BR112017002003A2 - biomarcadores de doença renal policística e usos dos mesmos - Google Patents
biomarcadores de doença renal policística e usos dos mesmosInfo
- Publication number
- BR112017002003A2 BR112017002003A2 BR112017002003A BR112017002003A BR112017002003A2 BR 112017002003 A2 BR112017002003 A2 BR 112017002003A2 BR 112017002003 A BR112017002003 A BR 112017002003A BR 112017002003 A BR112017002003 A BR 112017002003A BR 112017002003 A2 BR112017002003 A2 BR 112017002003A2
- Authority
- BR
- Brazil
- Prior art keywords
- protein
- drp
- patient
- kinase
- phosphorylated
- Prior art date
Links
- 208000030761 polycystic kidney disease Diseases 0.000 title abstract 2
- 239000000090 biomarker Substances 0.000 title 1
- 108050006400 Cyclin Proteins 0.000 abstract 2
- 102000016736 Cyclin Human genes 0.000 abstract 2
- 102000007665 Extracellular Signal-Regulated MAP Kinases Human genes 0.000 abstract 2
- 108010007457 Extracellular Signal-Regulated MAP Kinases Proteins 0.000 abstract 2
- 108091008611 Protein Kinase B Proteins 0.000 abstract 2
- 102000005765 Proto-Oncogene Proteins c-akt Human genes 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 102000004169 proteins and genes Human genes 0.000 abstract 2
- 108090000623 proteins and genes Proteins 0.000 abstract 2
- 102000004046 Caspase-2 Human genes 0.000 abstract 1
- 108090000552 Caspase-2 Proteins 0.000 abstract 1
- 102000004232 Mitogen-Activated Protein Kinase Kinases Human genes 0.000 abstract 1
- 108090000744 Mitogen-Activated Protein Kinase Kinases Proteins 0.000 abstract 1
- 108010051791 Nuclear Antigens Proteins 0.000 abstract 1
- 102000019040 Nuclear Antigens Human genes 0.000 abstract 1
- 101150008755 PCNA gene Proteins 0.000 abstract 1
- 201000000582 Retinoblastoma Diseases 0.000 abstract 1
- 102000003861 Ribosomal protein S6 Human genes 0.000 abstract 1
- 108090000221 Ribosomal protein S6 Proteins 0.000 abstract 1
- 230000004663 cell proliferation Effects 0.000 abstract 1
- 238000012544 monitoring process Methods 0.000 abstract 1
- 108091005981 phosphorylated proteins Proteins 0.000 abstract 1
- 210000003705 ribosome Anatomy 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/483—Physical analysis of biological material
- G01N33/487—Physical analysis of biological material of liquid biological material
- G01N33/49—Blood
- G01N33/492—Determining multiple analytes
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/34—Genitourinary disorders
- G01N2800/347—Renal failures; Glomerular diseases; Tubulointerstitial diseases, e.g. nephritic syndrome, glomerulonephritis; Renovascular diseases, e.g. renal artery occlusion, nephropathy
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/56—Staging of a disease; Further complications associated with the disease
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/60—Complex ways of combining multiple protein biomarkers for diagnosis
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Physics & Mathematics (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Biochemistry (AREA)
- Food Science & Technology (AREA)
- Analytical Chemistry (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Cell Biology (AREA)
- Ecology (AREA)
- Biophysics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462033031P | 2014-08-04 | 2014-08-04 | |
| PCT/US2015/043497 WO2016022500A2 (en) | 2014-08-04 | 2015-08-03 | Biomarkers of polycystic kidney disease and uses thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112017002003A2 true BR112017002003A2 (pt) | 2017-12-12 |
Family
ID=54035292
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112017002003A BR112017002003A2 (pt) | 2014-08-04 | 2015-08-03 | biomarcadores de doença renal policística e usos dos mesmos |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US10871495B2 (enExample) |
| EP (1) | EP3177932B1 (enExample) |
