BR112017004727A2 - dispositivo para aplicação de agente terapêutico com agulha e cânula avançáveis - Google Patents

dispositivo para aplicação de agente terapêutico com agulha e cânula avançáveis

Info

Publication number
BR112017004727A2
BR112017004727A2 BR112017004727A BR112017004727A BR112017004727A2 BR 112017004727 A2 BR112017004727 A2 BR 112017004727A2 BR 112017004727 A BR112017004727 A BR 112017004727A BR 112017004727 A BR112017004727 A BR 112017004727A BR 112017004727 A2 BR112017004727 A2 BR 112017004727A2
Authority
BR
Brazil
Prior art keywords
cannula
needle
therapeutic agent
actuation assembly
choroid
Prior art date
Application number
BR112017004727A
Other languages
English (en)
Other versions
BR112017004727B1 (pt
Inventor
L Ko Benjamin
J Oberkircher Brendan
W Price Daniel
J Khan Isaac
F Keane Michael
D Gordon Paul
h roth Robert
e meyer Thomas
Original Assignee
Janssen Biotech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Biotech Inc filed Critical Janssen Biotech Inc
Publication of BR112017004727A2 publication Critical patent/BR112017004727A2/pt
Publication of BR112017004727B1 publication Critical patent/BR112017004727B1/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/02—Surgical instruments, devices or methods, e.g. tourniquets for holding wounds open; Tractors
    • A61B17/0231—Surgical instruments, devices or methods, e.g. tourniquets for holding wounds open; Tractors for eye surgery
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/34—Trocars; Puncturing needles
    • A61B17/3417—Details of tips or shafts, e.g. grooves, expandable, bendable; Multiple coaxial sliding cannulas, e.g. for dilating
    • A61B17/3421—Cannulas
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00—Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • A61F9/0008—Introducing ophthalmic products into the ocular cavity or retaining products therein
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00—Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • A61F9/0008—Introducing ophthalmic products into the ocular cavity or retaining products therein
    • A61F9/0017—Introducing ophthalmic products into the ocular cavity or retaining products therein implantable in, or in contact with, the eye, e.g. ocular inserts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00—Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • A61F9/007—Methods or devices for eye surgery
    • A61F9/00736—Instruments for removal of intra-ocular material or intra-ocular injection, e.g. cataract instruments
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/34—Trocars; Puncturing needles
    • A61B17/3478—Endoscopic needles, e.g. for infusion
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/34—Trocars; Puncturing needles
    • A61B2017/347—Locking means, e.g. for locking instrument in cannula
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00—Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • A61F9/007—Methods or devices for eye surgery
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2210/00—Anatomical parts of the body
    • A61M2210/06—Head
    • A61M2210/0612—Eyes

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Surgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Vascular Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Medical Informatics (AREA)
  • Pathology (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Prostheses (AREA)

Abstract

a presente invenção se refere a um aparelho (410) para a aplicação de agente terapêutico a um olho, que compreende um corpo (440), uma cânula (420), uma agulha oca (430), um conjunto de atuação de cânula (500) e um conjunto de atuação de agulha (550). a cânula se estende distalmente a partir do corpo e é dimensionada e configurada para ser passível de inserção entre uma coroide e uma esclera do olho de um paciente. o conjunto de atuação de cânula é operável para atuar a cânula em relação ao corpo. o conjunto de atuação de agulha é operável para atuar a agulha em relação à cânula. a cânula pode ser inserida através de uma esclerotomia para posicionar uma extremidade distal da cânula em uma região posterior do olho, entre a coroide e a esclera. a agulha pode ser avançada através da coroide para liberar o agente terapêutico adjacente ao espaço potencial entre a retina neurossensorial e a camada de epitélio pigmentar retiniano, adjacente à área de atrofia geográfica.
BR112017004727-6A 2014-09-11 2015-09-10 Dispositivo para aplicação de agente terapêutico com agulha e cânula avançáveis BR112017004727B1 (pt)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201462049135P 2014-09-11 2014-09-11
US62/049,135 2014-09-11
US14/840,676 US10219936B2 (en) 2014-09-11 2015-08-31 Therapeutic agent delivery device with advanceable cannula and needle
US14/840,676 2015-08-31
PCT/US2015/049432 WO2016040636A1 (en) 2014-09-11 2015-09-10 Therapeutic agent delivery device with advanceable cannula and needle

