HUE050895T2 - Módszerek prader-willi szindrómával vagy smith-magenis szindrómával kezelt betegek kezelésére - Google Patents

Módszerek prader-willi szindrómával vagy smith-magenis szindrómával kezelt betegek kezelésére

Info

Publication number
HUE050895T2
HUE050895T2 HUE15859169A HUE15859169A HUE050895T2 HU E050895 T2 HUE050895 T2 HU E050895T2 HU E15859169 A HUE15859169 A HU E15859169A HU E15859169 A HUE15859169 A HU E15859169A HU E050895 T2 HUE050895 T2 HU E050895T2
Authority
HU
Hungary
Prior art keywords
syndrome
prader
smith
methods
treating patients
Prior art date
Application number
HUE15859169A
Other languages
English (en)
Hungarian (hu)
Inventor
Neil M Cowen
Original Assignee
Essentialis Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Essentialis Inc filed Critical Essentialis Inc
Publication of HUE050895T2 publication Critical patent/HUE050895T2/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/15—Six-membered rings
    • C07D285/16—Thiadiazines; Hydrogenated thiadiazines
    • C07D285/18—1,2,4-Thiadiazines; Hydrogenated 1,2,4-thiadiazines
    • C07D285/20—1,2,4-Thiadiazines; Hydrogenated 1,2,4-thiadiazines condensed with carbocyclic rings or ring systems
    • C07D285/22—1,2,4-Thiadiazines; Hydrogenated 1,2,4-thiadiazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/549—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame having two or more nitrogen atoms in the same ring, e.g. hydrochlorothiazide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/27—Growth hormone [GH], i.e. somatotropin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A61K9/0004—Osmotic delivery systems; Sustained release driven by osmosis, thermal energy or gas
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
    • A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
    • A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
    • A61K9/5047—Cellulose ethers containing no ester groups, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/15—Six-membered rings
    • C07D285/16—Thiadiazines; Hydrogenated thiadiazines
    • C07D285/18—1,2,4-Thiadiazines; Hydrogenated 1,2,4-thiadiazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Inorganic Chemistry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Steroid Compounds (AREA)
HUE15859169A 2014-11-14 2015-11-12 Módszerek prader-willi szindrómával vagy smith-magenis szindrómával kezelt betegek kezelésére HUE050895T2 (hu)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201462080150P 2014-11-14 2014-11-14
US201562138245P 2015-03-25 2015-03-25
US201562170035P 2015-06-02 2015-06-02
US201562221359P 2015-09-21 2015-09-21

Publications (1)

Publication Number Publication Date
HUE050895T2 true HUE050895T2 (hu) 2021-01-28

Family

ID=55955075

Family Applications (1)

Application Number Title Priority Date Filing Date
HUE15859169A HUE050895T2 (hu) 2014-11-14 2015-11-12 Módszerek prader-willi szindrómával vagy smith-magenis szindrómával kezelt betegek kezelésére

Country Status (19)

Country Link
US (8) US10058557B2 (enExample)
EP (1) EP3217963B1 (enExample)
JP (4) JP6709226B2 (enExample)
KR (4) KR102323613B1 (enExample)
CN (2) CN113599386B (enExample)
AU (2) AU2015346196B2 (enExample)
BR (1) BR112017009986A2 (enExample)
CA (4) CA3125839C (enExample)
DK (1) DK3217963T3 (enExample)
EA (1) EA036103B1 (enExample)
ES (1) ES2806977T3 (enExample)
HU (1) HUE050895T2 (enExample)
IL (1) IL252111B (enExample)
MX (2) MX393030B (enExample)
MY (1) MY187610A (enExample)
NZ (1) NZ768958A (enExample)
PL (1) PL3217963T3 (enExample)
SG (1) SG11201703721SA (enExample)
WO (1) WO2016077629A1 (enExample)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE463249T1 (de) 2004-08-25 2010-04-15 Essentialis Inc Pharmazeutische formulierungen von kalium-atp- kanalöffnern und deren verwendungen
US9757384B2 (en) 2005-04-06 2017-09-12 Essentialis, Inc. Methods for treating subjects with Prader-Willi syndrome or Smith-Magenis syndrome
CN101868239B (zh) 2006-01-05 2015-06-10 伊森舍丽斯有限公司 钾atp通道开放剂的盐及其用途
ES2806977T3 (es) 2014-11-14 2021-02-19 Essentialis Inc Métodos para tratar sujetos con síndrome de Prader-Willi o síndrome de Smith-Magenis
RU2748294C2 (ru) 2016-06-03 2021-05-21 Зе Трастис Оф Коламбия Юниверсити Ин Зе Сити Оф Нью-Йорк Способ лечения синдрома прадера-вилли
US11382881B2 (en) 2017-05-05 2022-07-12 Nino Sorgente Methods and compositions for diagnosing and treating glaucoma
CA3062170A1 (en) 2017-05-05 2018-11-08 Nino Sorgente Methods and compositions for improving eye health
CA3112185C (en) * 2018-09-20 2025-10-07 Acadia Pharmaceuticals Inc. STABLE INTRANASAL FORMULATIONS OF CARBETOCINE
CN111888330B (zh) * 2020-09-18 2022-08-16 常州市第四制药厂有限公司 一种二氮嗪口服混悬溶液及制备方法
US20250360142A1 (en) * 2022-10-18 2025-11-27 Rhythm Pharmaceuticals, Inc. Novel atp-sensitive potassium channel potentiators, their preparation and use
WO2025057119A1 (en) * 2023-09-15 2025-03-20 Soleno Therapeutics, Inc. Methods of managing glycemic control in prader-willi syndrome patients

