BR112017013904A2 - métodos para marcação de bibliotecas codificadas por dna - Google Patents
métodos para marcação de bibliotecas codificadas por dnaInfo
- Publication number
- BR112017013904A2 BR112017013904A2 BR112017013904-9A BR112017013904A BR112017013904A2 BR 112017013904 A2 BR112017013904 A2 BR 112017013904A2 BR 112017013904 A BR112017013904 A BR 112017013904A BR 112017013904 A2 BR112017013904 A2 BR 112017013904A2
- Authority
- BR
- Brazil
- Prior art keywords
- methods
- chemical
- phosphate
- oligonucleotides
- hydroxyl
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 6
- 239000000126 substance Substances 0.000 abstract 4
- 108091034117 Oligonucleotide Proteins 0.000 abstract 3
- JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 abstract 2
- 150000005829 chemical entities Chemical class 0.000 abstract 2
- ATDGTVJJHBUTRL-UHFFFAOYSA-N cyanogen bromide Chemical compound BrC#N ATDGTVJJHBUTRL-UHFFFAOYSA-N 0.000 abstract 2
- 229910019142 PO4 Inorganic materials 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 238000012804 iterative process Methods 0.000 abstract 1
- 239000003550 marker Substances 0.000 abstract 1
- 239000010452 phosphate Substances 0.000 abstract 1
- UEZVMMHDMIWARA-UHFFFAOYSA-M phosphonate Chemical compound [O-]P(=O)=O UEZVMMHDMIWARA-UHFFFAOYSA-M 0.000 abstract 1
- 239000000758 substrate Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1065—Preparation or screening of tagged libraries, e.g. tagged microorganisms by STM-mutagenesis, tagged polynucleotides, gene tags
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1068—Template (nucleic acid) mediated chemical library synthesis, e.g. chemical and enzymatical DNA-templated organic molecule synthesis, libraries prepared by non ribosomal polypeptide synthesis [NRPS], DNA/RNA-polymerase mediated polypeptide synthesis
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B50/00—Methods of creating libraries, e.g. combinatorial synthesis
- C40B50/08—Liquid phase synthesis, i.e. wherein all library building blocks are in liquid phase or in solution during library creation; Particular methods of cleavage from the liquid support
- C40B50/10—Liquid phase synthesis, i.e. wherein all library building blocks are in liquid phase or in solution during library creation; Particular methods of cleavage from the liquid support involving encoding steps
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Bioinformatics & Computational Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Structural Engineering (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462098037P | 2014-12-30 | 2014-12-30 | |
| US62/098,037 | 2014-12-30 | ||
| PCT/US2015/067667 WO2016109423A1 (en) | 2014-12-30 | 2015-12-28 | Methods for tagging dna-encoded libraries |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112017013904A2 true BR112017013904A2 (pt) | 2018-01-02 |
Family
ID=56284965
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112017013904-9A BR112017013904A2 (pt) | 2014-12-30 | 2015-12-28 | métodos para marcação de bibliotecas codificadas por dna |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US20180002688A1 (https=) |
| EP (1) | EP3240795A4 (https=) |
| JP (1) | JP6864621B2 (https=) |
| KR (1) | KR20170094445A (https=) |
| CN (1) | CN107428795B (https=) |
| AU (2) | AU2015374309B2 (https=) |
| BR (1) | BR112017013904A2 (https=) |
| CA (1) | CA2972275A1 (https=) |
| EA (1) | EA201791312A1 (https=) |
| HK (1) | HK1246301A1 (https=) |
| IL (2) | IL253154B (https=) |
| MA (1) | MA41298A (https=) |
| MX (1) | MX2017008772A (https=) |
| SG (1) | SG11201705350XA (https=) |
| WO (1) | WO2016109423A1 (https=) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11186836B2 (en) | 2016-06-16 | 2021-11-30 | Haystack Sciences Corporation | Oligonucleotide directed and recorded combinatorial synthesis of encoded probe molecules |
| EA201992476A1 (ru) * | 2017-04-18 | 2020-02-25 | Икс-Чем, Инк. | Способы идентификации соединений |
| EP3619340A4 (en) | 2017-05-02 | 2021-01-20 | Haystack Sciences Corporation | OLIGONUCLEOTID-DRIVEN COMBINATORY SYNTHESIS VERIFICATION MOLECULES AND ASSOCIATED MANUFACTURING AND USE PROCESSES |
| US11384376B2 (en) * | 2018-05-31 | 2022-07-12 | Roche Molecular Systems, Inc. | Reagents and methods for post-synthetic modification of nucleic acids |
