BR112016013020B1 - uso de quantidades sub-terapêuticas de fluralaner - Google Patents
uso de quantidades sub-terapêuticas de fluralaner Download PDFInfo
- Publication number
- BR112016013020B1 BR112016013020B1 BR112016013020-0A BR112016013020A BR112016013020B1 BR 112016013020 B1 BR112016013020 B1 BR 112016013020B1 BR 112016013020 A BR112016013020 A BR 112016013020A BR 112016013020 B1 BR112016013020 B1 BR 112016013020B1
- Authority
- BR
- Brazil
- Prior art keywords
- flea
- fleas
- fluralaner
- animal
- spp
- Prior art date
Links
- MLBZKOGAMRTSKP-UHFFFAOYSA-N fluralaner Chemical compound C1=C(C(=O)NCC(=O)NCC(F)(F)F)C(C)=CC(C=2CC(ON=2)(C=2C=C(Cl)C=C(Cl)C=2)C(F)(F)F)=C1 MLBZKOGAMRTSKP-UHFFFAOYSA-N 0.000 title claims description 41
- 229960004498 fluralaner Drugs 0.000 title description 38
- 241001465754 Metazoa Species 0.000 claims abstract description 44
- 238000007910 systemic administration Methods 0.000 claims abstract description 16
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- 238000000034 method Methods 0.000 abstract description 23
- 150000002547 isoxazolines Chemical class 0.000 abstract description 17
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- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 description 6
- WEQPBCSPRXFQQS-UHFFFAOYSA-N 4,5-dihydro-1,2-oxazole Chemical compound C1CC=NO1 WEQPBCSPRXFQQS-UHFFFAOYSA-N 0.000 description 5
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- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 description 3
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- FJBGLNSEMHYAPD-UHFFFAOYSA-N 5-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4h-1,2-oxazol-3-yl]-3-methyl-n-[2-oxo-2-(2,2,2-trifluoroethylamino)ethyl]thiophene-2-carboxamide Chemical compound S1C(C(=O)NCC(=O)NCC(F)(F)F)=C(C)C=C1C1=NOC(C(F)(F)F)(C=2C=C(Cl)C=C(Cl)C=2)C1 FJBGLNSEMHYAPD-UHFFFAOYSA-N 0.000 description 1
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- 101100495270 Caenorhabditis elegans cdc-26 gene Proteins 0.000 description 1
- 241000257161 Calliphoridae Species 0.000 description 1
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- 241001609899 Ceratophyllus gallinae Species 0.000 description 1
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- 241001480796 Haemaphysalis Species 0.000 description 1
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- 241001608644 Hippoboscidae Species 0.000 description 1
- 241000545744 Hirudinea Species 0.000 description 1
- 239000005907 Indoxacarb Substances 0.000 description 1
- 241000238889 Ixodidae Species 0.000 description 1
- 241001232872 Leptopsyllidae Species 0.000 description 1
- 241001113970 Linognathus Species 0.000 description 1
- 241000257162 Lucilia <blowfly> Species 0.000 description 1
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- 241000771994 Melophagus ovinus Species 0.000 description 1
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- 241000282339 Mustela Species 0.000 description 1
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- 201000008937 atopic dermatitis Diseases 0.000 description 1
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- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Chemical group BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 description 1
- 229910052794 bromium Inorganic materials 0.000 description 1
- 235000015111 chews Nutrition 0.000 description 1
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- 238000011156 evaluation Methods 0.000 description 1
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- 229940104536 fluralaner chewable tablet Drugs 0.000 description 1
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- 125000001188 haloalkyl group Chemical group 0.000 description 1