Publications (2)

Publication Number Publication Date
BR112017004727A2 true BR112017004727A2 (pt) 2017-12-05
BR112017004727B1 BR112017004727B1 (pt) 2021-12-21

Family

ID=55453674

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112017004727-6A BR112017004727B1 (pt) 2014-09-11 2015-09-10 Dispositivo para aplicação de agente terapêutico com agulha e cânula avançáveis

Country Status (16)

Country Link
US (1) US10219936B2 (pt)
EP (2) EP3191031B1 (pt)
JP (1) JP6608433B2 (pt)
KR (1) KR102268213B1 (pt)
CN (2) CN110960348A (pt)
AU (1) AU2015315045B2 (pt)
BR (1) BR112017004727B1 (pt)
CA (1) CA2960975C (pt)
ES (1) ES2961233T3 (pt)
MA (1) MA40630A (pt)
MX (1) MX2017003261A (pt)
PH (1) PH12017500460A1 (pt)
RU (1) RU2703689C2 (pt)
SG (1) SG11201701969WA (pt)
WO (1) WO2016040636A1 (pt)
ZA (1) ZA201702520B (pt)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9320647B2 (en) 2010-03-31 2016-04-26 Ocuject, Llc Device and method for intraocular drug delivery
US9408746B2 (en) 2010-03-31 2016-08-09 Ocuject, Llc Device and method for intraocular drug delivery
US9504603B2 (en) 2012-04-02 2016-11-29 Ocuject, Llc Intraocular delivery devices and methods therefor
US9421129B2 (en) 2012-04-02 2016-08-23 Ocuject, Llc Intraocular delivery devices and methods therefor
USD746443S1 (en) * 2013-10-02 2015-12-29 Medical Instrument Development Laboratories, Inc. Cannula insertion tool
US9968372B2 (en) 2013-10-02 2018-05-15 Medical Instrument Development Laboratories, Inc. Cannula insertion tool
BR122020011777B1 (pt) 2013-11-14 2022-01-25 AqueSys, Inc Dispositivo de inserção para o tratamento de glaucoma
EP3797742A1 (en) 2014-02-12 2021-03-31 Gyroscope Therapeutics Limited Apparatus for suprachoroidal administration of therapeutic agent
US10258502B2 (en) 2014-09-18 2019-04-16 Orbit Biomedical Limited Therapeutic agent delivery device
AU2016372824B2 (en) * 2015-12-14 2021-05-20 Alcon Inc. Uni-port hybrid gauge surgical apparatuses and methods
US10478553B2 (en) * 2016-03-09 2019-11-19 Orbit Biomedical Limited Apparatus for subretinal administration of therapeutic agent via a curved needle
US10390814B2 (en) 2016-04-20 2019-08-27 Medos International Sarl Meniscal repair devices, systems, and methods
US10806629B2 (en) 2016-06-17 2020-10-20 Gyroscope Therapeutics Limited Injection device for subretinal delivery of therapeutic agent
US10646374B2 (en) 2016-06-17 2020-05-12 Orbit Biomedical Limited Apparatus and method to form entry bleb for subretinal delivery of therapeutic agent
US11000410B2 (en) 2016-06-17 2021-05-11 Gyroscope Therapeutics Limited Guide apparatus for tangential entry into suprachoroidal space
JP7153650B2 (ja) * 2016-12-19 2022-10-14 ニュー ワールド メディカル インコーポレイテッド 眼球治療装置、及び関連する使用方法
US11273072B2 (en) 2017-01-13 2022-03-15 Gyroscope Therapeutics Limited Suprachoroidal injection device
US11076984B2 (en) 2017-03-13 2021-08-03 Gyroscope Therapeutics Limited Method of performing subretinal drainage and agent delivery
CA3093160A1 (en) * 2018-03-09 2019-09-12 Aquesys, Inc. Intraocular shunt inserter
US20190374248A1 (en) * 2018-06-06 2019-12-12 Alcon Inc. Trocar cannula with a guidance valve
KR20210053309A (ko) * 2018-08-29 2021-05-11 텔 하쇼머 메디컬 리서치 인프라스트럭쳐 앤드 서비시스 리미티드． 안구 수술 기구
US10722397B2 (en) 2018-10-24 2020-07-28 New World Medical, Inc. Ophthalmic device
CN113226230B (zh) * 2018-10-24 2023-10-03 新世界医学有限公司 眼科装置
US11759355B1 (en) 2019-02-26 2023-09-19 Gyroscope Therapeutics Limited Method of delivering leading blebs and agent to subretinal space
AU2020362958A1 (en) 2019-10-11 2022-04-14 Gyroscope Therapeutics Limited Dose clip assembly for syringe
MX2023001752A (es) * 2020-08-12 2023-02-22 Regeneron Pharma Sistemas y metodos para administracion de farmaco al tejido ocular.
WO2023132505A1 (ko) * 2022-01-04 2023-07-13 이오플로우㈜ 니들 어셈블리 및 이를 포함하는 약액 주입 장치
US20230301832A1 (en) * 2022-03-23 2023-09-28 New World Medical, Inc. Ophthalmic device
WO2024052733A1 (en) 2022-09-06 2024-03-14 Gyroscope Therapeutics Limited Apparatus for subretinal administration of therapeutic agent via dual-curved needle

