BR112017009986A2 - métodos para tratar indivíduos com síndrome de prader-willi ou síndrome de smith-magenis - Google Patents
métodos para tratar indivíduos com síndrome de prader-willi ou síndrome de smith-magenisInfo
- Publication number
- BR112017009986A2 BR112017009986A2 BR112017009986-1A BR112017009986A BR112017009986A2 BR 112017009986 A2 BR112017009986 A2 BR 112017009986A2 BR 112017009986 A BR112017009986 A BR 112017009986A BR 112017009986 A2 BR112017009986 A2 BR 112017009986A2
- Authority
- BR
- Brazil
- Prior art keywords
- methods
- syndrome
- katp
- prader
- smith
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- 201000010769 Prader-Willi syndrome Diseases 0.000 title abstract 2
- 201000001388 Smith-Magenis syndrome Diseases 0.000 title 1
- 102000016924 KATP Channels Human genes 0.000 abstract 3
- 108010053914 KATP Channels Proteins 0.000 abstract 3
- 102000018997 Growth Hormone Human genes 0.000 abstract 2
- 108010051696 Growth Hormone Proteins 0.000 abstract 2
- 239000000122 growth hormone Substances 0.000 abstract 2
- 208000031295 Animal disease Diseases 0.000 abstract 1
- 108091006146 Channels Proteins 0.000 abstract 1
- 230000002411 adverse Effects 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 230000002503 metabolic effect Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000003285 pharmacodynamic effect Effects 0.000 abstract 1
- 230000002035 prolonged effect Effects 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/549—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame having two or more nitrogen atoms in the same ring, e.g. hydrochlorothiazide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/27—Growth hormone [GH], i.e. somatotropin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
- A61K9/0004—Osmotic delivery systems; Sustained release driven by osmosis, thermal energy or gas
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
- A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
- A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
- A61K9/5047—Cellulose ethers containing no ester groups, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
- C07D285/15—Six-membered rings
- C07D285/16—Thiadiazines; Hydrogenated thiadiazines
- C07D285/18—1,2,4-Thiadiazines; Hydrogenated 1,2,4-thiadiazines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
- C07D285/15—Six-membered rings
- C07D285/16—Thiadiazines; Hydrogenated thiadiazines
- C07D285/18—1,2,4-Thiadiazines; Hydrogenated 1,2,4-thiadiazines
- C07D285/20—1,2,4-Thiadiazines; Hydrogenated 1,2,4-thiadiazines condensed with carbocyclic rings or ring systems
- C07D285/22—1,2,4-Thiadiazines; Hydrogenated 1,2,4-thiadiazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Child & Adolescent Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Steroid Compounds (AREA)
- Inorganic Chemistry (AREA)
- Oil, Petroleum & Natural Gas (AREA)
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462080150P | 2014-11-14 | 2014-11-14 | |
| US62/080,150 | 2014-11-14 | ||
| US201562138245P | 2015-03-25 | 2015-03-25 | |
| US62/138,245 | 2015-03-25 | ||
| US201562170035P | 2015-06-02 | 2015-06-02 | |
| US62/170,035 | 2015-06-02 | ||
| US201562221359P | 2015-09-21 | 2015-09-21 | |
| US62/221,359 | 2015-09-21 | ||
| PCT/US2015/060455 WO2016077629A1 (en) | 2014-11-14 | 2015-11-12 | Methods for treating subjects with prader-willi syndrome or smith-magenis syndrome |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112017009986A2 true BR112017009986A2 (pt) | 2018-02-14 |
