BR112016029024A2 - conjugados e composições de texafirina-pt(iv) para uso na superação da resistência à platina - Google Patents

conjugados e composições de texafirina-pt(iv) para uso na superação da resistência à platina

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Publication number
BR112016029024A2
BR112016029024A2 BR112016029024A BR112016029024A BR112016029024A2 BR 112016029024 A2 BR112016029024 A2 BR 112016029024A2 BR 112016029024 A BR112016029024 A BR 112016029024A BR 112016029024 A BR112016029024 A BR 112016029024A BR 112016029024 A2 BR112016029024 A2 BR 112016029024A2
Authority
BR
Brazil
Prior art keywords
compositions
texaphyrin
conjugates
platinum resistance
platinum
Prior art date
Application number
BR112016029024A
Other languages
English (en)
Other versions
BR112016029024A8 (pt
Inventor
Thiabaud Gregory
Arambula Jonathan
L Sessler Jonathan
H Siddik Zahid
Original Assignee
Univ Texas
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Texas filed Critical Univ Texas
Publication of BR112016029024A2 publication Critical patent/BR112016029024A2/pt
Publication of BR112016029024A8 publication Critical patent/BR112016029024A8/pt

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/555—Heterocyclic compounds containing heavy metals, e.g. hemin, hematin, melarsoprol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/409—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having four such rings, e.g. porphine derivatives, bilirubin, biliverdine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/545—Heterocyclic compounds
    • A61K47/546—Porphyrines; Porphyrine with an expanded ring system, e.g. texaphyrine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/547—Chelates, e.g. Gd-DOTA or Zinc-amino acid chelates; Chelate-forming compounds, e.g. DOTA or ethylenediamine being covalently linked or complexed to the pharmacologically- or therapeutically-active agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/085—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier conjugated systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/101—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals
    • A61K49/106—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being cyclic, e.g. DOTA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
    • C07F15/0006—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table compounds of the platinum group
    • C07F15/0086—Platinum compounds
    • C07F15/0093—Platinum compounds without a metal-carbon linkage

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Radiology & Medical Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

a presente divulgação se refere a conjugados ligados e composições de platina (iv) e de texafirina que compreendem uma texafirina e um agente de platina (iv). a presente divulgação fornece também composições farmacêuticas dos conjugados e composições. além disso, são fornecidos aqui métodos para o uso dos presentes compostos no tratamento de câncer, tal como um câncer resistente à platina.
BR112016029024A 2014-06-11 2015-06-11 composto, composição farmacêutica e uso BR112016029024A8 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462010841P 2014-06-11 2014-06-11
US201562135502P 2015-03-19 2015-03-19
PCT/US2015/035229 WO2015191797A1 (en) 2014-06-11 2015-06-11 Texaphyrin-pt(iv) conjugates and compositions for use in overcoming platinum resistance

Publications (2)

Publication Number Publication Date
BR112016029024A2 true BR112016029024A2 (pt) 2017-08-22
BR112016029024A8 BR112016029024A8 (pt) 2021-07-20

Family

ID=54834283

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112016029024A BR112016029024A8 (pt) 2014-06-11 2015-06-11 composto, composição farmacêutica e uso

Country Status (13)

Country Link
US (3) US10406167B2 (pt)
EP (1) EP3154541A4 (pt)
JP (3) JP7304128B2 (pt)
KR (1) KR102412203B1 (pt)
CN (2) CN106572991A (pt)
AU (1) AU2015274589B2 (pt)
BR (1) BR112016029024A8 (pt)
CA (1) CA2950305C (pt)
IL (1) IL249453B (pt)
MX (2) MX2019015527A (pt)
SG (1) SG11201610306RA (pt)
WO (1) WO2015191797A1 (pt)
ZA (1) ZA201608194B (pt)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG11201610306RA (en) * 2014-06-11 2017-01-27 Univ Texas Texaphyrin-pt(iv) conjugates and compositions for use in overcoming platinum resistance
US20190231888A1 (en) * 2016-10-03 2019-08-01 Board Of Regents, The University Of Texas System Texaphyrin and antitumor antibiotic conjugates
CN106543234B (zh) * 2016-10-14 2019-04-09 昆明理工大学 以饱和链为桥的手性双核铂配合物及其制备方法和应用
CN108732147B (zh) * 2018-04-23 2021-01-19 南京邮电大学 基于fret效应探测细胞凋亡过程的方法
KR20230067608A (ko) * 2020-08-14 2023-05-16 더 보드 오브 리젠츠 오브 더 유니버시티 오브 텍사스 시스템 망간 화학 요법, 광음향 이미징, 및 광열 요법을 위한 텍사피린 유도체
CN114539320A (zh) * 2020-11-25 2022-05-27 北京大学 辐射激活的四价铂配合物及其用途
CN113292578A (zh) * 2021-05-21 2021-08-24 弗兰克·杰瑞·拉罗德 一种texaphyrin-叶酸螯合物及其制备方法与应用

