BR112016015712A8 - método de tratamento de doenças hepáticas. - Google Patents

método de tratamento de doenças hepáticas. Download PDF

Info

Publication number
BR112016015712A8
BR112016015712A8 BR112016015712A BR112016015712A BR112016015712A8 BR 112016015712 A8 BR112016015712 A8 BR 112016015712A8 BR 112016015712 A BR112016015712 A BR 112016015712A BR 112016015712 A BR112016015712 A BR 112016015712A BR 112016015712 A8 BR112016015712 A8 BR 112016015712A8
Authority
BR
Brazil
Prior art keywords
treatment
liver disease
metabolite
compound
formula
Prior art date
Application number
BR112016015712A
Other languages
English (en)
Portuguese (pt)
Other versions
BR112016015712A2 (pt
Inventor
Matsuda Kazuko
Original Assignee
Medicinova Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medicinova Inc filed Critical Medicinova Inc
Publication of BR112016015712A2 publication Critical patent/BR112016015712A2/pt
Publication of BR112016015712A8 publication Critical patent/BR112016015712A8/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00—Preparations for use in therapy

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines Containing Plant Substances (AREA)
BR112016015712A 2014-01-10 2015-01-07 método de tratamento de doenças hepáticas. BR112016015712A8 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US14/152,924 US8962687B2 (en) 2012-12-05 2014-01-10 Method of treating liver disorders
PCT/US2015/010479 WO2015105874A1 (en) 2014-01-10 2015-01-07 Method of treating liver disorders

Publications (2)

Publication Number Publication Date
BR112016015712A2 BR112016015712A2 (pt) 2017-08-08
BR112016015712A8 true BR112016015712A8 (pt) 2018-04-17

Family

ID=50826043

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112016015712A BR112016015712A8 (pt) 2014-01-10 2015-01-07 método de tratamento de doenças hepáticas.

Country Status (10)

Country Link
US (2) US8962687B2 (https=)
EP (1) EP3091972B1 (https=)
JP (2) JP2017502056A (https=)
KR (1) KR102352729B1 (https=)
CN (1) CN105934243A (https=)
BR (1) BR112016015712A8 (https=)
CA (1) CA2935933C (https=)
ES (1) ES2917982T3 (https=)
TW (1) TW201609081A (https=)
WO (1) WO2015105874A1 (https=)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6469727B2 (ja) * 2014-06-02 2019-02-13 メディシノバ・インコーポレイテッドＭｅｄｉｃｉＮｏｖａ， Ｉｎｃ． 線維症の抑制又は治療方法
WO2016085994A1 (en) * 2014-11-26 2016-06-02 Medicinova, Inc. Ibudilast and telmisartan for treating non-alcoholic fatty liver disease, non alcoholic steatohepatitis, and advanced non alcoholic steatohepatitis
KR102399254B1 (ko) 2016-09-28 2022-05-17 아이거 바이오파마슈티컬스 인코포레이티드 비-알코올성 지방간염의 치료를 위한 방법 및 약제학적 조성물
CN110099690B (zh) * 2017-11-30 2021-10-26 北京通复堂生物科技股份有限公司 适于非酒精性脂肪性肝病和/或非酒精性脂肪性肝炎和/或肝脂肪变性的治疗的复方制剂
CA3217719A1 (en) 2021-05-28 2022-12-01 Kazuko Matsuda Phenoxyalkylcarboxylic acid derivatives and their use in lowering triglyceride levels

