BR112016030220A2 - método para produzir grânulos porosos de hidroxiapatita deficiente em cálcio - Google Patents

método para produzir grânulos porosos de hidroxiapatita deficiente em cálcio

Info

Publication number
BR112016030220A2
BR112016030220A2 BR112016030220A BR112016030220A BR112016030220A2 BR 112016030220 A2 BR112016030220 A2 BR 112016030220A2 BR 112016030220 A BR112016030220 A BR 112016030220A BR 112016030220 A BR112016030220 A BR 112016030220A BR 112016030220 A2 BR112016030220 A2 BR 112016030220A2
Authority
BR
Brazil
Prior art keywords
granules
calcium
ions
deficient hydroxyapatite
porous granules
Prior art date
Application number
BR112016030220A
Other languages
English (en)
Inventor
De Gasparo Alex
Vanderploeg Eric
Seeherman Howard
Bohner Marc
Van Garderen Noémie
Original Assignee
Bioventus Llc
Mathys Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bioventus Llc, Mathys Ag filed Critical Bioventus Llc
Publication of BR112016030220A2 publication Critical patent/BR112016030220A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C01—INORGANIC CHEMISTRY
    • C01B—NON-METALLIC ELEMENTS; COMPOUNDS THEREOF; METALLOIDS OR COMPOUNDS THEREOF NOT COVERED BY SUBCLASS C01C
    • C01B25/00—Phosphorus; Compounds thereof
    • C01B25/16—Oxyacids of phosphorus; Salts thereof
    • C01B25/26—Phosphates
    • C01B25/32—Phosphates of magnesium, calcium, strontium, or barium
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/143—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with inorganic compounds
    • C—CHEMISTRY; METALLURGY
    • C01—INORGANIC CHEMISTRY
    • C01P—INDEXING SCHEME RELATING TO STRUCTURAL AND PHYSICAL ASPECTS OF SOLID INORGANIC COMPOUNDS
    • C01P2004/00—Particle morphology
    • C01P2004/60—Particles characterised by their size
    • C01P2004/61—Micrometer sized, i.e. from 1-100 micrometer
    • C—CHEMISTRY; METALLURGY
    • C01—INORGANIC CHEMISTRY
    • C01P—INDEXING SCHEME RELATING TO STRUCTURAL AND PHYSICAL ASPECTS OF SOLID INORGANIC COMPOUNDS
    • C01P2006/00—Physical properties of inorganic compounds
    • C01P2006/12—Surface area
    • C—CHEMISTRY; METALLURGY
    • C01—INORGANIC CHEMISTRY
    • C01P—INDEXING SCHEME RELATING TO STRUCTURAL AND PHYSICAL ASPECTS OF SOLID INORGANIC COMPOUNDS
    • C01P2006/00—Physical properties of inorganic compounds
    • C01P2006/16—Pore diameter

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Inorganic Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Compounds Of Alkaline-Earth Elements, Aluminum Or Rare-Earth Metals (AREA)
  • Peptides Or Proteins (AREA)
  • Materials For Medical Uses (AREA)

Abstract

a presente invenção refere-se a um método para produzir grânulos porosos de hidroxiapatita deficiente em cálcio que compreende as seguintes etapas: (a) submeter os grânulos de sulfato de cálcio anidro (csa), sulfato de cálcio di-hidratado (csd) ou sulfato de cálcio hemi-hidratado (csh), os grânulos compreendendo poros interconectados com um diâmetro médio mínimo de 3 mícrons, a uma primeira incubação em uma solução aquosa alcalina tendo um valor de ph menor do que 10 e contendo íons de po43-; (b) submeter os grânulos a uma segunda incubação em uma solução aquosa alcalina tendo um valor de ph maior do que 10 e opcionalmente íons de po43-; (c) filtrar e secar os grânulos porosos obtidos de hidroxiapatita deficiente em cálcio; e onde (d) a soma das quantidades de íons de po43- presentes na primeira e na segunda incubação é ao menos tão grande quanto a quantidade de íons de so42- dos grânulos usados para a etapa (a). os grânulos porosos de hidroxiapatita deficiente em cálcio obtidos pela invenção podem ser usados intencionalmente como veículos para substâncias biologicamente ativas, em particular, para proteínas.
BR112016030220A 2014-06-23 2014-06-23 método para produzir grânulos porosos de hidroxiapatita deficiente em cálcio BR112016030220A2 (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/CH2014/000085 WO2015196306A1 (en) 2014-06-23 2014-06-23 Method for producing porous calcium deficient hydroxyapatite granules

Publications (1)

Publication Number Publication Date
BR112016030220A2 true BR112016030220A2 (pt) 2017-11-07

Family

ID=51210929

Family Applications (2)

Application Number Title Priority Date Filing Date
BR112016030220A BR112016030220A2 (pt) 2014-06-23 2014-06-23 método para produzir grânulos porosos de hidroxiapatita deficiente em cálcio
BR112016030184A BR112016030184A2 (pt) 2014-06-23 2015-06-22 Grânulos porosos de hidroxiapatita deficiente em cálcio, seu uso e método para sua produção

Family Applications After (1)

Application Number Title Priority Date Filing Date
BR112016030184A BR112016030184A2 (pt) 2014-06-23 2015-06-22 Grânulos porosos de hidroxiapatita deficiente em cálcio, seu uso e método para sua produção

Country Status (10)