Family Cites Families (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1285441C (en) * 1987-03-17 1991-07-02 Roy D. Mcnaughton Mcnaughton syringe shield type b
DE19741487C2 (de) * 1997-09-19 2000-08-31 Univ Eberhard Karls Vorrichtung für einen Zugang in den Subretinalraum eines Auges
US6368315B1 (en) 1999-06-23 2002-04-09 Durect Corporation Composite drug delivery catheter
US6585694B1 (en) * 2000-09-07 2003-07-01 Syntheon, Llc Knob-controlled endoscopic needle device
US7431710B2 (en) * 2002-04-08 2008-10-07 Glaukos Corporation Ocular implants with anchors and methods thereof
AU2003213075A1 (en) 2002-02-14 2003-09-04 Henry J. Kaplan Subretinal implantation device and surgical cannulas for use therewith
CN101791258A (zh) * 2002-07-19 2010-08-04 耶鲁大学 色素层巩膜引流装置
AU2003279055A1 (en) 2002-09-29 2004-04-19 Surmodics, Inc. Methods for treatment and/or prevention of retinal disease
US20040199130A1 (en) * 2003-04-03 2004-10-07 Chornenky Victor I. Apparatus and method for treatment of macular degeneration
JP4950660B2 (ja) 2003-06-27 2012-06-13 エチコン、インコーポレイテッド 分娩後由来細胞を使用する眼組織の修復および再生
US6939325B2 (en) * 2003-11-28 2005-09-06 Michael L. Haining Intravenous catheter and insertion device
EP2248494B1 (en) 2004-01-23 2013-06-05 iScience Interventional Corporation Composite ophthalmic microcannula
EP2380622A1 (en) * 2004-04-29 2011-10-26 iScience Interventional Corporation Method for ocular treatment
US20080058704A1 (en) 2004-04-29 2008-03-06 Michael Hee Apparatus and Method for Ocular Treatment
EP2468327A1 (en) * 2004-04-29 2012-06-27 iScience Interventional Corporation Apparatus and method for surgical enhancement of aqueous humor drainage
US20070060887A1 (en) * 2005-08-22 2007-03-15 Marsh David A Ophthalmic injector
ES2551782T3 (es) * 2006-01-17 2015-11-23 Transcend Medical, Inc. Dispositivo para el tratamiento de glaucoma
US20070202186A1 (en) 2006-02-22 2007-08-30 Iscience Interventional Corporation Apparatus and formulations for suprachoroidal drug delivery
US8197435B2 (en) 2006-05-02 2012-06-12 Emory University Methods and devices for drug delivery to ocular tissue using microneedle
US20120197175A1 (en) 2006-06-30 2012-08-02 Aquesys, Inc. Methods, systems and apparatus for relieving pressure in an organ
KR20090057984A (ko) * 2006-09-19 2009-06-08 더 트러스티이스 오브 콜롬비아 유니버시티 인 더 시티 오브 뉴욕 중공형 해부학적 부유 기관 상에서의 수술을 위한 시스템, 디바이스 및 방법
US20080281292A1 (en) * 2006-10-16 2008-11-13 Hickingbotham Dyson W Retractable Injection Port