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2585246A1 (fr) 1985-07-26 1987-01-30 Cortial Procede d'obtention de formes pharmaceutiques solides a liberation prolongee
US4788055A (en) 1985-12-09 1988-11-29 Ciba-Geigy Corporation Resinate sustained release dextromethorphan composition
GB8613688D0 (en) 1986-06-05 1986-07-09 Euro Celtique Sa Pharmaceutical composition
GB8613689D0 (en) 1986-06-05 1986-07-09 Euro Celtique Sa Pharmaceutical composition
US4816264A (en) 1986-06-06 1989-03-28 Warner-Lambert Company Sustained release formulations
FI76778C (fi) 1986-09-22 1988-12-12 Kyro Oy Foerfarande och anordning foer transport av glasskivor under upphettning och haerdning.
US4985585A (en) 1988-03-07 1991-01-15 Kyorin Pharmaceutical Co., Ltd. Phenoxyalkylcarboxylic acid derivatives and process for their preparations
US4996047A (en) 1988-11-02 1991-02-26 Richardson-Vicks, Inc. Sustained release drug-resin complexes
CA2002492A1 (en) 1988-11-11 1990-05-11 Sandra T. A. Malkowska Pharmaceutical ion exchange resin composition
US5133974A (en) 1989-05-05 1992-07-28 Kv Pharmaceutical Company Extended release pharmaceutical formulations
US5290812A (en) 1991-01-18 1994-03-01 Kyorin Pharmaceutical Co., Ltd. Phenoxyalkylcarboxylic acid derivatives and process of preparing the same
US7060854B2 (en) 2003-06-24 2006-06-13 Medicinova, Inc. Process for making polymorphic form A of 4-[6-acetyl-3-[3-(4-acetyl-3-hydroxy-2-propylphenylthio)propoxy]-2-propylphenoxy]butyric acid
US7064146B2 (en) 2003-06-24 2006-06-20 Medicinova, Inc. Pharmaceutical compositions of isolated orthorhombic crystalline 4-[6-acetyl-3-[3-(4-acetyl-3-hydroxy-2-propylphenylthio)propoxy]-2-propylphenoxy]butyric acid and methods of use
US8835499B2 (en) * 2011-12-08 2014-09-16 Medicinova, Inc. Method of treating non-alcoholic fatty liver disease and steatohepatitis

Also Published As

Publication number Publication date
EP3091972B1 (en) 2022-06-01
TW201609081A (zh) 2016-03-16
KR20160099716A (ko) 2016-08-22
KR102352729B1 (ko) 2022-01-18
US8962687B2 (en) 2015-02-24
JP2019218379A (ja) 2019-12-26
US20150209314A1 (en) 2015-07-30
CA2935933A1 (en) 2015-07-16
EP3091972A4 (en) 2017-08-23
ES2917982T3 (es) 2022-07-12
EP3091972A1 (en) 2016-11-16
CN105934243A (zh) 2016-09-07
CA2935933C (en) 2022-06-28
US20140155484A1 (en) 2014-06-05
WO2015105874A1 (en) 2015-07-16
BR112016015712A2 (pt) 2017-08-08
JP2017502056A (ja) 2017-01-19

Similar Documents

Publication Publication Date Title
IL282535A (en) Substituted 6-azabenzimidazole compounds as hpk1 inhibitors
DK3837263T3 (da) Nye heterocykliske forbindelser som monoacylglycerollipasehæmmere
DK3292116T3 (da) 3-aryl-4-amido-bicykliske [4,5,0]hydroxamsyrer som hdac-inhibitorer
WO2016011390A8 (en) Irak4 inhibiting agents
MX2017001980A (es) Derivado de quinolina muy puro y metodo para su produccion.
IL311677B1 (en) History of bicyclic heterocyclyls as IRAK4 inhibitors
NZ725165A (en) Analogues of 4h-pyrazolo[1,5-α]benzimidazole compound as parp inhibitors
UY36215A (es) Espirocicloheptanos como inhibidores de rock
PH12015502031A1 (en) Tetrahydropyrrolothiazine compounds
DK3447050T3 (da) Pyridin-2(1h)-on-quinolinderivater som mutant-isocitrat dehydrogenaseinhibitorer
EP3207708A4 (en) Methods of modifying search areas
EA201591634A1 (ru) Дигидропиридопиримидиновые соединения
WO2014031872A3 (en) Small molecule inhibitors for treating parasitic infections
DK3233843T3 (da) Isoxazol-hydraxamsyreforbindelser som LPXC-hæmmere
MX387796B (es) Compuestos de aminocarbonilcarbamato.
EA201791684A1 (ru) Селективные ингибиторы bace1
EA201690911A1 (ru) Соединения диметилбензойной кислоты
WO2015142903A3 (en) Method of controlling lactate production with piperdine-dione derivatives
EA201690894A1 (ru) Феноксиэтилы
EA201592183A1 (ru) Ингибиторы bace
EA201691670A1 (ru) Тетразолонзамещенные дигидропиридиноновые ингибиторы mgat2
BR112016015712A8 (pt) método de tratamento de doenças hepáticas.
LT3202766T (lt) Izoksazolo darinys, kaip mutuotos izocitrato dehidrogenazės 1 inhibitorius
MX2016010427A (es) Compuestos tetrahidropiridopirimidina novedoso o una sal del mismo.
DK3890828T3 (da) Heteroaromatiske forbindelser som vanin-hæmmere

Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]