Family Cites Families (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4265823A (en) 1979-01-04 1981-05-05 Robert E. Kosinski Aurothiosteroids
US4980473A (en) 1985-01-18 1990-12-25 The Trustees Of Columbia University In The City Of New York Chemical probes for left-handed DNA and chiral metal complexes as Z-specific anti-tumor agents
JPS62207283A (ja) 1986-03-07 1987-09-11 Yoshinori Kitani 新規な白金錯体
US5072011A (en) 1988-02-02 1991-12-10 Johnson Matthey, Inc. Pt(IV) complexes
US5162509A (en) 1989-03-06 1992-11-10 Board Of Regents, The University Of Texas System Process for preparing expanded porphyrins: large porphyrin-like tripyrroledimethine-derived macrocycles
US5599923A (en) 1989-03-06 1997-02-04 Board Of Regents, University Of Tx Texaphyrin metal complexes having improved functionalization
US5457183A (en) 1989-03-06 1995-10-10 Board Of Regents, The University Of Texas System Hydroxylated texaphyrins
US5272142A (en) 1989-03-06 1993-12-21 Board Of Regents, The University Of Texas System Expanded porphyrins: large porphyrin-like tripyrroledimethine-derived macrocycles and methods for treating tumors
US4935498A (en) 1989-03-06 1990-06-19 Board Of Regents, The University Of Texas System Expanded porphyrins: large porphyrin-like tripyrroledimethine-derived macrocycles
US5252720A (en) 1989-03-06 1993-10-12 Board Of Regents, The University Of Texas System Metal complexes of water soluble texaphyrins
US5624919A (en) 1993-09-14 1997-04-29 The University Of Vermont And State Agricultural College Trans platinum (IV) complexes
US5409915A (en) 1993-09-14 1995-04-25 The University Of Vermont And State Agricultural College Bis-platinum (IV) complexes as chemotherapeutic agents
US5633354A (en) 1994-09-21 1997-05-27 Pharmacyclics, Inc. Phosphoramidite derivatives of texaphyrins
US5756726A (en) 1995-06-02 1998-05-26 Pharmacyclics, Inc. Methods of producing singlet oxygen using compounds having improved functionalization
US5776925A (en) 1996-01-25 1998-07-07 Pharmacyclics, Inc. Methods for cancer chemosensitization
US5955586A (en) * 1996-03-22 1999-09-21 Sessler; Jonathan L. Highly boronated derivatives of texaphyrins
AU7711096A (en) 1996-12-03 1998-06-29 Rijsuniversiteit Utrecht Cisplatinum comprising pharmaceutical
JP2002516878A (ja) * 1998-06-05 2002-06-11 ボード オブ リージェンツ， ザ ユニバーシティ オブ テキサス システム テキサフィリン結合体およびその使用
EP1223982A2 (en) 1999-10-29 2002-07-24 Pharmacyclics, Inc. Conjugate for treating atheroma and other diseases
AU2001290580A1 (en) 2000-08-30 2002-03-13 Pharmacyclics, Inc. Non-symmetric tripyrrannes in the synthesis of novel macrocycles
FR2873037B1 (fr) 2004-07-13 2008-04-11 Univ Pasteur Methodes et compositions pour le traitement de cancers
CZ2004964A3 (cs) 2004-09-14 2006-03-15 Pliva-Lachema A. S. Perorální farmaceutická kompozice pro cílený transport komplexu platiny do kolorektální oblasti, zpusob její prípravy a tato kompozice pro pouzití jako lécivo
EP1845998A4 (en) * 2005-01-19 2008-06-18 Pharmacyclics Inc METHOD FOR TREATING NEUROLOGICAL DISEASES
US8246967B2 (en) 2005-08-02 2012-08-21 Macdonnell Frederick M Compounds with modifying activity enhanced under hypoxic conditions
US20070072838A1 (en) 2005-09-26 2007-03-29 Pharmacyclics, Inc. High-purity texaphyrin metal complexes
TW200728315A (en) 2005-12-06 2007-08-01 Nippon Chemical Ind Phosphorus transition-metal complex, method of producing the same, and anticancer agent forming the same
US20120164230A1 (en) 2007-05-08 2012-06-28 Rodney Feazell Soluble Nanoparticles as Delivery Systems for Prodrugs
CN101801369B (zh) 2007-08-06 2012-09-19 俄亥俄大学 磷铂及其在治疗顺铂和卡铂耐药性癌中的用途
CN101125865B (zh) 2007-09-29 2010-09-08 广东药学院 手性钌配合物及其作为抗肿瘤药物的应用
WO2010027428A1 (en) 2008-08-26 2010-03-11 Massachusetts Institute Of Technology Platinum ( iv) complexes for use in dual mode pharmaceutical therapy
WO2010105691A1 (en) 2009-03-20 2010-09-23 Universita' Degli Studi Di Padova Gold (iii) complexes with oligopeptides functionalized with sulfur donors and use thereof as antitumor agents
US8563712B2 (en) 2009-10-28 2013-10-22 The University Of Hong Kong Hydroxy-substituted gold(III) porphyrin complexes as histone deacetylase inhibitors
CN102058576B (zh) 2010-12-28 2012-07-25 中国科学院深圳先进技术研究院 顺铂前体药物及其制备方法、核壳纳米颗粒及其制备方法
WO2012138988A2 (en) 2011-04-07 2012-10-11 The Research Foundation Of The City University Of New York Organometallic anti-cancer complexes
CN103917227A (zh) 2011-06-21 2014-07-09 麻省理工学院 用于治疗癌症的组合物和方法
JP5179628B2 (ja) 2011-07-15 2013-04-10 ユニーテック株式会社 ４価白金錯体及びそれを含む医薬組成物
CN102408452B (zh) * 2011-12-13 2014-09-03 中山大学 四吡啶基卟啉桥联十字形四核铂配合物及其制备方法和抗肿瘤活性
US8729286B2 (en) 2012-05-10 2014-05-20 Massachusetts Institute Of Technology Platinum compounds as treatment for cancers, and related methods, kits, and compositions
US8828984B2 (en) 2012-11-19 2014-09-09 The University Of Hong Kong Gold(III) complexes containing N-heterocyclic carbene ligand, synthesis, and their applications in cancer treatment and thiol detection
WO2014160216A2 (en) 2013-03-13 2014-10-02 Massachusetts Institute Of Technology Dual targeting anticancer agents
WO2014165782A2 (en) 2013-04-05 2014-10-09 Massachusetts Institute Of Technology Compositions, methods, and kits comprising platinum compounds associated with a ligand comprising a targeting moiety
SG11201610306RA (en) 2014-06-11 2017-01-27 Univ Texas Texaphyrin-pt(iv) conjugates and compositions for use in overcoming platinum resistance

