BR112017003891A2 - métodos e composições para induzir imunidade protetora contra infecção por filovírus - Google Patents

métodos e composições para induzir imunidade protetora contra infecção por filovírus

Info

Publication number
BR112017003891A2
BR112017003891A2 BR112017003891A BR112017003891A BR112017003891A2 BR 112017003891 A2 BR112017003891 A2 BR 112017003891A2 BR 112017003891 A BR112017003891 A BR 112017003891A BR 112017003891 A BR112017003891 A BR 112017003891A BR 112017003891 A2 BR112017003891 A2 BR 112017003891A2
Authority
BR
Brazil
Prior art keywords
immunity against
protective immunity
compositions
methods
inducing protective
Prior art date
Application number
BR112017003891A
Other languages
English (en)
Inventor
Volkmann Ariane
Christophe Stephan Callendret Benoit
A Ward Lucy
Grazia Pau Maria
Steigerwald Robin
DIRMEIER Ulrike
Original Assignee
Bavarian Nordic As
Janssen Vaccines & Prevention Bv
Us Health
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bavarian Nordic As, Janssen Vaccines & Prevention Bv, Us Health filed Critical Bavarian Nordic As
Publication of BR112017003891A2 publication Critical patent/BR112017003891A2/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5254—Virus avirulent or attenuated
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5256—Virus expressing foreign proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
    • A61K2039/572—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2 cytotoxic response
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
    • A61K2039/575—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2 humoral response
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/70—Multivalent vaccine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/10011—Adenoviridae
    • C12N2710/10041—Use of virus, viral particle or viral elements as a vector
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/24011—Poxviridae
    • C12N2710/24041—Use of virus, viral particle or viral elements as a vector
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/14011—Filoviridae
    • C12N2760/14111—Ebolavirus, e.g. Zaire ebolavirus
    • C12N2760/14134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/14011—Filoviridae
    • C12N2760/14111—Ebolavirus, e.g. Zaire ebolavirus
    • C12N2760/14171—Demonstrated in vivo effect
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/14011—Filoviridae
    • C12N2760/14211—Marburgvirus, e.g. lake Victoria marburgvirus
    • C12N2760/14234—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Virology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Microbiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

a presente invenção se refere a composições, vacinas e métodos para induzir a imunidade protetora contra a infecção por filo-vírus, particularmente a imunidade protetora contra a infecção de um ou mais subtipos de ebolavírus e vírus de marburg.
BR112017003891A 2014-09-03 2015-09-03 métodos e composições para induzir imunidade protetora contra infecção por filovírus BR112017003891A2 (pt)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201462045522P 2014-09-03 2014-09-03
US201562116021P 2015-02-13 2015-02-13
US201562189109P 2015-07-06 2015-07-06
PCT/US2015/048357 WO2016036955A1 (en) 2014-09-03 2015-09-03 Methods and compositions for inducing protective immunity against filovirus infection

Publications (1)

Publication Number Publication Date
BR112017003891A2 true BR112017003891A2 (pt) 2017-12-26

Family

ID=54186280

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112017003891A BR112017003891A2 (pt) 2014-09-03 2015-09-03 métodos e composições para induzir imunidade protetora contra infecção por filovírus

Country Status (26)

Country Link
US (3) US10561721B2 (pt)
EP (2) EP3188753B1 (pt)
JP (1) JP6462861B2 (pt)
KR (1) KR101963985B1 (pt)
CN (1) CN107454848B (pt)
AU (1) AU2015311852B2 (pt)
BR (1) BR112017003891A2 (pt)
CA (1) CA2960092C (pt)
DK (2) DK3656395T3 (pt)
EA (1) EA035504B1 (pt)
ES (1) ES2777323T3 (pt)
FI (1) FI3656395T3 (pt)
HR (2) HRP20240163T1 (pt)
HU (1) HUE048318T2 (pt)
IL (1) IL250743B (pt)
LT (2) LT3188753T (pt)
MX (1) MX2017002889A (pt)
MY (1) MY183072A (pt)
NZ (1) NZ730511A (pt)
PL (2) PL3656395T3 (pt)
PT (2) PT3188753T (pt)
SG (1) SG11201701741QA (pt)
SI (2) SI3188753T1 (pt)
UA (1) UA125013C2 (pt)
WO (1) WO2016036955A1 (pt)
ZA (1) ZA201701815B (pt)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3023098A1 (en) * 2016-05-05 2017-11-09 The Trustees Of The University Of Pennsylvania Filovirus consensus antigens, nucleic acid constructs and vaccines made therefrom, and methods of using same
US10925955B2 (en) 2016-07-15 2021-02-23 Janssen Vaccines & Prevention B.V. Methods and compositions for inducing protective immunity against a Marburg virus infection
WO2018011768A1 (en) * 2016-07-15 2018-01-18 Janssen Vaccines And Prevention B.V. Methods and compositions for inducing protective immunity against a marburg virus infection
US11173204B2 (en) 2017-04-06 2021-11-16 Janssen Vaccines & Prevention B.V. MVA-BN and Ad26.ZEBOV or Ad26.filo prime-boost regimen
CA3083576A1 (en) * 2017-09-07 2019-03-14 Hawaii Biotech, Inc. Filovirus vaccine and methods of use
WO2020049151A1 (en) 2018-09-06 2020-03-12 Bavarian Nordic A/S Storage improved poxvirus compositions
JP2023516201A (ja) 2020-03-12 2023-04-18 バヴァリアン・ノルディック・アクティーゼルスカブ ポックスウイルスの安定性を改善する組成物
WO2023198815A1 (en) 2022-04-14 2023-10-19 Janssen Vaccines & Prevention B.V. Sequential administration of adenoviruses