| JP (2) | JP6730252B2 (enExample) |
| KR (1) | KR20170033436A (enExample) |
| CN (1) | CN106716136B (enExample) |
| AU (1) | AU2015301278A1 (enExample) |
| BR (1) | BR112017002003A2 (enExample) |
| CO (1) | CO2017001596A2 (enExample) |
| MX (1) | MX2017001648A (enExample) |
| RU (1) | RU2017106891A (enExample) |
| SG (1) | SG11201700290SA (enExample) |
| WO (1) | WO2016022500A2 (enExample) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11116755B2 (en) | 2015-11-18 | 2021-09-14 | Genzyme Corporation | Biomarker of polycystic kidney disease and uses thereof |
| GB201719520D0 (en) * | 2017-11-24 | 2018-01-10 | Univ College Cardiff Consultants Ltd | Neuroprotectvie peptide |
| KR102859441B1 (ko) * | 2019-11-22 | 2025-09-12 | 서울대학교산학협력단 | Opn 검출용 제제를 포함하는, 다낭신의 진단용 조성물 및 이의 이용 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2003500418A (ja) * | 1999-05-24 | 2003-01-07 | エイブイアイ バイオファーマ， インコーポレイテッド | 多発性嚢胞腎疾患の処置のためのｃ−ｍｙｃに対するアンチセンス |
| US9006181B2 (en) | 2004-07-21 | 2015-04-14 | The Administrators Of The Tulane Educational Fund | Treatment of renal dysfunction and multiple myeloma using PACAP compounds |
| EP1808694A1 (en) | 2006-01-17 | 2007-07-18 | Universitätsklinikum Freiburg | Method for diagnosing polycystic kidney disease |
| US20120077263A1 (en) | 2009-06-05 | 2012-03-29 | Mayo Foundation For Medical Education And Research | Methods and materials for isolating exosomes |
| CN102018702B (zh) * | 2009-09-16 | 2012-07-18 | 北京大学 | 银杏内酯b的一种用途 |
| US20140079769A1 (en) * | 2010-10-01 | 2014-03-20 | Fabiola Terzi | Methods for predicting the progression and treating a chronic kidney disease in a patient |
| US20130276513A1 (en) * | 2010-10-14 | 2013-10-24 | The Regents Of The University Of California | Methods for diagnosing and assessing kidney disease |
| ES2982997T3 (es) | 2012-07-03 | 2024-10-21 | Fond Centro San Raffaele | 2-desoxiglucosa para uso en el tratamiento de la enfermedad renal poliquística dominante autosomal o enfermedad hepática poliquística |
| JOP20130273B1 (ar) | 2012-09-11 | 2021-08-17 | Genzyme Corp | مثبطات انزيم (سينثاز) غلوكوسيل سيراميد |
-
2015
- 2015-08-03 JP JP2017506291A patent/JP6730252B2/ja active Active
- 2015-08-03 AU AU2015301278A patent/AU2015301278A1/en not_active Abandoned
- 2015-08-03 SG SG11201700290SA patent/SG11201700290SA/en unknown
- 2015-08-03 BR BR112017002003A patent/BR112017002003A2/pt not_active Application Discontinuation
- 2015-08-03 WO PCT/US2015/043497 patent/WO2016022500A2/en not_active Ceased
- 2015-08-03 RU RU2017106891A patent/RU2017106891A/ru not_active Application Discontinuation
- 2015-08-03 MX MX2017001648A patent/MX2017001648A/es unknown
- 2015-08-03 KR KR1020177005740A patent/KR20170033436A/ko not_active Withdrawn
- 2015-08-03 EP EP15757363.5A patent/EP3177932B1/en active Active
- 2015-08-03 US US15/501,496 patent/US10871495B2/en active Active
- 2015-08-03 CN CN201580053081.4A patent/CN106716136B/zh active Active
-
2017
- 2017-02-17 CO CONC2017/0001596A patent/CO2017001596A2/es unknown
-
2020
- 2020-07-01 JP JP2020113693A patent/JP7005695B2/ja active Active
Also Published As
| Publication number | Publication date |
|---|---|
| EP3177932A2 (en) | 2017-06-14 |
| JP2020170013A (ja) | 2020-10-15 |
| RU2017106891A3 (enExample) | 2019-03-14 |
| RU2017106891A (ru) | 2018-09-06 |
| EP3177932B1 (en) | 2021-07-14 |
| JP6730252B2 (ja) | 2020-07-29 |
| JP7005695B2 (ja) | 2022-02-04 |
| CN106716136A (zh) | 2017-05-24 |
| CN106716136B (zh) | 2020-06-23 |
| KR20170033436A (ko) | 2017-03-24 |
| US20170227551A1 (en) | 2017-08-10 |
| MX2017001648A (es) | 2017-04-27 |
| US10871495B2 (en) | 2020-12-22 |
| CO2017001596A2 (es) | 2017-05-19 |
| WO2016022500A3 (en) | 2016-04-07 |
| SG11201700290SA (en) | 2017-02-27 |
| WO2016022500A2 (en) | 2016-02-11 |
| JP2017525955A (ja) | 2017-09-07 |
