BR112016008956A2 - Detecção de atividade de clivagem de uma enzima - Google Patents
Detecção de atividade de clivagem de uma enzimaInfo
- Publication number
- BR112016008956A2 BR112016008956A2 BR112016008956A BR112016008956A BR112016008956A2 BR 112016008956 A2 BR112016008956 A2 BR 112016008956A2 BR 112016008956 A BR112016008956 A BR 112016008956A BR 112016008956 A BR112016008956 A BR 112016008956A BR 112016008956 A2 BR112016008956 A2 BR 112016008956A2
- Authority
- BR
- Brazil
- Prior art keywords
- enzyme
- detection
- cleavage activity
- enzyme cleavage
- activity
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/573—Immunoassay; Biospecific binding assay; Materials therefor for enzymes or isoenzymes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/40—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against enzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
- C12Q1/37—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving peptidase or proteinase
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54366—Apparatus specially adapted for solid-phase testing
- G01N33/54386—Analytical elements
- G01N33/54387—Immunochromatographic test strips
- G01N33/54388—Immunochromatographic test strips based on lateral flow
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/914—Hydrolases (3)
- G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
- G01N2333/95—Proteinases, i.e. endopeptidases (3.4.21-3.4.99)
- G01N2333/964—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue
- G01N2333/96425—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals
- G01N2333/96427—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general
- G01N2333/9643—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general with EC number
- G01N2333/96486—Metalloendopeptidases (3.4.24)
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/12—Pulmonary diseases
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/12—Pulmonary diseases
- G01N2800/122—Chronic or obstructive airway disorders, e.g. asthma COPD
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/38—Pediatrics
- G01N2800/382—Cystic fibrosis
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Organic Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biotechnology (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Cell Biology (AREA)
- General Physics & Mathematics (AREA)
- Food Science & Technology (AREA)
- Pathology (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Enzymes And Modification Thereof (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB201318728A GB201318728D0 (en) | 2013-10-23 | 2013-10-23 | Detection of cleavage activity of an enzyme |
| PCT/GB2014/053171 WO2015059487A2 (en) | 2013-10-23 | 2014-10-23 | Detection of cleavage activity of an enzyme |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112016008956A2 true BR112016008956A2 (pt) | 2017-09-19 |
Family
ID=49727217
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112016008956A BR112016008956A2 (pt) | 2013-10-23 | 2014-10-23 | Detecção de atividade de clivagem de uma enzima |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US10866236B2 (https=) |
| EP (1) | EP3060915B1 (https=) |
| JP (1) | JP6496322B2 (https=) |
| CN (1) | CN105940304B (https=) |
| AU (1) | AU2014338709B2 (https=) |
| BR (1) | BR112016008956A2 (https=) |
| CA (1) | CA2928308C (https=) |
| GB (1) | GB201318728D0 (https=) |
| MX (1) | MX371379B (https=) |
| RU (1) | RU2016119422A (https=) |
| WO (1) | WO2015059487A2 (https=) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201605110D0 (en) | 2016-03-24 | 2016-05-11 | Mologic Ltd | Detecting sepsis |
