BR112016006182A8 - composição veterinária de longa duração, uso de uma isoxazolina espirocíclica para preparação da mesma, bem como processo para a preparação de uma microesfera - Google Patents

composição veterinária de longa duração, uso de uma isoxazolina espirocíclica para preparação da mesma, bem como processo para a preparação de uma microesfera Download PDF

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Publication number
BR112016006182A8
BR112016006182A8 BR112016006182A BR112016006182A BR112016006182A8 BR 112016006182 A8 BR112016006182 A8 BR 112016006182A8 BR 112016006182 A BR112016006182 A BR 112016006182A BR 112016006182 A BR112016006182 A BR 112016006182A BR 112016006182 A8 BR112016006182 A8 BR 112016006182A8
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BR
Brazil
Prior art keywords
preparing
long
microsphere
prepare
well
Prior art date
Application number
BR112016006182A
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English (en)
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BR112016006182A2 (pt
BR112016006182B1 (pt
Inventor
Luo Laibin
P Foster Todd
Original Assignee
Zoetis Services Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zoetis Services Llc filed Critical Zoetis Services Llc
Publication of BR112016006182A2 publication Critical patent/BR112016006182A2/pt
Publication of BR112016006182A8 publication Critical patent/BR112016006182A8/pt
Publication of BR112016006182B1 publication Critical patent/BR112016006182B1/pt

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A61K31/422—Oxazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/14—Ectoparasiticides, e.g. scabicides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Inorganic Chemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

a presente invenção descreve uma composição veterinária injetável de longa duração que compreende uma isoxazolina espirocí-clica, pelo menos um biopolímero, e opcionalmente, pelo menos um veículo, solvente ou excipiente veterinário aceitável, ou qualquer mistura dos mesmos. a invenção também inclui um método para o tratamento de um animal com uma infestação parasítica através da administração da composição de biopolímero ao animal que esteja necessitando da mesma, e um processo para a preparação da composição biopolimérica.
BR112016006182-9A 2013-09-30 2014-09-26 Composição veterinária de longa duração e seus usos BR112016006182B1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361884467P 2013-09-30 2013-09-30
US61/884,467 2013-09-30
PCT/US2014/057588 WO2015048371A1 (en) 2013-09-30 2014-09-26 Long-acting spiro-isoxazoline formulations

Publications (3)

Publication Number Publication Date
BR112016006182A2 BR112016006182A2 (pt) 2017-08-01
BR112016006182A8 true BR112016006182A8 (pt) 2020-02-18
BR112016006182B1 BR112016006182B1 (pt) 2023-01-10

Family

ID=51794952

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112016006182-9A BR112016006182B1 (pt) 2013-09-30 2014-09-26 Composição veterinária de longa duração e seus usos

Country Status (10)

Country Link
US (1) US10350196B2 (pt)
EP (1) EP3052080A1 (pt)
JP (1) JP6209272B2 (pt)
CN (1) CN105579029B (pt)
AU (1) AU2014324837B2 (pt)
BR (1) BR112016006182B1 (pt)
CA (1) CA2924537C (pt)
HK (1) HK1223270A1 (pt)
MX (1) MX2016004035A (pt)
WO (1) WO2015048371A1 (pt)

