BR112017024662A2 - métodos de entrega de agente em ovos e embriões de animais aquáticos produtores de ovos para triagem de fármacos, ensaio de toxicidade de agente e produção de peixe infértil - Google Patents
métodos de entrega de agente em ovos e embriões de animais aquáticos produtores de ovos para triagem de fármacos, ensaio de toxicidade de agente e produção de peixe infértilInfo
- Publication number
- BR112017024662A2 BR112017024662A2 BR112017024662A BR112017024662A BR112017024662A2 BR 112017024662 A2 BR112017024662 A2 BR 112017024662A2 BR 112017024662 A BR112017024662 A BR 112017024662A BR 112017024662 A BR112017024662 A BR 112017024662A BR 112017024662 A2 BR112017024662 A2 BR 112017024662A2
- Authority
- BR
- Brazil
- Prior art keywords
- eggs
- agent
- methods
- egg
- drug screening
- Prior art date
Links
- 235000013601 eggs Nutrition 0.000 title abstract 10
- 239000003795 chemical substances by application Substances 0.000 title abstract 7
- 238000000034 method Methods 0.000 title abstract 5
- 241001465754 Metazoa Species 0.000 title abstract 4
- 241000251468 Actinopterygii Species 0.000 title abstract 2
- 238000007877 drug screening Methods 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 231100000041 toxicology testing Toxicity 0.000 title abstract 2
- 210000002257 embryonic structure Anatomy 0.000 title 1
- 208000021267 infertility disease Diseases 0.000 title 1
- ZRALSGWEFCBTJO-UHFFFAOYSA-N Guanidine Chemical compound NC(N)=N ZRALSGWEFCBTJO-UHFFFAOYSA-N 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 230000004720 fertilization Effects 0.000 abstract 2
- 230000002710 gonadal effect Effects 0.000 abstract 2
- CHJJGSNFBQVOTG-UHFFFAOYSA-N N-methyl-guanidine Natural products CNC(N)=N CHJJGSNFBQVOTG-UHFFFAOYSA-N 0.000 abstract 1
- 238000009360 aquaculture Methods 0.000 abstract 1
- 244000144974 aquaculture Species 0.000 abstract 1
- 210000001136 chorion Anatomy 0.000 abstract 1
- SWSQBOPZIKWTGO-UHFFFAOYSA-N dimethylaminoamidine Natural products CN(C)C(N)=N SWSQBOPZIKWTGO-UHFFFAOYSA-N 0.000 abstract 1
- 230000002708 enhancing effect Effects 0.000 abstract 1
- 238000007654 immersion Methods 0.000 abstract 1
- 210000004681 ovum Anatomy 0.000 abstract 1
- 230000035699 permeability Effects 0.000 abstract 1
- 241000894007 species Species 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2207/00—Modified animals
- A01K2207/05—Animals modified by non-integrating nucleic acids, e.g. antisense, RNAi, morpholino, episomal vector, for non-therapeutic purpose
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2207/00—Modified animals
- A01K2207/20—Animals treated with compounds which are neither proteins nor nucleic acids
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/40—Fish
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/02—Animal zootechnically ameliorated
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/11—Antisense
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/32—Chemical structure of the sugar
- C12N2310/323—Chemical structure of the sugar modified ring structure
- C12N2310/3233—Morpholino-type ring
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/35—Nature of the modification
- C12N2310/351—Conjugate
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2320/00—Applications; Uses
- C12N2320/30—Special therapeutic applications
- C12N2320/32—Special delivery means, e.g. tissue-specific
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A40/00—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production
- Y02A40/80—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production in fisheries management