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- 239000007902 hard capsule Substances 0.000 description 1
- 230000012447 hatching Effects 0.000 description 1
- VBCVPMMZEGZULK-NRFANRHFSA-N indoxacarb Chemical compound C([C@@]1(OC2)C(=O)OC)C3=CC(Cl)=CC=C3C1=NN2C(=O)N(C(=O)OC)C1=CC=C(OC(F)(F)F)C=C1 VBCVPMMZEGZULK-NRFANRHFSA-N 0.000 description 1
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- 238000010255 intramuscular injection Methods 0.000 description 1
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- PWPJGUXAGUPAHP-UHFFFAOYSA-N lufenuron Chemical compound C1=C(Cl)C(OC(F)(F)C(C(F)(F)F)F)=CC(Cl)=C1NC(=O)NC(=O)C1=C(F)C=CC=C1F PWPJGUXAGUPAHP-UHFFFAOYSA-N 0.000 description 1
- 229960000521 lufenuron Drugs 0.000 description 1
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- 125000004184 methoxymethyl group Chemical group [H]C([H])([H])OC([H])([H])* 0.000 description 1
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- 125000005767 propoxymethyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])[#8]C([H])([H])* 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/72—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms
- A01N43/80—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms five-membered rings with one nitrogen atom and either one oxygen atom or one sulfur atom in positions 1,2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/14—Ectoparasiticides, e.g. scabicides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
- C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
- C07D261/08—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Environmental Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Agronomy & Crop Science (AREA)
- Pest Control & Pesticides (AREA)
- Plant Pathology (AREA)
- Engineering & Computer Science (AREA)
- Dentistry (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Tropical Medicine & Parasitology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP13196539 | 2013-12-10 | ||
| EP13196539.4 | 2013-12-10 | ||
| PCT/EP2014/076959 WO2015086551A1 (en) | 2013-12-10 | 2014-12-09 | Antiparasitic use of isoxazoline compounds |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| BR112016013020A2 BR112016013020A2 (pt) | 2017-08-08 |
| BR112016013020B1 true BR112016013020B1 (pt) | 2020-12-01 |
Family
ID=49759099
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112016013020-0A BR112016013020B1 (pt) | 2013-12-10 | 2014-12-09 | uso de quantidades sub-terapêuticas de fluralaner |
Country Status (14)
| Country | Link |
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| CN (1) | CN105992517B (https=) |
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| PT (1) | PT3079474T (https=) |
| RU (1) | RU2673723C1 (https=) |
| WO (1) | WO2015086551A1 (https=) |
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| BR112017027855B1 (pt) * | 2015-06-23 | 2022-11-16 | Intervet International B.V. | Composição farmacêutica, seu uso, água potável medicamentosa e método para sua preparação |
| CN107535510A (zh) * | 2017-09-29 | 2018-01-05 | 北京科发伟业农药技术中心 | 一种含fluralaner的组合物 |
| US11648238B2 (en) | 2017-12-12 | 2023-05-16 | Intervet Inc. | Implantable isoxazoline pharmaceutical compositions and uses thereof |
| BR112022000982A2 (pt) | 2019-07-22 | 2022-03-08 | Intervet Int Bv | Forma de dosagem veterinária mastigável macia |
| EP4075981A1 (en) * | 2019-12-16 | 2022-10-26 | Intervet International B.V. | Composition for lice control |
| EP4077286A1 (en) | 2019-12-18 | 2022-10-26 | Elanco Tiergesundheit AG | Isoxazoline derivatives as pesticides |
| KR20230043904A (ko) | 2020-07-24 | 2023-03-31 | 엘랑코 유에스 인코포레이티드 | 이속사졸린 화합물 및 이의 중간체의 제조 공정 |
| CN116744917A (zh) | 2020-09-04 | 2023-09-12 | 礼蓝美国公司 | 适口调配物 |