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1341245C (en) 1988-01-12 2001-06-05 F. Hoffmann-La Roche Ag Recombinant vaccinia virus mva
AU4255397A (en) 1996-09-06 1998-03-26 Trustees Of The University Of Pennsylvania, The Chimpanzee adenovirus vectors
GB0023203D0 (en) 2000-09-21 2000-11-01 Isis Innovation Vaccination method
WO2000000616A2 (en) * 1998-06-29 2000-01-06 U.S. Medical Research Institute Of Infectious Diseases Marburg virus vaccines
WO2000008131A2 (en) * 1998-08-04 2000-02-17 Purdue Research Foundation Pseudotyped retroviruses and stable cell lines for their production
KR100741247B1 (ko) 1999-05-17 2007-07-19 크루셀 홀란드 비.브이. 아데노바이러스 타입 35의 적어도 하나의 구성성분을포함하는 아데노바이러스 유래 유전자 전달체
US6913922B1 (en) 1999-05-18 2005-07-05 Crucell Holland B.V. Serotype of adenovirus and uses thereof
DK1335987T4 (en) 2000-11-23 2016-09-19 Bavarian Nordic As Modified variant of vaccinia virus Ankara
JP2005517639A (ja) * 2001-11-30 2005-06-16 イシス イノベーション リミテッド ワクチン
CN101397574A (zh) 2001-12-04 2009-04-01 巴法里安诺迪克有限公司 黄病毒ns1亚单位疫苗
DK1497438T3 (da) 2002-04-25 2010-01-04 Crucell Holland Bv Midler og fremgangsmåder til fremstilling af adenovirusvektorer
PL208588B1 (pl) 2002-04-25 2011-05-31 Crucell Holland Bv Rekombinowane adenowirusy, wyizolowane kwasy nukleinowe, komórki pakujące oraz sposoby zwiększania stabilności i/lub pojemności upakowania rekombinowanego adenowirusa
PL2163260T3 (pl) 2004-01-23 2017-12-29 Msd Italia S.R.L. Szympansie adenowirusowe nośniki szczepionek
JP5046941B2 (ja) 2004-09-27 2012-10-10 アメリカ合衆国 エボラ及び他のウイルスに対する防御に最適化されたワクチン
US20100143302A1 (en) 2006-03-16 2010-06-10 Crucell Holland B.V. Recombinant Adenoviruses Based on Serotype 26 and 48, and Use Thereof
US8603468B2 (en) 2007-11-06 2013-12-10 The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services Neutralization of HCV
WO2010057650A1 (en) * 2008-11-21 2010-05-27 Bavarian Nordic A/S Vector comprising multiple homologous nucleotide sequences
KR101763093B1 (ko) 2009-02-02 2017-07-28 글락소스미스클라인 바이오로지칼즈 에스.에이. 시미안 아데노바이러스 핵산- 및 아미노산-서열, 이를 포함하는 벡터 및 이의 용도
WO2010085984A1 (en) 2009-02-02 2010-08-05 Okairos Ag Simian adenovirus nucleic acid- and amino acid-sequences, vectors containing same, and uses thereof
EP2529010B1 (en) 2010-01-28 2017-04-19 Bavarian Nordic A/S Vaccinia virus mutants containing the major genomic deletions of mva
WO2011130627A2 (en) * 2010-04-16 2011-10-20 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Chimpanzee adenoviral vector-based filovirus vaccines
US9701718B2 (en) * 2010-12-14 2017-07-11 Janssen Vaccines & Prevention B.V. Adenovirus serotype 26 and serotype 35 filovirus vaccines
WO2012106490A1 (en) * 2011-02-03 2012-08-09 The Government Of The U.S.A., As Represented By The Secretary, Department Of Health & Human Services Multivalent vaccines for rabies virus and filoviruses
KR20220012403A (ko) * 2012-04-12 2022-02-03 더 트러스티스 오브 더 유니버시티 오브 펜실베니아 필로바이러스 공통 항원, 이로부터 제조된 핵산 구조체 및 백신, 및 이를 사용하는 방법
WO2014005643A1 (en) * 2012-07-05 2014-01-09 Okairos Ag Novel prime-boosting regimens involving immunogenic polypeptides encoded by polynucleotides
WO2014037124A1 (en) * 2012-09-04 2014-03-13 Bavarian Nordic A/S Methods and compositions for enhancing vaccine immune responses
GB201303406D0 (en) 2013-02-26 2013-04-10 Health Prot Agency Crimean-Congo Haemorrhagic Fever Virus Antigenic Composition

