AU2001290580A1 - Non-symmetric tripyrrannes in the synthesis of novel macrocycles - Google Patents
Non-symmetric tripyrrannes in the synthesis of novel macrocyclesInfo
- Publication number
- AU2001290580A1 AU2001290580A1 AU2001290580A AU9058001A AU2001290580A1 AU 2001290580 A1 AU2001290580 A1 AU 2001290580A1 AU 2001290580 A AU2001290580 A AU 2001290580A AU 9058001 A AU9058001 A AU 9058001A AU 2001290580 A1 AU2001290580 A1 AU 2001290580A1
- Authority
- AU
- Australia
- Prior art keywords
- tripyrrannes
- symmetric
- synthesis
- novel macrocycles
- macrocycles
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/333—Radicals substituted by oxygen or sulfur atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
- A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
- A61K41/0076—PDT with expanded (metallo)porphyrins, i.e. having more than 20 ring atoms, e.g. texaphyrins, sapphyrins, hexaphyrins, pentaphyrins, porphocyanines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/335—Radicals substituted by nitrogen atoms not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/337—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US22924700P | 2000-08-30 | 2000-08-30 | |
US60/229,247 | 2000-08-30 | ||
PCT/US2001/026755 WO2002017925A1 (en) | 2000-08-30 | 2001-08-28 | Non-symmetric tripyrrannes in the synthesis of novel macrocycles |
Publications (1)
Publication Number | Publication Date |
---|---|
AU2001290580A1 true AU2001290580A1 (en) | 2002-03-13 |
Family
ID=22860407
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AU2001290580A Abandoned AU2001290580A1 (en) | 2000-08-30 | 2001-08-28 | Non-symmetric tripyrrannes in the synthesis of novel macrocycles |
Country Status (3)
Country | Link |
---|---|
US (1) | US7112671B2 (en) |
AU (1) | AU2001290580A1 (en) |
WO (1) | WO2002017925A1 (en) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2002032294A2 (en) * | 2000-10-19 | 2002-04-25 | Bracco Research Usa | Radiopharmaceutical formulations |
US20070072838A1 (en) * | 2005-09-26 | 2007-03-29 | Pharmacyclics, Inc. | High-purity texaphyrin metal complexes |
US9599591B2 (en) | 2009-03-06 | 2017-03-21 | California Institute Of Technology | Low cost, portable sensor for molecular assays |
AU2015274589B2 (en) | 2014-06-11 | 2020-12-03 | Board Of Regents, The University Of Texas System | Texaphyrin-Pt(IV) conjugates and compositions for use in overcoming platinum resistance |
WO2022036292A1 (en) | 2020-08-14 | 2022-02-17 | Board Of Regents, The University Of Texas System | Texaphyrin derivatives for manganese chemotherapy, photoacoustic imaging, and photothermal therapy |
Family Cites Families (31)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2047149T3 (en) | 1988-01-20 | 1994-02-16 | Ciba Geigy Ag | PROCEDURE FOR OBTAINING COMPLEX COMPOUNDS. |
CA1340527C (en) | 1988-05-31 | 1999-05-04 | Lidia Vallarino | Macrocyclic complexes of yttrium, the lanthanides and the actinides having peripheral coupling functionalities |
US5041087A (en) * | 1988-08-11 | 1991-08-20 | Loo George D H | Needle-less parenteral fluid injector |
US5162509A (en) | 1989-03-06 | 1992-11-10 | Board Of Regents, The University Of Texas System | Process for preparing expanded porphyrins: large porphyrin-like tripyrroledimethine-derived macrocycles |
US5272142A (en) | 1989-03-06 | 1993-12-21 | Board Of Regents, The University Of Texas System | Expanded porphyrins: large porphyrin-like tripyrroledimethine-derived macrocycles and methods for treating tumors |
US5256399A (en) | 1989-03-06 | 1993-10-26 | Board Of Regents, The University Of Texas System | Aromatic pentadentate expanded porphyrins in magnetic resonance imaging |