| WO2022192623A1 (en) * | 2021-03-11 | 2022-09-15 | In The Bowl Animal Health, Inc. | Oral canine feed and methods for controlling flea infestations in a canine |
| CN117769356A (zh) * | 2021-06-25 | 2024-03-26 | 碗中动物健康公司 | 猫科动物口服饲料和在猫科动物中控制蜱侵袭的方法 |
| DK182016B1 (en) | 2023-03-13 | 2025-05-28 | Zoetis Services Llc | Degradation of isoxazolines in ozonated sea water |
Family Cites Families (16)
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| WO1984001100A1 (en) | 1982-09-17 | 1984-03-29 | Edward Ireland | Improved dental matrix band |
| CN1103544C (zh) * | 1996-08-02 | 2003-03-26 | 诺瓦提斯公司 | 陆栖哺乳动物用2,4－二烯酸型杀虫剂系统性给药的改进方法 |
| EP1119256B1 (en) * | 1998-10-09 | 2003-06-04 | Novartis AG | Oral combination of lufenuron and nitenpyram against fleas |
| US20070043011A1 (en) | 2003-09-30 | 2007-02-22 | Eitatsu Ikeda | Substituted benzanilide compound and noxious organism controlling agent |
| CN101768129B (zh) | 2004-03-05 | 2012-05-23 | 日产化学工业株式会社 | 异*唑啉取代苯甲酰胺化合物的制备中间体 |
| TWI412322B (zh) | 2005-12-30 | 2013-10-21 | Du Pont | 控制無脊椎害蟲之異唑啉 |
| WO2008108448A1 (ja) | 2007-03-07 | 2008-09-12 | Nissan Chemical Industries, Ltd. | イソキサゾリン置換ベンズアミド化合物及び有害生物防除剤 |
| DE102007028871A1 (de) | 2007-06-22 | 2008-12-24 | Clariant International Limited | Verfahren zur Herstellung von reinem C.I. Pigment Orange 74 |
| TWI430995B (zh) | 2007-06-26 | 2014-03-21 | Du Pont | 萘異唑啉無脊椎有害動物控制劑 |
| KR101769728B1 (ko) | 2007-06-27 | 2017-08-18 | 이 아이 듀폰 디 네모아 앤드 캄파니 | 동물 해충 방제 방법 |
| TWI556741B (zh) | 2007-08-17 | 2016-11-11 | 英特威特國際股份有限公司 | 異唑啉組成物及其作為抗寄生蟲藥上的應用 |
| TWI411395B (zh) | 2007-12-24 | 2013-10-11 | Syngenta Participations Ag | 殺蟲化合物 |
| US8377942B2 (en) | 2008-12-18 | 2013-02-19 | Novartis Ag | Isoxazolines derivatives and their use as pesticide |
| HUE015568T4 (en) | 2008-12-19 | 2017-10-30 | Elanco Tiergesundheit Ag | Isoxazoline derivatives and their use as pesticides |
| EP3216448B8 (en) | 2012-02-06 | 2019-06-05 | Boehringer Ingelheim Animal Health USA Inc. | Parasiticidal oral veterinary compositions comprising systemically-acting active agents, methods and uses thereof |
| WO2013150055A1 (en) | 2012-04-04 | 2013-10-10 | Intervet International B.V. | Solid oral pharmaceutical compositions for isoxazoline compounds |
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2014
- 2014-12-09 US US15/101,430 patent/US9655884B2/en active Active
- 2014-12-09 ES ES14809838T patent/ES2742815T3/es active Active
- 2014-12-09 PL PL14809838T patent/PL3079474T3/pl unknown
- 2014-12-09 CN CN201480067168.2A patent/CN105992517B/zh active Active
- 2014-12-09 PT PT14809838T patent/PT3079474T/pt unknown
- 2014-12-09 HU HUE14809838A patent/HUE046067T2/hu unknown
- 2014-12-09 JP JP2016537438A patent/JP6530753B2/ja active Active
- 2014-12-09 CA CA2932790A patent/CA2932790C/en active Active
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- 2014-12-09 RU RU2016127304A patent/RU2673723C1/ru active
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Also Published As
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| WO2015086551A1 (en) | 2015-06-18 |
| DK3079474T3 (da) | 2019-09-16 |
| JP2016539960A (ja) | 2016-12-22 |
| EP3079474B1 (en) | 2019-07-03 |
| CA2932790A1 (en) | 2015-06-18 |
| RU2673723C1 (ru) | 2018-11-29 |
| ES2742815T3 (es) | 2020-02-17 |
| JP6530753B2 (ja) | 2019-06-12 |
| AU2014363695A1 (en) | 2016-06-09 |
| HUE046067T2 (hu) | 2020-02-28 |
| US20160303086A1 (en) | 2016-10-20 |
| CN105992517B (zh) | 2020-03-06 |
| CN105992517A (zh) | 2016-10-05 |
| US9655884B2 (en) | 2017-05-23 |
| AU2014363695B2 (en) | 2018-12-13 |
| PT3079474T (pt) | 2019-09-10 |
| EP3079474A1 (en) | 2016-10-19 |
| BR112016013020A2 (pt) | 2017-08-08 |
| PL3079474T3 (pl) | 2019-10-31 |
| CA2932790C (en) | 2021-10-12 |
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