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ATE463249T1 (de) * 2004-08-25 2010-04-15 Essentialis Inc Pharmazeutische formulierungen von kalium-atp- kanalöffnern und deren verwendungen
CN101043879A (zh) * 2004-08-25 2007-09-26 伊森舍丽斯有限公司 钾atp通道开放剂的药物制剂及其应用
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CN101257897A (zh) * 2005-07-07 2008-09-03 西特里斯药业公司 用于治疗或预防肥胖、胰岛素抵抗障碍和线粒体相关障碍的方法和相关组合物
CN101868239B (zh) 2006-01-05 2015-06-10 伊森舍丽斯有限公司 钾atp通道开放剂的盐及其用途
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US20120238554A1 (en) 2007-07-02 2012-09-20 Cowen Neil M Salts of potassium atp channel openers and uses thereof
US20120053172A1 (en) * 2009-02-12 2012-03-01 Cooperatieve Mirzorg U.A. Use of a combination of diazoxide and metformin for treating obesity or obesity related disorders
RS58237B1 (sr) * 2011-12-15 2019-03-29 Millendo Therapeutics Sas Fragmenti neacilovanog grelina za upotrebu u lečenju prader-willi sindroma
WO2013130411A1 (en) 2012-02-27 2013-09-06 Essentialis, Inc. Salts of potassium atp channel openers and uses thereof
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WO2014197753A1 (en) 2013-06-08 2014-12-11 Sedogen, Llc Method of treating prader willi syndrome and conditions associated with low basal metabolic rate or hyperphagia
ES2806977T3 (es) 2014-11-14 2021-02-19 Essentialis Inc Métodos para tratar sujetos con síndrome de Prader-Willi o síndrome de Smith-Magenis

Also Published As

Publication number Publication date
US20210322434A1 (en) 2021-10-21
BR112017009986A2 (pt) 2018-02-14
CA3125835A1 (en) 2016-05-19
JP7645913B2 (ja) 2025-03-14
US12178823B1 (en) 2024-12-31
US12419895B1 (en) 2025-09-23
JP7232300B2 (ja) 2023-03-02
WO2016077629A1 (en) 2016-05-19
NZ731565A (en) 2021-06-25
EA036103B1 (ru) 2020-09-29
DK3217963T3 (da) 2020-07-20
US20190105327A1 (en) 2019-04-11
HK1243954A1 (en) 2018-07-27
JP2017533972A (ja) 2017-11-16
US20250288593A1 (en) 2025-09-18
NZ768958A (en) 2021-07-30
JP2021193148A (ja) 2021-12-23
US10874676B2 (en) 2020-12-29
CA3210794A1 (en) 2016-05-19
IL252111A0 (en) 2017-07-31
KR20230049760A (ko) 2023-04-13
KR20220124289A (ko) 2022-09-13
KR20170082625A (ko) 2017-07-14
CA2966907C (en) 2021-09-07
JP2023056025A (ja) 2023-04-18
EP3217963A1 (en) 2017-09-20
US12109216B2 (en) 2024-10-08
US20200147100A1 (en) 2020-05-14
KR102452254B1 (ko) 2022-10-11
CN113599386B (zh) 2025-12-05
SG11201703721SA (en) 2017-06-29
MY187610A (en) 2021-10-04
PL3217963T3 (pl) 2020-10-19
EP3217963A4 (en) 2018-07-04
US20250120979A1 (en) 2025-04-17
IL252111B (en) 2021-09-30
AU2019202906B2 (en) 2020-05-21
EP3217963B1 (en) 2020-05-20
US20240423996A1 (en) 2024-12-26
CA3125839A1 (en) 2016-05-19
AU2019202906A1 (en) 2019-05-16
CA3125835C (en) 2023-01-03
KR20210134843A (ko) 2021-11-10
JP6709226B2 (ja) 2020-06-10
US10456408B2 (en) 2019-10-29
MX2021003982A (es) 2022-06-09
CN113599386A (zh) 2021-11-05
CA2966907A1 (en) 2016-05-19
MX2017006244A (es) 2018-02-26
KR102598666B1 (ko) 2023-11-07
AU2015346196B2 (en) 2019-01-31
JP2020073566A (ja) 2020-05-14
US20240207284A1 (en) 2024-06-27
US20180021344A1 (en) 2018-01-25
KR102323613B1 (ko) 2021-11-09
AU2015346196A1 (en) 2017-06-29
CA3125839C (en) 2023-10-24
JP6955039B2 (ja) 2021-10-27
US12343348B2 (en) 2025-07-01
CN107106500A (zh) 2017-08-29
MX381305B (es) 2025-03-12
US10058557B2 (en) 2018-08-28
MX393030B (es) 2025-03-24
EA201791067A1 (ru) 2017-11-30
ES2806977T3 (es) 2021-02-19
CN107106500B (zh) 2021-07-30
KR102517840B1 (ko) 2023-04-05

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