US5041078A (en) | 1989-03-06 | 1991-08-20 | Baylor Research Foundation, A Nonprofit Corporation Of The State Of Texas | Photodynamic viral deactivation with sapphyrins |
US5252720A (en) | 1989-03-06 | 1993-10-12 | Board Of Regents, The University Of Texas System | Metal complexes of water soluble texaphyrins |
US4935498A (en) | 1989-03-06 | 1990-06-19 | Board Of Regents, The University Of Texas System | Expanded porphyrins: large porphyrin-like tripyrroledimethine-derived macrocycles |
US5567687A (en) | 1989-03-06 | 1996-10-22 | University Of Texas | Texaphyrins and uses thereof |
US5559207A (en) | 1989-03-06 | 1996-09-24 | Board Of Regents, University Of Texas | Texaphyrin metal complex mediated ester hydrolysis |
US5457183A (en) | 1989-03-06 | 1995-10-10 | Board Of Regents, The University Of Texas System | Hydroxylated texaphyrins |
US5599923A (en) | 1989-03-06 | 1997-02-04 | Board Of Regents, University Of Tx | Texaphyrin metal complexes having improved functionalization |
US5159065A (en) | 1989-12-21 | 1992-10-27 | Board Of Regents, The University Of Texas System | Sapphyrins, derivatives and syntheses |
US5457195A (en) | 1989-12-21 | 1995-10-10 | Board Of Regents, The University Of Texas System | Sapphyrin derivatives and conjugates |
US5543514A (en) | 1989-12-21 | 1996-08-06 | Board Of Regents, The University Of Texas System | Water-soluble sapphyrins |
US5120411A (en) | 1989-12-21 | 1992-06-09 | Board Of Regents, The University Of Texas System | Photodynamic activity of sapphyrins |
US5594136A (en) | 1989-12-21 | 1997-01-14 | Pharmacyclics, Inc. | Texaphyrin solid supports and devices |
US5696240A (en) | 1991-03-15 | 1997-12-09 | Vallarino; Lidia M. | Macrocyclic complexes of yttrium, the lanthanides and the actinides having peripheral coupling functionalities |
US5595726A (en) | 1992-01-21 | 1997-01-21 | Pharmacyclics, Inc. | Chromophore probe for detection of nucleic acid |
US5565552A (en) | 1992-01-21 | 1996-10-15 | Pharmacyclics, Inc. | Method of expanded porphyrin-oligonucleotide conjugate synthesis |
US5888997A (en) * | 1994-04-14 | 1999-03-30 | Pharmacyclics, Inc. | Radiation sensitization using texaphyrins |
US5607924A (en) | 1992-01-21 | 1997-03-04 | Pharmacyclics, Inc. | DNA photocleavage using texaphyrins |
US5798491A (en) | 1993-06-09 | 1998-08-25 | Board Of Regents, The University Of Texas System | Multi-mechanistic chemical cleavage using certain metal complexes |
US5756726A (en) | 1995-06-02 | 1998-05-26 | Pharmacyclics, Inc. | Methods of producing singlet oxygen using compounds having improved functionalization |
US5714328A (en) | 1995-06-07 | 1998-02-03 | Board Of Regents, The University Of Texas System | RNA photocleavage using texaphyrins |
US5776925A (en) | 1996-01-25 | 1998-07-07 | Pharmacyclics, Inc. | Methods for cancer chemosensitization |
AU717193B2 (en) | 1996-03-26 | 2000-03-23 | Pharmacyclics, Inc. | Use of a texaphyrin in photodynamic therapy of pigment-related lesions |
JP2000512279A (en) | 1996-06-04 | 2000-09-19 | ファーマサイクリクス,インコーポレイテッド | Membrane uptake of texaphyrin |
JP2000516631A (en) | 1996-08-20 | 2000-12-12 | ファーマサイクリックス,インコーポレイテッド | Nucleic acids internally derivatized with texaphyrin metal complexes and uses thereof |
US5886173A (en) | 1997-07-30 | 1999-03-23 | Pharmacyclics, Inc. | Metallation of macrocycles with 2,4-dicarbonyl-metal complexes |
-
2001
- 2001-08-28 WO PCT/US2001/026755 patent/WO2002017925A1/en active Application Filing
- 2001-08-28 US US10/363,401 patent/US7112671B2/en not_active Expired - Lifetime
- 2001-08-28 AU AU2001290580A patent/AU2001290580A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
WO2002017925A1 (en) | 2002-03-07 |
US20030232800A1 (en) | 2003-12-18 |
US7112671B2 (en) | 2006-09-26 |
WO2002017925A8 (en) | 2002-09-12 |
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