US9399130B2 (en) * 2007-04-25 2016-07-26 Medtronic, Inc. Cannula configured to deliver test stimulation
EP2173289A4 (en) * 2007-07-17 2010-11-24 Transcend Medical Inc EYE IMPLANT WITH HYDROGEL EXPANSION CAPABILITIES
NZ586144A (en) * 2008-01-07 2012-11-30 Salutaris Md Curved cannula for delivery of radiation to the posterior portion of the eye
AU2009221859B2 (en) * 2008-03-05 2013-04-18 Alcon Inc. Methods and apparatus for treating glaucoma
US8425473B2 (en) * 2009-01-23 2013-04-23 Iscience Interventional Corporation Subretinal access device
US8287494B2 (en) 2009-03-23 2012-10-16 Colin Ma Intravitreal injection devices and methods of injecting a substance into the vitreous chamber of the eye
CA2762071A1 (en) 2009-05-15 2010-11-18 Iscience Interventional Corporation Methods and apparatus for sub-retinal catheterization
WO2011050360A1 (en) * 2009-10-23 2011-04-28 Ivantis, Inc. Ocular implant system and method
US9408746B2 (en) 2010-03-31 2016-08-09 Ocuject, Llc Device and method for intraocular drug delivery
US8523873B2 (en) * 2010-04-08 2013-09-03 Warsaw Orthopedic, Inc. Neural-monitoring enabled sleeves for surgical instruments
JP5996544B2 (ja) 2010-10-15 2016-09-21 クリアサイド・バイオメディカル・インコーポレーテッドＣｌｅａｒｓｉｄｅ Ｂｉｏｍｅｄｉｃａｌ Ｉｎｃｏｒｐｏｒａｔｅｄ 眼球アクセス用装置
US8663150B2 (en) * 2011-12-19 2014-03-04 Ivantis, Inc. Delivering ocular implants into the eye
US9095412B2 (en) * 2012-03-20 2015-08-04 Sight Sciences, Inc. Ocular delivery systems and methods
US9241832B2 (en) * 2012-04-24 2016-01-26 Transcend Medical, Inc. Delivery system for ocular implant
US20150209180A1 (en) 2012-08-27 2015-07-30 Clearside Biomedical, Inc. Apparatus and Methods for Drug Delivery Using Microneedles
CN104884049A (zh) 2012-11-08 2015-09-02 克莱尔塞德生物医学股份有限公司 用于在人类受试者中治疗眼部疾病的方法和装置
EP3797742A1 (en) 2014-02-12 2021-03-31 Gyroscope Therapeutics Limited Apparatus for suprachoroidal administration of therapeutic agent
US20180042765A1 (en) 2014-06-17 2018-02-15 Clearside Biomedical, Inc. Methods and devices for treating posterior ocular disorders
MX2016017028A (es) 2014-06-20 2017-08-07 Clearside Biomedical Inc Canula de diametro variable y metodos para el control de la profundidad de insercion para administracion de medicamentos.
CA2956273A1 (en) * 2014-08-12 2016-02-18 Patrick Gooi Device, delivery system, and method for ocular therapy
GB201516066D0 (en) 2015-09-10 2015-10-28 Young & Co Llp D Treatment of retinitis pigmentosa

