BR112016004375A2 - método de produção de acilaminoácidos - Google Patents

método de produção de acilaminoácidos

Info

Publication number
BR112016004375A2
BR112016004375A2 BR112016004375A BR112016004375A BR112016004375A2 BR 112016004375 A2 BR112016004375 A2 BR 112016004375A2 BR 112016004375 A BR112016004375 A BR 112016004375A BR 112016004375 A BR112016004375 A BR 112016004375A BR 112016004375 A2 BR112016004375 A2 BR 112016004375A2
Authority
BR
Brazil
Prior art keywords
amino acid
acyltransferase
recombinant
production method
acid
Prior art date
Application number
BR112016004375A
Other languages
English (en)
Inventor
Wolter Jan
Corthals Jasmin
Grammann Katrin
Reinecke Liv
Olfert Maik
Potgrave Nicole
Schaffer Steffen
Haas Thomas
Original Assignee
Evonik Degussa Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Evonik Degussa Gmbh filed Critical Evonik Degussa Gmbh
Publication of BR112016004375A2 publication Critical patent/BR112016004375A2/pt

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1025—Acyltransferases (2.3)
    • C12N9/1029—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/93—Ligases (6)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/02—Amides, e.g. chloramphenicol or polyamides; Imides or polyimides; Urethanes, i.e. compounds comprising N-C=O structural element or polyurethanes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y203/00—Acyltransferases (2.3)
    • C12Y203/01—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
    • C12Y203/01065—Bile acid-CoA:amino acid N-acyltransferase (2.3.1.65)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y203/00—Acyltransferases (2.3)
    • C12Y203/01—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
    • C12Y203/01086—Fatty-acyl-CoA synthase (2.3.1.86)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

resumo da patente de invenção para: "método de produção de acilaminoácidos". a presente invenção refere-se a uma célula que expressa uma aminoácido n-aciltransferase, a qual é de preferência recombinante, e uma acil-coa sintetase, a qual é preferencialmente recombinante, tendo a célula uma capacidade de degradação de ácidos gordos reduzida, a um método de produção de acilaminoácidos que compreende a etapa de pôr em contato um aminoácido e um acil-coa na presença de uma aminoácido n-aciltransferase, a qual é de preferência isolada e/ou recombinante, em que a aminoácido n-aciltransferase é de preferência uma aminoácido n-aciltransferase humana, ou a cultura da célula e uma mistura reacional composta por uma aminoácido n-aciltransferase, a qual é de preferência isolada e/ou recombinante, uma acil-coa sintetase, a qual é de preferência isolada e/ou recombinante, um aminoácido e quer ácido gordo-coa ou um ácido gordo e uma acil-coa sintetase.
BR112016004375A 2013-08-27 2014-08-25 método de produção de acilaminoácidos BR112016004375A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP20130181841 EP2843043A1 (en) 2013-08-27 2013-08-27 A method for producing acyl amino acids
EP20140169650 EP2842542A1 (en) 2013-08-27 2014-05-23 A method for producing acyl amino acids
PCT/EP2014/067990 WO2015028423A1 (en) 2013-08-27 2014-08-25 A method for producing acyl amino acids

Publications (1)

Publication Number Publication Date
BR112016004375A2 true BR112016004375A2 (pt) 2017-10-17

Family

ID=49029032

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112016004375A BR112016004375A2 (pt) 2013-08-27 2014-08-25 método de produção de acilaminoácidos

Country Status (6)

