BR112017009029A2 - ensaios de detecção de anticorpo anti-hcv de um indivíduo utilizando peptídeos de captura ns3 - Google Patents
ensaios de detecção de anticorpo anti-hcv de um indivíduo utilizando peptídeos de captura ns3Info
- Publication number
- BR112017009029A2 BR112017009029A2 BR112017009029A BR112017009029A BR112017009029A2 BR 112017009029 A2 BR112017009029 A2 BR 112017009029A2 BR 112017009029 A BR112017009029 A BR 112017009029A BR 112017009029 A BR112017009029 A BR 112017009029A BR 112017009029 A2 BR112017009029 A2 BR 112017009029A2
- Authority
- BR
- Brazil
- Prior art keywords
- individual
- peptides
- antibody detection
- conjugated
- capture peptides
- Prior art date
Links
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 7
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 5
- 238000001514 detection method Methods 0.000 title abstract 2
- 238000003556 assay Methods 0.000 title 1
- 238000000034 method Methods 0.000 abstract 2
- 108060004795 Methyltransferase Proteins 0.000 abstract 1
- 239000003638 chemical reducing agent Substances 0.000 abstract 1
- 238000002347 injection Methods 0.000 abstract 1
- 239000007924 injection Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 238000005406 washing Methods 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/576—Immunoassay; Biospecific binding assay; Materials therefor for hepatitis
- G01N33/5767—Immunoassay; Biospecific binding assay; Materials therefor for hepatitis non-A, non-B hepatitis
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/005—Assays involving biological materials from specific organisms or of a specific nature from viruses
- G01N2333/08—RNA viruses
- G01N2333/18—Togaviridae; Flaviviridae
- G01N2333/183—Flaviviridae, e.g. pestivirus, mucosal disease virus, bovine viral diarrhoea virus, classical swine fever virus (hog cholera virus) or border disease virus
- G01N2333/186—Hepatitis C; Hepatitis NANB
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/914—Hydrolases (3)
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2469/00—Immunoassays for the detection of microorganisms
- G01N2469/20—Detection of antibodies in sample from host which are directed against antigens from microorganisms
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Biotechnology (AREA)
- Analytical Chemistry (AREA)
- Cell Biology (AREA)
- Communicable Diseases (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Peptides Or Proteins (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
Abstract
a presente invenção fornece métodos, kits e composições para detectar anticorpos anti-hcv de um indivíduo em uma amostra utilizando peptídeos de captura ns3. em certas modalidades, são utilizados em conjunto, pelo menos, dois peptídeos de captura de helicase da ns3 (ns3h) e pelo menos dois peptídeos conjugados (por exemplo, peptídeos conjugados ns3h), o que permite uma ampla faixa dinâmica de detecção de anticorpos de um indivíduo em um ensaio de uma etapa. em outras modalidades, são fornecidos métodos para detectar anticorpos de um indivíduo específicos para ns3 sem o uso de um agente redutor. em algumas modalidades, os anticorpos de um indivíduo específicos para ns3 são detectados com uma "injeção dupla" de peptídeo conjugado ns3 (ex., peptídeo conjugado adicionado a uma amostra antes e depois da lavagem).
