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN201510500930 2015-08-14
CN201510500930.8 2015-08-14
PCT/CN2016/095307 WO2017028768A1 (en) 2015-08-14 2016-08-15 Method for obtaining glyphosate-resistant rice by site-directed nucleotide substitution

Publications (1)

Publication Number Publication Date
BR112018002026A2 true BR112018002026A2 (pt) 2018-09-18

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BR112018002026-5A BR112018002026A2 (pt) 2015-08-14 2016-08-15 método para se obter arroz resistente a glifosato através da substituição de nucleotídeo direcionada ao sítio

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US (1) US11767536B2 (pt)
EP (1) EP3334832A4 (pt)
JP (1) JP2018527920A (pt)
KR (2) KR20200078685A (pt)
CN (1) CN106467909A (pt)
AR (1) AR105713A1 (pt)
AU (1) AU2016309392A1 (pt)
BR (1) BR112018002026A2 (pt)
CA (1) CA2994883A1 (pt)
EA (1) EA201890492A1 (pt)
WO (1) WO2017028768A1 (pt)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2012333134B2 (en) 2011-07-22 2017-05-25 John Paul Guilinger Evaluation and improvement of nuclease cleavage specificity
US9163284B2 (en) 2013-08-09 2015-10-20 President And Fellows Of Harvard College Methods for identifying a target site of a Cas9 nuclease
US9359599B2 (en) 2013-08-22 2016-06-07 President And Fellows Of Harvard College Engineered transcription activator-like effector (TALE) domains and uses thereof
US9737604B2 (en) 2013-09-06 2017-08-22 President And Fellows Of Harvard College Use of cationic lipids to deliver CAS9
US9340800B2 (en) 2013-09-06 2016-05-17 President And Fellows Of Harvard College Extended DNA-sensing GRNAS
US9388430B2 (en) 2013-09-06 2016-07-12 President And Fellows Of Harvard College Cas9-recombinase fusion proteins and uses thereof
US9068179B1 (en) 2013-12-12 2015-06-30 President And Fellows Of Harvard College Methods for correcting presenilin point mutations
AU2015298571B2 (en) 2014-07-30 2020-09-03 President And Fellows Of Harvard College Cas9 proteins including ligand-dependent inteins
WO2017070632A2 (en) 2015-10-23 2017-04-27 President And Fellows Of Harvard College Nucleobase editors and uses thereof
CA3032699A1 (en) 2016-08-03 2018-02-08 President And Fellows Of Harvard College Adenosine nucleobase editors and uses thereof
WO2018031683A1 (en) 2016-08-09 2018-02-15 President And Fellows Of Harvard College Programmable cas9-recombinase fusion proteins and uses thereof
WO2018039438A1 (en) 2016-08-24 2018-03-01 President And Fellows Of Harvard College Incorporation of unnatural amino acids into proteins using base editing
EP3526320A1 (en) 2016-10-14 2019-08-21 President and Fellows of Harvard College Aav delivery of nucleobase editors
US10745677B2 (en) 2016-12-23 2020-08-18 President And Fellows Of Harvard College Editing of CCR5 receptor gene to protect against HIV infection
EP3592853A1 (en) 2017-03-09 2020-01-15 President and Fellows of Harvard College Suppression of pain by gene editing
JP2020510439A (ja) 2017-03-10 2020-04-09 プレジデント アンド フェローズ オブ ハーバード カレッジ シトシンからグアニンへの塩基編集因子
KR102687373B1 (ko) 2017-03-23 2024-07-23 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 핵산 프로그램가능한 dna 결합 단백질을 포함하는 핵염기 편집제
JP2020519310A (ja) * 2017-05-11 2020-07-02 インスティテュート・オブ・ジェネティクス・アンド・ディヴェロプメンタル・バイオロジー、チャイニーズ・アカデミー・オブ・サイエンシズＩｎｓｔｉｔｕｔｅ ｏｆ Ｇｅｎｅｔｉｃｓ ａｎｄ Ｄｅｖｅｌｏｐｍｅｎｔａｌ Ｂｉｏｌｏｇｙ， Ｃｈｉｎｅｓｅ Ａｃａｄｅｍｙ ｏｆ Ｓｃｉｅｎｃｅｓ 除草剤耐性遺伝子の創出およびその使用
WO2018209320A1 (en) 2017-05-12 2018-11-15 President And Fellows Of Harvard College Aptazyme-embedded guide rnas for use with crispr-cas9 in genome editing and transcriptional activation
CN109082436A (zh) * 2017-06-13 2018-12-25 未名生物农业集团有限公司 利用bcs1l基因和向导rna/cas核酸内切酶体系改良植物农艺性状的方法
EP3658573A1 (en) 2017-07-28 2020-06-03 President and Fellows of Harvard College Methods and compositions for evolving base editors using phage-assisted continuous evolution (pace)
WO2019139645A2 (en) 2017-08-30 2019-07-18 President And Fellows Of Harvard College High efficiency base editors comprising gam
CN111757937A (zh) 2017-10-16 2020-10-09 布罗德研究所股份有限公司 腺苷碱基编辑器的用途
MY195997A (en) * 2018-04-18 2023-02-27 Kimagri Corp Sdn Bhd Recombinant Gene
WO2019233349A1 (zh) 2018-06-04 2019-12-12 青岛清原化合物有限公司 突变型对羟苯基丙酮酸双氧化酶、其编码核酸以及应用
WO2020191249A1 (en) 2019-03-19 2020-09-24 The Broad Institute, Inc. Methods and compositions for editing nucleotide sequences
CN109943578A (zh) * 2019-03-21 2019-06-28 浙江大学 一种水稻epsp合成酶突变基因、突变体及其应用
CN114615880B (zh) * 2019-11-01 2024-08-02 先正达农作物保护股份公司 杂草控制方法和相关组合物及植物
MX2022014008A (es) 2020-05-08 2023-02-09 Broad Inst Inc Métodos y composiciones para la edición simultánea de ambas cadenas de una secuencia de nucleótidos de doble cadena objetivo.
CN114836446B (zh) * 2022-04-26 2023-12-19 上海交通大学 一种抗草甘膦的植物及其制法