Also Published As

Publication number Publication date
US11389459B2 (en) 2022-07-19
AU2015274589B2 (en) 2020-12-03
JP2023078171A (ja) 2023-06-06
SG11201610306RA (en) 2017-01-27
CA2950305C (en) 2023-03-14
NZ726729A (en) 2023-08-25
AU2015274589A1 (en) 2016-12-15
CA2950305A1 (en) 2015-12-17
ZA201608194B (en) 2023-05-31
MX2019015527A (es) 2022-06-17
US20200069698A1 (en) 2020-03-05
KR20170016933A (ko) 2017-02-14
JP2017519004A (ja) 2017-07-13
CN106572991A (zh) 2017-04-19
IL249453B (en) 2021-01-31
EP3154541A1 (en) 2017-04-19
US10406167B2 (en) 2019-09-10
CN116178456A (zh) 2023-05-30
MX370673B (es) 2019-12-19
JP7304128B2 (ja) 2023-07-06
JP2021102616A (ja) 2021-07-15
KR102412203B1 (ko) 2022-06-23
MX2016016419A (es) 2017-04-06
BR112016029024A8 (pt) 2021-07-20
US20170246182A1 (en) 2017-08-31
WO2015191797A1 (en) 2015-12-17
EP3154541A4 (en) 2017-12-20
US20230113036A1 (en) 2023-04-13
IL249453A0 (en) 2017-02-28

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