BR112016030018A2 - sal composto de heterocíclico substituído com halogênio - Google Patents

sal composto de heterocíclico substituído com halogênio

Info

Publication number
BR112016030018A2
BR112016030018A2 BR112016030018A BR112016030018A BR112016030018A2 BR 112016030018 A2 BR112016030018 A2 BR 112016030018A2 BR 112016030018 A BR112016030018 A BR 112016030018A BR 112016030018 A BR112016030018 A BR 112016030018A BR 112016030018 A2 BR112016030018 A2 BR 112016030018A2
Authority
BR
Brazil
Prior art keywords
halogen substituted
substituted heterocyclic
salt
metal
heterocyclic salt
Prior art date
Application number
BR112016030018A
Other languages
English (en)
Other versions
BR112016030018B1 (pt
BR112016030018A8 (pt
Inventor
Okanari Eiji
Matsunaga Hirofumi
Nishida Hiroshi
Nishikawa Kenji
Okudo Makoto
Ito Masaaki
Matoyama Masaaki
Iwase Noriaki
Ushiyama Shigeru
Kono Shigeyuki
Kimura Tomio
Original Assignee
Ube Industries
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ube Industries filed Critical Ube Industries
Publication of BR112016030018A2 publication Critical patent/BR112016030018A2/pt
Publication of BR112016030018A8 publication Critical patent/BR112016030018A8/pt
Publication of BR112016030018B1 publication Critical patent/BR112016030018B1/pt

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D333/00Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/30Hetero atoms other than halogen
    • C07D333/36Nitrogen atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/38Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/381Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/04Drugs for skeletal disorders for non-specific disorders of the connective tissue
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Urology & Nephrology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pulmonology (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

é fornecido um novo sal composto de tiofeno substituído com a-halogênio que tem uma potente ação antagonista do receptor de lpa e é útil como um produto farmacêutico. um sal representado pela fórmula geral (i): em que r é um átomo de hidrogênio ou um grupo metóxi; x é um átomo de halogênio; a é selecionado do grupo que consiste nos seguintes grupos: a; m é um metal alcalino ou um metal alcalinoterroso e n é 1 quando m é um metal alcalino e é 2 quando m é um metal alcalino-terroso].
BR112016030018-1A 2014-06-27 2015-06-26 Sal composto de heterocíclico substituído com halogênio, antagonista do receptor de lpa, composição farmacêutica e uso do referido sal BR112016030018B1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2014132413 2014-06-27
JP2014-132413 2014-06-27
PCT/JP2015/068575 WO2015199234A1 (ja) 2014-06-27 2015-06-26 ハロゲン置換へテロ環化合物の塩

Publications (3)

Publication Number Publication Date
BR112016030018A2 true BR112016030018A2 (pt) 2017-08-22
BR112016030018A8 BR112016030018A8 (pt) 2023-05-09
BR112016030018B1 BR112016030018B1 (pt) 2023-07-04

Family

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Also Published As

Publication number Publication date
JP6579103B2 (ja) 2019-09-25
US20170158663A1 (en) 2017-06-08
EP3162801B1 (en) 2020-07-22
ES2824801T3 (es) 2021-05-13
KR102433588B1 (ko) 2022-08-19
JPWO2015199234A1 (ja) 2017-04-27
EP3162801A4 (en) 2018-01-24
CN106458964A (zh) 2017-02-22
MX2016017371A (es) 2017-05-01
US10023554B2 (en) 2018-07-17
RU2689315C2 (ru) 2019-05-27
KR20170016988A (ko) 2017-02-14
RU2017102513A (ru) 2018-07-27
AU2015281021B2 (en) 2019-03-14
BR112016030018A8 (pt) 2023-05-09
AU2015281021B9 (en) 2019-03-28
WO2015199234A1 (ja) 2015-12-30
CA2953472A1 (en) 2015-12-30
CN106458964B (zh) 2019-11-22
MX370408B (es) 2019-12-11
AU2015281021A1 (en) 2017-01-19
EP3162801A1 (en) 2017-05-03
CA2953472C (en) 2022-08-02
RU2017102513A3 (pt) 2018-12-11

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Legal Events

Date Code Title Description
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]

Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS.

B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B25D Requested change of name of applicant approved

Owner name: UBE CORPORATION (JP)

B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 26/06/2015, OBSERVADAS AS CONDICOES LEGAIS