Family
ID=55955075
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112017009986-1A BR112017009986A2 (pt) | 2014-11-14 | 2015-11-12 | métodos para tratar indivíduos com síndrome de prader-willi ou síndrome de smith-magenis |
Country Status (19)
| Country | Link |
|---|---|
| US (8) | US10058557B2 (enExample) |
| EP (1) | EP3217963B1 (enExample) |
| JP (4) | JP6709226B2 (enExample) |
| KR (4) | KR102323613B1 (enExample) |
| CN (2) | CN113599386B (enExample) |
| AU (2) | AU2015346196B2 (enExample) |
| BR (1) | BR112017009986A2 (enExample) |
| CA (4) | CA3210794A1 (enExample) |
| DK (1) | DK3217963T3 (enExample) |
| EA (1) | EA036103B1 (enExample) |
| ES (1) | ES2806977T3 (enExample) |
| HU (1) | HUE050895T2 (enExample) |
| IL (1) | IL252111B (enExample) |
| MX (2) | MX393030B (enExample) |
| MY (1) | MY187610A (enExample) |
| NZ (1) | NZ768958A (enExample) |
| PL (1) | PL3217963T3 (enExample) |
| SG (1) | SG11201703721SA (enExample) |
| WO (1) | WO2016077629A1 (enExample) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060051418A1 (en) | 2004-08-25 | 2006-03-09 | Essentialis, Inc. | Pharmaceutical formulations of potassium ATP channel openers and uses thereof |
| US9757384B2 (en) | 2005-04-06 | 2017-09-12 | Essentialis, Inc. | Methods for treating subjects with Prader-Willi syndrome or Smith-Magenis syndrome |
| ES2374963T3 (es) | 2006-01-05 | 2012-02-23 | Essentialis, Inc. | Sales de agentes de apertura del canal de potasio dependiente de atp y usos de las mismas. |
| CN113599386B (zh) | 2014-11-14 | 2025-12-05 | 伊森舍丽斯有限公司 | 用于治疗患有普拉德-威利综合征或史密斯-马吉利综合征的受试者的方法 |
| RU2748294C2 (ru) * | 2016-06-03 | 2021-05-21 | Зе Трастис Оф Коламбия Юниверсити Ин Зе Сити Оф Нью-Йорк | Способ лечения синдрома прадера-вилли |
| CA3062170A1 (en) | 2017-05-05 | 2018-11-08 | Nino Sorgente | Methods and compositions for improving eye health |
| US11382881B2 (en) | 2017-05-05 | 2022-07-12 | Nino Sorgente | Methods and compositions for diagnosing and treating glaucoma |
| CA3112185C (en) * | 2018-09-20 | 2025-10-07 | Acadia Pharmaceuticals Inc. | STABLE INTRANASAL FORMULATIONS OF CARBETOCINE |
| CN111888330B (zh) * | 2020-09-18 | 2022-08-16 | 常州市第四制药厂有限公司 | 一种二氮嗪口服混悬溶液及制备方法 |
| AR130798A1 (es) * | 2022-10-18 | 2025-01-22 | Rhythm Pharmaceuticals Inc | Potenciadores novedosos de los canales de potasio sensibles a atp, su preparación y uso |
| WO2025057119A1 (en) * | 2023-09-15 | 2025-03-20 | Soleno Therapeutics, Inc. | Methods of managing glycemic control in prader-willi syndrome patients |
Family Cites Families (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2986573A (en) | 1961-01-18 | 1961-05-30 | Schering Corp | Method for the treatment of hypertension |
| GB8601204D0 (en) | 1986-01-18 | 1986-02-19 | Boots Co Plc | Therapeutic agents |
| GB2186485B (en) | 1986-02-13 | 1988-09-07 | Ethical Pharma Ltd | Slow release formulation |
| US5284845A (en) | 1991-03-14 | 1994-02-08 | Paulsen Elsa P | Use of oral diazoxide for the treatment of disorders in glucose metabolism |
| US5629045A (en) | 1992-09-17 | 1997-05-13 | Richard L. Veech | Biodegradable nosiogenic agents for control of non-vertebrate pests |
| US5399359A (en) | 1994-03-04 | 1995-03-21 | Edward Mendell Co., Inc. | Controlled release oxybutynin formulations |
| FR2725623A1 (fr) | 1994-10-18 | 1996-04-19 | Flamel Tech Sa | Microcapsules medicamenteuses et/ou nutritionnelles pour administration per os |