Also Published As

Publication number Publication date
HUE048318T2 (hu) 2020-07-28
US20200038500A1 (en) 2020-02-06
CN107454848B (zh) 2021-06-22
IL250743B (en) 2022-08-01
MY183072A (en) 2021-02-10
DK3188753T3 (da) 2020-03-23
ZA201701815B (en) 2021-01-27
WO2016036955A1 (en) 2016-03-10
US11173201B2 (en) 2021-11-16
EP3656395A1 (en) 2020-05-27
EP3656395B1 (en) 2023-11-08
EP3188753B1 (en) 2019-12-18
AU2015311852A1 (en) 2017-04-20
CA2960092A1 (en) 2016-03-10
KR20170058952A (ko) 2017-05-29
UA125013C2 (uk) 2021-12-29
LT3188753T (lt) 2020-04-10
PL3656395T3 (pl) 2024-04-02
SI3188753T1 (sl) 2020-07-31
KR101963985B1 (ko) 2019-07-31
US20170290904A1 (en) 2017-10-12
PL3188753T3 (pl) 2020-05-18
EP3188753A1 (en) 2017-07-12
CN107454848A (zh) 2017-12-08
PT3656395T (pt) 2024-02-09
US20220088170A1 (en) 2022-03-24
NZ730511A (en) 2022-04-29
DK3656395T3 (da) 2024-02-12
FI3656395T3 (fi) 2024-02-05
JP2017527568A (ja) 2017-09-21
CA2960092C (en) 2021-05-04
US11918639B2 (en) 2024-03-05
SI3656395T1 (sl) 2024-03-29
EA035504B1 (ru) 2020-06-25
SG11201701741QA (en) 2017-04-27
HRP20240163T1 (hr) 2024-04-12
JP6462861B2 (ja) 2019-01-30
PT3188753T (pt) 2020-03-25
IL250743A0 (en) 2017-04-30
LT3656395T (lt) 2024-02-26
ES2777323T3 (es) 2020-08-04
AU2015311852B2 (en) 2018-12-13
EA201790517A1 (ru) 2017-07-31
US10561721B2 (en) 2020-02-18
HRP20200285T1 (hr) 2020-08-07
MX2017002889A (es) 2017-10-11

Similar Documents

Publication Publication Date Title
BR112017003891A2 (pt) métodos e composições para induzir imunidade protetora contra infecção por filovírus
IL265733B (en) Methods and compositions for inducing protective immunity against human immunodeficiency virus infection
PH12017500207B1 (en) Indoles for use in influenza virus infection
BR112017013858A2 (pt) n4-hidroxicitidina e derivados e usos antivirais relacionados aos mesmos
CL2017000064A1 (es) Vacunas contra virus influenza y usos de las mismas
EA201790571A1 (ru) Пирролопиримидины для применения при инфекции, вызванной вирусом гриппа
CL2017000063A1 (es) Vacunas contra virus influenza y usos de las mismas
CR20160502A (es) Anticuerpos de hemaglutinina contra el virus de la influenza b y métodos de uso
BR112017004197A2 (pt) composições de vacina contra doenças do vírus da dengue
UY36221A (es) Derivados de isoindolinona
MX2018014955A (es) Vacunas atenuadas vivas del virus de la influenza equina.
BR112017025316A2 (pt) estratégia de vacina baseada em nanopartículas contra o vírus da gripe suína
BR112017016181A2 (pt) mdv1 recombinante e usos do mesmo
ZA201700164B (en) Influenza virus vaccines and uses thereof
TR201402220A2 (tr) Hemaglütinin esteraz baskılama niteliği sergileyen pikroretosit türevlerini ihtiva eden bir kompozisyon ve bu kompozisyonun viral enfeksiyonların tedavisinde kullanımı.
TH1601001266A (th) วิธีการและองค์ประกอบทางเภสัชกรรมสำหรับการบำบัดการติดเชื้อไวรัสตับอักเสบ b

Legal Events

Date Code Title Description
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]