BR112016024488A2 - compostos de ciclo-hexenila, composições que compreendem esses e o uso dos mesmos - Google Patents
compostos de ciclo-hexenila, composições que compreendem esses e o uso dos mesmosInfo
- Publication number
- BR112016024488A2 BR112016024488A2 BR112016024488A BR112016024488A BR112016024488A2 BR 112016024488 A2 BR112016024488 A2 BR 112016024488A2 BR 112016024488 A BR112016024488 A BR 112016024488A BR 112016024488 A BR112016024488 A BR 112016024488A BR 112016024488 A2 BR112016024488 A2 BR 112016024488A2
- Authority
- BR
- Brazil
- Prior art keywords
- compositions
- compounds
- cyclohexenyl compounds
- cyclohexenyl
- obesity
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D295/145—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/15—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Emergency Medicine (AREA)
- Obesity (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Pain & Pain Management (AREA)
- Child & Adolescent Psychology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
trata-se dos compostos ciclo-hexenil fenila substituída de fórmula (i), com-posições que compreendem esses e as utilizações dos mesmos para a preparação de medicamentos para o tratamento da obesidade e de qualquer doença ou distúr-bio associado à mesma, para a redução do consumo de alimento e para o tratamen-to de inflamação e distúrbios associados a isso.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201461981997P | 2014-04-21 | 2014-04-21 | |
PCT/IL2015/050420 WO2015162610A1 (en) | 2014-04-21 | 2015-04-21 | Cyclohexenyl compounds, compositions comprising them and uses thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112016024488A2 true BR112016024488A2 (pt) | 2017-08-15 |
Family
ID=53276955
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112016024488A BR112016024488A2 (pt) | 2014-04-21 | 2015-04-21 | compostos de ciclo-hexenila, composições que compreendem esses e o uso dos mesmos |
Country Status (8)
Country | Link |
---|---|
US (3) | US20170029391A1 (pt) |
EP (2) | EP3134393B1 (pt) |
CN (1) | CN106232588B (pt) |
BR (1) | BR112016024488A2 (pt) |
CA (1) | CA2944837C (pt) |
ES (1) | ES2856204T3 (pt) |
IL (1) | IL248256B (pt) |
WO (1) | WO2015162610A1 (pt) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20210009549A1 (en) * | 2018-02-13 | 2021-01-14 | Beetlebung Pharma Ltd. | Cannabinoid derivatives and conjugates and uses thereof |
CN112279786B (zh) * | 2020-11-23 | 2023-05-09 | 汤文建 | 一种大麻二酚氨基甲酸酯类化合物、药物制剂及制备方法与应用 |
CN116253642B (zh) * | 2021-04-06 | 2024-07-09 | 山东绿叶制药有限公司 | 大麻二酚前药及其药物组合物和应用 |
JP2024527932A (ja) * | 2021-07-29 | 2024-07-26 | エモリー ユニバーシティー | カンナビノイドのホスフェートプロドラッグ |
WO2024009324A1 (en) * | 2022-07-08 | 2024-01-11 | Council Of Scientific & Industrial Research | Prodrugs of cannbidiol [cbd]-type phytocannabinoids and a process for preparation thereof |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB2438682A (en) * | 2006-06-01 | 2007-12-05 | Gw Pharma Ltd | New use for cannabinoids |
GB2439393B (en) * | 2006-06-23 | 2011-05-11 | Gw Pharma Ltd | Cannabinoids for use in the treatment of neuropathic pain |
WO2008107879A1 (en) * | 2007-03-05 | 2008-09-12 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Novel cannabidiol derivatives and their use as anti-inflammatory agents |
CA2694325C (en) * | 2007-07-30 | 2015-09-22 | Alltranz Inc. | Prodrugs of cannabidiol, compositions comprising prodrugs of cannabidiol and methods of using the same |
-
2015
- 2015-04-21 WO PCT/IL2015/050420 patent/WO2015162610A1/en active Application Filing
- 2015-04-21 BR BR112016024488A patent/BR112016024488A2/pt not_active Application Discontinuation
- 2015-04-21 EP EP15726740.2A patent/EP3134393B1/en active Active
- 2015-04-21 EP EP20201781.0A patent/EP3786158A1/en not_active Withdrawn