| EP3440113A1 (en) * | 2016-04-08 | 2019-02-13 | Gilead Sciences, Inc. | Compositions and methods for treating cancer, inflammatory diseases and autoimmune diseases |
| US20190360019A1 (en) * | 2016-11-16 | 2019-11-28 | Universal Biosensors Pty Ltd | Cleavage event transduction methods and products |
| ES2931536T3 (es) * | 2017-08-31 | 2022-12-30 | Somaprobes Sl | Ensayo de flujo lateral para detectar la presencia de una célula de mamífero o bacterias específicas en una muestra biológica |
| CN111630162A (zh) * | 2017-10-04 | 2020-09-04 | 博德研究所 | 基于crispr效应系统的诊断 |
| US11732009B2 (en) * | 2018-06-08 | 2023-08-22 | Glympse Bio, Inc. | Activity sensor with tunable analyte |
| GB201812331D0 (en) * | 2018-07-27 | 2018-09-12 | Mologic Ltd | Bacterial vaginosis diagnostic |
| JP2022515728A (ja) * | 2018-12-20 | 2022-02-22 | 武田薬品工業株式会社 | 好中球エラスターゼの新規な活性ベースのプローブおよびその使用 |
| JP2023542867A (ja) | 2020-09-11 | 2023-10-12 | グリンプス バイオ， インコーポレイテッド | 疾患の検出／診断、病期分類、モニタリング及び処置のための生体外でのプロテアーゼ活性検出 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4795702A (en) | 1986-02-05 | 1989-01-03 | Immunogon Associates | Diagnostic method for gonorrhea by assay of IgA1 fragments |
| WO2003102544A2 (en) | 2002-05-31 | 2003-12-11 | Cognosci, Inc. | Assays for measuring matrix metalloproteinase activities |
| EP1452868A2 (en) * | 2003-02-27 | 2004-09-01 | Pepscan Systems B.V. | Method for selecting a candidate drug compound |
| WO2004099784A2 (en) | 2003-05-06 | 2004-11-18 | Anamar Medical Ab | Method for determining a tissue degradation process by detection of fibromodulin neoepitopes |
| GB0311961D0 (en) * | 2003-05-23 | 2003-06-25 | Health Prot Agency | Mass-based toxin assay and substrates therefor |
| US20050079566A1 (en) * | 2003-09-10 | 2005-04-14 | Caterer Nigel Robert | Analytical methods for determination of proteolytic cleavage at specific sites |
| ATE488766T1 (de) * | 2004-06-21 | 2010-12-15 | Progenra Inc | Diagnostik und screening-methode und kit in verbindung mit proteolytischer aktivität |
| EP1889919A4 (en) | 2005-05-20 | 2009-04-15 | Mitsubishi Kagaku Iatron Inc | PROCESS FOR ENZYMANALYSIS |
| GB2435511A (en) * | 2006-02-23 | 2007-08-29 | Mologic Ltd | Protease detection |
| GB2437311A (en) | 2006-04-07 | 2007-10-24 | Mologic Ltd | A protease detection product |
| US7897360B2 (en) * | 2006-12-15 | 2011-03-01 | Kimberly-Clark Worldwide, Inc. | Enzyme detection techniques |
| WO2012154272A1 (en) * | 2011-02-25 | 2012-11-15 | Wellstat Diagnostics, Llc | Assays for detecting enzymatic activity |
| WO2013116791A1 (en) | 2012-02-02 | 2013-08-08 | Mosaic Biosciences, Inc. | Biomaterials for delivery of blood extracts and methods of using same |
| GB201206976D0 (en) | 2012-04-20 | 2012-06-06 | Mologic Ltd | An enzyme detection device |
-
2013
- 2013-10-23 GB GB201318728A patent/GB201318728D0/en not_active Ceased
-
2014
- 2014-10-23 CN CN201480067890.6A patent/CN105940304B/zh active Active
- 2014-10-23 EP EP14790689.5A patent/EP3060915B1/en active Active
- 2014-10-23 MX MX2016005313A patent/MX371379B/es active IP Right Grant
- 2014-10-23 JP JP2016549647A patent/JP6496322B2/ja active Active
- 2014-10-23 AU AU2014338709A patent/AU2014338709B2/en active Active
- 2014-10-23 RU RU2016119422A patent/RU2016119422A/ru unknown
- 2014-10-23 US US15/031,600 patent/US10866236B2/en active Active
- 2014-10-23 WO PCT/GB2014/053171 patent/WO2015059487A2/en not_active Ceased
- 2014-10-23 BR BR112016008956A patent/BR112016008956A2/pt not_active Application Discontinuation
- 2014-10-23 CA CA2928308A patent/CA2928308C/en active Active