| US6225310B1 (en) * | 1996-01-17 | 2001-05-01 | Novo Nordisk A/S | Fused 1,2,4-thiadiazine derivatives, their preparation and use |
| WO1998010786A2 (en) | 1996-09-12 | 1998-03-19 | Yarom Cohen | Pharmaceutical composition for the treatment of syndrome x of reaven |
| US6197765B1 (en) | 1999-06-08 | 2001-03-06 | Pnina Vardi | Use of diazoxide for the treatment of metabolic syndrome and diabetes complications |
| AU2001265839A1 (en) | 2000-06-26 | 2002-01-08 | Novo-Nordisk A/S | Use of potassium channel agonists for the treatment of cancer |
| TW478039B (en) | 2001-04-09 | 2002-03-01 | Promos Technologies Inc | Phase shift alignment system |
| US6669955B2 (en) | 2001-08-28 | 2003-12-30 | Longwood Pharmaceutical Research, Inc. | Combination dosage form containing individual dosage units of a cholesterol-lowering agent, an inhibitor of the renin-angiotensin system, and aspirin |
| US6960346B2 (en) | 2002-05-09 | 2005-11-01 | University Of Tennessee Research Foundation | Vehicles for delivery of biologically active substances |
| US20040143213A1 (en) | 2002-11-12 | 2004-07-22 | Collegium Pharmaceutical, Inc. | Inertial drug delivery system |
| US20040204472A1 (en) | 2003-03-04 | 2004-10-14 | Pharmacia Corporation | Treatment and prevention of obesity with COX-2 inhibitors alone or in combination with weight-loss agents |
| WO2006000607A1 (es) * | 2004-06-23 | 2006-01-05 | Neurotec Pharma, S.L. | Uso de activadores de los canales de katp (kco), en particular el diazóxido, en el tratamiento de la inflamación crónica de snc asociada a algunas efermedades |
| CN101043879A (zh) * | 2004-08-25 | 2007-09-26 | 伊森舍丽斯有限公司 | 钾atp通道开放剂的药物制剂及其应用 |
| US20060051418A1 (en) | 2004-08-25 | 2006-03-09 | Essentialis, Inc. | Pharmaceutical formulations of potassium ATP channel openers and uses thereof |
| AU2005298692A1 (en) * | 2004-10-25 | 2006-05-04 | Solvay Pharmaceuticals Gmbh | Pharmaceutical compositions comprising CB1 cannabinoid receptor antagonists and potassium channel openers for the treatment of diabetes mellitus type I, obesity and related conditions |
| US9757384B2 (en) | 2005-04-06 | 2017-09-12 | Essentialis, Inc. | Methods for treating subjects with Prader-Willi syndrome or Smith-Magenis syndrome |
| CN101257897A (zh) * | 2005-07-07 | 2008-09-03 | 西特里斯药业公司 | 用于治疗或预防肥胖、胰岛素抵抗障碍和线粒体相关障碍的方法和相关组合物 |
| ES2374963T3 (es) | 2006-01-05 | 2012-02-23 | Essentialis, Inc. | Sales de agentes de apertura del canal de potasio dependiente de atp y usos de las mismas. |
| WO2007146900A2 (en) * | 2006-06-15 | 2007-12-21 | Gilead Colorado, Inc. | Antihypertensive therapy method |
| WO2009006483A1 (en) | 2007-07-02 | 2009-01-08 | Essentialis, Inc. | Salts of potassium atp channel openers and uses thereof |
| US20120238554A1 (en) | 2007-07-02 | 2012-09-20 | Cowen Neil M | Salts of potassium atp channel openers and uses thereof |
| EP2395987A1 (en) * | 2009-02-12 | 2011-12-21 | Coöperatieve Mirzorg U.A., Arnhem | Use of a combination of diazoxide and metformin for treating obesity or obesity related disorders |
| DK2790721T3 (en) * | 2011-12-15 | 2019-02-04 | Millendo Therapeutics Sas | FRAGMENTS OF NON-ACYLATED GHRELIN FOR USING TREATMENT FOR PRADER-WILLI SYNDROME |
| EP2819675A4 (en) | 2012-02-27 | 2015-07-22 | Essentialis Inc | SALTS OF KALIUM ATP CHANNEL OPENERS AND USES THEREOF |
| JP2014074004A (ja) * | 2012-10-05 | 2014-04-24 | Shinichi Niijima | 精神症状の改善剤 |
