BR112016013804A2 - imunoterapia de câncer distribuindo antígenos mhc de classe ii usando um replicon de vlp - Google Patents

imunoterapia de câncer distribuindo antígenos mhc de classe ii usando um replicon de vlp

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Publication number
BR112016013804A2
BR112016013804A2 BR112016013804A BR112016013804A BR112016013804A2 BR 112016013804 A2 BR112016013804 A2 BR 112016013804A2 BR 112016013804 A BR112016013804 A BR 112016013804A BR 112016013804 A BR112016013804 A BR 112016013804A BR 112016013804 A2 BR112016013804 A2 BR 112016013804A2
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BR
Brazil
Prior art keywords
vlp
replicon
antigens
delivering
mhc class
Prior art date
Application number
BR112016013804A
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English (en)
Inventor
K Chatterjee Deb
J Kaczmarczyk Stanislaw
Original Assignee
Us Health
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Publication date
Application filed by Us Health filed Critical Us Health
Publication of BR112016013804A2 publication Critical patent/BR112016013804A2/pt

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Abstract

a presente invenção refere-se a um método de prevenir ou tratar uma doença em um sujeito mamífero, compreendendo administrar para o sujeito que está em necessidade do mesmo, uma dosagem eficaz de uma composição farmacêutica compreendendo uma partícula tipo vírus(vlp) compreendendo: um replicon de alfavírus compreendendo um polinucleotídeo recombinante, em que o polinucleotídeo compreende uma sequência codificando ambas, subunidades de um antígeno de histocompatibilidade principal de ser humano de classe ii, uma proteína gag retroviral, e uma proteína fusogênica de envelope, em que o vlp não contém um gene de proteína estrutural alfavírus.
BR112016013804A 2013-12-16 2014-12-16 imunoterapia de câncer distribuindo antígenos mhc de classe ii usando um replicon de vlp BR112016013804A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361916394P 2013-12-16 2013-12-16
PCT/US2014/070552 WO2015095167A2 (en) 2013-12-16 2014-12-16 Cancer immunotherapy by delivering class ii mhc antigens using a vlp-replicon

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BR112016013804A2 true BR112016013804A2 (pt) 2017-10-10

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US (3) US20160312242A1 (pt)
EP (3) EP3659620B1 (pt)
JP (2) JP6861516B2 (pt)
KR (1) KR102467982B1 (pt)
CN (2) CN106232807A (pt)
AU (1) AU2014365777B2 (pt)
BR (1) BR112016013804A2 (pt)
CA (1) CA2934075C (pt)
ES (1) ES2899078T3 (pt)
MX (1) MX2016007726A (pt)
SG (2) SG11201604868YA (pt)
WO (1) WO2015095167A2 (pt)

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EP3663395A1 (en) 2012-03-26 2020-06-10 The United States of America, as Represented by The Secretary, Department of Health and Human Services Office of Technology Transfer Delivery of packaged rna to mammalian cells
KR102467982B1 (ko) * 2013-12-16 2022-11-16 더 유나이티드 스테이츠 오브 어메리카, 애즈 리프리젠티드 바이 더 세크러테리, 디파트먼트 오브 헬쓰 앤드 휴먼 서비씨즈 Vlp-레플리콘을 이용한 클래스 ii mhc 항원의 전달에 의한 암 면역요법
WO2022261355A1 (en) 2021-06-09 2022-12-15 Chimeron Bio Corporation Self-amplifying rna-based vlp vaccines
WO2022261343A1 (en) 2021-06-09 2022-12-15 Chimeron Bio Corporation Peptide vlp-based vaccines
CN117778432B (zh) * 2024-02-26 2024-05-28 苏州左旋星生物科技有限公司 自复制rna载体、其制备方法及应用

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