- Y02A40/81—Aquaculture, e.g. of fish
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A90/00—Technologies having an indirect contribution to adaptation to climate change
- Y02A90/40—Monitoring or fighting invasive species
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Chemical & Material Sciences (AREA)
- Environmental Sciences (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Animal Husbandry (AREA)
- Animal Behavior & Ethology (AREA)
- Biodiversity & Conservation Biology (AREA)
- Veterinary Medicine (AREA)
- Farming Of Fish And Shellfish (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Enzymes And Modification Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562163511P | 2015-05-19 | 2015-05-19 | |
| US201662274958P | 2016-01-05 | 2016-01-05 | |
| PCT/US2016/032873 WO2016187198A2 (en) | 2015-05-19 | 2016-05-17 | Methods of agent delivery into eggs and embryos of egg-producing aquatic animals for drug screening, agent toxicity assay and production of infertile fish |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112017024662A2 true BR112017024662A2 (pt) | 2018-09-11 |
Family
ID=56084421
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112017024662A BR112017024662A2 (pt) | 2015-05-19 | 2016-05-17 | métodos de entrega de agente em ovos e embriões de animais aquáticos produtores de ovos para triagem de fármacos, ensaio de toxicidade de agente e produção de peixe infértil |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US10709119B2 (enExample) |
| EP (1) | EP3297429A2 (enExample) |
| JP (1) | JP6756960B2 (enExample) |
| CN (1) | CN108040459B (enExample) |
| AU (1) | AU2016265929B2 (enExample) |
| BR (1) | BR112017024662A2 (enExample) |
| CA (1) | CA2984644A1 (enExample) |
| CL (1) | CL2017002864A1 (enExample) |
| DK (1) | DK180094B1 (enExample) |
| IL (1) | IL255338B (enExample) |
| MX (1) | MX386910B (enExample) |
| RU (1) | RU2741645C2 (enExample) |
| WO (1) | WO2016187198A2 (enExample) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3068216B1 (en) | 2013-11-15 | 2024-04-10 | University of Maryland at Baltimore County | Method of producing infertile fish and egg-producing aquatic animals and of delivering compounds into eggs and embryos |
| ES2987265T3 (es) | 2017-12-15 | 2024-11-14 | Acd Pharmaceuticals As | Métodos para la producción de peces estériles |
| EA202191695A1 (ru) * | 2018-12-17 | 2021-09-24 | Альфред-Вегенер-Институт Хельмхольтц-Центрум Фюр Полар- Унд Меересфоршунг | Способ, служащий для получения икры или икорного продукта из живых, зрелых икринок рыб или ракообразных, и такие продукты |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7115794B2 (en) * | 2003-05-19 | 2006-10-03 | University Of Hawaii | Method for direct nucleic acid uptake |
| US7194978B2 (en) | 2003-08-22 | 2007-03-27 | University Of Maryland Biotechnology Institute | Inducing sterility in fish by disrupting the development of the GnRH system |
| CN1294808C (zh) | 2003-09-26 | 2007-01-17 | 中国科学院水生生物研究所 | 不育转基因鱼的制备方法 |
| CN1274822C (zh) | 2004-02-19 | 2006-09-13 | 武汉康祥科技发展有限公司 | 活体化学诱导鱼类雌核发育方法 |
| CN101553210A (zh) * | 2006-09-20 | 2009-10-07 | 奈克斯特安全有限公司 | 经吸入输送药物的方法和系统 |
| CN101652475B (zh) | 2007-01-26 | 2014-03-19 | 辛那杰瓦生物制药股份有限公司 | 在禽类中进行转基因表达 |
| US7935816B2 (en) | 2007-10-25 | 2011-05-03 | Gene Tools, Llc | Molecular transporter compositions comprising dendrimeric oligoguanidine with a triazine core that facilitate delivery into cells in vivo |
| US8383880B2 (en) | 2009-02-18 | 2013-02-26 | Academia Sinica | Infertility control of genetically modified fish |