- 2015-04-21 ES ES15726740T patent/ES2856204T3/es active Active
- 2015-04-21 CN CN201580020978.7A patent/CN106232588B/zh active Active
- 2015-04-21 CA CA2944837A patent/CA2944837C/en active Active
-
2016
- 2016-10-09 IL IL248256A patent/IL248256B/en active IP Right Grant
- 2016-10-13 US US15/293,155 patent/US20170029391A1/en not_active Abandoned
-
2017
- 2017-11-22 US US15/821,720 patent/US10239848B2/en active Active
-
2019
- 2019-02-12 US US16/274,107 patent/US11149014B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
US20190169148A1 (en) | 2019-06-06 |
WO2015162610A1 (en) | 2015-10-29 |
IL248256B (en) | 2018-07-31 |
CA2944837C (en) | 2021-10-26 |
CN106232588A (zh) | 2016-12-14 |
CN106232588B (zh) | 2020-01-14 |
EP3134393A1 (en) | 2017-03-01 |
US20170029391A1 (en) | 2017-02-02 |
EP3134393B1 (en) | 2020-12-09 |
US11149014B2 (en) | 2021-10-19 |
US20180093959A1 (en) | 2018-04-05 |
CA2944837A1 (en) | 2015-10-29 |
ES2856204T3 (es) | 2021-09-27 |
US10239848B2 (en) | 2019-03-26 |
EP3786158A1 (en) | 2021-03-03 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ECSP19052302A (es) | Derivados de benzooxazol como inmunomoduladores | |
CL2018003701A1 (es) | Compuestos heterocíclicos como inmunomoduladores. | |
CY1121170T1 (el) | Νεες ενωσεις ως ρυθμιστες πρωτεϊνικων κινασων | |
CY1121413T1 (el) | Διυδροπυρρολοπυριδινης αναστολεις ror-γαμμα | |
BR112016015838A8 (pt) | compostos heterocíclicos aromáticos, composição farmacêutica compreendendo os referidos compostos e produto de combinação | |
BR112017009648A2 (pt) | composto, métodos para tratamento de doenças alérgicas ou outras condições inflamatórias ou prevenção de doença, de rinite alérgica ou asma, composição, e, uso de um composto. | |
BR112018070859A2 (pt) | degradantes da proteína de bet | |
BR112018004532A2 (pt) | uso de akkermansia pasteurizado para o tratamento de distúrbios metabólicos | |
GEP20217316B (en) | Aromatic sulfonamide derivatives | |
CL2018002814A1 (es) | Composiciones y metodos para el tratamiento de heridas, trastornos, y enfermedades de la piel. | |
BR112015023349A2 (pt) | composto, composição farmacêutica, e, método de tratamento de uma doença, condição de saúde ou distúrbio | |
NI201600071A (es) | Compuestos de inhibidor de autotaxina | |
EA201691872A1 (ru) | Гетероциклические соединения для применения в лечении pi3k-гамма-опосредованных расстройств | |
EA201691134A1 (ru) | Новые ингибиторы глутаминазы | |
UA116648C2 (uk) | Фумарати як проліки та їх застосування при лікуванні різних захворювань | |
EA201592024A1 (ru) | Замещенные 5-(3,5-диметилизоксазол-4-ил)-индолин-2-оны | |
BR112016028845A2 (pt) | composto, composição farmacêutica e uso de um composto | |
BR112015010109A2 (pt) | derivados de indol-5-ol substituídos e suas aplicações terapêuticas | |
BR112021017831A2 (pt) | Derivados heteroaromáticos e aromáticos heterobicíclicos para o tratamento de distúrbios relacionados com ferroptose | |
BR112017005202A2 (pt) | anticorpos anti-met e composições | |
EA201792604A1 (ru) | Ингибиторы аутотаксина и их применения | |
BR112016024488A2 (pt) | compostos de ciclo-hexenila, composições que compreendem esses e o uso dos mesmos | |
BR112017004173A2 (pt) | composto, composição farmacêutica, e, método para tratar uma doença ou condição patológica. | |
BR112017022158A2 (pt) | compostos, composições farmacêuticas e uso de um composto | |
BR112017010402A2 (pt) | carboxamida substituída à base de tiazol e oxazol e derivados de ureia como ligantes de receptor vanilóide ii |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
B11A | Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing | ||
B11Y | Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette] | ||
B350 | Update of information on the portal [chapter 15.35 patent gazette] |