| WO2020001560A1 (zh) * | 2018-06-29 | 2020-01-02 | 成都先导药物开发股份有限公司 | 一种合成dna编码化合物中的反应监测方法 |
| CN109468310B (zh) * | 2018-10-25 | 2020-12-01 | 深圳劲宇生物科技有限公司 | Dna编码碎片分子库的合成方法和连接基团的筛选方法 |
| CA3131890A1 (en) * | 2019-03-14 | 2020-09-17 | Haystack Sciences Corporation | Methods and systems for processing or analyzing oligonucleotide encoded molecules |
| CN112941634B (zh) * | 2019-12-10 | 2023-09-26 | 成都先导药物开发股份有限公司 | 通过dna编码化合物库筛选同时结合多个生物靶标的化合物的方法 |
| AU2021376394A1 (en) * | 2020-11-06 | 2023-06-15 | The University Of Chicago | Hairpin oligonucleotides and uses thereof |
| WO2025053257A1 (ja) * | 2023-09-07 | 2025-03-13 | 旭化成ファーマ株式会社 | オリゴヌクレオチドによりコード化された化合物の製造方法、およびその応用 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1996038726A1 (en) * | 1995-05-30 | 1996-12-05 | Ecole Polytechnique Federale De Lausanne (Epfl) | Covalently immobilized phospholipid bilayers on solid surfaces |
| PT2348125T (pt) * | 2002-10-30 | 2017-08-29 | Nuevolution As | Método para a síntese de um complexo bifuncional |
| CN1898257B (zh) * | 2003-12-17 | 2010-06-23 | 普雷西斯药品公司 | 合成编码文库的方法 |
| US8846883B2 (en) * | 2011-08-16 | 2014-09-30 | University Of Southhampton | Oligonucleotide ligation |
| DK2748357T3 (en) * | 2011-09-07 | 2018-07-16 | X Chem Inc | Methods for labeling DNA-encoded libraries |
| EA201992285A1 (ru) * | 2012-07-13 | 2020-05-31 | Икс-Чем, Инк. | Днк-кодированные библиотеки, содержащие связи кодирующих олигонуклеотидов, не доступные для считывания полимеразами |
-
2015
- 2015-12-27 MA MA041298A patent/MA41298A/fr unknown
- 2015-12-28 KR KR1020177019616A patent/KR20170094445A/ko not_active Withdrawn
- 2015-12-28 SG SG11201705350XA patent/SG11201705350XA/en unknown
- 2015-12-28 WO PCT/US2015/067667 patent/WO2016109423A1/en not_active Ceased
- 2015-12-28 US US15/540,284 patent/US20180002688A1/en not_active Abandoned
- 2015-12-28 BR BR112017013904-9A patent/BR112017013904A2/pt active Search and Examination
- 2015-12-28 MX MX2017008772A patent/MX2017008772A/es unknown
- 2015-12-28 CA CA2972275A patent/CA2972275A1/en active Pending
- 2015-12-28 CN CN201580077171.7A patent/CN107428795B/zh not_active Expired - Fee Related
- 2015-12-28 JP JP2017534592A patent/JP6864621B2/ja not_active Expired - Fee Related
- 2015-12-28 HK HK18105560.9A patent/HK1246301A1/zh unknown
- 2015-12-28 EA EA201791312A patent/EA201791312A1/ru unknown
- 2015-12-28 EP EP15876097.5A patent/EP3240795A4/en not_active Withdrawn
- 2015-12-28 AU AU2015374309A patent/AU2015374309B2/en not_active Ceased
-
2017
- 2017-06-25 IL IL253154A patent/IL253154B/en active IP Right Grant
-
2020
- 2020-09-11 AU AU2020230345A patent/AU2020230345A1/en not_active Withdrawn
- 2020-10-18 IL IL278117A patent/IL278117A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU2015374309B2 (en) | 2020-06-11 |
| CN107428795B (zh) | 2021-06-18 |
| AU2015374309A1 (en) | 2017-07-27 |
| EA201791312A1 (ru) | 2017-10-31 |
| MX2017008772A (es) | 2018-03-15 |
| JP2018501796A (ja) | 2018-01-25 |
| IL253154B (en) | 2020-10-29 |
| CN107428795A (zh) | 2017-12-01 |
| IL278117A (en) | 2020-11-30 |
| WO2016109423A1 (en) | 2016-07-07 |
| HK1246301A1 (zh) | 2018-09-07 |
| EP3240795A4 (en) | 2019-02-13 |
| JP6864621B2 (ja) | 2021-04-28 |
| IL253154A0 (en) | 2017-08-31 |
| US20180002688A1 (en) | 2018-01-04 |
| SG11201705350XA (en) | 2017-08-30 |
| EP3240795A1 (en) | 2017-11-08 |
| MA41298A (fr) | 2017-11-07 |
| CA2972275A1 (en) | 2016-07-07 |
| AU2020230345A1 (en) | 2020-10-01 |
| KR20170094445A (ko) | 2017-08-17 |
| WO2016109423A8 (en) | 2017-07-20 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] |
Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS. |
|
| B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] | ||
| B06U | Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette] | ||
| B15K | Others concerning applications: alteration of classification |
Free format text: A CLASSIFICACAO ANTERIOR ERA: C07H 21/02 Ipc: C07H 21/02 (2006.01), C07H 1/00 (2006.01), ... |
|
| B15K | Others concerning applications: alteration of classification |
Free format text: AS CLASSIFICACOES ANTERIORES ERAM: C07H 21/02 , C07H 1/00 , C40B 50/10 Ipc: C07H 21/02 (2006.01), C07H 1/00 (2006.01), C40B 50 |
|
| B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
| B11D | Dismissal acc. art. 38, par 2 of ipl - failure to pay fee after grant in time |