CA2932790C - Antiparasitic use of isoxazoline compounds - Google Patents

Antiparasitic use of isoxazoline compounds Download PDF

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Publication number
CA2932790C
CA2932790C CA2932790A CA2932790A CA2932790C CA 2932790 C CA2932790 C CA 2932790C CA 2932790 A CA2932790 A CA 2932790A CA 2932790 A CA2932790 A CA 2932790A CA 2932790 C CA2932790 C CA 2932790C
Authority
CA
Canada
Prior art keywords
compound
fleas
flea
isoxazoline
fluralaner
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CA2932790A
Other languages
English (en)
French (fr)
Other versions
CA2932790A1 (en
Inventor
Heike Williams
Hartmut Zoller
Anja Regina Heckeroth
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Intervet International BV
Original Assignee
Intervet International BV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=49759099&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CA2932790(C) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Intervet International BV filed Critical Intervet International BV
Publication of CA2932790A1 publication Critical patent/CA2932790A1/en
Application granted granted Critical
Publication of CA2932790C publication Critical patent/CA2932790C/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/72Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms
    • A01N43/80Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms five-membered rings with one nitrogen atom and either one oxygen atom or one sulfur atom in positions 1,2
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42Oxazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0053Mouth and digestive tract, i.e. intraoral and peroral administration
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00Antiparasitic agents
    • A61P33/14Ectoparasiticides, e.g. scabicides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D261/00Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C07D261/06Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
    • C07D261/08Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Environmental Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Agronomy & Crop Science (AREA)
  • Pest Control & Pesticides (AREA)
  • Plant Pathology (AREA)
  • Engineering & Computer Science (AREA)
  • Dentistry (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
CA2932790A 2013-12-10 2014-12-09 Antiparasitic use of isoxazoline compounds Active CA2932790C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP13196539 2013-12-10
EP13196539.4 2013-12-10
PCT/EP2014/076959 WO2015086551A1 (en) 2013-12-10 2014-12-09 Antiparasitic use of isoxazoline compounds

Publications (2)

Publication Number Publication Date
CA2932790A1 CA2932790A1 (en) 2015-06-18
CA2932790C true CA2932790C (en) 2021-10-12

Family

ID=49759099

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2932790A Active CA2932790C (en) 2013-12-10 2014-12-09 Antiparasitic use of isoxazoline compounds

Country Status (14)

Country Link
US (1) US9655884B2 (https=)
EP (1) EP3079474B1 (https=)
JP (1) JP6530753B2 (https=)
CN (1) CN105992517B (https=)
AU (1) AU2014363695B2 (https=)
BR (1) BR112016013020B1 (https=)
CA (1) CA2932790C (https=)
DK (1) DK3079474T3 (https=)
ES (1) ES2742815T3 (https=)
HU (1) HUE046067T2 (https=)
PL (1) PL3079474T3 (https=)
PT (1) PT3079474T (https=)
RU (1) RU2673723C1 (https=)
WO (1) WO2015086551A1 (https=)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112017027855B1 (pt) * 2015-06-23 2022-11-16 Intervet International B.V. Composição farmacêutica, seu uso, água potável medicamentosa e método para sua preparação
CN107535510A (zh) * 2017-09-29 2018-01-05 北京科发伟业农药技术中心 一种含fluralaner的组合物
US11648238B2 (en) 2017-12-12 2023-05-16 Intervet Inc. Implantable isoxazoline pharmaceutical compositions and uses thereof
BR112022000982A2 (pt) 2019-07-22 2022-03-08 Intervet Int Bv Forma de dosagem veterinária mastigável macia
EP4075981A1 (en) * 2019-12-16 2022-10-26 Intervet International B.V. Composition for lice control
EP4077286A1 (en) 2019-12-18 2022-10-26 Elanco Tiergesundheit AG Isoxazoline derivatives as pesticides
KR20230043904A (ko) 2020-07-24 2023-03-31 엘랑코 유에스 인코포레이티드 이속사졸린 화합물 및 이의 중간체의 제조 공정
CN116744917A (zh) 2020-09-04 2023-09-12 礼蓝美国公司 适口调配物
WO2022192623A1 (en) * 2021-03-11 2022-09-15 In The Bowl Animal Health, Inc. Oral canine feed and methods for controlling flea infestations in a canine
CN117769356A (zh) * 2021-06-25 2024-03-26 碗中动物健康公司 猫科动物口服饲料和在猫科动物中控制蜱侵袭的方法
DK182016B1 (en) 2023-03-13 2025-05-28 Zoetis Services Llc Degradation of isoxazolines in ozonated sea water