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201462072266P | 2014-10-29 | 2014-10-29 | |
PCT/US2015/057845 WO2016069762A2 (en) | 2014-10-29 | 2015-10-28 | Subject anti-hcv antibody detection assays employing ns3 capture peptides |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112017009029A2 true BR112017009029A2 (pt) | 2018-02-06 |
Family
ID=54479000
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112017009029A BR112017009029A2 (pt) | 2014-10-29 | 2015-10-28 | ensaios de detecção de anticorpo anti-hcv de um indivíduo utilizando peptídeos de captura ns3 |
Country Status (8)
Country | Link |
---|---|
US (3) | US10088483B2 (pt) |
EP (1) | EP3213083B1 (pt) |
JP (2) | JP6821562B2 (pt) |
KR (1) | KR102441636B1 (pt) |
CN (1) | CN107110868B (pt) |
BR (1) | BR112017009029A2 (pt) |
ES (1) | ES2828713T3 (pt) |
WO (1) | WO2016069762A2 (pt) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US10088483B2 (en) | 2014-10-29 | 2018-10-02 | Abbott Laboratories | Subject anti-HCV antibody detection assays employing NS3 capture peptides |
KR20200032695A (ko) * | 2017-07-27 | 2020-03-26 | 에프. 호프만-라 로슈 아게 | Hcv 항원의 다중-에피토프 융합 단백질 및 이의 용도 |
CN112341527B (zh) * | 2020-09-16 | 2021-08-31 | 菲鹏生物股份有限公司 | Hcv重组抗原及应用 |
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US5063081A (en) | 1988-11-14 | 1991-11-05 | I-Stat Corporation | Method of manufacturing a plurality of uniform microfabricated sensing devices having an immobilized ligand receptor |
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CA2131727A1 (en) | 1992-03-30 | 1993-10-14 | Diana E. Clarisse | Reagents and methods for the detection and quantification of thyroxine in fluid samples |
DE4428705A1 (de) * | 1994-08-12 | 1996-02-15 | Boehringer Mannheim Gmbh | Rekombinantes Antigen aus der NS3-Region des Hepatitis C Virus |
NZ516848A (en) | 1997-06-20 | 2004-03-26 | Ciphergen Biosystems Inc | Retentate chromatography apparatus with applications in biology and medicine |
ATE340870T1 (de) | 1998-04-03 | 2006-10-15 | Compound Therapeutics Inc | Adressierbare protein arrays |
PT1071955E (pt) | 1998-04-17 | 2005-02-28 | Innogenetics Nv | Ensaios melhorados de diagnostico imunologico utilizando agentes redutores |
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US7101683B2 (en) | 2001-06-26 | 2006-09-05 | Abbott Laboratories | Methods for the simultaneous detection of HCV antigens and HCV antibodies |
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US20040018577A1 (en) | 2002-07-29 | 2004-01-29 | Emerson Campbell John Lewis | Multiple hybrid immunoassay |
US20040152070A1 (en) * | 2003-02-04 | 2004-08-05 | Shah Dinesh O. | Method of detection of HCV antibodies in combination assay or sole antibody assay |
US20050014136A1 (en) | 2003-05-28 | 2005-01-20 | Innogenetics N.V. | Modified HCV NS5 |
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US10088483B2 (en) * | 2014-10-29 | 2018-10-02 | Abbott Laboratories | Subject anti-HCV antibody detection assays employing NS3 capture peptides |
-
2015
- 2015-10-28 US US14/925,778 patent/US10088483B2/en active Active
- 2015-10-28 JP JP2017523343A patent/JP6821562B2/ja active Active
- 2015-10-28 BR BR112017009029A patent/BR112017009029A2/pt active Search and Examination
- 2015-10-28 ES ES15791861T patent/ES2828713T3/es active Active
- 2015-10-28 EP EP15791861.6A patent/EP3213083B1/en active Active
- 2015-10-28 KR KR1020177014533A patent/KR102441636B1/ko active IP Right Grant
- 2015-10-28 CN CN201580071470.XA patent/CN107110868B/zh active Active
- 2015-10-28 WO PCT/US2015/057845 patent/WO2016069762A2/en active Application Filing
-
2018
- 2018-09-05 US US16/122,261 patent/US10816551B2/en active Active
-
2020
- 2020-10-15 US US17/071,976 patent/US11340230B2/en active Active
-
2021
- 2021-01-05 JP JP2021000346A patent/JP2021063827A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
JP2021063827A (ja) | 2021-04-22 |
EP3213083B1 (en) | 2020-08-19 |
US20160131653A1 (en) | 2016-05-12 |
JP2017534056A (ja) | 2017-11-16 |
WO2016069762A3 (en) | 2016-07-07 |
WO2016069762A2 (en) | 2016-05-06 |
US10088483B2 (en) | 2018-10-02 |
US20210041442A1 (en) | 2021-02-11 |
KR102441636B1 (ko) | 2022-09-13 |
ES2828713T3 (es) | 2021-05-27 |
US10816551B2 (en) | 2020-10-27 |
US20190064169A1 (en) | 2019-02-28 |
EP3213083A2 (en) | 2017-09-06 |
CN107110868A (zh) | 2017-08-29 |
JP6821562B2 (ja) | 2021-01-27 |
US11340230B2 (en) | 2022-05-24 |
KR20170072338A (ko) | 2017-06-26 |
CN107110868B (zh) | 2020-08-21 |
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