Country Link
US (1) US20160272950A1 (pt)
EP (3) EP2843043A1 (pt)
JP (1) JP2016528904A (pt)
CN (1) CN105813625A (pt)
BR (1) BR112016004375A2 (pt)
WO (1) WO2015028423A1 (pt)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8647642B2 (en) 2008-09-18 2014-02-11 Aviex Technologies, Llc Live bacterial vaccines resistant to carbon dioxide (CO2), acidic PH and/or osmolarity for viral infection prophylaxis or treatment
EP2746400A1 (de) 2012-12-21 2014-06-25 Evonik Industries AG Herstellung von Aminen und Diaminen aus einer Carbonsäure oder Dicarbonsäure oder eines Monoesters davon
EP2759598A1 (de) 2013-01-24 2014-07-30 Evonik Industries AG Verfahren zur Herstellung von alpha, omega-Alkandiol
EP2944697A1 (en) 2014-05-13 2015-11-18 Evonik Degussa GmbH Method of producing nylon
ES2937642T3 (es) * 2014-06-11 2023-03-30 Univ Duke Composiciones y métodos para el control de flujo rápido y dinámico usando válvulas metabólicas sintéticas
EP3081639A1 (en) * 2015-04-14 2016-10-19 Evonik Degussa GmbH Acyl amino acid production
EP3091080A1 (en) * 2015-05-05 2016-11-09 Evonik Degussa GmbH Process for producing acyl amino acids employing lipases
US10626424B2 (en) * 2015-07-22 2020-04-21 Dupont Industrial Biosciences Usa, Llc High level production of long-chain dicarboxylic acids with microbes
WO2017102952A1 (en) 2015-12-17 2017-06-22 Evonik Degussa Gmbh A genetically modified acetogenic cell
MY187786A (en) 2016-07-27 2021-10-22 Evonik Operations Gmbh N-acetyl homoserine
US11129906B1 (en) 2016-12-07 2021-09-28 David Gordon Bermudes Chimeric protein toxins for expression by therapeutic bacteria
US11180535B1 (en) 2016-12-07 2021-11-23 David Gordon Bermudes Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria
JP6878607B2 (ja) 2017-02-21 2021-05-26 デューク ユニバーシティ ロバストな動的な代謝コントロールの為の組成物及び方法
WO2018157150A1 (en) * 2017-02-27 2018-08-30 Duke University In vivo protein n-acylation
EP3778912A4 (en) 2018-04-13 2022-01-26 Ajinomoto Co., Inc. PROCESS FOR PREPARING AN N-ACYL AMINO GROUP CONTAINING COMPOUND
US11203744B2 (en) 2018-06-21 2021-12-21 Duke University Compositions and methods for the production of pyruvic acid and related products using dynamic metabolic control
JPWO2021070942A1 (pt) 2019-10-10 2021-04-15
KR102207867B1 (ko) * 2020-01-21 2021-01-26 씨제이제일제당 주식회사 Nadp 의존적 글리세르알데하이드-3-포스페이트 디하이드로지나제를 포함하는 미생물을 이용하여 ｌ-아미노산을 생산하는 방법

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5141602B2 (pt) 1973-12-12 1976-11-11
GB8918709D0 (en) * 1989-08-16 1989-09-27 Unilever Plc Cosmetic composition
DE69225631T2 (de) * 1991-02-19 1998-12-17 Nat Food Research Inst Ministr Acylaminosäure-Verbindungen und Verfahren zu ihrer Herstellung
US5734070A (en) 1994-02-17 1998-03-31 Degussa Aktiengesellschaft Hardening of unsaturated fats, fatty acids or fatty acid esters
US7217856B2 (en) * 1999-01-14 2007-05-15 Martek Biosciences Corporation PUFA polyketide synthase systems and uses thereof
RU2212447C2 (ru) 2000-04-26 2003-09-20 Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" Штамм escherichia coli - продуцент аминокислоты (варианты) и способ получения аминокислот (варианты)
WO2008131002A2 (en) * 2007-04-16 2008-10-30 Modular Genetics, Inc. Generation of acyl amino acids
WO2010127318A2 (en) * 2009-05-01 2010-11-04 The Regents Of The University Of California Product of fatty acid esters from biomass polymers
EP2415451A1 (en) * 2010-08-05 2012-02-08 KPSS-Kao Professional Salon Services GmbH Cleansing composition
EP3222713A1 (en) * 2010-08-24 2017-09-27 North-West University Recombinant therapeutic glycine n-acyltransferase
KR20150040359A (ko) 2012-08-10 2015-04-14 오피엑스 바이오테크놀로지스, 인크. 지방산 및 지방산 유도된 산물의 생산을 위한 미생물 및 방법
US9970036B2 (en) * 2013-03-15 2018-05-15 Modular Genetics, Inc. Generation of acyl amino acids

Also Published As

Publication number Publication date
CN105813625A (zh) 2016-07-27
EP3038595B1 (en) 2019-08-14
EP3038595A1 (en) 2016-07-06
US20160272950A1 (en) 2016-09-22
EP2842542A1 (en) 2015-03-04
JP2016528904A (ja) 2016-09-23
EP2843043A1 (en) 2015-03-04
WO2015028423A1 (en) 2015-03-05

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B350 Update of information on the portal [chapter 15.35 patent gazette]