Also Published As

Publication number Publication date
CA2960975C (en) 2021-05-18
ZA201702520B (en) 2019-06-26
EP4248922A2 (en) 2023-09-27
MX2017003261A (es) 2018-02-23
ES2961233T3 (es) 2024-03-11
KR20170052663A (ko) 2017-05-12
BR112017004727B1 (pt) 2021-12-21
RU2017112035A3 (pt) 2019-04-12
CN106999294A (zh) 2017-08-01
EP4248922A3 (en) 2024-01-10
AU2015315045B2 (en) 2019-04-04
RU2017112035A (ru) 2018-10-11
SG11201701969WA (en) 2017-04-27
CA2960975A1 (en) 2016-03-17
EP3191031A1 (en) 2017-07-19
MA40630A (fr) 2016-03-17
WO2016040636A1 (en) 2016-03-17
EP3191031B1 (en) 2023-08-16
US20160074211A1 (en) 2016-03-17
AU2015315045A1 (en) 2017-03-30
RU2703689C2 (ru) 2019-10-21
CN110960348A (zh) 2020-04-07
JP6608433B2 (ja) 2019-11-20
PH12017500460A1 (en) 2017-07-31
KR102268213B1 (ko) 2021-06-24
US10219936B2 (en) 2019-03-05
JP2017526477A (ja) 2017-09-14

Similar Documents

Publication Publication Date Title
BR112017004727A2 (pt) dispositivo para aplicação de agente terapêutico com agulha e cânula avançáveis
BR112017004828A2 (pt) injeção supracoroidal motorizada de agente terapêutico
BR112017004822A2 (pt) método e aparelho para detecção de posição entre as camadas de um olho
BR112017005790A2 (pt) dispositivos de reparo vascular e métodos de uso
BR112018067896A2 (pt) aparelho para administração sub-retinal de agente terapêutico através de uma agulha curva
BR112019004857A2 (pt) composições farmacêuticas
BR112015017803A2 (pt) interface de paciente birradial
BR112016028550A2 (pt) guia e introdutor do cateter com agulha sub-retinal tangencial
WO2015095772A3 (en) Formulations and methods for targeted ocular delivery of therapeutic agents
MX2016016836A (es) Metodos y dispositivos para tratar trastornos oculares posteriores.
BR112018012876A2 (pt) bisturi oftálmico e métodos de uso
BR112015027723A2 (pt) dispositivo para entrega de medicamento
BR112014008789A2 (pt) prevenção e tratamento de condições oculares
BR112014016938A2 (pt) método, kit cirúrgico e dispositivo para tratar glaucoma
BR112016007096A2 (pt) dispositivo de agulha de segurança
BR112015010566A2 (pt) métodos e dispositivos para o tratamento de doenças oculares em indivíduos humanos
EA201590502A1 (ru) Система доставки глазного имплантата
WO2015195748A3 (en) Devices and methods to provide hands free scleral depression during ophthalmic procedures
MX355770B (es) Composicion farmaceutica de ibuprofeno y tramadol para uso oftalmico.
MX2018001918A (es) Aplicación cuantitativa periorbital de farmacos oftalmologicos.
BR112017002985A2 (pt) conjunto e porta de acesso cirúrgico
BR112016015490A2 (pt) Aparelho, que inclui uma fonte de luz, para tratamento endoscópico ou intracraniano
BR112012023749A2 (pt) método para reduzir a pressão intraocular em humanos utilizando n6-ciclopentiladenosina (cpa), derivados de cpa ou pró-fármacos desses
CL2020001426A1 (es) Composición tópica oftálmica que comprende ácido dobesilico para tratar enfermedades del segmento posterior del ojo.
EP3737381A4 (en) MEDICAL DEVICE AND PHARMACEUTICAL COMPOSITION FOR TREATMENT OF AN EYE DISEASE OR DISEASE

Legal Events

Date Code Title Description
B25A Requested transfer of rights approved

Owner name: ORBIT MEDICAL LIMITED (GB)

B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B25G Requested change of headquarter approved

Owner name: ORBIT MEDICAL LIMITED (GB)

B25A Requested transfer of rights approved

Owner name: GYROSCOPE THERAPEUTICS LIMITED (UK)

B09A Decision: intention to grant [chapter 9.1 patent gazette]
B25G Requested change of headquarter approved

Owner name: GYROSCOPE THERAPEUTICS LIMITED (UK)

B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 10/09/2015, OBSERVADAS AS CONDICOES LEGAIS.