BR112016022715A2 - Piridinonas antifibróticas - Google Patents
Piridinonas antifibróticasInfo
- Publication number
- BR112016022715A2 BR112016022715A2 BR112016022715A BR112016022715A BR112016022715A2 BR 112016022715 A2 BR112016022715 A2 BR 112016022715A2 BR 112016022715 A BR112016022715 A BR 112016022715A BR 112016022715 A BR112016022715 A BR 112016022715A BR 112016022715 A2 BR112016022715 A2 BR 112016022715A2
- Authority
- BR
- Brazil
- Prior art keywords
- pyridinones
- antifibrotic
- compounds
- pyridinone
- methods
- Prior art date
Links
- 150000005299 pyridinones Chemical class 0.000 title abstract 3
- 230000003510 anti-fibrotic effect Effects 0.000 title abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 125000003367 polycyclic group Chemical group 0.000 abstract 2
- UBQKCCHYAOITMY-UHFFFAOYSA-N pyridin-2-ol Chemical compound OC1=CC=CC=N1 UBQKCCHYAOITMY-UHFFFAOYSA-N 0.000 abstract 2
- 206010016654 Fibrosis Diseases 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 230000004761 fibrosis Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- WHMDPDGBKYUEMW-UHFFFAOYSA-N pyridine-2-thiol Chemical class SC1=CC=CC=N1 WHMDPDGBKYUEMW-UHFFFAOYSA-N 0.000 abstract 1
Classifications
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- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/433—Thidiazoles
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system having sulfur as a ring hetero atom, e.g. ticlopidine
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- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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- A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
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- C07C225/20—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of the carbon skeleton
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- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
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- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
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- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
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- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
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Abstract
PIRIDINONAS ANTIFIBRÓTICAS. A presente invenção refere-se a compostos policíclicos com um núcleo de piridinona ou derivado da piridinona incluindo piridinonas substituídas, heterociclos 5,6- e 6,6-bicíclicos e piridina-tionas substituídas. O presente pedido também revela métodos para preparar esses compostos policíclicos, composições farmacêuticas e medicamentos compreendendo os referidos compostos e métodos para tratar, prevenir ou diagnosticar doenças, distúrbios ou condições associados à fibrose.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201461974334P | 2014-04-02 | 2014-04-02 | |
US61/974,334 | 2014-04-02 | ||
PCT/US2015/023712 WO2015153683A1 (en) | 2014-04-02 | 2015-03-31 | Anti-fibrotic pyridinones |
Publications (2)
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BR112016022715A2 true BR112016022715A2 (pt) | 2017-08-15 |
BR112016022715B1 BR112016022715B1 (pt) | 2023-07-18 |
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JP2017512784A (ja) | 2017-05-25 |
KR20160138289A (ko) | 2016-12-02 |
JP6525437B2 (ja) | 2019-06-05 |
US20190144467A1 (en) | 2019-05-16 |
KR102373700B1 (ko) | 2022-03-11 |
US10544161B2 (en) | 2020-01-28 |
EP3126362A1 (en) | 2017-02-08 |
RU2016137181A3 (pt) | 2018-10-08 |
WO2015153683A8 (en) | 2016-10-13 |
US20170121345A1 (en) | 2017-05-04 |
EP3126362B1 (en) | 2022-01-12 |
RU2692485C2 (ru) | 2019-06-25 |
JP2020128418A (ja) | 2020-08-27 |
CN106459042B (zh) | 2019-06-28 |
JP6745926B2 (ja) | 2020-08-26 |
WO2015153683A1 (en) | 2015-10-08 |
CN110452216B (zh) | 2022-08-26 |
JP2019070047A (ja) | 2019-05-09 |
US10233195B2 (en) | 2019-03-19 |
CN110452216A (zh) | 2019-11-15 |
CA2943363A1 (en) | 2015-10-08 |
MX2016012808A (es) | 2017-01-05 |
RU2016137181A (ru) | 2018-05-10 |
CN106459042A (zh) | 2017-02-22 |
EP3126362A4 (en) | 2017-08-16 |
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