BR112017010483B1 - Composição de reidratação oral e uso da mesma - Google Patents
Composição de reidratação oral e uso da mesma Download PDFInfo
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- BR112017010483B1 BR112017010483B1 BR112017010483-0A BR112017010483A BR112017010483B1 BR 112017010483 B1 BR112017010483 B1 BR 112017010483B1 BR 112017010483 A BR112017010483 A BR 112017010483A BR 112017010483 B1 BR112017010483 B1 BR 112017010483B1
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- oral rehydration
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- diarrhea
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Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
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| EA033940B1 (ru) | 2014-11-19 | 2019-12-11 | Калмарна Лимитед | Пероральный регидратационный раствор и способ его приготовления |
| CN111867400A (zh) * | 2018-03-15 | 2020-10-30 | 潘可士玛股份公司 | 用于改善哺乳动物健康和行为表现的饲料 |
| DE202018105142U1 (de) * | 2018-04-29 | 2018-10-08 | Kalmarna Limited - CCS Trustees Limited | Zusammensetzungen zur oralen Verabreichung zum Beeinflussen der Nachkommenschaft von Säugetieren |
| DE202018105143U1 (de) * | 2018-04-29 | 2018-10-05 | Kalmarna Limited - CCS Trustees Limited | Zusammensetzungen zum Nähren von Säugetieren |
| WO2020039443A1 (en) * | 2018-08-23 | 2020-02-27 | Kalmarna Limited | Compositions and methods for controlling mammalian pathogens |
| US20200396961A1 (en) * | 2019-06-18 | 2020-12-24 | Susu Pets, Llc | Container for an aqueous composition |
| MX2022001281A (es) * | 2019-07-29 | 2022-05-03 | Nutreco Ip Assets Bv | Composicion de electrolitos y metodos de uso. |
| CN111035651A (zh) * | 2019-12-19 | 2020-04-21 | 孙庆 | 一种改善口感和缓和胃刺激的补钾制剂及其制备 |
| JP7463115B2 (ja) * | 2020-01-30 | 2024-04-08 | 森永乳業株式会社 | 電解質補給飲料及びその製造方法 |
| PL242445B1 (pl) * | 2020-03-15 | 2023-02-20 | Anwipharma Spolka Z Ograniczona Odpowiedzialnoscia | Sposób otrzymywania preparatu i preparat zawierający elektrolity dla zwierząt kopytnych, zwłaszcza koni |
| WO2022251624A1 (en) * | 2021-05-28 | 2022-12-01 | The Coca-Cola Company | Amino acid hydration formulation and method of use |
| IT202200014092A1 (it) * | 2022-07-04 | 2024-01-04 | Farm Del Corso Snc Di Ferri Sonia & C | Nuova composizione |
| AU2023321712A1 (en) * | 2022-08-11 | 2025-01-23 | Unilever Global Ip Limited | Hydration composition |
| WO2025073885A1 (en) * | 2023-10-05 | 2025-04-10 | Aarhus Universitet | Composition for use in patients with ileostomy |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2539006A1 (fr) * | 1983-01-12 | 1984-07-13 | Agronomique Inst Nat Rech | Composition rehydratante utilisable notamment dans l'alimentation de jeunes animaux ne pouvant plus digerer normalement le lait et complement pour sa preparation |
| GB8512345D0 (en) * | 1985-05-15 | 1985-06-19 | Scras | Anti-diarrhea compositions |
| EP0226332B1 (en) * | 1985-11-18 | 1992-03-25 | Beecham Group Plc | Veterinary compositions |
| GB9212737D0 (en) | 1992-06-16 | 1992-07-29 | Norbrook Lab | Veterinary product |
| US5489440A (en) | 1995-03-06 | 1996-02-06 | Abbott Laboratories | Rice flour-based oral rehydration solution |
| GB9609993D0 (en) | 1996-05-14 | 1996-07-17 | Norbrook Lab Ltd | Oral rehydration product |
| US7026298B2 (en) * | 2001-06-04 | 2006-04-11 | Abbott Laboratories | Oral rehydration compositions |
| US7160565B2 (en) * | 2003-03-31 | 2007-01-09 | Breakthru Products, Llc | Hydration beverage and method of delivering nutrients |
| JP4528925B2 (ja) * | 2003-05-30 | 2010-08-25 | 独立行政法人理化学研究所 | アミノ酸組成物及び補液 |
| US8956652B2 (en) * | 2005-09-15 | 2015-02-17 | Tower Laboratories, Ltd. | Effervescent rehydrating beverage tablet/granules |
| EP2726083A4 (en) * | 2011-07-01 | 2014-12-17 | Drip Drop Inc | ORAL REHYDRATION COMPOSITION |
| US8557301B2 (en) * | 2011-07-01 | 2013-10-15 | Drip Drop, Inc. | Oral rehydration composition |
| WO2013133442A1 (ja) * | 2012-03-09 | 2013-09-12 | 株式会社明治 | 水分吸収性に優れた飲食品 |
| CN102824362B (zh) * | 2012-09-20 | 2014-03-12 | 西安安健药业有限公司 | 一种口服补液盐的药物组合物 |
| CN103479664B (zh) * | 2013-09-24 | 2015-01-07 | 辽宁亿灵科创生物医药科技有限公司 | 一种液态口服补液盐 |
| EA033940B1 (ru) | 2014-11-19 | 2019-12-11 | Калмарна Лимитед | Пероральный регидратационный раствор и способ его приготовления |
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2018
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