AU2015374309B2 - Methods for tagging DNA-encoded libraries - Google Patents
Methods for tagging DNA-encoded libraries Download PDFInfo
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- AU2015374309B2 AU2015374309B2 AU2015374309A AU2015374309A AU2015374309B2 AU 2015374309 B2 AU2015374309 B2 AU 2015374309B2 AU 2015374309 A AU2015374309 A AU 2015374309A AU 2015374309 A AU2015374309 A AU 2015374309A AU 2015374309 B2 AU2015374309 B2 AU 2015374309B2
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- nucleotides
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1065—Preparation or screening of tagged libraries, e.g. tagged microorganisms by STM-mutagenesis, tagged polynucleotides, gene tags
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1068—Template (nucleic acid) mediated chemical library synthesis, e.g. chemical and enzymatical DNA-templated organic molecule synthesis, libraries prepared by non ribosomal polypeptide synthesis [NRPS], DNA/RNA-polymerase mediated polypeptide synthesis
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- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B50/00—Methods of creating libraries, e.g. combinatorial synthesis
- C40B50/08—Liquid phase synthesis, i.e. wherein all library building blocks are in liquid phase or in solution during library creation; Particular methods of cleavage from the liquid support
- C40B50/10—Liquid phase synthesis, i.e. wherein all library building blocks are in liquid phase or in solution during library creation; Particular methods of cleavage from the liquid support involving encoding steps
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Priority Applications (1)
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|---|---|---|---|
| AU2020230345A AU2020230345A1 (en) | 2014-12-30 | 2020-09-11 | Methods for tagging DNA-encoded libraries |
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| US201462098037P | 2014-12-30 | 2014-12-30 | |
| US62/098,037 | 2014-12-30 | ||
| PCT/US2015/067667 WO2016109423A1 (en) | 2014-12-30 | 2015-12-28 | Methods for tagging dna-encoded libraries |
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| AU2020230345A Division AU2020230345A1 (en) | 2014-12-30 | 2020-09-11 | Methods for tagging DNA-encoded libraries |
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| US11186836B2 (en) | 2016-06-16 | 2021-11-30 | Haystack Sciences Corporation | Oligonucleotide directed and recorded combinatorial synthesis of encoded probe molecules |
| EA201992476A1 (ru) * | 2017-04-18 | 2020-02-25 | Икс-Чем, Инк. | Способы идентификации соединений |
| EP3619340A4 (en) | 2017-05-02 | 2021-01-20 | Haystack Sciences Corporation | OLIGONUCLEOTID-DRIVEN COMBINATORY SYNTHESIS VERIFICATION MOLECULES AND ASSOCIATED MANUFACTURING AND USE PROCESSES |
| US11384376B2 (en) * | 2018-05-31 | 2022-07-12 | Roche Molecular Systems, Inc. | Reagents and methods for post-synthetic modification of nucleic acids |
| WO2020001560A1 (zh) * | 2018-06-29 | 2020-01-02 | 成都先导药物开发股份有限公司 | 一种合成dna编码化合物中的反应监测方法 |
| CN109468310B (zh) * | 2018-10-25 | 2020-12-01 | 深圳劲宇生物科技有限公司 | Dna编码碎片分子库的合成方法和连接基团的筛选方法 |
| CA3131890A1 (en) * | 2019-03-14 | 2020-09-17 | Haystack Sciences Corporation | Methods and systems for processing or analyzing oligonucleotide encoded molecules |
| CN112941634B (zh) * | 2019-12-10 | 2023-09-26 | 成都先导药物开发股份有限公司 | 通过dna编码化合物库筛选同时结合多个生物靶标的化合物的方法 |
| AU2021376394A1 (en) * | 2020-11-06 | 2023-06-15 | The University Of Chicago | Hairpin oligonucleotides and uses thereof |
| WO2025053257A1 (ja) * | 2023-09-07 | 2025-03-13 | 旭化成ファーマ株式会社 | オリゴヌクレオチドによりコード化された化合物の製造方法、およびその応用 |
Citations (2)
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|---|---|---|---|---|
| WO2013036810A1 (en) * | 2011-09-07 | 2013-03-14 | X-Chem, Inc. | Methods for tagging dna-encoded libraries |
| WO2014012010A1 (en) * | 2012-07-13 | 2014-01-16 | X-Chem, Inc. | Dna-encoded libraries having encoding oligonucleotide linkages not readable by polymerases |
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| WO1996038726A1 (en) * | 1995-05-30 | 1996-12-05 | Ecole Polytechnique Federale De Lausanne (Epfl) | Covalently immobilized phospholipid bilayers on solid surfaces |
| PT2348125T (pt) * | 2002-10-30 | 2017-08-29 | Nuevolution As | Método para a síntese de um complexo bifuncional |
| CN1898257B (zh) * | 2003-12-17 | 2010-06-23 | 普雷西斯药品公司 | 合成编码文库的方法 |
| US8846883B2 (en) * | 2011-08-16 | 2014-09-30 | University Of Southhampton | Oligonucleotide ligation |
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- 2015-12-28 US US15/540,284 patent/US20180002688A1/en not_active Abandoned
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- 2015-12-28 CN CN201580077171.7A patent/CN107428795B/zh not_active Expired - Fee Related
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2013036810A1 (en) * | 2011-09-07 | 2013-03-14 | X-Chem, Inc. | Methods for tagging dna-encoded libraries |
| WO2014012010A1 (en) * | 2012-07-13 | 2014-01-16 | X-Chem, Inc. | Dna-encoded libraries having encoding oligonucleotide linkages not readable by polymerases |
Also Published As
| Publication number | Publication date |
|---|---|
| CN107428795B (zh) | 2021-06-18 |
| AU2015374309A1 (en) | 2017-07-27 |
| EA201791312A1 (ru) | 2017-10-31 |
| MX2017008772A (es) | 2018-03-15 |
| JP2018501796A (ja) | 2018-01-25 |
| IL253154B (en) | 2020-10-29 |
| CN107428795A (zh) | 2017-12-01 |
| IL278117A (en) | 2020-11-30 |
| WO2016109423A1 (en) | 2016-07-07 |
| HK1246301A1 (zh) | 2018-09-07 |
| EP3240795A4 (en) | 2019-02-13 |
| BR112017013904A2 (pt) | 2018-01-02 |
| JP6864621B2 (ja) | 2021-04-28 |
| IL253154A0 (en) | 2017-08-31 |
| US20180002688A1 (en) | 2018-01-04 |
| SG11201705350XA (en) | 2017-08-30 |
| EP3240795A1 (en) | 2017-11-08 |
| MA41298A (fr) | 2017-11-07 |
| CA2972275A1 (en) | 2016-07-07 |
| AU2020230345A1 (en) | 2020-10-01 |
| KR20170094445A (ko) | 2017-08-17 |
| WO2016109423A8 (en) | 2017-07-20 |
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