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1984001100A1 (en) 1982-09-17 1984-03-29 Edward Ireland Improved dental matrix band
CN1103544C (zh) * 1996-08-02 2003-03-26 诺瓦提斯公司 陆栖哺乳动物用2,4-二烯酸型杀虫剂系统性给药的改进方法
EP1119256B1 (en) * 1998-10-09 2003-06-04 Novartis AG Oral combination of lufenuron and nitenpyram against fleas
US20070043011A1 (en) 2003-09-30 2007-02-22 Eitatsu Ikeda Substituted benzanilide compound and noxious organism controlling agent
CN101768129B (zh) 2004-03-05 2012-05-23 日产化学工业株式会社 异*唑啉取代苯甲酰胺化合物的制备中间体
TWI412322B (zh) 2005-12-30 2013-10-21 Du Pont 控制無脊椎害蟲之異唑啉
WO2008108448A1 (ja) 2007-03-07 2008-09-12 Nissan Chemical Industries, Ltd. イソキサゾリン置換ベンズアミド化合物及び有害生物防除剤
DE102007028871A1 (de) 2007-06-22 2008-12-24 Clariant International Limited Verfahren zur Herstellung von reinem C.I. Pigment Orange 74
TWI430995B (zh) 2007-06-26 2014-03-21 Du Pont 萘異唑啉無脊椎有害動物控制劑
KR101769728B1 (ko) 2007-06-27 2017-08-18 이 아이 듀폰 디 네모아 앤드 캄파니 동물 해충 방제 방법
TWI556741B (zh) 2007-08-17 2016-11-11 英特威特國際股份有限公司 異唑啉組成物及其作為抗寄生蟲藥上的應用
TWI411395B (zh) 2007-12-24 2013-10-11 Syngenta Participations Ag 殺蟲化合物
US8377942B2 (en) 2008-12-18 2013-02-19 Novartis Ag Isoxazolines derivatives and their use as pesticide
HUE015568T4 (en) 2008-12-19 2017-10-30 Elanco Tiergesundheit Ag Isoxazoline derivatives and their use as pesticides
EP3216448B8 (en) 2012-02-06 2019-06-05 Boehringer Ingelheim Animal Health USA Inc. Parasiticidal oral veterinary compositions comprising systemically-acting active agents, methods and uses thereof
WO2013150055A1 (en) 2012-04-04 2013-10-10 Intervet International B.V. Solid oral pharmaceutical compositions for isoxazoline compounds

Also Published As

Publication number Publication date
BR112016013020B1 (pt) 2020-12-01
WO2015086551A1 (en) 2015-06-18
DK3079474T3 (da) 2019-09-16
JP2016539960A (ja) 2016-12-22
EP3079474B1 (en) 2019-07-03
CA2932790A1 (en) 2015-06-18
RU2673723C1 (ru) 2018-11-29
ES2742815T3 (es) 2020-02-17
JP6530753B2 (ja) 2019-06-12
AU2014363695A1 (en) 2016-06-09
HUE046067T2 (hu) 2020-02-28
US20160303086A1 (en) 2016-10-20
CN105992517B (zh) 2020-03-06
CN105992517A (zh) 2016-10-05
US9655884B2 (en) 2017-05-23
AU2014363695B2 (en) 2018-12-13
PT3079474T (pt) 2019-09-10
EP3079474A1 (en) 2016-10-19
BR112016013020A2 (pt) 2017-08-08
PL3079474T3 (pl) 2019-10-31

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