| US20140364367A1 (en) | 2013-06-08 | 2014-12-11 | Sedogen, Llc | Methods of treating prader willi syndrome and conditions associated with low basal metabolic rate or hyperphagia using a katp channel opener |
| CN113599386B (zh) | 2014-11-14 | 2025-12-05 | 伊森舍丽斯有限公司 | 用于治疗患有普拉德-威利综合征或史密斯-马吉利综合征的受试者的方法 |
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2015
- 2015-11-12 CN CN202110786768.6A patent/CN113599386B/zh active Active
- 2015-11-12 WO PCT/US2015/060455 patent/WO2016077629A1/en not_active Ceased
- 2015-11-12 CA CA3210794A patent/CA3210794A1/en active Pending
- 2015-11-12 EP EP15859169.3A patent/EP3217963B1/en active Active
- 2015-11-12 MX MX2021003982A patent/MX393030B/es unknown
- 2015-11-12 AU AU2015346196A patent/AU2015346196B2/en active Active
- 2015-11-12 CA CA3125835A patent/CA3125835C/en active Active
- 2015-11-12 MX MX2017006244A patent/MX381305B/es unknown
- 2015-11-12 KR KR1020177016089A patent/KR102323613B1/ko active Active
- 2015-11-12 EA EA201791067A patent/EA036103B1/ru unknown
- 2015-11-12 NZ NZ768958A patent/NZ768958A/en unknown
- 2015-11-12 BR BR112017009986-1A patent/BR112017009986A2/pt not_active Application Discontinuation
- 2015-11-12 PL PL15859169T patent/PL3217963T3/pl unknown
- 2015-11-12 CA CA3125839A patent/CA3125839C/en active Active
- 2015-11-12 SG SG11201703721SA patent/SG11201703721SA/en unknown
- 2015-11-12 CA CA2966907A patent/CA2966907C/en active Active
- 2015-11-12 KR KR1020237010935A patent/KR102598666B1/ko active Active
- 2015-11-12 JP JP2017544842A patent/JP6709226B2/ja active Active
- 2015-11-12 DK DK15859169.3T patent/DK3217963T3/da active
- 2015-11-12 KR KR1020217035884A patent/KR102452254B1/ko active Active
- 2015-11-12 CN CN201580072525.9A patent/CN107106500B/zh active Active
- 2015-11-12 KR KR1020227029800A patent/KR102517840B1/ko active Active
- 2015-11-12 HU HUE15859169A patent/HUE050895T2/hu unknown
- 2015-11-12 MY MYPI2017701659A patent/MY187610A/en unknown
- 2015-11-12 ES ES15859169T patent/ES2806977T3/es active Active
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2017
- 2017-05-04 IL IL252111A patent/IL252111B/en unknown
- 2017-08-08 US US15/671,792 patent/US10058557B2/en active Active
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2018
- 2018-07-20 US US16/041,237 patent/US10456408B2/en active Active
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2019
- 2019-04-25 AU AU2019202906A patent/AU2019202906B2/en active Active
- 2019-09-17 US US16/573,965 patent/US10874676B2/en active Active
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2020
- 2020-01-10 JP JP2020002555A patent/JP6955039B2/ja active Active
- 2020-11-25 US US17/104,433 patent/US20210322434A1/en not_active Abandoned
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2021
- 2021-09-30 JP JP2021160423A patent/JP7232300B2/ja active Active
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2023
- 2023-02-17 JP JP2023023047A patent/JP7645913B2/ja active Active
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2024
- 2024-01-24 US US18/421,914 patent/US12109216B2/en active Active
- 2024-09-04 US US18/824,811 patent/US12178823B1/en active Active
- 2024-12-19 US US18/988,636 patent/US12343348B2/en active Active
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2025
- 2025-05-30 US US19/224,580 patent/US12419895B1/en active Active
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