| US9914745B2 (en) * | 2009-08-14 | 2018-03-13 | Indian Association For The Cultivation Of Science | Morpholino-based antisense agent |
| US8921643B2 (en) * | 2010-02-09 | 2014-12-30 | National University Corporation Hokkaido University | Method for acquiring genetically identical gamete from lethal fish haploid-derived germ cell via germ line chimera |
| WO2012106026A2 (en) | 2011-02-01 | 2012-08-09 | Purdue Research Foundation | Efficient sterilization of fish by disruption of germ cell development |
| GB201117538D0 (en) * | 2011-10-11 | 2011-11-23 | Royal Veterinary College The | Methods |
| RU2504389C2 (ru) * | 2012-02-16 | 2014-01-20 | Федеральное государственное бюджетное учреждение науки Институт биохимии и физиологии микроорганизмов им. Г.К. Скрябина Российской академии наук (ИБФМ РАН) | СПОСОБ ПОРОФОРМИРОВАНИЯ В МЕМБРАНАХ КЛЕТОК ПЕЧЕНИ С ПОМОЩЬЮ ОБРАБОТКИ ИХ ГЕМОЛИЗИНОМ II Bacillus cereus |
| US9538734B2 (en) | 2013-03-12 | 2017-01-10 | The General Hospital Corporation | Germ cell ablation compounds and uses thereof |
| EP3068216B1 (en) * | 2013-11-15 | 2024-04-10 | University of Maryland at Baltimore County | Method of producing infertile fish and egg-producing aquatic animals and of delivering compounds into eggs and embryos |
-
2016
- 2016-05-17 RU RU2017142635A patent/RU2741645C2/ru active
- 2016-05-17 CN CN201680028215.1A patent/CN108040459B/zh active Active
- 2016-05-17 US US15/568,729 patent/US10709119B2/en active Active
- 2016-05-17 MX MX2017014856A patent/MX386910B/es unknown
- 2016-05-17 CA CA2984644A patent/CA2984644A1/en active Pending
- 2016-05-17 EP EP16725715.3A patent/EP3297429A2/en active Pending
- 2016-05-17 BR BR112017024662A patent/BR112017024662A2/pt not_active Application Discontinuation
- 2016-05-17 AU AU2016265929A patent/AU2016265929B2/en active Active
- 2016-05-17 DK DKPA201770877A patent/DK180094B1/en active IP Right Grant
- 2016-05-17 JP JP2017559661A patent/JP6756960B2/ja active Active
- 2016-05-17 WO PCT/US2016/032873 patent/WO2016187198A2/en not_active Ceased
-
2017
- 2017-10-30 IL IL255338A patent/IL255338B/en unknown
- 2017-11-10 CL CL2017002864A patent/CL2017002864A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CN108040459A (zh) | 2018-05-15 |
| CL2017002864A1 (es) | 2018-05-18 |
| JP6756960B2 (ja) | 2020-09-16 |
| DK201770877A1 (en) | 2017-11-27 |
| RU2017142635A3 (enExample) | 2019-12-16 |
| DK180094B1 (en) | 2020-04-27 |
| MX386910B (es) | 2025-03-19 |
| MX2017014856A (es) | 2018-04-20 |
| WO2016187198A3 (en) | 2017-01-12 |
| AU2016265929B2 (en) | 2022-03-31 |
| WO2016187198A2 (en) | 2016-11-24 |
| EP3297429A2 (en) | 2018-03-28 |
| CA2984644A1 (en) | 2016-11-24 |
| JP2018515116A (ja) | 2018-06-14 |
| US10709119B2 (en) | 2020-07-14 |
| RU2741645C2 (ru) | 2021-01-28 |
| CN108040459B (zh) | 2021-09-21 |
| IL255338A0 (en) | 2017-12-31 |
| NZ737306A (en) | 2025-02-28 |
| RU2017142635A (ru) | 2019-06-20 |
| US20180295817A1 (en) | 2018-10-18 |
| AU2016265929A1 (en) | 2017-11-09 |
| IL255338B (en) | 2022-05-01 |
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Legal Events
| Date | Code | Title | Description |
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| B06U | Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette] | ||
| B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
| B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
| B06G | Technical and formal requirements: other requirements [chapter 6.7 patent gazette] | ||
| B09B | Patent application refused [chapter 9.2 patent gazette] | ||
| B12B | Appeal against refusal [chapter 12.2 patent gazette] |