BR112016024488A2 - compostos de ciclo-hexenila, composições que compreendem esses e o uso dos mesmos - Google Patents

compostos de ciclo-hexenila, composições que compreendem esses e o uso dos mesmos

Info

Publication number
BR112016024488A2
BR112016024488A2 BR112016024488A BR112016024488A BR112016024488A2 BR 112016024488 A2 BR112016024488 A2 BR 112016024488A2 BR 112016024488 A BR112016024488 A BR 112016024488A BR 112016024488 A BR112016024488 A BR 112016024488A BR 112016024488 A2 BR112016024488 A2 BR 112016024488A2
Authority
BR
Brazil
Prior art keywords
compositions
compounds
cyclohexenyl compounds
cyclohexenyl
obesity
Prior art date
Application number
BR112016024488A
Other languages
English (en)
Inventor
Breuer Aviva
Mechoulam Raphael
Gallily Ruth
Original Assignee
Yissum Res Dev Co Of Hebrew Univ Jerusalem Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yissum Res Dev Co Of Hebrew Univ Jerusalem Ltd filed Critical Yissum Res Dev Co Of Hebrew Univ Jerusalem Ltd
Publication of BR112016024488A2 publication Critical patent/BR112016024488A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/145—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/15—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Emergency Medicine (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pain & Pain Management (AREA)
  • Child & Adolescent Psychology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

trata-se dos compostos ciclo-hexenil fenila substituída de fórmula (i), com-posições que compreendem esses e as utilizações dos mesmos para a preparação de medicamentos para o tratamento da obesidade e de qualquer doença ou distúr-bio associado à mesma, para a redução do consumo de alimento e para o tratamen-to de inflamação e distúrbios associados a isso.
BR112016024488A 2014-04-21 2015-04-21 compostos de ciclo-hexenila, composições que compreendem esses e o uso dos mesmos BR112016024488A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201461981997P 2014-04-21 2014-04-21
PCT/IL2015/050420 WO2015162610A1 (en) 2014-04-21 2015-04-21 Cyclohexenyl compounds, compositions comprising them and uses thereof

Publications (1)

Publication Number Publication Date
BR112016024488A2 true BR112016024488A2 (pt) 2017-08-15

Family

ID=53276955

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112016024488A BR112016024488A2 (pt) 2014-04-21 2015-04-21 compostos de ciclo-hexenila, composições que compreendem esses e o uso dos mesmos

Country Status (8)

Country Link
US (3) US20170029391A1 (pt)
EP (2) EP3786158A1 (pt)
CN (1) CN106232588B (pt)
BR (1) BR112016024488A2 (pt)
CA (1) CA2944837C (pt)
ES (1) ES2856204T3 (pt)
IL (1) IL248256B (pt)
WO (1) WO2015162610A1 (pt)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3091088A1 (en) * 2018-02-13 2019-08-22 Beetlebung Pharma Ltd. Cannabinoid derivatives and conjugates and uses thereof
CN112279786B (zh) * 2020-11-23 2023-05-09 汤文建 一种大麻二酚氨基甲酸酯类化合物、药物制剂及制备方法与应用
CN115315418B (zh) * 2021-04-06 2023-03-21 山东绿叶制药有限公司 大麻二酚前药及其药物组合物和应用
WO2023009817A2 (en) * 2021-07-29 2023-02-02 Emory University Phosphate prodrugs of cannabinoids
WO2024009324A1 (en) * 2022-07-08 2024-01-11 Council Of Scientific & Industrial Research Prodrugs of cannbidiol [cbd]-type phytocannabinoids and a process for preparation thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2438682A (en) * 2006-06-01 2007-12-05 Gw Pharma Ltd New use for cannabinoids
GB2439393B (en) * 2006-06-23 2011-05-11 Gw Pharma Ltd Cannabinoids for use in the treatment of neuropathic pain
WO2008107879A1 (en) * 2007-03-05 2008-09-12 Yissum Research Development Company Of The Hebrew University Of Jerusalem Novel cannabidiol derivatives and their use as anti-inflammatory agents
JP2010535238A (ja) * 2007-07-30 2010-11-18 オールトランツ インコーポレイティド カンナビジオールのプロドラッグ、カンナビジオールのプロドラッグを含む組成物及びその使用方法

Also Published As

Publication number Publication date
EP3786158A1 (en) 2021-03-03
IL248256B (en) 2018-07-31
US10239848B2 (en) 2019-03-26
CA2944837A1 (en) 2015-10-29
US11149014B2 (en) 2021-10-19
US20190169148A1 (en) 2019-06-06
CN106232588A (zh) 2016-12-14
EP3134393B1 (en) 2020-12-09
US20170029391A1 (en) 2017-02-02
US20180093959A1 (en) 2018-04-05
CN106232588B (zh) 2020-01-14
EP3134393A1 (en) 2017-03-01
WO2015162610A1 (en) 2015-10-29
CA2944837C (en) 2021-10-26
ES2856204T3 (es) 2021-09-27

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Legal Events

Date Code Title Description
B11A Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing
B11Y Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette]
B350 Update of information on the portal [chapter 15.35 patent gazette]