| AU2015301278A1 (en) | 2017-02-09 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| BR112012009284A2 (pt) | método e sistema para avaliar automaticamente a semelhança entre uma região geológica alvo de interesse e uma pluralidade de regiões geológicas conhecidas de interesse. | |
| EP4614155A3 (en) | Methods of assaying proteins | |
| BR112019000512A2 (pt) | anticorpo, ácido nucleico, vetor de expressão, célula hospedeira, composição, métodos de tratamento de uma doença, para produzir um anticorpo biespecífico e para detectar se a reticulação entre as células que expressam cd40 e cd137 ocorre em uma amostra, uso de um anticorpo multiespecífico, e, kit | |
| MX2017015260A (es) | Anticuerpos anti receptor de factor de necrosis tumoral inducible por glucocorticoide (gitr) para diagnostico del cancer. | |
| BR112014018331A8 (pt) | Biomarcadores e terapias combinadas usando vírus oncolítico e imunomodulação | |
| BR112016007348A2 (pt) | membro de ligação específica que se liga ao receptor do fator de crescimento epidérmico humano 2 (her2) para uso em um método de tratamento do câncer em um paciente, método de tratamento de câncer em um paciente, método de identificação de um câncer em um paciente, método para prognosticar a resposta de um câncer | |
| BR112015023262A2 (pt) | anticorpo isolado, ácido nucleico isolado, célula hospedeira, método para produzir um anticorpo, imunoconjugado, formulação farmacêutica e usos do anticorpo | |
| BR112014018970A8 (pt) | Dispositivos de coleta de amostra com agentes de estabilização sanguínea | |
| JOP20170041B1 (ar) | اجسام مضادة ضد vista (b7h5) | |
| SG10201903822XA (en) | Method for the enrichment of circulating tumor dna | |
| BR112017009728A2 (pt) | anticorpos isolados, ácido nucleico isolado, vetor, célula hospedeira, método para produzir o anticorpo, composição, usos de um anticorpo e métodos de tratamento de um distúrbio | |
| BR112017023131A2 (pt) | anticorpos anti- fcrn | |
| BR112014018729A8 (pt) | Método e aparelho para testar materiais de circulação perdidos para formações subterrâneas | |
| BR112018008799A2 (pt) | método de prognóstico | |
| BR112014032304A2 (pt) | método, sistema e ensaio tipo sanduíche para a determinação quantitativa ou qualitativa de um componente alvo em uma amostra líquida, kit para preparar uma amostra líquida, e, dispositivo microfluídico. | |
| MX2016011059A (es) | Sistemas, dispositivos y metodos para verificacion de la integridad de muestras. | |
| BR112020016330A8 (pt) | Receptores de células t específicas a ciclina a1 e usos dos mesmos | |
| BR112019005025A8 (pt) | Sistema e método para caracterizar um painel | |
| HK1258649A1 (zh) | 来自病原体的免疫原性抗原鉴定以及与临床效力的相关性 | |
| EP3546937A4 (en) | METHOD, SYSTEM, REAGENT KIT AND SYSTEM FOR CHECKING A HIGH DOSE HOOK SAMPLE AND FOR IMMUNOASSAY | |
| MX2024011859A (es) | Biomarcadores de arn para angioedema hereditario | |
| MX374415B (es) | Composiciones y métodos para identificar un riesgo de cáncer en un sujeto. | |
| BR112019021352A8 (pt) | Método para determinar e mitigar o risco de formação de cera de uma composição de hidrocarboneto, método para reduzir os riscos de formação de cera e sistema para uso de análise preditiva no gerenciamento de um processamento de hidrocarbonetos para determinar e mitigar a formação de cera | |
| BR112017002003A2 (pt) | biomarcadores de doença renal policística e usos dos mesmos | |
| BR112018074472A2 (pt) | interfaces proteicas |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B06U | Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette] | ||
| B11B | Dismissal acc. art. 36, par 1 of ipl - no reply within 90 days to fullfil the necessary requirements | ||
| B350 | Update of information on the portal [chapter 15.35 patent gazette] | ||
| B350 | Update of information on the portal [chapter 15.35 patent gazette] |