-
2020
- 2020-06-23 US US16/909,309 patent/US12320804B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| CA2928308C (en) | 2023-07-11 |
| RU2016119422A (ru) | 2017-11-28 |
| MX2016005313A (es) | 2017-03-01 |
| JP2016535282A (ja) | 2016-11-10 |
| GB201318728D0 (en) | 2013-12-04 |
| US20200378963A1 (en) | 2020-12-03 |
| US10866236B2 (en) | 2020-12-15 |
| CN105940304A (zh) | 2016-09-14 |
| EP3060915A2 (en) | 2016-08-31 |
| AU2014338709A1 (en) | 2016-06-02 |
| EP3060915B1 (en) | 2018-12-05 |
| CN105940304B (zh) | 2019-09-13 |
| US20160238596A1 (en) | 2016-08-18 |
| CA2928308A1 (en) | 2015-04-30 |
| WO2015059487A3 (en) | 2015-09-17 |
| MX371379B (es) | 2020-01-28 |
| WO2015059487A2 (en) | 2015-04-30 |
| AU2014338709B2 (en) | 2020-06-25 |
| US12320804B2 (en) | 2025-06-03 |
| JP6496322B2 (ja) | 2019-04-03 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| BR112016008956A2 (pt) | Detecção de atividade de clivagem de uma enzima | |
| BR112016010510A2 (pt) | método, arranjo e uso do mesmo | |
| BR112013025024A2 (pt) | sistema para análise química quantitativa de amostras, em particular no campo médico, com calibragem da resposta instrumental da instrumentação usada para detectar os dados quantitativos dos analitos presentes nas amostras analisadas e o método correspondente | |
| BR112014031509B8 (pt) | Método para a determinação simultânea in vitro em tempo real do curso da atividade da enzima proteolítica e da resistência do coágulo de fibrina, reômetro rotativo e uso de um reômetro rotativo | |
| BR112015009932A8 (pt) | métodos | |
| BR112014010718A2 (pt) | métodos e sistemas para detecção de analito em amostra | |
| BR112014011818A2 (pt) | método para realizar ensaios de quantificação | |
| MX366275B (es) | Metodos para detectar y medir la agregacion. | |
| BR112016029634A2 (pt) | kit, dispositivo e método para a detecção de câncer de fígado | |
| CO6680668A2 (es) | Ensayos biomarcadores para detectar o medir inhibición de actividad quinasa tor | |
| BR112017007163A2 (pt) | sistema e métodos para medição do teor de gás em fluidos de perfuração. | |
| BR112013021590A2 (pt) | detecção de capacitância em ensaio eletroquímico com resposta otimizada | |
| BR112015018434A2 (pt) | método, e, conjunto para medir uma vitamina d | |
| BR112015030246A2 (pt) | dispositivo, sistema, e método para medir a distância entre um primeiro dispositivo e um segundo dispositivo | |
| BR112013007156A2 (pt) | sistemas e métodos para estabilidade aperfeiçoada de sensores eletroquímicos | |
| BR112016007037A2 (pt) | método para detectar câncer pancreático, anticorpo monoclonal e kit | |
| IN2014DE01077A (https=) | ||
| BR112016002668A2 (pt) | métodos e kits para prognosticar o risco de ter uma doença ou evento cardiovasculares | |
| GB201206977D0 (en) | An enzyme detection device | |
| PE20141450A1 (es) | Ensayo de lisiloxidasa-homologo 2 y metodos de uso del mismo | |
| MX2016013462A (es) | Metodos y dispositivos para deteccion de resistencia a un inhibidor de enzima. | |
| BR112019006731A2 (pt) | sistema de análise para testagem de uma amostra | |
| BR112016002237A2 (pt) | método e sistema para determinação precisa da posição de cabos instrumentados | |
| BR112012021411A2 (pt) | mutações braf que conferem resistência a inibidores braf. | |
| BR112017004207A2 (pt) | dispositivo de teste e método para testar analito em amostra coletada |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B11A | Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing | ||
| B11Y | Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette] |