Country Link
US (4) US10131543B2 (pt)
EP (2) EP3157861B1 (pt)
JP (2) JP6609311B2 (pt)
KR (2) KR20170091081A (pt)
CN (2) CN107428533A (pt)
AU (2) AU2014399287B2 (pt)
BR (2) BR112016030220A2 (pt)
CA (2) CA2953165A1 (pt)
IL (2) IL249693A0 (pt)
WO (2) WO2015196306A1 (pt)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107847638A (zh) * 2014-12-29 2018-03-27 佰欧维恩图斯有限责任公司 用于骨修复中改善骨诱导性分子递送的系统和方法
US10661225B2 (en) * 2016-12-07 2020-05-26 Solvay Sa Copper supported catalyst comprising a Ca-deficient hydroxyapatite for waste gas NOx removal
US11529438B2 (en) 2018-06-25 2022-12-20 Bioventus, Llc Porous carrier matrix
JP7244901B2 (ja) * 2018-12-28 2023-03-23 株式会社バイオアパタイト ハイドロキシアパタイト、その製造方法及びβ－ＴＣＰの製造方法
EP4335466A1 (de) 2022-09-08 2024-03-13 Heraeus Medical GmbH Zusammensetzung zur herstellung eines knochenersatzmaterials, verfahren zur herstellung eines pharmazeutischen wirkstoffträgers, pharmazeutischer wirkstoffträger sowie dessen verwendung

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GB1455844A (en) * 1973-02-01 1976-11-17 Bpb Industries Ltd Granulating gypsum
JPH0832551B2 (ja) 1989-06-24 1996-03-29 旭光学工業株式会社 多孔質リン酸カルシウム系化合物粒子及びその製造方法
US5462722A (en) 1991-04-17 1995-10-31 Liu; Sung-Tsuen Calcium phosphate calcium sulfate composite implant material
JP3437970B2 (ja) 1994-01-18 2003-08-18 上村工業株式会社 ハイドロキシアパタイトの製造方法
JP3959564B2 (ja) * 1997-12-24 2007-08-15 村樫石灰工業株式会社 表層から芯部まで多孔質アパタイトに転換された固体物質の製造方法
JP3400740B2 (ja) * 1999-04-13 2003-04-28 東芝セラミックス株式会社 リン酸カルシウム系多孔質焼結体およびその製造方法
JP2004284890A (ja) 2003-03-24 2004-10-14 Saga Prefecture 水酸アパタイトの製造方法
EP1829564A1 (en) * 2006-02-17 2007-09-05 Progentix B.V. i.o. Osteoinductive calcium phosphate
JP5486790B2 (ja) 2008-10-10 2014-05-07 地方独立行政法人東京都立産業技術研究センター 多孔質アパタイトおよびその製造方法
RU2395476C1 (ru) 2009-05-15 2010-07-27 Учреждение Российской академии наук Институт физики прочности и материаловедения Сибирское отделение РАН (ИФПМ СО РАН) Способ получения пористых гидроксиапатитовых гранул
KR101239112B1 (ko) * 2010-12-27 2013-03-06 전북대학교산학협력단 표면 다공성 티타늄-수산화인회석 복합체의 제조방법
LV14492B (lv) 2011-12-28 2012-07-20 Rīgas Tehniskā Universitāte Poraina hidroksilapatīta keramika ar bimodālu poru sadalījumu un tās izgatavošanas paņēmiens
US20130266721A1 (en) * 2012-04-06 2013-10-10 Tapash Ranjan Rautray Preparation of controlled drug release porous hydroxyapatite microspheres with interconnected pore channels
WO2014141287A1 (en) * 2013-03-12 2014-09-18 Amrita Vishwa Vidyapeetham University The art, method, manner, process and system of multifunctional nanobiomaterial for molecular imaging and drug- delivery
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Also Published As

Publication number Publication date
EP3157862A1 (en) 2017-04-26
EP3157861A1 (en) 2017-04-26
BR112016030184A2 (pt) 2017-08-22
CN107428533A (zh) 2017-12-01
US20170158510A1 (en) 2017-06-08
US10150672B2 (en) 2018-12-11
KR20170063506A (ko) 2017-06-08
JP6609311B2 (ja) 2019-11-20
CN107428534A (zh) 2017-12-01
WO2015196309A1 (en) 2015-12-30
IL249693A0 (en) 2017-02-28
IL249752A0 (en) 2017-02-28
US20170197833A1 (en) 2017-07-13
JP2017521351A (ja) 2017-08-03
CA2953165A1 (en) 2015-12-30
US10807869B2 (en) 2020-10-20
AU2015281761A1 (en) 2017-01-19
WO2015196306A1 (en) 2015-12-30
US20190047862A1 (en) 2019-02-14
KR20170091081A (ko) 2017-08-08
AU2014399287A1 (en) 2017-01-12
US20190031511A1 (en) 2019-01-31
AU2015281761B2 (en) 2018-08-09
US10131543B2 (en) 2018-11-20
JP2017521350A (ja) 2017-08-03
IL249752B (en) 2018-07-31
US11377352B2 (en) 2022-07-05
CA2953172A1 (en) 2015-12-30
JP6785760B2 (ja) 2020-11-18
EP3157861B1 (en) 2021-03-03
AU2014399287B2 (en) 2018-12-20
EP3157862B1 (en) 2021-04-14
AU2015281761C1 (en) 2019-02-07

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B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B11B Dismissal acc. art. 36, par 1 of ipl - no reply within 90 days to fullfil the necessary requirements