Family Cites Families (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1288073C (en) 1985-03-07 1991-08-27 Paul G. Ahlquist Rna transformation vector
US5736369A (en) 1994-07-29 1998-04-07 Pioneer Hi-Bred International, Inc. Method for producing transgenic cereal plants
US6051409A (en) 1995-09-25 2000-04-18 Novartis Finance Corporation Method for achieving integration of exogenous DNA delivered by non-biological means to plant cells
NZ504300A (en) * 1997-11-18 2002-06-28 Pioneer Hi Bred Int A method for directional stable transformation of eukaryotic cells using non-identical recombination sites
WO2000066746A1 (en) 1999-04-29 2000-11-09 Syngenta Limited Herbicide resistant plants
US6603061B1 (en) 1999-07-29 2003-08-05 Monsanto Company Agrobacterium-mediated plant transformation method
AU2001287862B2 (en) 2000-09-29 2006-12-14 Syngenta Limited Herbicide resistant plants
US20030135891A1 (en) 2001-12-04 2003-07-17 The Texas A&M University System Method of transforming intact plants
AU2003247962B2 (en) * 2002-07-18 2008-06-12 Monsanto Technology Llc Methods for using artificial polynucleotides and compositions thereof to reduce transgene silencing
JP5702144B2 (ja) * 2007-09-27 2015-04-15 ダウ アグロサイエンシィズ エルエルシー ５−エノールピルビルシキミ酸−３−リン酸シンターゼ遺伝子をターゲッティングする改変ジンクフィンガータンパク質
JP2011120478A (ja) 2008-03-31 2011-06-23 Japan Tobacco Inc アグロバクテリウム菌による形質転換植物の作成方法
US10030245B2 (en) 2011-03-23 2018-07-24 E I Du Pont De Nemours And Company Methods for producing a complex transgenic trait locus
WO2013096567A2 (en) * 2011-12-21 2013-06-27 Duke University The hsf-like transcription factor, tbf1, is a major molecular switch for growth-to-defense transition in plants
CN102558309B (zh) 2012-02-10 2014-09-17 浙江大学 一对转录激活子样效应因子核酸酶及其编码基因与应用
US9637739B2 (en) 2012-03-20 2017-05-02 Vilnius University RNA-directed DNA cleavage by the Cas9-crRNA complex
KR102091298B1 (ko) 2012-05-02 2020-03-19 다우 아그로사이언시즈 엘엘씨 말산 탈수소효소의 표적화된 변형
CN104471067B (zh) * 2012-05-07 2020-08-14 桑格摩生物治疗股份有限公司 用于核酸酶介导的转基因靶向整合的方法和组合物
DK2800811T3 (en) 2012-05-25 2017-07-17 Univ Vienna METHODS AND COMPOSITIONS FOR RNA DIRECTIVE TARGET DNA MODIFICATION AND FOR RNA DIRECTIVE MODULATION OF TRANSCRIPTION
US8697359B1 (en) 2012-12-12 2014-04-15 The Broad Institute, Inc. CRISPR-Cas systems and methods for altering expression of gene products