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HUE066811T2 (hu) 2013-12-20 2024-09-28 Intervet Int Bv Izoxazolin kompozíciók és azok felhasználása parazitafertõzések megelõzésében és kezelésében állatokban
KR102593069B1 (ko) * 2015-04-08 2023-10-23 뵈링거 잉겔하임 애니멀 헬스 유에스에이 인코포레이티드 이속사졸린 활성제를 포함하는 서방형 주사 제형, 이의 방법 및 용도
US20180169073A1 (en) 2015-06-23 2018-06-21 Intervet Inc. Isoxazoline solution containing vitamin e for use with sanitized drinking water
UY37137A (es) * 2016-02-24 2017-09-29 Merial Inc Compuestos antiparasitarios de isoxazolina, formulaciones inyectables de acción prolongada que los comprenden, métodos y usos de los mismos
WO2017201134A1 (en) * 2016-05-20 2017-11-23 Avista Pharma Solutions, Inc. Synthetic process and novel intermediates
US11331316B2 (en) 2016-10-12 2022-05-17 Intra-Cellular Therapies, Inc. Amorphous solid dispersions
RU2767410C2 (ru) 2017-03-24 2022-03-17 Интра-Селлулар Терапиз, Инк. Новые композиции и способы
NZ765172A (en) 2017-11-07 2024-05-31 Intervet Int Bv Process for preparing large size isoxazoline particles
EP3707128B1 (en) 2017-11-07 2023-12-20 Intervet International B.V. Injectable isoxazoline pharmaceutical compositions and their use against parasite infestation
BR112020011506A2 (pt) 2017-12-12 2020-11-17 Intervet International B.V. composições farmacêuticas de isoxazolina implantáveis e usos das mesmas
AR113997A1 (es) 2017-12-21 2020-07-08 Intervet Int Bv Composiciones antiparasitarias para unción dorsal continua
CN110787661A (zh) * 2018-08-01 2020-02-14 台鉅生技股份有限公司 聚合物-胶原蛋白复合膜及其制造方法
CN109053751A (zh) * 2018-08-30 2018-12-21 成都海博锐药业有限公司 具有螺环结构的fxr调节剂
CN112584837A (zh) 2018-08-31 2021-03-30 细胞内治疗公司 新方法
EP3843739A4 (en) 2018-08-31 2022-06-01 Intra-Cellular Therapies, Inc. NEW METHODS
KR20220004158A (ko) 2019-05-03 2022-01-11 인터벳 인터내셔널 비.브이. 주사가능한 제약 조성물 및 그의 용도
US20230310386A1 (en) * 2020-05-20 2023-10-05 Intervet Inc. Injectable pharmaceutical compositions and uses thereof

Family Cites Families (13)

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Publication number Priority date Publication date Assignee Title
BE744162A (fr) 1969-01-16 1970-06-15 Fuji Photo Film Co Ltd Procede d'encapsulage
JPS523342B2 (pt) 1972-01-26 1977-01-27
US4389330A (en) 1980-10-06 1983-06-21 Stolle Research And Development Corporation Microencapsulation process
JPS6098823A (ja) 1983-11-02 1985-06-01 株式会社東芝 電力変換装置
US6136838A (en) * 1998-03-19 2000-10-24 Merck & Co., Inc. Sulfurpentafluorophenylpyrazoles for controlling ectoparasitic infestations
US6726918B1 (en) 2000-07-05 2004-04-27 Oculex Pharmaceuticals, Inc. Methods for treating inflammation-mediated conditions of the eye
GB2386066A (en) 2002-02-28 2003-09-10 Norbrook Lab Ltd Long-acting parasiticidal composition with improved bioavailability comprising a salicylanilide, a further anti-parasitic compound & a polymeric species
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TW200846029A (en) * 2007-02-09 2008-12-01 Wyeth Corp High dose, long-acting ectoparasiticide for extended control
WO2012001083A2 (en) * 2010-06-29 2012-01-05 Ceva Sante Animale Sa Novel eprinomectin injectable compositions
BR112013023068B8 (pt) * 2011-03-10 2022-11-22 Zoetis Llc Derivados de isoxazolina espirocíclica, seu uso e seu processo de preparação, e composições veterinárias
BRPI1103229B1 (pt) * 2011-07-18 2020-10-06 Universidade Federal Do Rio De Janeiro Composições farmacêuticas microparticuladas contendo antiparasitários para terapia subcutânea prolongada, uso das ditas composições farmacêuticas para a produção de um medicamento e método de tratamento de parasitoses

Also Published As

Publication number Publication date
MX2016004035A (es) 2016-06-02
CN105579029A (zh) 2016-05-11
JP6209272B2 (ja) 2017-10-04
CA2924537A1 (en) 2015-04-02
AU2014324837A1 (en) 2016-03-17
US10350196B2 (en) 2019-07-16
AU2014324837B2 (en) 2019-01-17
WO2015048371A1 (en) 2015-04-02
BR112016006182A2 (pt) 2017-08-01
BR112016006182B1 (pt) 2023-01-10
EP3052080A1 (en) 2016-08-10
US20160235720A1 (en) 2016-08-18
CN105579029B (zh) 2019-03-05
JP2016536272A (ja) 2016-11-24
CA2924537C (en) 2018-01-16
HK1223270A1 (zh) 2017-07-28

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Legal Events

Date Code Title Description
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B25G Requested change of headquarter approved

Owner name: ZOETIS SERVICES LLC (US)

B07G Grant request does not fulfill article 229-c lpi (prior consent of anvisa) [chapter 7.7 patent gazette]

Free format text: NOTIFICACAO DE DEVOLUCAO DO PEDIDO POR NAO SE ENQUADRAR NO ART. 229-C DA LPI.

B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 26/09/2014, OBSERVADAS AS CONDICOES LEGAIS