AU2014227831B2 (en) 2013-03-15 2020-01-30 Regents Of The University Of Minnesota Engineering plant genomes using CRISPR/Cas systems
WO2014194190A1 (en) 2013-05-30 2014-12-04 The Penn State Research Foundation Gene targeting and genetic modification of plants via rna-guided genome editing
AU2014279694B2 (en) 2013-06-14 2020-07-23 Cellectis Methods for non-transgenic genome editing in plants
CN103382468B (zh) 2013-07-04 2015-04-29 中国科学院遗传与发育生物学研究所 一种水稻基因组定点改造方法
CN103343120B (zh) 2013-07-04 2015-03-04 中国科学院遗传与发育生物学研究所 一种小麦基因组定点改造方法
ES2744407T3 (es) * 2013-07-16 2020-02-25 Advanced Substrate Tech A/S Método para el ciclado de biomasas entre cultivo de hongos y fermentación anaeróbica con biogás, y para separar y secar una biomasa desgastada
CN103555711A (zh) 2013-07-22 2014-02-05 安徽省农业科学院水稻研究所 一种主要农作物非转基因的基因组定向分子改良方法和应用
BR112016003591A8 (pt) 2013-08-22 2018-01-30 Du Pont promotor u6 de polimerase iii de soja e métodos de uso
BR102014027448A8 (pt) * 2013-11-04 2021-08-24 Dow Agrosciences Llc cassete de doador de polinucleotídeo, uso de uma planta, de uma parte de planta, ou de uma célula vegetal compreendendo o referido cassete, e método para integração direcionada do mesmo
US10787684B2 (en) * 2013-11-19 2020-09-29 President And Fellows Of Harvard College Large gene excision and insertion
CN103667338B (zh) 2013-11-28 2016-01-27 中国科学院遗传与发育生物学研究所 一种玉米基因组定点改造方法
EP3178935B1 (en) 2014-08-06 2022-12-21 Toolgen Incorporated Genome editing using campylobacter jejuni crispr/cas system-derived rgen
WO2016084084A1 (en) 2014-11-27 2016-06-02 Danziger Innovations Ltd. Nucleic acid constructs for genome editing
DE102015004187A1 (de) 2015-04-02 2016-10-06 Kws Saat Se Männlich sterile Pflanze der Gattung Triticum
CN106811479B (zh) 2015-11-30 2019-10-25 中国农业科学院作物科学研究所 利用CRISPR/Cas9系统定点修饰ALS基因获得抗除草剂水稻的系统及其应用

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KR20180031765A (ko) 2018-03-28
KR20200078685A (ko) 2020-07-01
US11767536B2 (en) 2023-09-26
CA2994883A1 (en) 2017-02-23
US20190062779A1 (en) 2019-02-28
AU2016309392A1 (en) 2018-02-22
EA201890492A1 (ru) 2018-08-31
WO2017028768A1 (en) 2017-02-23
CN106467909A (zh) 2017-03-01
EP3334832A4 (en) 2019-06-26
AR105713A1 (es) 2017-11-01
EP3334832A1 (en) 2018-06-20
KR102127418B1 (ko) 2020-06-26
JP2018527920A (ja) 2018-09-27

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